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Background and objective Total en bloc spondylectomy (TES) is an excision surgery for spinal tumors. TES is a procedure that requires tremendous skills, and hence it is associated with a potential risk of neurological complications. This study aimed to examine the incidence of postoperative neurological dysfunction and to evaluate the recovery of neurological outcomes and walking ability after TES. Methods We identified 71 patients who underwent TES for primary and metastatic spine tumors between 2010 and 2017. Perioperative neurological function and ambulation status were evaluated preoperatively, at one week, and one, three, and six months postoperatively. Results Postoperative neurological deficits were observed in 26 patients (37%). In patients with preoperative neurological deficits, an improved modified Frankel grade was observed up to six months (22/31, 71%). Six months after the surgery, the ambulation rate was significantly higher compared to that before surgery. All 14 of 40 patients (35%) with no neurological deficits preoperatively who had neurological deficits postoperatively recovered the neurological function and were able to walk at three months postoperatively. Conclusions Although some patients in our cohort showed postoperative neurological deterioration after TES, their neurological function and walking ability continued to improve over a prolonged period.
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http://dx.doi.org/10.7759/cureus.80675 | DOI Listing |
Elife
September 2025
Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine signaling from the gut to brain glial cells regulates sleep. Under healthy conditions, this pathway promotes wakefulness.
View Article and Find Full Text PDFPLoS One
September 2025
Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.
Stroke significantly contributes to long-term disability, one of the problems is with impaired balance control, increasing the risk of falls. The risk of falls may be mitigated using reactive balance training (RBT) which has been shown to effectively reduce fall risk by enhancing reactive stepping following repeated balance perturbations. However, the optimal RBT intensity for people with chronic stroke remains unknown.
View Article and Find Full Text PDFCereb Cortex
August 2025
Brain and Cognition, KU Leuven, Tiensestraat 102, 3000 Leuven, Belgium.
Centro-parietal electroencephalogram signals (centro-parietal positivity and error positivity) correlate with the reported level of confidence. According to recent computational work these signals reflect evidence which feeds into the computation of confidence, not directly confidence. To test this prediction, we causally manipulated prior beliefs to selectively affect confidence, while leaving objective task performance unaffected.
View Article and Find Full Text PDFRNA Biol
September 2025
Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Neural stem cells (NSCs) are multipotent stem cells with self-renewal capacity, able to differentiate into all neural lineages of the central nervous system, including neurons, oligodendrocytes, and astrocytes; thus, their proliferation and differentiation are essential for embryonic neurodevelopment and adult brain homoeostasis. Dysregulation in these processes is implicated in neurological disorders, highlighting the need to elucidate how NSCs proliferate and differentiate to clarify the mechanisms of neurogenesis and uncover potential therapeutic targets. MicroRNAs (miRNAs) are small, post-transcriptional regulators of gene expression involved in many aspects of nervous system development and function.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202.
Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC compartmentalization in both health and disease states.
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