The relationship between fear of negative evaluation and social anxiety in parents of children with ASD: The chain mediating role of perceived social support and coping styles.

Parents of children with ASD face significantly greater parenting challenges than those raising typically developing children due to prolonged exposure to their children's developmental disorders, emotional distress, and atypical behaviors, underscoring the urgency of addressing their mental health concerns. This study examined the relationship between fear of negative evaluation (FNE) and social anxiety in parents of children with ASD, with a focus on the mediating roles of perceived social support and coping styles. A cross-sectional survey was conducted among 585 parents of children with ASD using validated instruments: the Brief Fear of Negative Evaluation Scale (BFNE), the Social Anxiety Scale, the Perceived Social Support Scale, and the Simple Coping Style Questionnaire.

Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca flux through MAMs.

Background: Mitochondria-associated membranes (MAMs) regulate cellular Ca and contribute to cardiovascular disease pathogenesis. The IP3R-GRP75-VDAC1 complex is the primary MAMs pathway regulating Ca flux and cardiomyocyte calcium homeostasis. Yiqi Huoxue decoction (YQHX), a Traditional Chinese Medicine formula, shows potential for myocardial infarction (MI) prevention and treatment.

A bibliometric and visualized analysis of research on mitochondria in myocardial ischemia from 2015 to 2024.

Background: Mitochondria, as the powerhouse of myocardial energy metabolism, have garnered considerable interest in the realm of myocardial ischemia (MI) therapy research. The purpose of this study is to illustrate the hot spots and frontiers of mitochondrial research in MI in the past decade through bibliometric analysis.

Methods: Both articles and reviews of mitochondrial research in MI from 2015 to 2024 were retrieved from the Web of Science Core Collection database.

Impact of agricultural machinery input on agricultural green production efficiency in the YREB from a spatial spillover perspective.

Agricultural machinery input (AMI) plays a crucial role in promoting agricultural green development and advancing agricultural modernization. Based on panel data from 130 cities in the Yangtze River Economic Belt (YREB) from 2013 to 2022, we employ the spatial Durbin model for empirical analysis and draws the following. (1) The AMI in the YREB promotes local agricultural green production efficiency (AGPE) but inhibits that of neighboring areas.

Anti-aliasing multi-bit sigma-delta modulated cobweb-like disk resonator gyroscope with extending input range.

A novel cobweb-like disk resonator gyroscope (CDRG) is introduced in this paper, which integrates a multi-bit electro-mechanical sigma-delta modulation (ΣΔΜ) system to significantly expand the input angular rate signal range, improving performance metrics like signal-to-noise ratio (SNR) and noise reduction. This design seeks to overcome the limitations associated with single-bit ΣΔΜ gyroscope systems by incorporating a linear multi-bit force feedback mechanism that utilizes nonlinear actuators driven by pulse density modulation. The proposed gyroscope system effectively broadens the input range without necessitating higher actuation voltages.

Whole-body cryotherapy can reduce the inflammatory response in humans: a meta-analysis based on 11 randomized controlled trials.

Whole-body cryotherapy (WBC) is increasingly being studied and used in various populations, mainly focusing on improving the body's regenerative capacity. More comprehensive summaries of anti-inflammatory responses are needed. To systemically assess the effect of WBC on the inflammatory response in humans based on randomized controlled trials (RCTs).

Biological Evaluation of d-[F]Fluoroalanine and d-[F]Fluoroalanine- as Positron Emission Tomography Imaging Tracers for Bacterial Infection.

d-Amino acids such as d-alanine are substrates for bacterial peptidoglycan biosynthesis and are selectively taken up by bacteria and not mammalian cells. Consequently, d-amino acid metabolism is an attractive target for antibiotic discovery and the development of bacteria-specific imaging agents. d-Fluoroalanine and the deuterium-labeled analogue fludalanine (MK641) were originally explored as antibiotics by Merck but failed in clinical trials due to unaccepted toxicity.

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled l-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection.

To fully explore the potential of F-labeled l-fluoroalanine for imaging cancer and other chronic diseases, a simple and mild radiosynthesis method has been established to produce optically pure l-3-[F]fluoroalanine (l-[F]FAla), using a serine-derivatized, five-membered-ring sulfamidate as the radiofluorination precursor. A deuterated analogue, l-3-[F]fluoroalanine-d (l-[F]FAla-d), was also prepared to improve metabolic stability. Both l-[F]FAla and l-[F]FAla-d were rapidly taken up by 9L/lacZ, MIA PaCa-2, and U87MG cells and were shown to be substrates for the alanine-serine-cysteine (ASC) amino acid transporter.

Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure.

Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure. Mesothelial cell loss is an initiating event for peritoneal fibrosis. We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E, driving downstream inflammatory responses, including the activation of macrophages.

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy.

This study aimed to explore the oxidative stress-protective effect of crocetin on H2O2-mediated H9c2 myocardial cells through in vitro experiments, and further explore whether its mechanism is related to the impact of mitophagy. This study also aimed to demonstrate the therapeutic effect of safflower acid on oxidative stress in cardiomyocytes and explore whether its mechanism is related to the effect of mitophagy. Here, an H2O2-based oxidative stress model was constructed and assessed the degree of oxidative stress injury of cardiomyocytes by detecting the levels of lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH Px).

Prediction of Acute Kidney Injury by Fibroblast Growth Factor 23 (FGF-23) in Adult Patients, A Meta-analysis Study.

Introduction: The aim of the current meta-analysis was to assess the predictive value of blood fibroblast growth factor 23 (FGF-23) for acute kidney injury (AKI) in adult patients.

Methods: We retrieved relative publications from electronic databases including the Cochrane Library, PubMed, Google Scholar, Scopus, web of science, and Wanfang Data from their inception to Aug 2022.

Results: This meta-analysis study included seven prospective cohort trials comprising 1,655 adult patients.

Combatting Antibiotic Resistance Using Supramolecular Assemblies.

Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance.

Automatic Rate and Rate-Integrating Mode-Switchable Axisymmetric Gyroscope.

This paper describes a novel rate and rate-integrating mode-switchable axisymmetric gyroscope. A precession angle tracking algorithm is developed to enable the gyro to switch automatically between rate and rate-integrating modes at preset rate points through a digital control system within the gyro. We also propose a vibrating amplitude control method for the rate-integrating mode that directly extracts the angular rate output to ensure switching stability.

Capsaicin ameliorates intermittent high glucose-mediated endothelial senescence via the TRPV1/SIRT1 pathway.

Background: Patients with diabetes have accelerated vascular aging when compared with healthy individuals. Hyperglycemia, especially intermittent high glucose (IHG), is the main cause of vascular endothelial senescence. Capsaicin, a major component of chili pepper is thought to contribute to cardiovascular protection by spicy food.

Effect of Quadrature Control Mode on ZRO Drift of MEMS Gyroscope and Online Compensation Method.

The quadrature coupling error is an important factor that affects the detection output of microelectromechanical system (MEMS) gyroscopes. In this study, two quadrature error control methods, quadrature force-to-rebalance control (Mode I) and quadrature stiffness control (Mode II) were analyzed. We obtained the main factors affecting the zero-rate output (ZRO) under force-to-rebalance (FTR) closed-loop detection.

Rutaecarpine Prevents High Glucose-Induced Endothelial Cell Senescence Through Transient Receptor Potential Vanilloid Subtype 1/ SIRT1 Pathway.

SIRT1 functions as a longevity factor to counteract vascular aging induced by high glucose. Our previous study revealed that rutaecarpine, the natural agonist of transient receptor potential vanilloid subtype 1 (TRPV1), prevented high glucose-induced endothelial dysfunction. The present study aims to evaluate the effects of rutaecarpine on endothelial cell senescence induced by high glucose, and focus on the regulatory effect on SIRT1 expression.

Real-Time Built-In Self-Test of MEMS Gyroscope Based on Quadrature Error Signal.

In high-reliability applications, the health condition of the MEMS gyroscope needs to be known in real time to ensure that the system does not fail due to the wrong output signal. Because the MEMS gyroscope self-test based on the principle of electrostatic force cannot be performed during the working state. We propose that by monitoring the quadrature error signal of the MEMS gyroscope in real time, an online self-test of the MEMS gyroscope can be realized.

Effects of Decoction on Post-Myocardial Infarction Cardiac Nerve Remodeling and Cardiomyocyte Hypertrophy in Rats.

Myocardial infarction can lead to ventricular remodeling and arrhythmia, which is closely related to nerve remodeling. Our previous study found that decoction (YQHX) can improve ventricular remodeling and reduce myocardial damage. Therefore, in this study, we observed the effect of YQHX on cardiac neural remodeling and cardiomyocyte hypertrophy and its possible mechanism.

Conjugated Polymer-Ferrocence Nanoparticle as an NIR-II Light Powered Nanoamplifier to Enhance Chemodynamic Therapy.

Chemodynamic therapy (CDT) is a promising therapeutic modality with transition metal ions and endogenous HO as reagents, but its efficiency is impaired by low endogenous HO levels and nonregeneration of metal ions. Most intracellular HO supplement strategies use oxidases and are intensively dependent on oxygen participation. The hypoxia microenvironments of solid tumors weaken their performance.

NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant HO supply.

Chemodynamic therapy (CDT) is an ideal therapeutic modality with endogenous HO as stimulus. Most intracellular HO supplement strategies for improving CDT efficiency are strongly rely on oxygen participation, and the hypoxia tumor microenvironment impairs their performance. Here we develop a self-assembled metal-organic coordinated nanoparticle Cu-OCNP/Lap with NIR-II reinforced intracellular cyclic reaction to enhance CDT efficiency.

Integrating network pharmacology and experimental evidence to decipher the cardioprotective mechanism of Yiqihuoxue decoction in rats after myocardial infarction.

Ethnopharmacological Relevance: "Qi deficiency and blood stasis" syndrome is one of the most common syndromes treated with Traditional Chinese Medicine among ischemic heart disease (IHD) patients in clinic. As a Chinese herbal formula with the function of tonifying Qi and activating blood, Yiqihuoxue Decoction (YQHX) has been frequently proven to be effective in the clinical treatment of IHD.

Aim Of The Study: The cardioprotective mechanisms of YQHX in treating ischemic heart disease were investigated, with emphasis on the key targets and pathways.

Near-Infrared Photo-controlled Permeability of a Biomimetic Polymersome with Sustained Drug Release and Efficient Tumor Therapy.

Synthetic polymersomes have structure similarity to bio-vesicles and could disassemble in response to stimuli for "on-demand" release of encapsulated cargos. Though widely applied as a drug delivery carrier, the burst release mode with structure complete destruction is usually taken for most responsive polymersomes, which would shorten the effective drug reaction time and impair the therapeutic effect. Inspired by the cell organelles' communication mode via regulating membrane permeability for transportation control, we highlight here a biomimetic polymersome with sustained drug release over a specific period of time via near-infrared (NIR) pre-activation.

Synthesis and Bioactivity of Guanidinium-Functionalized Pillar[5]arene as a Biofilm Disruptor.

Due to the inherent resistance of bacterial biofilms to antibiotics and their serious threat to global public health, novel therapeutic agents and strategies to tackle biofilms are urgently needed. To this end, we designed and synthesized a novel guanidinium-functionalized pillar[5]arene (GP5) that exhibited high antibacterial potency against Gram-negative E. coli (BH101) and Gram-positive S.