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| http://dx.doi.org/10.3350/cmh.2025.0264 | DOI Listing |
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Modulation of PRL-1 in Placental MSCs: A Novel Therapeutic Strategy for Hepatic Fibrosis: Editorial on "Modulation of PRL-1 within placental MSCs instigates the transition between EMT and MET subsequent to hepatic fibrosis".
Clin Mol Hepatol
March 2025
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis.
Clin Mol Hepatol
July 2025
Department of Biomedical Science, CHA University, Seongnam, Korea.
Background/aims: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in hepatic fibrogenesis and liver repair in chronic liver disease. Our research highlights the antifibrotic potential of placenta-derived mesenchymal stem cells (PD-MSCs) and the role of phosphatase of regenerating liver-1 (PRL-1) in promoting liver regeneration.
Methods: We evaluated the efficacy of PD-MSCs overexpressing PRL-1 (PD-MSCsPRL-1) in a bile duct ligationinduced rat injury model, focusing on their ability to regulate EMT.
Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model.
Mol Ther Nucleic Acids
March 2023
Department of Biomedical Science, CHA University, 689, Sampyeong-dong, Bundang-gu, Seongnam-si 13488, Republic of Korea.
Article Synopsis
- Mesenchymal stem cell (MSC) therapy can help treat chronic liver disease by improving mitochondrial anaerobic metabolism, which is crucial for liver function.
- A study created genetically modified bone marrow MSCs (BM-MSCs) that overexpress a protein called PRL-1 to assess their effects on rats with bile duct injury.
- The modified BM-MSCs showed better antioxidant abilities, increased mitochondrial respiration, and improved liver function, highlighting their potential as a therapy for liver damage.
Phosphatase of Regenerating Liver-1 (PRL-1)-Overexpressing Placenta-Derived Mesenchymal Stem Cells Enhance Antioxidant Effects via Peroxiredoxin 3 in TAA-Injured Rat Livers.
Antioxidants (Basel)
December 2022
Department of Bio Convergence Science, CHA University, Seongnam-si 13488, Republic of Korea.
Article Synopsis
- DNA damage repair is essential for cell survival and involves mechanisms linked to antioxidant enzymes like peroxiredoxins (Prxs) and catalase (CAT).
- Research showed that placenta-derived mesenchymal stem cells (PD-MSCs) overexpressing PRL-1 promote liver regeneration and have a significant impact on DNA repair mechanisms.
- In TAA-injured rat livers, PRL-1(+) cells led to reduced apoptosis, increased antioxidant markers, and decreased levels of DNA damage compared to the non-transplanted control group.
Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway.
Stem Cell Res Ther
March 2022
Department of Biomedical Science, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-si, Gyeonggi-Do, 13488, Republic of Korea.
Article Synopsis
- - The study investigates how placenta-derived mesenchymal stem cells (PD-MSCs) overexpressing phosphatase regenerating liver-1 (PRL-1) can improve ovarian function and vascular remodeling in a rat model of ovarian insufficiency.
- - After conducting a series of experiments where naive and PRL-1-overexpressed PD-MSCs were transplanted into ovariectomized rats, findings showed significant improvements in vascular structures and follicle development in the PRL-1 group compared to controls.
- - The results highlighted that PRL-1 not only enhanced blood vessel formation but also increased the expression of critical growth factors and genes that aid in vascular remodeling and ovarian tissue health.