Effect of Preoperative Nutritional Status on Postoperative Clinical Outcomes of Patients with Metastatic Spinal Tumors: Japan Association of Spine Surgeons with Ambition Multicenter Study.

Study Design: A multicenter prospective study.

Objective: To evaluate the effect of preoperative nutritional status, assessed using the Prognostic Nutritional Index (PNI), on clinical outcomes, including survival prognosis, postoperative complications, hospitalization duration, and functional prognosis, in patients with metastatic spinal tumors undergoing surgery.

Summary Of Background Data: Malnutrition is common in patients with cancer and is associated with poor clinical outcomes.

Postoperative function of lower extremity muscles and walking ability after total en bloc spondylectomy for lumbar spinal tumors.

Background Context: Total en bloc spondylectomy (TES) for lumbar tumors significantly impacts lower extremity motor function because of surgical stress on the lumbar nerve roots and psoas muscles.

Purpose: The aim of this study was to assess the strength of the major lower extremity muscles and walking function following lumbar TES using prospectively collected data and identify functional differences based on the levels of the resected vertebrae.

Study Design/setting: Retrospective study with prospectively collected data PATIENT SAMPLE: Data were collected from 34 patients who underwent single-level TES for lumbar spinal tumors at our institution between January 2010 and December 2021.

Degenerative Changes in the Disc, Facet Joint, and Paraspinal Muscle After Adolescent Idiopathic Scoliosis Surgery: A Five-Year MRI-Based Follow-Up.

Background and objectives This study aimed to comprehensively assess degenerative changes in the intervertebral disc, facet joint, and paraspinal muscle after adolescent idiopathic scoliosis surgery and to evaluate clinical outcomes at a five-year follow-up using magnetic resonance imaging (MRI). We hypothesized that the pattern of degeneration would differ based on the distal level of fusion. Materials and methods We retrospectively reviewed patients with adolescent idiopathic scoliosis who underwent surgery between 2006 and 2015.

The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study.

The usefulness of spine stabilization for treating metastatic spinal tumors with tumor-induced instability has been reported. However, no reports have prospectively evaluated the effectiveness of adding posterior decompression to stabilization surgery for improving symptoms. This multicenter prospective study aimed to determine whether adding posterior decompression to spine stabilization surgery for metastatic spinal tumors affects postoperative outcomes and complications.

The Recovery of Neurological Function and Walking Ability After Total En Bloc Spondylectomy for Spinal Tumors.

Background and objective Total en bloc spondylectomy (TES) is an excision surgery for spinal tumors. TES is a procedure that requires tremendous skills, and hence it is associated with a potential risk of neurological complications. This study aimed to examine the incidence of postoperative neurological dysfunction and to evaluate the recovery of neurological outcomes and walking ability after TES.

Risk Factors for Early 3-Month Postoperative Mortality in Metastatic Spinal Tumor Surgery: A JASA Multicenter Prospective Study.

Study Design: Prospective multicenter study.

Objective: To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators.

Summary Of Background Data: Metastatic spinal tumors affect patient morbidity and mortality.

Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning.

Study Design: Retrospective analysis of data collected across multiple centers.

Objective: To develop machine learning models for predicting neurological outcomes one month postoperatively in patients with metastatic spinal tumors undergoing surgery, and to identify key factors influencing neurological recovery.

Summary Of Background Data: The increasing prevalence of spinal metastases has led to a growing need for surgical intervention to address mechanical instability and neurological deficits.

Intratumoral Flow Void Diameter as a Predictor of High Intraoperative Blood Loss in Palliative Excisional Surgery for Metastatic Spinal Tumors.

Massive intraoperative blood loss (IBL) is one of the major complications in metastatic spinal tumor surgery (MSTS), and understanding the predictors of this risk is essential. This study aimed to determine the impact of the intratumoral flow void (IFV) observed on standard magnetic resonance imaging (MRI) and its association with IBL in palliative surgery for metastatic spinal tumors. This retrospective analysis included 88 palliative excisional surgeries performed at a single hospital between 2010 and 2024.

Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient's Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study.

Study DesignProspective multicenter study.ObjectivesPalliative surgery is crucial for maintaining the quality of life (QOL) in patients with spinal metastases. This study aimed to compare the short-term outcomes of QOL after palliative surgery between patients with metastatic spinal tumors at different segments.

Relationship between Respiratory Function and the Strength of the Abdominal Trunk Muscles Including the Diaphragm in Middle-Aged and Older Adult Patients.

Respiration plays an important function in sustaining life. The diaphragm is the primary muscle involved in respiration, and plays an important role in trunk stabilization. Although it has been reported that respiratory function is important for trunk muscle stability, the correlation between respiratory function and abdominal trunk muscle strength remains undetermined.

Posterior Column Reconstruction of the Lumbar Spine Using En Bloc Resected Vertebral Arch in Spinal Tumor and Deformity Surgeries.

Introduction: In high-grade spinal osteotomy involving large anterior column resection, restoration of the structural integrity of the posterior column at the osteotomy site can reduce postoperative instrumentation failure (IF). This study aimed to describe our technique of posterior strut bone grafting using an en bloc resected vertebral arch, which is useful for posterior column reconstruction after high-grade osteotomies during surgeries for spinal tumor and deformity in the lower lumbar spine.

Technical Note: Using a posterior approach, en bloc resection of the targeted vertebral arch was performed in accordance with the surgical technique for total en bloc spondylectomy (TES).

Clinical Outcomes of Total En Bloc Spondylectomy for Previously Irradiated Spinal Metastases: A Retrospective Propensity Score-Matched Comparative Study.

This study aimed to investigate the clinical outcomes of total en bloc spondylectomy (TES) for spinal metastases previously treated with radiotherapy (RT). This study enrolled 142 patients who were divided into two groups: those with and those without an RT history. Forty-two patients were selected from each group through propensity score matching, and postoperative complications, local recurrence, and overall survival rates were compared.

The Impact of Frailty on Postoperative Complications in Total En Bloc Spondylectomy for Spinal Tumors.

Total en bloc spondylectomy (TES) is an effective treatment for spinal tumors. However, its complication rate is high, and the corresponding risk factors remain unclear. This study aimed to clarify the risk factors for postoperative complications after TES, including the patient's general condition, such as frailty and their levels of inflammatory biomarkers.

Metastasectomy of spinal lesions from thyroid carcinomas.

Patients with differentiated thyroid carcinomas (DTCs) have a favourable long-term survival. Spinal metastases (SMs) cause a decline in performance status (PS), directly affecting mortality and indirectly preventing the use of systemic therapies. Metastasectomy is indicated, if feasible, as it yields the best local tumour control.

Biomechanical investigation of long spinal fusion models using three-dimensional finite element analysis.

Background: This study represents the first finite element (FE) analysis of long-instrumented spinal fusion from the thoracic vertebrae to the pelvis in the context of adult spinal deformity (ASD) with osteoporosis. We aimed to evaluate the von Mises stress in long spinal instrumentation for models that differ in terms of spinal balance, fusion length, and implant type.

Methods: In this three-dimensional FE analysis, FE models were developed based on computed tomography images from a patient with osteoporosis.

Characteristics and risk factors of instrumentation failure following total en bloc spondylectomy.

Aims: The aim of this study was to investigate the incidence and characteristics of instrumentation failure (IF) after total en bloc spondylectomy (TES), and to analyze risk factors for IF.

Methods: The medical records from 136 patients (65 male, 71 female) with a mean age of 52.7 years (14 to 80) who underwent TES were retrospectively reviewed.

The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis.

Introduction: Amino acid transporters are transmembrane proteins that are known to mediate the transfer of amino acids. As one of the amino acid transporters, LAT1, which is encoded by Slc7a5, mediates the cellular uptake of the essential amino acids. Recently, most studies have focused on examining the relationship between LAT1 and skeletal formation in terms of development.

The influence of costal resection on pulmonary function after total en bloc spondylectomy for spine tumor.

Background: Total en bloc spondylectomy (TES) is one of the surgical procedures which has been recognized as a complete resection for spine tumors. Although the surgery achieves favorable local control for solitary spinal lesion, performing the procedure in the thoracic spine requires circumferential dissection around the vertebral body and bilateral rib resections which might result in decline of pulmonary function postoperatively. This study aimed to clarify whether the number of rib resections negatively impacts pulmonary function after the procedure.

Evaluation of locomotive syndrome in patients receiving surgical treatment for degenerative musculoskeletal diseases: A multicentre prospective study using the new criteria.

Objectives: This study aimed to evaluate the condition of patients with locomotive syndrome (LS) and their improvement after undergoing surgery for degenerative musculoskeletal diseases using the new criteria, including stage 3.

Methods: In total, 435 patients aged ≥40 years (167 middle-aged and 268 older) were divided into four groups based on the disease location: the lumbar (n = 118), hip (n = 191), knee (n = 80), and foot and ankle (n = 46) groups. Patients were evaluated by pre- and 1 year postoperative LS risk tests, including the stand-up test, two-step test, and 25-Question Geriatric Locomotive Function Scale.

Effects of Radiation on the Bone Strength of Spinal Vertebrae in Rats.

Study Design: A controlled laboratory study.

Objective: The aim of this study was to examine bone damage caused by irradiation to spinal vertebrae in rats.

Summary Of Background Data: Radiotherapy is widely used in the treatment of malignant spine tumors.