Effect of Preoperative Nutritional Status on Postoperative Clinical Outcomes of Patients with Metastatic Spinal Tumors: Japan Association of Spine Surgeons with Ambition Multicenter Study.

Study Design: A multicenter prospective study.

Objective: To evaluate the effect of preoperative nutritional status, assessed using the Prognostic Nutritional Index (PNI), on clinical outcomes, including survival prognosis, postoperative complications, hospitalization duration, and functional prognosis, in patients with metastatic spinal tumors undergoing surgery.

Summary Of Background Data: Malnutrition is common in patients with cancer and is associated with poor clinical outcomes.

Postoperative function of lower extremity muscles and walking ability after total en bloc spondylectomy for lumbar spinal tumors.

Background Context: Total en bloc spondylectomy (TES) for lumbar tumors significantly impacts lower extremity motor function because of surgical stress on the lumbar nerve roots and psoas muscles.

Purpose: The aim of this study was to assess the strength of the major lower extremity muscles and walking function following lumbar TES using prospectively collected data and identify functional differences based on the levels of the resected vertebrae.

Study Design/setting: Retrospective study with prospectively collected data PATIENT SAMPLE: Data were collected from 34 patients who underwent single-level TES for lumbar spinal tumors at our institution between January 2010 and December 2021.

Effects of boysenberry on postprandial energy metabolism in healthy adults: A randomized controlled crossover trial.

Brown adipose tissue (BAT) is essential for thermoregulation and energy metabolism, converting fatty acids into thermal energy in response to cold exposure and dietary intake, thereby contributing to both cold-induced thermogenesis and diet-induced thermogenesis (DIT). Our previous research suggests that boysenberry anthocyanins (BoyACs) may activate BAT under cold conditions, and we hypothesized that BoyACs could also influence DIT through the activation of BAT. This pilot randomized, double-blind crossover trial aimed to evaluate the effects of daily intake of BoyACs on DIT in healthy adults (registration number: UMIN000047413).

Degenerative Changes in the Disc, Facet Joint, and Paraspinal Muscle After Adolescent Idiopathic Scoliosis Surgery: A Five-Year MRI-Based Follow-Up.

Background and objectives This study aimed to comprehensively assess degenerative changes in the intervertebral disc, facet joint, and paraspinal muscle after adolescent idiopathic scoliosis surgery and to evaluate clinical outcomes at a five-year follow-up using magnetic resonance imaging (MRI). We hypothesized that the pattern of degeneration would differ based on the distal level of fusion. Materials and methods We retrospectively reviewed patients with adolescent idiopathic scoliosis who underwent surgery between 2006 and 2015.

Machine Learning Based Semi-Automatic Iterative Annotation Method of Similar Laboratory Test Item Combination Between Multiple Facilities.

Data-driven research has emerged as a prominent trend in clinical studies particularly following discussions on the secondary use of clinical datasets. The construction of big data from multiple facilities using Electronic Health Records (EHRs) poses significant challenges. Creation and management of a common laboratory test master across multiple facilities impose a considerable burden in building such databases.

The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study.

The usefulness of spine stabilization for treating metastatic spinal tumors with tumor-induced instability has been reported. However, no reports have prospectively evaluated the effectiveness of adding posterior decompression to stabilization surgery for improving symptoms. This multicenter prospective study aimed to determine whether adding posterior decompression to spine stabilization surgery for metastatic spinal tumors affects postoperative outcomes and complications.

Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study.

Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer.

Nationwide analysis of spinal surgery in Japan from 1994 to 2021.

Purpose: In this study, we aimed to compare the latest 2021 survey data with findings from 1994, 2001, and 2011 to elucidate the trends and transformations in spinal surgery over the past quarter-century.

Methods: Data from the 2021 survey were compared with retrospective data from previous surveys. The 2021 survey collected data on patient demographics, surgical techniques, and perioperative complications of spinal surgeries performed in November 2021 from 739 facilities.

Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study.

Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been widely employed to treat patients with lumbar disc herniation (LDH) in Japan. Although it is an effective and relatively safe treatment for radicular neuropathy in patients with LDH, there have been no reports that investigate how severe low back pain (LBP) changes after condoliase injection. In this multicenter study, the effectiveness of condoliase injection for reducing severe LBP in patients with LDH was evaluated.

Japanese 2021 nationwide survey on complications from spine surgery.

Purpose: To provide an updated analysis of perioperative complications, patient demographics, and surgical techniques in spinal surgeries across Japan and examine their impact on risk management.

Methods: Data were collected prospectively from 739 of 1,106 registered facilities across Japan using the JSSR database. All spinal surgeries conducted in November 2021 were included, capturing complications within 1 month post-surgery.

Does Advanced Age Negatively Impact Treatment Outcomes of Cervical Ossification of the Posterior Longitudinal Ligament? A Prospective Multicenter Study.

Study Design: A multicenter prospective cohort study.

Objective: To comprehensively evaluate the surgical impact, including patient-reported outcomes (PROs), in elderly patients with cervical ossification of the posterior longitudinal ligament (OPLL).

Summary Of Background Data: With the rise of aging populations worldwide, understanding the impact of age on treatment outcomes for cervical OPLL has become increasingly important.

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole bipyridyl complex, which was converted to the corresponding stable Pt(IV) complex upon oxidation with iodobenzene dichloride. Oxidation of the platinum center did not result in the C-C bond formation between two pyrrole units via reductive elimination.

How did Johann Christian Reil feel the insular cortex? as a seat of mind.

Johann Christian Reil was the first to coin the term "psychiatry" in 1808, prior to that he had proposed (), which is interpreted as referring to the integrated information of all senses and emotions. On the other hand, in 1809, Reil formally described the insular cortex as and considered the insular cortex to serve as the pedestal of mental activity. The background to Reil's research had been the social, religious, cultural, and political context of social upheaval in Europe at the time, particularly in Germany and France, which had a major impact on the academic and medical systems he advocated.

Effect of surgery for ankle osteoarthritis on locomotive syndrome.

Locomotive syndrome (LS) is characterized by a decline in locomotor function due to musculoskeletal disorders. However, few studies have explored its association with ankle osteoarthritis (AOA) or surgical impact. This study evaluated LS and its improvement following corrective osteotomy (CO) or arthrodesis for AOA and compared outcomes between procedures.

The Recovery of Neurological Function and Walking Ability After Total En Bloc Spondylectomy for Spinal Tumors.

Background and objective Total en bloc spondylectomy (TES) is an excision surgery for spinal tumors. TES is a procedure that requires tremendous skills, and hence it is associated with a potential risk of neurological complications. This study aimed to examine the incidence of postoperative neurological dysfunction and to evaluate the recovery of neurological outcomes and walking ability after TES.

Risk Factors for Early 3-Month Postoperative Mortality in Metastatic Spinal Tumor Surgery: A JASA Multicenter Prospective Study.

Study Design: Prospective multicenter study.

Objective: To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators.

Summary Of Background Data: Metastatic spinal tumors affect patient morbidity and mortality.

Prevalence of diabetes mellitus and dialysis risk based on annual health checkup frequency among National Health Insurance citizens in Japan.

Background: In Japan, type 2 diabetes mellitus (T2DM) is a major health concern due to its increasing prevalence and associated complications, including diabetic nephropathy and dialysis. Although the positive relationship between annual health checkups and health outcomes is well-documented, the impact of skipping health checkups on T2DM and its progression to dialysis remains unclear. This study aimed to explore the association between the frequency of annual health checkups and DM-related indices and the potential impact of early intervention in preventing dialysis.

Impact of Signal Intensity Change in MRI on the Clinical Outcomes of Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study.

Study Design: A multicenter prospective cohort study.

Objective: To evaluate the clinical significance of intramedullary signal intensity (SI) changes on T2-weighted magnetic resonance imaging (MRI) in patients with cervical ossification of the posterior longitudinal ligament (OPLL) and assess their impact on surgical outcomes.

Summary Of Background Data: In OPLL, SI changes on MRI are frequently observed, but their prognostic significance remains unclear.

Spinal Cord Müllerian-Like Cyst at the T12 Vertebral Level: A Case Report and Literature Review.

Müllerian cysts are rare developmental anomalies, typically found in the pelvis, with extrapelvic occurrences reported but spinal cord involvement being exceedingly rare. We present the first reported case of a Müllerian-like cyst located on the surface of the spinal cord at the T12 vertebral level. A 49-year-old woman presented with low back and right leg pain, including electric shock-like sensations during sneezing.

Predicting Postoperative Neurological Outcomes in Metastatic Spinal Tumor Surgery Using Machine Learning.

Study Design: Retrospective analysis of data collected across multiple centers.

Objective: To develop machine learning models for predicting neurological outcomes one month postoperatively in patients with metastatic spinal tumors undergoing surgery, and to identify key factors influencing neurological recovery.

Summary Of Background Data: The increasing prevalence of spinal metastases has led to a growing need for surgical intervention to address mechanical instability and neurological deficits.

Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library.

LaeA is a putative nuclear methyltransferase protein that epigenetically influences secondary metabolite production in fungi. LaeA has drawn attention as one of the promising approaches to activate fungal chemical production, and the gene has been introduced into some fungal strains with the aim of producing secondary metabolic changes mainly based on the evaluation of mycotoxicity. However, these studies were applied for limited fungal species, and its utility and versatility for broad fungal species remained unclear.

Risk factors for residual neuropathic pain using specific screening tools in postoperative patients with ossification of the posterior longitudinal ligament of the cervical spine.

Purpose: Ageing, long illness duration, and poor preoperative Japanese Orthopaedic Association (JOA) score were reported to be risk factors for residual pain after cervical ossification of the posterior longitudinal ligament (cOPLL). In this study, we focused on residual neuropathic pain (NeP) and aimed to elucidate risk factors for residual NeP after cOPLL.

Methods: Total of 234 patients who underwent cOPLL surgery were included.

A deep learning-based prediction model for prognosis of cervical spine injury: a Japanese multicenter survey.

Purpose: Cervical spine injuries in the elderly (defined as individuals aged 65 years and older) are increasing, often resulting from falls and minor trauma. Prognosis varies widely, influenced by multiple factors. This study aimed to develop a deep-learning-based predictive model for post-injury outcomes.

Impurity profiling of synthetic cyclic peptides based on orthogonality between hydrophilic-interaction and reversed-phase liquid chromatography.

Owing to their high selectivity and low toxicity, synthetic cyclic peptides hold promise as bioactive therapeutics. The corresponding impurity analysis typically relies on reversed-phase high-performance liquid chromatography (RP-HPLC), which, however, often provides inaccurate results because of the abundance of chemically similar impurities. To bridge this gap, hydrophilic-interaction liquid chromatography (HILIC), a technique orthogonal to RP-HPLC, was herein used with an ultraviolet detector to analyze the impurities of four cyclic peptides.

Intratumoral Flow Void Diameter as a Predictor of High Intraoperative Blood Loss in Palliative Excisional Surgery for Metastatic Spinal Tumors.

Massive intraoperative blood loss (IBL) is one of the major complications in metastatic spinal tumor surgery (MSTS), and understanding the predictors of this risk is essential. This study aimed to determine the impact of the intratumoral flow void (IFV) observed on standard magnetic resonance imaging (MRI) and its association with IBL in palliative surgery for metastatic spinal tumors. This retrospective analysis included 88 palliative excisional surgeries performed at a single hospital between 2010 and 2024.