Vacancy Engineered Zero-Valent Iron Steer Hydrogen Spillover toward Per- and Polychlorinated Organics Rapid Complete Dechlorination.

The elevated toxicity and persistent bioaccumulative propensity of per- and polychlorinated organics (PCOs) pose a substantial environmental hazard; however, current dechlorination technologies encounter challenges in surmounting the cumulative reductive inertia inherent to PCOs, resulting in low dechlorination efficiency and the persistence of ecotoxicity. Here, a vacancy-engineered zero-valent iron (ZVI) is proposed to address this challenge. The surface-modified carbon vacancies can extract outward-flowing electrons from lattice copper-doped ZVI (CvCu-ZVI), which react with trapped protons to generate reactive hydrogen in situ that subsequently spills over onto ZVI.

Heat shock protein family H member 1 HSPH1 expression correlates with progression and prognosis of hepatocellular carcinoma.

Heat shock proteins (HSPs) are evolutionarily conserved molecular chaperones that maintain cellular proteostasis under physiological and stress conditions. HSPH1 (Heat Shock Protein Family H Member 1, also known as HSP105 or HSP110) belongs to the HSP110 family and functions as a nucleotide exchange factor for HSP70, enhancing its folding activity. Beyond its canonical role, HSPH1 is increasingly recognized for its involvement in tumor progression.

mRNA decapping enzyme2 DCP2 expression correlates with progression and prognosis of hepatocellular carcinoma.

mRNA decapping enzyme 2 (DCP2) is a key regulator of mRNA degradation, influencing RNA metabolism and gene expression. While implicated in various diseases, its role in Hepatocellular carcinoma (HCC) remains unclear. This study explores DCP2 as a potential biomarker for HCC through bioinformatics and experimental analyses.

Steroid hormone biosynthesis and dietary related metabolites associated with excessive daytime sleepiness.

Background: Excessive daytime sleepiness (EDS) is a complex sleep problem that affects approximately 33% of the United States population. Although EDS usually occurs in conjunction with insufficient sleep and other sleep and circadian disorders, recent studies have shown unique genetic markers and metabolic pathways underlying EDS. Here, we aimed to further elucidate the biological profile of EDS using large-scale single- and pathway-level metabolomics analyses.

Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.

Sleep irregularity, characterized by inconsistent sleep patterns from day to day, has become increasingly prevalent in today's 24/7 society. As a key component of multidimensional sleep health, the potential impact of sleep irregularity on cardiometabolic disease and mortality has recently received attention in research. In this review, we summarize the current evidence from epidemiological, clinical, and mechanistic studies to highlight the role of sleep irregularity in obesity, metabolic syndrome, diabetes, cardiovascular disease, and mortality.

Reconfigurable Integrated High-Speed Thermal Metamaterial Pixel Arrays.

Thermal signatures carry unique infrared appearances and spectral fingerprints of objects, but controlling them across spatial, temporal, and spectral domains remains challenging due to thermal emission's slow, diffuse, and broadband emitting nature. We demonstrate a reconfigurable ultrafast thermal metamaterial pixel array integrating active metasurfaces with dual-gate graphene transistors (Gr-FETs). Each pixel's Gr-FETs provide heater-switch dual functionalities: one as a broadband transparent microheater supporting arbitrary metasurface designs for multicolor, narrowband infrared emission with ultrafast modulation speed of minimum 187 kHz, and the other as an electrical switch enabling unified array control without compromising emission intensity.

Vocal Fatigue in Mandarin-Speaking Teachers: Characteristics of Phonation and Resonance.

Objective: To investigate phonatory and resonatory characteristics in Mandarin-speaking female teachers with vocal fatigue (VF).

Methods: A case-control study was conducted among teachers in Shanghai, China. Participants included 18 vocal-fatigued teachers (VF), 17 non-vocal-fatigued teachers (NVF), and 16 nonoccupational voice users (NOVU).

Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft.

Introduction: The limited regenerative capacity of the nervous system represents a significant clinical challenge in the context of peripheral nerve injuries. An innovative strategy for sciatic nerve repair has been developed using tissue-engineered nerve grafts (TENGs) composed of skin-derived precursor Schwann-like cells (SKP-SCs) and a silk fibroin-chitosan scaffold. However, the reason why SKP-SCs-TENG demonstrated superior enhanced nerve regeneration compared to the autograft and scaffold groups remains unclear.

Self-Limiting Partial Lithiation Induced by Interfacial Heavy Doping Boosts Li-Storage Performance in Holey Silicon Nanosheets.

Partial lithiation has emerged as a promising strategy to mitigate the volume expansion in silicon anodes. However, current implementations predominantly rely on externally imposed constraint approaches and inevitably sacrifice substantial capacity. Herein, an innovative self-limiting partial lithiation strategy driven by interfacial heavy doping is proposed.

Clinical utility of self-reported sleep duration and insomnia symptoms in type 2 diabetes prediction.

Aims/hypothesis: Suboptimal sleep health is linked to higher risks for incident type 2 diabetes. We aimed to assess the clinical utility of adding self-reported sleep traits to a type 2 diabetes prediction model.

Methods: In this cohort study, we used UK Biobank data and Cox proportional hazards models to examine how self-reported sleep duration and insomnia symptoms were associated with incident type 2 diabetes risk.

Inhibition of anti-apoptotic Bcl-2 family members promotes synergistic cell death with ER stress inducers by disrupting autophagy in glioblastoma.

Glioblastoma (GBM) remains one of the most aggressive and challenging brain tumors. Unfortunately, current clinical treatment options offer limited efficacy, highlighting the necessity for uncovering novel therapeutic strategies. Here, monotherapy and combination library screening were employed, and identified that the efficacy of obatoclax, a pan-Bcl-2 family inhibitor, was improved significantly when combined with ER-stress inducers, including tunicamycin.

Sleep Duration Irregularity and Risk for Incident Cardiovascular Disease in the UK Biobank.

Background: Emerging evidence supports a link between circadian disruption as measured by higher night-to-night variation in sleep duration and increased risk of cardiovascular disease (CVD). It remains unclear whether this association varies by CVD types or may be modified by average sleep duration and genetic risk for CVD.

Methods: Our prospective analysis included 86 219 UK Biobank participants who were free from CVD when completing 7 days of accelerometer measurement from 2013 to 2015.

Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank.

Background: The intricate interplay of various sleep characteristics may influence dementia risk through different pathogenic pathways. However, few studies have examined multi-dimensional sleep health in relation to dementia risk or explored potential etiologic heterogeneity by dementia subtypes.

Methods: Our study included 313,248 UK Biobank participants aged ≥ 50 years who were dementia-free in 2006-2010.

Plasma and ovarian metabolomic responses to chronic stress in female mice.

Introduction: Chronic stress has been linked with higher risk of ovarian cancer and one posited pathway is through altered metabolism of amino acids, lipids, and other small molecule metabolites. However, the types of alterations that occur may not be uniform across tissue types.

Objectives: We aim to examine and compare the impacts of chronic stress on metabolomic changes in circulation and ovarian tissue.

History of Breastfeeding in Relation to Circulating Inflammatory and Metabolic Biomarkers.

Background: Breastfeeding history has been associated with reduced risk of chronic diseases, although the underlying biological link is unclear.

Methods: The study included 16,165 parous women in the Nurses' Health Studies who reported lactation history and biomarkers measured using plasma samples collected at midlife. We calculated multivariable-adjusted geometric means of 10 inflammatory biomarkers [high-sensitivity C-reactive protein, IL6, IL8, IL10, insulin-like growth factor 1 (IGF1), soluble TNFα receptor 2, B cell-activating factor, C-X-C motif chemokine ligand 13, soluble IL2 receptor α, and soluble IL6 receptor-α] and eight metabolic biomarkers (triglyceride, total cholesterol, high- and low-density lipoprotein, leptin, soluble leptin receptor, adiponectin, and retinol-binding protein 4) by the self-reported history of breastfeeding prior to blood collection.

The Joint Association of Diet Quality and Sleep Regularity with Incident Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis.

Background/objectives: Diet quality and sleep regularity both influence cardiovascular disease (CVD) risk and may influence each other, but there is scarce evidence for their joint or interacting associations in relation to CVD. We assessed these associations in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: Participants free of CVD with valid diet and sleep measures in 2010-2013 were included and followed through 2020 for detection of incident CVD (188 events detected over 8.

Chronotype, Life's Essential 8, and risk of cardiovascular disease: a prospective cohort study in UK Biobank.

Introduction: Individuals with an evening chronotype often experience circadian misalignment, which may disrupt health behaviors and circadian regulation of cardiometabolic functions such as blood pressure. However, the associations of chronotype with modifiable cardiovascular disease (CVD) risk factors and incident CVD are not fully understood.

Methods: We conducted a prospective study in 322,777 UK Biobank participants aged 39-74 years who were free of known CVD (2006-2010).

Emotion Regulation and Favorable Cardiovascular Health Among Women.

Objective: Emerging evidence suggests maladaptive (e.g., suppression) versus adaptive (e.

Methylation risk score of C-reactive protein associates sleep health with related health outcomes.

C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos.

Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer.

Aims: To investigate the expression and clinical significance of heat shock protein H1 (HSPH1) in non-small cell lung cancer (NSCLC). To provide new and reliable biomarkers for the treatment of NSCLC.

Main Methods: Various public databases were used to analyse the molecular characteristics, disease relevance and expression differences of HSPH1 and to investigate the correlation between HSPH1 expression and prognosis in NSCLC patients.

Paeonol Improves Cardiac Remodelling in MI Mice by Suppressing NOX2 mRNA Expression to Mitigate Oxidative Stress and Mitochondrial Dysfunction.

Myocardial infarction (MI), a primary contributor to mortality from cardiovascular diseases, continues to pose a significant challenge in clinical treatment. In this study, our objective was to investigate the cardioprotective effects of paeonol (PAE) on mice with MI, and to delve into the precise mechanisms underlying these effects. We developed the MI model by ligating the left anterior descending artery in mice and replicated this model in vitro by stimulating H9C2 cells with levarterenol (LN).

cPDS Promotes Cell Apoptosis by Reducing the Translational Efficiency of BIRC3 mRNA in HCC.

Background: Hepatocellular carcinoma (HCC) is one of the primary liver tumors with high incidence and mortality. RNA G-quadruplexes (rG4) are nucleic acid structures involved in gene expression and genome duplication. rG4 exerts its function by interacting with rG4-binding proteins.

Association between accelerometer-measured irregular sleep duration and longitudinal changes in body mass index in older adults.

Background: Irregular sleep duration may disrupt circadian rhythms and contribute to metabolic, behavioral, and mood changes, potentially increasing the risk for obesity. However, quantitative data on the relationship between sleep duration irregularity and weight change are lacking.

Methods: In this prospective study, we analyzed data from 10,572 participants (mean age: 63 years) in the UK Biobank who wore accelerometers for a week between 2013 and 2015 and had two body mass index (BMI; kg/m²) measurements on average 2.

The basic-region/leucine-zipper-motif 53 improves cotton's salt tolerance by inhibiting tryptophan-arginine-lysine-tyrosine 68 expression and enhancing superoxide dismutase activity.

Basic-region/leucine-zipper-motif (bZIP) transcription factors are key players in modulating plant response to saline stress. However, whether and how GhbZIP53 regulates salt tolerance in cotton (Gossypium hirsutum) is an enigma. Here, GhbZIP53 expression was demonstrated to be activated by NaCl, and GhbZIP53 positively regulated salt resistance by enhancing superoxide dismutase (SOD) activity.