Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet's disease.

Behçet's disease (BD) is a life-threatening systemic vasculitis characterized by polymorphonuclear neutrophils (PMN) and macrophage activation. However, the interaction of PMN and macrophages remains elusive. To elucidate the potential dysregulation of BD PMN exosomes on macrophage activation, PMN exosomes from both BD patients and healthy controls are isolated, quantified and incubated with macrophages.

Whole-Workflow Robotic-Assisted Percutaneous Endoscopic Lumbar Discectomy via a Two-Step Access Method: Technical Report and Preliminary Results.

Purpose: The spinal surgery robot can provide precise preoperative or intraoperative surgical planning and guide the implementation of the surgical plan under real-time navigation monitoring. Researchers have recently begun exploring the use of robotic systems to assist in performing Percutaneous Endoscopic Lumbar Discectomy (PELD). However, prior studies have primarily focused on robotic-assisted transforaminal puncture.

Dynamic ubiquitination networks in liver cancer: decoding E3 ligases and deubiquitinases as gatekeepers of therapeutic resistance.

Patients with advanced hepatocellular carcinoma are treated using conventional therapeutic approaches and a variety of molecularly targeted drugs. Nevertheless, therapeutic resistance emerges because of the high heterogeneity of the malignancy, often restricting the effectiveness of these interventions. Therefore, therapeutic resistance represents a significant obstacle in managing liver cancer.

, a longer snouted psittacosaurid from the Lower Cretaceous Lujiatun Unit of Yixian Formation, China, with the synonymy of the unresolved genus revisited.

The taxonomic validity of some genera and species within Psittacosauridae has been disputed, including that of , which has been synonymized with previously. To assess the validity of the former genus and species and elucidate the taxonomy and diversity in Psittacosauridae, we describe a nearly complete psittacosaurid skull (ZMNH M12414) with the aid of computed-tomography techniques. The specimen comes from the Lujiatun Unit of the Lower Cretaceous Yixian Formation, Liaoning, northeastern China, which has also produced , , and .

The efficacy and safety of monoclonal anti-TNF antibodies in the treatment of vascular Behçet's syndrome: A systematic review and meta-analysis.

Objectives: This study is the first meta-analysis to evaluate the efficacy and safety of monoclonal anti-TNF antibodies in patients with vascular Behçet's syndrome (VBS).

Methods: A comprehensive literature search was conducted on PubMed, Embase, Cochrane Library, Medline Complete, and Web of Science. Pooled estimates of clinical response including complete response (CR) and partial response (PR), were calculated at 3, 6, and 12 months.

Artificial Intelligence-Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease.

The diagnosis of Behçet's disease (BD) predominantly relies on clinical symptoms, indicating an urgent for identifying potential biomarkers for early diagnosis and disease stratification. We employed an in-depth proteomics platform based on data-independent acquisition mass spectrometry (DIA-MS) and customizable antibody microarray technology, combined with machine learning methods. By analyzing the proteomic data in the training cohort, we trained an XGBoost machine learning model, and validated the model in an independent cohort.

Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021.

Background: Congenital birth defects (CBDs) significantly affect child mortality and disability worldwide, yet regional understandings of their burden and contributing factors remain poorly defined. This study examines global trends in prevalence, disability-adjusted life years (DALYs), and mortality related to CBDs and their 11 subtypes from 1990 to 2021.

Methods: Employing data from the Global Burden of Disease Study 2021, this cross-sectional analysis covers CBD prevalence, mortality, and DALYs among children aged 0-14 years.

2025 Chinese guideline for the imaging diagnosis and evaluation of Takayasu arteritis.

Background: Takayasu arteritis (TAK) presents as systemic vasculitis. Imaging is crucial for the diagnosis and evaluation of TAK, but the rational selection of imaging methods and interpretation of imaging results are major challenges in clinical practice, which can affect treatment decisions. This guideline aims to establish standardized protocols for selecting imaging modalities (as well as interpreting their findings) in TAK.

Feasibility and accuracy evaluation of novel 2D instant navigation system on spinal surgery - a preclinical study.

Background: Intraoperative navigation has significantly facilitated spinal surgery and enhanced surgical accuracy. Nevertheless, it is often encumbered by the need for expensive equipment, a complex workflow, and frequently exhibits inefficiencies. Leveraging permanent calibration technology, we have developed a novel two-dimensional fluoroscopic image navigation system with the aim of streamlining and expediting the navigation process.

Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) poses a significant therapeutic challenge, driving the need for novel treatment strategies. This study investigates the combination of photothermal therapy (PTT) and metalloimmunotherapy for HCC treatment using Co + diABZI@J-dICG nanoparticles. Indocyanine green (ICG), an FDA-approved near-infrared (NIR) dye, is dimerized into J-aggregates to enhance PTT by improving light absorption and photothermal efficiency.

KYNA Ameliorates Hepatic Ischemia-Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO-Dependent m6A Demethylation of LATS1.

Hepatic ischemia-reperfusion injury (HIRI) substantially influences the prognosis of liver transplant recipients. Although kynurenic acid (KYNA) has been associated with protective effects against ischemia-reperfusion injury in various organs, the precise mechanisms underlying its protective role in HIRI are not well elucidated. In this study, a 70% mouse HIRI model and an in vitro hypoxia/reoxygenation model were employed to examine the protective effects of KYNA on HIRI.

Decoding the role of nucleic acid binding protein 2 in lipid dysregulation and hepatocellular carcinoma progression through LKB1-mediated mitochondrial dysfunction.

Nucleic Acid Binding Protein 2 (NABP2), a crucial regulator in the single-stranded DNA-binding protein family, has been linked to the progression of hepatocellular carcinoma (HCC) and poor prognosis. However, the precise mechanisms by which NABP2 regulates HCC development, especially through metabolic pathways, remain unclear. In this study, we evaluated NABP2 expression in clinical HCC samples and analyzed its correlation with patient survival outcomes.

Dietary Fatty Acids and Bladder Cancer Risk: Insights from the PLCO Cancer Screening Trial.

This study aimed to evaluate the relationship between the consumption of different dietary fatty acids and the risk of bladder cancer. A quantitative analysis was conducted using data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, which included 101,731 participants. The Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for bladder cancer risk in relation to dietary fatty acid intake.

Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.

The aim of the study was to investigate the therapeutic potential of exosomes secreted by endothelial cells (EC-exos) on steroid-induced osteonecrosis of femoral head (SNFH). First, we successfully obtained EC-exos through differential centrifugation. Then, the effects of EC-exos on mouse embryo osteoblast precursor (MC3T3-E1) cells under high concentration of dexamethasone (Dex) were analysed , which included cell migration, viability, and apoptosis.

Encoding of pretrained large language models mirrors the genetic architectures of human psychological traits.

Recent advances in large language models (LLMs) have prompted a frenzy in utilizing them as universal translators for biomedical terms. However, the black box nature of LLMs has forced researchers to rely on artificially designed benchmarks without understanding what exactly LLMs encode. We demonstrate that pretrained LLMs can already explain up to 51% of the genetic correlation between items from a psychometrically-validated neuroticism questionnaire, without any fine-tuning.

Clinicopathological characteristics of severe aortic valve regurgitation caused by Behçet's syndrome.

Objectives: Aortic valve regurgitation (AR) caused by Behçet's syndrome (BS) has high mortality. Preoperative biologics reduced systemic inflammation, but their effect on lesion inflammation remains unclear.

Methods: Twenty-two BS patients with severe AR who underwent cardiac surgery with retained pathological specimens were included.

IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.

Autophagy is associated with chemoresistance, which is the leading cause of failure in chemotherapeutic treatments. Among the various aspects of autophagy, autophagic flux serves as a critical indicator for evaluating the dynamic processes involved.We report herein that the multifunctional protein HAX-1 promotes chemoresistance by effectively blocking the fusion of autophagosomes with lysosomes.

MultiOmics analysis of metabolic dysregulation and immune features in breast cancer.

Metabolic disorders and diminished immune response are hallmark characteristics of tumors. However, limited studies have comprehensively integrated metabolic and immunological factors to evaluate or predict the prognosis of cancer patients. In this study, we utilized 72 metabolic pathway gene sets from the MsigDB database to conduct GSVA, univariate regression, and prognostic analyses on 247 breast cancer samples sourced from the TCGA and GEO databases.

Trend of HIV/AIDS disease burden in China from 1990 to 2021: An age-period-cohort model analysis.

Background: Understanding the burden of HIV/AIDS in China over the last few decades is vital for creating effective control strategies.

Methods: This study systematically retrieved data from the Global Burden of Disease (GBD) study 2021, including information related to HIV/AIDS in China. It assessed the burden of HIV/AIDS using specific indicators and methods, such as incidence, mortality and disability-adjusted life-years (DALYs).

Developing a quantitative adulteration discrimination model for forest-grown Panax notoginseng using near-infrared spectroscopy with a dual-branch network.

The ecological cultivation of herbs is gaining popularity due to its superior quality and greater economic value, with increasing applications in functional foods. However, profit-driven motives have led to the mislabeling of conventionally grown herbs as ecologically cultivated. Species consistency presents new challenges in authenticity identification, especially in detecting adulteration.

Optimal timing of surgical treatment for Behcet's disease aortic or peripheral artery pseudoaneurysms.

Objective: The aim of this study was to assess the optimal thresholds of surgical intervention for Behcet's disease (BD) aortic or peripheral artery pseudoaneurysms.

Methods: This was a retrospective single-center study of 2138 patients with BD, including 96 patients with vascular BD (4.5%) with 151 pseudoaneurysms between January 2002 and December 2021.

Development and clinical validation of a novel platelet count-based nomogram for predicting microvascular invasion in HCC.

We aimed to develop a convenient nomogram to predict preoperative MVI in patients with hepatocellular carcinoma (HCC). Patients who underwent surgical resection due to HCC from June 2018 to June 2023 at the Third Affiliated Hospital of Sun Yat-sen University were retrospectively reviewed. Univariate and multivariable logistic linear regression analyses were used to investigate potential risk factors for MVI.

Oral administration of Folium Artemisiae Argyi-derived exosome-like nanovesicles can improve ulcerative colitis by regulating intestinal microorganisms.

Background: Ulcerative colitis (UC), an inflammatory disease characterized by intestinal barrier dysfunction, poses significant challenges because of the toxicity and adverse effects commonly associated with conventional therapies. Safer and more efficacious treatment strategies are needed.

Purpose: The purpose of this study was to treat UC with Folium Artemisiae Argyi exosome-like nanovesicles (FAELNs) and to explore its related mechanism to provide a safer and more effective means for the treatment of ulcerative colitis.