NeuroVI-based wave compensation system control for offshore wind turbines.

In deep-sea areas, the hoisting operation of offshore wind turbines is seriously affected by waves, and the secondary impact is prone to occur between the turbine and the pile foundation. To address this issue, this study proposes an integrated wave compensation system for offshore wind turbines based on a neuromorphic vision (NeuroVI) camera. The system employs a NeuroVI camera to achieve non-contact, high-precision, and low-latency displacement detection of hydraulic cylinders, overcoming the limitations of traditional magnetostrictive displacement sensors, which exhibit slow response and susceptibility to interference in harsh marine conditions.

Quassin exerts anti-neuroinflammatory and antidepressant effects through upregulation of A20-mediated modulation of microglia polarization.

Depression is strongly associated with microglia-mediated neuroinflammation, with various studies reporting that modulating the polarization state of microglia is an effective strategy to inhibit neuroinflammation. Quassin, a natural triterpenoid found in the bark of the Quassin amara, has been reported to possess several pharmacological activities. However, its anti-neuroinflammatory and antidepressant effects remain unknown.

Burden of Rheumatic Heart Disease in Chinese Children and Adolescents versus Adults: An Analysis from the "Global Burden of Disease" Study.

Introduction: Rheumatic heart disease (RHD) is a globally important public health issue. China, as a populous country, has daunting challenges posed by RHD-related morbidity and mortality in the public health system. Evaluating and comparing the differences in the RHD burden of children and adolescents versus adults in China not only helps optimize domestic prevention and control strategies but also provides a reference for regional practices in RHD control.

Genomic landscape of paired primary and peritoneal metastatic lesions in gastric cancer highlights evolutionary dynamics and mutational drivers.

Introduction: Peritoneal metastasis is a prevalent form of gastric cancer spread, often resulting in poor outcomes. Due to the lack of clinical recommendation for surgery, current omics studies are limited to analyzing suspending malignant cells in ascites using external controls, rather than examining peritoneal metastatic nodules alongside their paired primary tumors.

Objectives: This study aims to elucidate the genomic landscape of gastric cancer peritoneal metastasis and identify key genetic drivers by comparing peritoneal dissemination lesions and their corresponding primary samples.

Surrogate-assisted global and distributed local collaborative optimization algorithm for expensive constrained optimization problems.

This paper presents a surrogate-assisted global and distributed local collaborative optimization (SGDLCO) algorithm for expensive constrained optimization problems where two surrogate optimization phases are executed collaboratively at each generation. As the complexity of optimization problems and the cost of solutions increase in practical applications, how to efficiently solve expensive constrained optimization problems with limited computational resources has become an important area of research. Traditional optimization algorithms often struggle to balance the efficiency of global and local searches, especially when dealing with high-dimensional and complex constraint conditions.

Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway.

Megakaryopoiesis and platelet production is a complex process that is underpotential regulation at multiple stages. Many long non-coding RNAs (lncRNAs) are distributed in hematopoietic stem cells and platelets. lncRNAs may play important roles as key epigenetic regulators in megakaryocyte differentiation and proplatelet formation.

The disappearance of gastric metastasis and liver metastasis in non-small cell lung adenocarcinoma is due to osimertinib.

Purpose: Gastric metastasis of lung cancer is rare, and the cases of disappearance of gastric metastasis and liver metastasis caused by oxitinib treatment have not been reported.

Methods: A 47-year-old male patient with no history of diabetes, hypertension or smoking presented with chest discomfort after eating. At the time of consultation, the diagnosis of adenocarcinoma of the right lower lobe of the lung with liver and gastric metastasis was considered by pathological examination of biopsy of the fundus of the stomach near the cardia, pathological examination of CT-guided lung aspiration and pathological examination of liver occupancy aspiration, combined with immunohistochemical results.

The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.

In recent years, the role and mechanism of long non-coding RNA (LncRNA) in cardiovascular diseases have received increasing attention. The chemotherapy agent, doxorubicin (DOX), is one of the most effective drugs for various cancers, but its efficacy is limited by its cardiotoxicity. Therefore, further exploration is required for the molecular mechanism of DOX-induced cardiotoxicity.

Efficacy of anti-programmed cell death protein 1 monoclonal antibody combined with bevacizumab and/or Pseudomonas aeruginosa injection in transplanted tumor of mouse forestomach carcinoma cell gastric cancer in mice and its mechanism in regulating tumor immune microenvironment.

Tumor immunotherapy represented by programmed cell death protein 1 (PD-1) inhibitors is considered as the most promising cancer treatment method and has been widely used in the treatment of advanced gastric cancer (GC). However, the effective rate of PD-1 inhibitor monotherapy is low. In this study, we constructed a transplanted tumor model in GC mice by inoculating mouse forestomach carcinoma cell (MFC) GC cells into 615 mice.

Recyclable ferroferric oxide@titanium dioxide@molybdenum disulfide with enhanced enzyme-like activity under visible light for effectively inhibiting the growth of drug-resistant bacteria in sewage.

With the development of social industry and the increase in domestic sewage discharge, pathogenic bacterial contamination in water has become a serious health and environmental problem. It is important to design sewage treatment reagents with effective pathogenic bacterial removal and recyclability. In this work, we developed a nanocomposite, FeO@TiO@MoS, with once-for-all effects of photocatalytic, magnetic, and peroxidase-like activities for solving the above-mentioned problems.

NeuroVI-based new datasets and space attention network for the recognition and falling detection of delivery packages.

With the popularity of online-shopping, more and more delivery packages have led to stacking at sorting centers. Robotic detection can improve sorting efficiency. Standard datasets in computer vision are crucial for visual detection.

Photothermal Regulated Nanozyme of CuFeS Nanoparticles for Efficiently Promoting Wound Healing Infected by Multidrug Resistant Bacteria.

Peroxidase-mediated chemokinetic therapy (CDT) can effectively resist bacteria; however, factors such as the high dosage of drugs seriously limit the antibacterial effect. Herein, CuFeS nanoparticles (NPs) nanozyme antibacterial system with the photothermal effect and peroxidase-like catalytic activity are proposed as a combined antibacterial agent with biosafety, high-efficiency, and broad-spectrum antibacterial ability. In addition, the as-obtained CuFeS NPs with a low doses of Cu and Fe can change the permeability of bacterial cell membranes and break the antioxidant balance by consuming intracellular glutathione (GSH), which results in more conducive ROS production.

Visible-Light-Driven Photocatalysis-Enhanced Nanozyme of TiO Nanotubes@MoS Nanoflowers for Efficient Wound Healing Infected with Multidrug-Resistant Bacteria.

To enhance the catalytic activity of the nanozymes for efficient wound healing infected with multidrug-resistant bacteria, photo-based motivations have been suggested, but attention is mainly focused on the external stimulus of near-infrared light, while the inexhaustible visible one is promising but lack of study. Herein, an efficient visible light-stimulated peroxidase-like nanozyme system, TiO nanotubes coated with MoS nanoflowers (TiO NTs@MoS ), is discovered for efficient bacterial treatment. Based on the synergetic effects between the two components, the bandgap of the TiO NTs can be narrowed from 3.

To Love and to Kill: Accurate and Selective Colorimetry for Both Chloride and Mercury Ions Regulated by Electro-Synthesized Oxidase-like SnTe Nanobelts.

Herein, SnTe nanobelts (NBs) with efficient oxidase-mimetic activity were synthesized by the simple electrochemical exfoliation method. A specific inhibition effect of Cl on the enzymatic behavior of the pure SnTe NBs was discovered, which was accordingly used for establishing a highly feasible, sensitive, selective, and stable Cl colorimetric assay. The detection concentration range was 50 nM to 1 mM, and the lowest detection limit was 20 nM for Cl.

Establishment of anti-oxidation platform based on few-layer molybdenum disulfide nanosheet-coated titanium dioxide nanobelt nanocomposite.

The nanozyme-based antioxidant system could protect normal cells from oxidative stress due to their reactive oxygen species (ROS) scavenging activity and good chemical stability. However, its use is limited for practical in vivo applications due to the high cost and poor biocompatibility (low catalytic efficiency). Herein, MoS decorated on TiO nanobelts (MoS@TiO) was prepared for antioxidation applications.

Near-Infrared Regulated Nanozymatic/Photothermal/Photodynamic Triple-Therapy for Combating Multidrug-Resistant Bacterial Infections via Oxygen-Vacancy Molybdenum Trioxide Nanodots.

Bacterial infections have become a major danger to public health because of the appearance of the antibiotic resistance. The synergistic combination of multiple therapies should be more effective compared with the respective one alone, but has been rarely demonstrated in combating bacterial infections till now. Herein, oxygen-vacancy molybdenum trioxide nanodots (MoO NDs) are proposed as an efficient and safe bacteriostatic.

Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS-induced sepsis.

Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with coagulation disorders remains undetermined. The present study aimed to evaluate the effect of unfractionated heparin (UFH) and N-acetylheparin (NAH), which is a non-anticoagulant heparin derivative, on endothelial glycocalyx and coagulation function in a lipopolysaccharide (LPS)-induced sepsis rat model, and to compare the differences observed in coagulation function between UFH and NAH.

Phillyrin Relieves Lipopolysaccharide-Induced AKI by Protecting Against Glycocalyx Damage and Inhibiting Inflammatory Responses.

Damage to the integrity of heparin sulfate (HS) in the endothelial glycocalyx is an important factor of glomerular filtration barrier dysfunction, which is the basic pathological feature of acute kidney injury (AKI). AKI is a common clinical critical illness with few drugs options offering effective treatment. Phillyrin (Phil), the main pharmacological component of Forsythia suspensa, possesses a wide range of pharmacological activities.

Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis.

Noncoding RNAs (ncRNAs), such as microRNA (miRNA), long ncRNA (lncRNA), and circular RNA (circRNA), are regulators of important biological functions. Therefore, understanding their crosstalk and regulatory patterns can provide treatment for diseases. In this study, differentially expressed RNA transcripts were obtained by RNA sequencing in bleomycin-induced pulmonary fibrosis in mice.

Evaluating the biochemical changes of LPS-stimulated endothelial cells by synchrotron FTIR microspectroscopy at a single-cell level.

Endothelial damage is a major manifestation in many forms of heart and lung injuries induced by lipopolysaccharide (LPS), but the biochemical responses and activation mechanisms of endothelial cells have not been fully explicit. In this study, the biochemical changes to endothelial cells exposed to LPS were investigated by synchrotron FTIR microspectroscopy at a single-cell level. We found that the whole infrared spectrum of endothelial cells shifted after LPS treatment, indicating chemical component changes within cells.

Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis.

Circular RNAs (circRNAs) are becoming new therapeutic drug targets. However, their profiles under astilbin treatment have not been reported yet. In this study, we analysed the global reprogramming of circRNA transcriptome and a regulatory network of circRNAs with their targeted genes under astilbin treatment in pulmonary fibrosis.

Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability.

Acute respiratory distress syndrome (ARDS) is a severe acute disease that threatens human health, and few drugs that can effectively treat this disease are available. Fraxin, one of the main active ingredients of Cortex Fraxini, a Chinese herbal medicine, has presented various pharmacological and biological activities. However, the effects of fraxin on ARDS have yet to be reported.

Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.

In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis, a plant used in traditional Chinese medicine that exerts multiple pharmacological effects.