Efficacy of Chemonucleolysis With Condoliase Versus Minimally Invasive Discectomy for Lumbar Disc Herniation: A Propensity Score-Matched Retrospective Cohort Study.

Study DesignRetrospective cohort study.ObjectiveCondoliase is a chemonucleolysis for lumbar disc herniation (LDH) that enzymatically degrades herniated disc material with high specificity for chondroitin sulfate and hyaluronic acid. Few studies have compared condoliase treatment with surgical treatments.

Effect of Preoperative Nutritional Status on Postoperative Clinical Outcomes of Patients with Metastatic Spinal Tumors: Japan Association of Spine Surgeons with Ambition Multicenter Study.

Study Design: A multicenter prospective study.

Objective: To evaluate the effect of preoperative nutritional status, assessed using the Prognostic Nutritional Index (PNI), on clinical outcomes, including survival prognosis, postoperative complications, hospitalization duration, and functional prognosis, in patients with metastatic spinal tumors undergoing surgery.

Summary Of Background Data: Malnutrition is common in patients with cancer and is associated with poor clinical outcomes.

Cement leakage risk reduction and propensity score matching analysis of clinical efficacy for Cement-Augmented fenestrated pedicle screw in patients with osteoporosis.

Purpose: To identify risk factors for cement leakage (CL) in spinal fusion surgery using cement-augmented fenestrated pedicle screw (CAFPS). As a secondary objective, clinical outcomes were compared between CAFPS and conventional pedicle screw (CPS) in patients with osteoporosis.

Methods: We included 67 patients (272 screws) who underwent spinal fusion surgery with CAFPS and 104 patients with CPS.

Predicting osteoporosis-related complications in lumbar spine surgery using Hounsfield unit and vertebral bone quality scores: A 5-Year follow-up study with principal component analysis insights.

Objective: Osteoporosis is a well-known risk factor for incident vertebral fractures (VFs) and postoperative mechanical complications. However, the specific Hounsfield unit (HU) and vertebral bone quality (VBQ) cutoff values for predicting these complications, as well as the diagnostic and clinical significance of the differences between these two measurements, remain unclear. This study sought to evaluate the predictive value of HU and VBQ scores and to establish specific cutoff points for osteoporosis-related complications in lumbar spine surgery.

Deep learning algorithm for identifying osteopenia/osteoporosis using cervical radiography.

Due to symptomatic gait imbalance and a high incidence of falls, patients with cervical disease-including degenerative cervical myelopathy-have a significantly increased risk of fragility fractures. To prevent such fractures in patients with cervical disease, treating osteoporosis is an important strategy. This study aimed to validate the diagnostic yield of a deep learning algorithm for detecting osteopenia/osteoporosis using cervical radiography and compare its diagnostic accuracy with that of spine surgeons.

"Koshimagari Exercise" for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study.

Introduction: Adult spinal deformity (ASD) is prevalent among older adults, considerably affecting their quality of life. Although surgical interventions are effective, they have high complication rates and medical costs. Furthermore, there is a lack of evidence supporting the effectiveness of nonsurgical treatments (e.

Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study.

Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been widely employed to treat patients with lumbar disc herniation (LDH) in Japan. Although it is an effective and relatively safe treatment for radicular neuropathy in patients with LDH, there have been no reports that investigate how severe low back pain (LBP) changes after condoliase injection. In this multicenter study, the effectiveness of condoliase injection for reducing severe LBP in patients with LDH was evaluated.

Who benefits from home-based exercise for adult spinal deformity? A prospective multicenter study on clinical and radiographic predictors.

Purpose: The prevalence of adult spinal deformity (ASD) is expected to exceed 60 million by 2050 due to an aging population and increased life expectancy. Despite advances in surgery, high complication rates and the economic burden highlight the need for effective non-surgical treatments. This study assesses the "Koshimagari Exercise," a self-exercise program for ASD patients, and aims to develop a classification system to identify those who would benefit most.

Risk Factors for Early 3-Month Postoperative Mortality in Metastatic Spinal Tumor Surgery: A JASA Multicenter Prospective Study.

Study Design: Prospective multicenter study.

Objective: To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators.

Summary Of Background Data: Metastatic spinal tumors affect patient morbidity and mortality.

Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning.

Study Design: Retrospective analysis of data collected across multiple centers.

Objective: To develop machine learning models for predicting neurological outcomes one month postoperatively in patients with metastatic spinal tumors undergoing surgery, and to identify key factors influencing neurological recovery.

Summary Of Background Data: The increasing prevalence of spinal metastases has led to a growing need for surgical intervention to address mechanical instability and neurological deficits.

Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surgery: A 5-year Follow-up Study.

Introduction: The risk factors for the development of progressive segment degeneration (PSD) after decompression surgery are still unknown. In this study, the risk factors for PSD in patients who undergo decompression surgery for lumbar spinal stenosis with and without coexisting spondylolisthesis and scoliosis were examined, focusing on decompression and non-decompression segments.

Methods: We reviewed the data of patients with >5 years of postoperative follow up.

Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note.

Introduction: Sacral perineural cysts are rarely symptomatic; however, they may occasionally cause various symptoms. As the patient exhibits multiple cysts, it often becomes difficult to determine if these cysts are symptomatic.

Technical Note: Six patients with multiple sacral cysts, identified using magnetic resonance imaging (MRI), were further examined using myelography and computed tomography (CT) immediately and 6-18 h after myelography.

A deep learning-based prediction model for prognosis of cervical spine injury: a Japanese multicenter survey.

Purpose: Cervical spine injuries in the elderly (defined as individuals aged 65 years and older) are increasing, often resulting from falls and minor trauma. Prognosis varies widely, influenced by multiple factors. This study aimed to develop a deep-learning-based predictive model for post-injury outcomes.

Impact of Antiplatelet Medication Continuation on Surgical Outcomes after Minimally Invasive Posterior Lumbar Decompression Surgery: Retrospective Cohort Study.

Study DesignRetrospective cohort study.ObjectivesSpinal surgeons face a dilemma regarding the continuation or discontinuation of antiplatelet agents during the perioperative period. Guidelines recommend considering the balance between thrombotic and bleeding risks.

Open-Door Cervical Laminoplasty Using Instrumentation of Every Level Versus Alternate Levels: A Multicenter, Randomized Controlled Trial.

Background: In the setting of cervical open-door laminoplasty, the question of whether or not every opened laminar level should be instrumented has not been sufficiently investigated. We postulated that the surgical outcomes of open-door laminoplasty with instrumentation of every second opened level (skip-fixation) might not be inferior to those of laminoplasty with instrumentation of every opened level (all-fixation). The purpose of the present study was to test the noninferiority of laminoplasty with skip-fixation in improving myelopathy at 2 years postoperatively compared with all-fixation.

The Risk of Intravenous Cement Leakage and Short-term Outcomes of Selective Cement-augmented Pedicle Screws: A Multicenter Retrospective Study.

Study Design: Multicenter retrospective cohort study.

Objective: To evaluate the efficacy and safety of using cement-augmented pedicle screw (CAPS) fixation only for the cephalad and caudal vertebral bodies.

Summary Of Background Data: Pedicle screw fixation is less effective in patients with low-quality bone.

Effect of romosozumab administration on proximal junctional kyphosis in corrective spinal fusion surgery.

Background Context: The effect of romosozumab administration in patients undergoing corrective spinal fusion surgery has not yet been analyzed.

Purpose: To examine the effect of romosozumab administration on reducing the incidence of proximal junctional kyphosis (PJK), particularly PJK due to fractures (PJK-Fx), in patients undergoing spinal corrective fusion surgery.

Design: Retrospective cohort study.

Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis? A Multicenter Survey.

Introduction: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury.

Minimum Clinically Important Difference of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for Patients with Lumbar Spine Disease Undergoing Posterior Surgery by Generation.

Introduction: Few studies have assessed the minimum clinically important difference (MCID) of each Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) domain. This study assessed MCIDs of JOABPEQ in patients with lumbar spine disease by generation.

Methods: We evaluated the JOABPEQ score of 805 consecutive patients with lumbar spine disease undergoing posterior surgery preoperatively and 1 year postoperatively.

Does cessation of combustible cigarette and heated tobacco product smoking immediately following a fracture benefit fracture healing? In vivo and in vitro validation.

Combustible cigarette and heated tobacco products (HTPs), the two most frequently used tobacco products, negatively affect bone healing. However, whether smoking cessation following fracture benefits bone healing is unclear. Therefore, this study investigated the effect of smoking cessation immediately after surgery on reduced fracture healing induced by smoking.

Risk Factors for Residual Back Pain After Balloon Kyphoplasty for Osteoporotic Vertebral Fracture.

Background: Balloon kyphoplasty (BKP) is a method for the management of osteoporotic vertebral body fracture (OVF). However, improvement in back pain (BP) is poor in some patients, also previous reports have not elucidated the exact incidence and risk factors for residual BP after BKP. We clarified the characteristics of residual BP after BKP in patients with OVF.