Research Parameters in RBC Indices Shows Vital Importance in Screening α-Thalassemia.

Background: The percentage of microcytic cells (%MICRO) and the percentage of hypochromic cells (%HYPO) were very useful in differentiating microcytic anemia, and hematological parameters had significant potential as predictive markers of the degree of α-gene deletions. This study aims to evaluate the value of these research parameters in screening for α-thalassemia compared to classical indices.

Methods: We analyzed the data of 402 subjects with α-thalassemia deletions and 553 normal subjects and evaluated the performance of each parameter with receiver operating characteristic (ROC) curves, sensitivity, and specificity.

Association between the frequency of different modes of delivery and depression: a national cross-sectional study.

Background: Depression is a significant mental health concern among women. The objective of this study was to explore the relationship between reproductive factors such as parity and the frequency of different modes of delivery and depression.

Methods: The analysis was conducted based on the National Health and Nutrition Examination Survey (NHANES) 2005-2014, involving 5,401 non-pregnant women aged 20 years or older.

Economic burden due to hearing loss among individuals in Hebei, China.

Background: Hearing loss is a common sensory disorder that imposes a significant economic burden on both society and families. However, there is a paucity of research analyzing the economic burden of hearing loss, particularly in-depth regional analyses.

Methods: This study employed a convenience sampling method and a custom-designed questionnaire.

Characterization of the Pore Structure and Influencing Factors of CH Adsorption Capacity in Marine Shale Gas Reservoirs.

To enhance the understanding of the gas-bearing characteristics of marine shale gas reservoirs, shale samples from well ZG3, southern Sichuan Basin, China, were selected as the focus of this study. A series of analyses, namely total organic carbon (TOC) content, large-field stitching scanning electron microscope technology (LFS-SEM), X-ray diffraction (XRD), gas adsorption (CO+N), and CH adsorption experiment, were conducted to characterize the micropore structure of the shale comprehensively. Utilizing fractal theory, the study explored the relationships among the shale pore structure, organic pore content, heterogeneity, and CH adsorption capacity.

Assessment the carrier frequency of monogenic diseases in populations requiring assisted reproductive technology.

Purpose: The objective of this study is to assess the carrier frequency and pathogenic variation of monogenetic diseases in a population of 114 subjects in Han Chinese from Hebei province who are undergoing assisted reproductive technology through the utilization of Expanded Carrier Screening (ECS).

Methods: The study utilized a panel consisting of 155 severe monogenic recessive genetic diseases for ECS. Next-generation sequencing technology was employed to identify specific variants associated with ECS in a cohort of 114 subjects from 97 couples, comprising 97 females and 17 male spouses.

Association between depression and infertility based on the PHQ-9 score: Analyses of NHANES 2013-2018.

Background: Over the past decade, nationally representative research elucidating the association between depression and infertility has been notably lacking. Our study aimed to investigate the association between depression and infertility among women of childbearing age.

Methods: Our study encompassed 3,654 women aged 18 to 45 years from the National Health and Nutrition Examination Survey (NHANES) 2013-2018.

Facility for spectral radiance calibration at low light level.

The spectral radiance measurement at daytime level can be realized with high accuracy, while it's difficult when the spectral radiance is at nighttime level. We design a spectral radiance calibration facility which has the characteristics of completely unchanged spectrum over 3 orders of magnitude and approximately unchanged spectrum for about 6 orders of magnitude. It combines a spectral radiance light source, a precision aperture and a white diffuser together, make it easy to reproduce the spectral radiance at 380 nm from 4 × 10 W/(m·sr·nm) to 4 × 10 W/(m·sr·nm).

Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment.

NIK plays a crucial role in the noncanonical NF-κB signaling pathway associated with diverse inflammatory and autoimmune diseases. Our study presents compound , a novel NIK inhibitor, designed through a structure-based scaffold-hopping approach from the previously identified B022. Compound demonstrates remarkable selectivity and potency against NIK both in vitro and in vivo, effectively suppressing pro-inflammatory cytokines and nitric oxide production.

CHARGE syndrome with early fetal ear abnormalities: A case report.

Key Clinical Message: CHARGE syndrome is a rare genetic disorder characterized by several distinct features. The presence of fetal ear abnormalities could be the early indicator of CHARGE syndrome. Subsequent prenatal diagnosis is essential to confirm the disorder.

Association between cardiovascular health and abdominal aortic calcification: Analyses of NHANES 2013-2014.

Background: Abdominal aortic calcification (AAC) is closely connected to cardiovascular disease. We aimed to measure the association between cardiovascular health (CVH) levels, assessed by the Life's Essential 8 (LE8) score, and AAC within a nationally representative sample of the US.

Methods: The National Health and Nutrition Examination Survey 2013-2014 participants were chosen for this cross-sectional investigation.

Marginal zone lymphoma with severe rashes: A case report.

Background: Marginal zone lymphoma (MZL) is an indolent subtype of non-Hodgkin lymphoma (NHL), which is rare clinically with severe rashes as the initial symptom.

Case Summary: This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge. First-line treatment with rituximab combined with zanubrutinib had poor effects.

Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years.

Background: Although many studies have proven the harmful effects of smoking on human health, the associations between smoking status and infertility are limited in large epidemiologic studies. We aimed to investigate the associations between smoking status and infertility among child-bearing women in the United States of America (USA).

Methods: A total of 3,665 female participants (aged 18-45) from the National Health and Nutrition Examination Survey (NHANES) (2013-2018) were included in this analysis.

FRCNN-AA-CIF: An automatic detection model of colon polyps based on attention awareness and context information fusion.

It is noted that the foreground and background of the polyp images detected under colonoscopy are not highly differentiated, and the feature map extracted by common deep learning object detection models keep getting smaller as the number of networks increases. Therefore, these models tend to ignore the details in pictures, resulting in a high polyp missed detection rate. To reduce the missed detection rate, this paper proposes an automatic detection model of colon polyps based on attention awareness and context information fusion (FRCNN-AA-CIF) based on a two-stage object detection model Faster Region-Convolutional Neural Network (FR-CNN).

Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy.

A multifunctional undecapeptide, YYDPLGLADYY, was designed and synthesized for the photowrapping of silica-coated gold nanorods. The obtained nanocapsules, bearing a well-defined core-shell structure, were able to encapsulate a therapeutic drug, respond to an MMP-upregulated tumor microenvironment, and achieve NIR-triggered anticancer chemo-photothermal therapy with favorable efficacy.

A Novel Low Molecule Peptides-calcium Chelate from Silkworm Pupae Protein Hydrolysate: Preparation, Antioxidant Activity, and Bioavailability.

Background: The antioxidant properties of active peptides from silkworm pupae protein hydrolysate are of interest, and it serves as a novel source of calcium supplement.

Methods: Optimize the preparation parameters of silkworm pupae bioactive peptide-calcium chelate, and investigate the mechanism and bioavailability of silkworm pupae active peptide as a transport carrier to promote calcium ion absorption using simulated gastrointestinal digestion and Caco-2 monolayer cell model.

Results: The optimal process parameters for preparing peptide calcium chelate were the peptide calcium mass ratio of 3:1, pH of 6.

Adverse Event Profiles of PARP Inhibitors: Analysis of Spontaneous Reports Submitted to FAERS.

Several poly ADP ribose polymerase inhibitors (PARPis) are currently approved for the treatment of a variety of cancers. The safety profile of PARPis has not yet been systemically analyzed in the real world. We conducted this pharmacovigilance analysis using the US FDA's Adverse Event Reporting System (FAERS) database to explore the difference in adverse events (AEs) among PARPis.

Attractin Participates in Schizophrenia by Affecting Testosterone Levels.

Attractin (ATRN) is a widely expressed glycoprotein that is involved in energy homeostasis, neurodevelopment, and immune response. It is encoded by a gene spanning 180 kb on chromosome 20p13, a region previously implicated in schizophrenia by linkage studies. To address a possible role of in disorders of the central nervous system, we created an knockout zebrafish line and performed behavioral tests.

A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.

Mitochondrial disorders are collectively common, genetically heterogeneous disorders in both pediatric and adult populations. They are caused by molecular defects in oxidative phosphorylation, failure of essential bioenergetic supply to mitochondria, and apoptosis. Here, we present three affected individuals from a consanguineous family of Pakistani origin with variable seizures and intellectual disability.

A transcriptional regulatory module controls lipid accumulation in soybean.

Soybean (Glycine max) is one of the most important oilseed crops. However, the regulatory mechanism that governs the process of oil accumulation in soybean remains poorly understood. In this study, GmZF392, a tandem CCCH zinc finger (TZF) protein which was identified in our previous RNA-seq analysis of seed-preferred transcription factors, was found to function as a positive regulator of lipid production.

Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression.

Background: Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fibroblast proliferation and prevent collagen synthesis.

Results: High doses of arecoline (> 32 μg/ml) could inhibit human oral fibroblast proliferation, while low doses of arecoline (< 16 μg/ml) could promote the proliferation of human oral fibroblasts.

Whole exome sequencing identified mutations causing hearing loss in five consanguineous Pakistani families.

Background: Hearing loss is the most common sensory defect, and it affects over 6% of the population worldwide. Approximately 50-60% of hearing loss patients are attributed to genetic causes. Currently, more than 100 genes have been reported to cause non-syndromic hearing loss.