Philological analysis of ancient Egyptian recipes supported by modern chemical profiling approaches.

Ethnopharmacological Relevance: Ancient Egyptian sickness categories are poorly described, making it a challenge to correlate use of materia medica with sickness experience. Nevertheless, many identified ingredients are reported to have therapeutic potential, often used to support Egyptological interpretations of categories. Crucially, these interpretations fail to consider the impact of ancient processing methods.

Acid-Modified Biochar Derived from Agricultural Waste for Efficiently Capturing Low-Concentration Nitrous Oxide (NO): Mechanisms and Environmental Implications.

Low-concentration NO (≤5%) emissions from agricultural fields and waste treatment facilities in China reach 7.333 × 10 t annually, making them a significant but inadequately controlled contributor to global warming. Agricultural wastes were selected as precursors to prepare biochar, including pecan shell (SH), poplar sawdust (JM), wheat straw (XM), and corn straw (YM), which were subsequently acid-modified with 0.

Influence of roof cutting depth on stability of gob side entry in thick coal seams with a bulky limestone roof.

For the gob-side entry retained by roof cutting, the roof pre-splitting depth is directly related to its stability, especially under the condition of fully mechanized mining in 4.5 m thick coal seam underneath 13.7 m thick limestone roof.

The intricate dance of RNA-binding proteins: unveiling the mechanisms behind male infertility.

Background: RNA-binding proteins (RBPs) are indispensable for transcriptional and post-transcriptional processes during spermatogenesis, orchestrating germ cell proliferation, differentiation, and maturation. Despite their established importance, the contributions of RBPs in male infertility remain underexplored. Recently, a seminal Science publication reported an RBP atlas of 1744 murine testicular RBPs, 22 loss-of-function variants, and 137 deleterious missense variants identified in 1046 infertile patients, providing unprecedented opportunities to investigate their molecular and clinical relevance.

Decoding the roles of CCL11 in human malignancies and clinical implications.

C-C motif chemokine ligand 11 (CCL11), alternatively designated as eotaxin-1, is a low molecular weight chemokine that plays a crucial role in the mediation of allergic inflammation and immune regulation. This is achieved through the recruitment of eosinophils, T helper 2 (Th2) cells, and basophils via its primary receptor, CC chemokine receptor 3 (CCR3). Recent studies have identified elevated levels of CCL11 in the serum of cancer patients, suggesting its potential involvement in tumor biology.

High-performance photodetector based on MoS/vertical graphene.

Graphene offers a broad spectral response as a photodetector sensing layer with its zero-bandgap structure. However, its atomic thickness restricts light absorption to merely about 2% in the visible spectrum. To address this, MoShas been integrated with graphene to form heterojunctions, thereby enhancing light absorption and facilitating efficient electron-hole pair separation.

Plasmonic Coupling-Engineered MXene/Au Nanocomposites for High-Performance Saturable Absorption in Ultrafast Fiber Lasers.

The pursuit of high-performance saturable absorbers (SAs) demands synergistic optimization of modulation depth, saturation intensity, and response speed─a challenge persisting in ultrafast photonics. While two-dimensional (2D) MXenes exhibit great potential as SA candidates, their intrinsic limitations, including weak surface plasmon resonance (SPR) and insufficient near-infrared nonlinear optical responses, hinder further practical laser applications. Herein, guided by the plasmonic coupling theory, we proposed a TiCT/Au nanoparticle (T/A) nanocomposite synthesized via a facile ultrasonic-assisted strategy.

Research note: Phosphoproteomic analysis of macrophage immunity stimulated by egg white glycopeptide.

Egg white glycopeptides (EWG) are dietary peptides with immune regulatory activities; however, the underlying immune regulation mechanisms of EWG-mediated have not been fully elucidated. Phosphorylation represents a crucial protein modification in immune cell signaling. In this study, phosphoproteomic technology was employed to investigate alterations in macrophage phosphoprotein profiles in response to EWG stimulation (EWG group) using lipopolysaccharide stimulation as a positive control (LPS group), and bioinformatics approaches were used to analyze the associated signaling pathways.

Eucalyptus grandis MYB-Like and RAN-Like Zinc Finger Proteins Display Dual Roles in Regulating Plant Immunity and Symbiosis Pathways.

Plant roots live in constant contact with diverse microbes in the soil. Plant fitness, therefore, relies on signaling pathways that mount an effective immune response against pathogens while fostering mutualistic symbioses. Plant pathways, and specifically immune genes that may act as "switches," discriminating between pathogenic or mutualistic fungi, remain largely unknown.

An insect β1-3-galactosyltransferase enables efficient synthesis of multi-sites T antigen glycoconjugates.

Tumor-associated carbohydrate antigens (TACAs), particularly the T antigen characterized by the Galβ1-3GalNAc structure, are commonly expressed in various human cancers. However, the in vitro enzymatic synthesis of the Galβ1-3GalNAc structure has remained a significant challenge. In this study, we report the characterization of a β1-3-galactosyltransferase, DmC1GalT1, derived from D.

Updated insights on memory disorder associated risk of medication: A real-world pharmacovigilance analysis.

Objective: This study aims to use the Food and Drug Administration Adverse Event Reporting System (FAERS) to identify medications linked to memory disorders and to offer updated insights into medication-induced memory disorders.

Methods: We analyzed adverse event (AE) reports related to memory disorders in the FAERS database from 2004 to 2023 and compiled a list of potential medications along with their associated AEs. The disproportionality analysis was employed to assess the potential associations between medications and memory disorder events.

Analysis of three cases of disseminated BCG infection in infants after BCG vaccination in Beijing, China.

We report and analyze three cases of disseminated BCG infection in infants after BCG vaccination that occurred between 2022 and 2024 in Chaoyang District, Beijing, which were the only three monitored during the clinical application we conducted. All the patients had primary immunodeficiency disease (PID). Two cases had defects in the JAK3 and TNFRSF13B genes; one case had multiple gene defects in CR2, IFNAR2, TLR2, and exon 13 of DOCK11.

Multiwavelength-Responsive Plasticity in a Bias-Free Perovskite Synaptic Device for Neuromorphic Vision.

Low-power and color-sensitive neuromorphic vision systems are critical to the next generation of intelligent devices. Here, we report a coral-inspired, lead-free synaptic device based on CsBiBr perovskite nanocrystals prepared by centrifugal casting into a porous thin film. The device exhibits wavelength-dependent plasticity under 405, 520, and 635 nm illumination without an external bias.

Hierarchical Flaky Spinel Structure with Al and Mn Co-Doping Towards Preferable Oxygen Evolution Performance.

As an efficient clean energy technology, water electrolysis for hydrogen production has its efficiency limited by the sluggish oxygen evolution reaction (OER) kinetics, which drives the demand for the development of high-performance anode OER catalysts. This work constructs bimetallic (Al, Mn) co-doped nanoporous spinel CoFeO (np-CFO) with a tunable structure and composition as an OER catalyst through a simple two-step dealloying strategy. The as-formed np-CFO (Al and Mn) features a hierarchical flaky configuration; that is, there are a large number of fine nanosheets attached to the surface of a regular micron-sized flake, which not only increases the number of active sites but also enhances mass transport efficiency.

Equal-intensity beam splitter fabricated by tandem dielectric beam splitters for passive laser speckle reduction.

An equal-intensity beam splitter that utilizes tandem dielectric beam splitters with specific splitting ratios and a high-reflectivity mirror for passive laser speckle reduction is presented. The beam splitter coatings of the dielectric beam splitters were designed using Essential Macleod software simulations; specifically, three laser sub-beams of equal optical intensities were generated. The optical path delay between laser sub-beams destroyed the temporal and spatial coherence of the laser.

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization.

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects represents a critical breakthrough for managing gout progression. Natural products with polypharmacological properties offer promising leads for drug discovery. In this study, β-carboline-1-propionic acid, a bioactive constituent of Eurycoma longifolia Jack, served as the starting point for drug design.

Convolutional neural network based on transfer learning for discriminating the fermentation degree of black tea.

Black tea is among the most widely consumed tea. The fermentation process is crucial for developing the flavor of black tea. Currently, many producers rely on personal experience to gauge fermentation, which can be inconsistent and subjective.

The interplay between perceived stress, academic control, achievement motivation, and procrastination among nursing graduate students: A network analysis.

Background: Procrastination is common among nursing graduate students and is linked to poor academic performance, student attrition, and various potential physical and mental health issues. In light of the global nursing shortage, understanding the factors that contribute to procrastination is essential for developing effective interventions to mitigate its impact.

Objectives: This study aimed to examine the associations between perceived stress, academic control, achievement motivation, and procrastination among nursing graduate students through network analysis.

GLP-1R as a potential link between diabetes and Alzheimer's disease.

There is growing interest in the relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the glucagon-like peptide-1 receptor (GLP-1R) may be an important link between these two diseases. The role of GLP-1R in DM is principally to regulate glycemic control by stimulating insulin secretion, inhibiting glucagon secretion, and improving insulin signaling, thereby reducing blood glucose levels. In AD, GLP-1R attenuates the pathological features of AD through mechanisms such as anti-inflammatory effects, the reduction in amyloid-beta (Aβ) deposition, the promotion of Aβ clearance, and improvements in insulin signaling.

Study on Strontium Isotope Characteristics in Plants: Providing Reference for Food Production Area Traceability.

Tracing agricultural products' origin via Sr/Sr is critical for food quality. This study identifies optimal proxy samples for baseline maps by analyzing Sr isotopes in three vegetation life-forms (perennial herbs, shrubs, trees) and their soils under diverse parent materials. The results indicate significant differences in Sr-isotopic composition between roots and soils, likely due to the heterogeneous geological origin of eolian soils.

Enhanced therapeutic efficacy of Lour. -butanol fractions in ulcerative colitis: a dual administration approach with comprehensive mucosal protection and anti-inflammatory effects.

This study systematically evaluated the intestinal mucosal protective effects of Lour. tuber's -butanol fraction (rich in condensed tannins) against DSS-induced colitis using dual intragastric and enema administration. Analytical approaches included Disease Activity Index (DAI), haematoxylin and eosin (HE) staining, Alcian blue-periodic acid Schiff (AB-PAS) staining, ELISA, immunohistochemistry, immunofluorescence, and Western blot.

Clinical Observational Study on HBV Reactivation After Direct-Acting Antiviral Therapy in HCV/HBV Coinfected Patients in Guizhou, China.

The objective of this study is to analyse the prevalence and clinical characteristics of HCV/HBV coinfection in Guizhou, and evaluate the rate of HBV reactivation during and after anti-HCV treatment in a real-world study. This retrospective study included 1652 patients with hepatitis C virus (HCV) infection who received direct-acting antiviral (DAA) therapy at the Guiyang Public Health Clinical Center between January 2018 and December 2022 Baseline, on-treatment and posttreatment data were collected, including HCV RNA, HCV genotypes, liver function, hepatitis B virus (HBV) markers (HBsAg, HBcAb) and HBV DNA levels. The HCV/HBV coinfection rate was analysed, and the risk of HBV reactivation and disease progression following DAA therapy was assessed.

KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion.

Gastric cancer is a significant global health concern due to its high morbidity and mortality. Gastric cancer-associated mesenchymal stem cells (GC-MSCs) significantly contribute to its progression, with circ_0024107 being notably elevated in these cells and essential for their tumor-promoting activities. However, the expression and function of this circRNA in gastric cancer cells as well as its upstream regulators remain unclear.

The efficacy of the three-port bimanual technique for direct perfluorocarbon liquid-silicone oil exchange in vitrectomy for the treatment of advanced proliferative vitreoretinopathy.

Purpose: To evaluate the therapeutic effect of three-port, bimanual technique for direct perfluorocarbon liquid (PFCL)-silicone oil (SO) exchange in avoiding retinal re-detachment and shortening the surgical duration in 23-gauge (23 G) pars plana vitrectomy (PPV) for the treatment of advanced proliferative vitreoretinopathy (PVR) complicating primary rhegmatogenous retinal detachment (RRD).

Methods: A Retrospective, comparative, consecutive, single-center study was conducted. Fifty-one eyes of 51 patients diagnosed with RRD complicated by PVR at the severe C stage, according to the standardized grading system, were retrospectively reviewed over a 3-year period.