Case Report: Novel splicing mutations in causing MHC class II deficiency.

Mutations of the Regulatory Factor X5 () have been associated with the autosomal recessive major histocompatibility class II (MHC-II) deficiency, which is a severe immunodeficiency characterized by constitutive and interferon-gamma induced MHC II expression disorder and leads to the absence of cellular and humoral T-cell response to antigen challenge. The compound heterozygous splicing mutations of : c.353 + 6T>G (maternally inherited) and c.

Upconverted persistent luminescent ZnGaSnO: Cr, Yb, Er phosphor for composite anti-counterfeiting ink.

Herein, a novel colorless anti-counterfeiting luminous ink composite material, to the best of our knowledge, was prepared by incorporating upconverted persistent luminescent :1, 5, 0.5 (ZGSO: Cr,Yb,Er) phosphors into a resin solution, followed by stirring. Owing to its small particle size and uniform distribution, ZGSO: Cr, Yb, Er exhibits long-lasting, persistent near-infrared emission at 696 nm following the stoppage of excitation by a 274 nm ultraviolet light and a 980 nm excitation.

Dynamic Prediction of Internet Financial Market Based on Deep Learning.

P2P lending is an important part of Internet finance, which is popular among users because of its efficiency, low cost, wide range, and ease of operation. The problem of predicting loan defaults is affected by many factors, such as the linear and nonlinear nature of the data itself and time dependence and multiple external factors, which have not been well captured in the previous work. In this paper, we propose a multiattention mechanism to capture the different effects of various time slices and various external factors on the results, introduce ARIMA and LSTM to capture the linear and nonlinear characteristics of the lending data respectively, and establish a Time Series Multiattention Prediction Model (MAT-ALSTM) based on LSTM and ARIMA.

Label-free single-particle imaging approach for ultra-rapid detection of pathogenic bacteria in clinical samples.

Rapid detection of pathogenic bacteria within a few minutes is the key to control infectious disease. However, rapid detection of pathogenic bacteria in clinical samples is quite a challenging task due to the complex matrix, as well as the low abundance of bacteria in real samples. Herein, we employ a label-free single-particle imaging approach to address this challenge.

Molecular and functional characterization of zinc finger aspartate-histidine-histidine-cysteine (DHHC)-type containing 1, ZDHHC1 in Chinese perch Siniperca chuatsi.

In the present study, the zinc finger aspartate-histidine-histidine-cysteine (DHHC)-type containing 1 (ZDHHC1) gene was identified in a commercial fish, the Chinese perch Siniperca chuatsi. The ZDHHC1 has five putative transmembrane motifs and conserved DHHC domain, showing high amino-acid identity with other teleost fish, and vertebrate ZDHHC1 loci are conserved from fish to human. In vivo expression analysis indicated that ZDHHC1 gene was constitutively transcribed in all the examined organs/tissues, and was induced following infectious spleen and kidney necrosis virus (ISKNV) infection.

Research progress of exosomes in orthopedics.

Exosomes are nano-extracellular vesicles secreted by a variety of cells. They are composed of a double-layer membrane that can transport a variety of proteins, coding and non-coding genes, and bioactive substances. Exosomes participate in information transmission between cells and regulate processes such as cell proliferation, migration, angiogenesis, and phenotypic transformation.

Distribution Characteristics and Restoration Application of Vegetation in Chengcun Bay Surrounding Areas of Yangjiang City.

In recent years, global warming and sea level rise have further aggravated the risk of coastal erosion. Coastal vegetation plays an important role in resisting storm surges and alleviating coastal erosion. Therefore, screening plant species for the purpose of constructing ecological seawalls to protect or repair damaged coastal zones has become a hot issue.

Fibroblast growth factor receptor 1/Klothoβ agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD: A phase 1b randomized trial.

Background And Aims: BFKB8488A is a bispecific antibody targeting fibroblast growth factor receptor 1c and Klothoβ. This phase 1b study assessed safety, tolerability, pharmacokinetics, immunogenicity, and pharmacodynamics of BFKB8488A in patients with type 2 diabetes mellitus (T2DM) or NAFLD.

Approach And Results: Patients were randomized to receive multiple doses of BFKB8488A at various dose levels and dosing intervals (weekly, every 2 weeks, or every 4 weeks) or placebo for 12 weeks.

Structure of Industrial Sacrificial Fragile Cementitious Foams.

Sacrificial fragile cementitious foams (SFCFs) act as a core material of the engineered material arresting system (EMAS) installed in airports to enhance the safe take-offs and landings of aircrafts. The foam structures and foaming mechanisms that greatly impact the collapse strength, specific energy, and arresting efficiency of SFCFs, however, have not been fully addressed. Herein, the engineering properties, chemical characteristics, and pore-skeleton structures of three batches of industrial SFCFs were experimentally investigated.

The impact of Sacubitril/Valsartan on cardiac fibrosis early after myocardial infarction in hypertensive rats.

Background: Sacubitril/Valsartan, a dual inhibitor of the neprilysin and angiotensin receptor, exerts cardioprotective effects in heart failure. Little is known on the impact of Sacubitril/Valsartan in hypertensive patients early post myocardial infarction.

Methods: Spontaneously hypertensive rats (SHR) were pretreated by daily angiotensin receptor blocker (ARB; 30 mg/kg intraperitoneally), Sacubitril/Valsartan (ARNI; 60 mg/kg intraperitoneally) or the same dosage of physiological saline for 1 week.

A rapid staged protocol for efficient recovery of microplastics from soil and sediment matrices based on hydrophobic separation.

Microplastics (MPs) in soil and sediment (SS) matrices are emerging pollution hazards to ecosystems and humans. To mitigate MP pollution, suitable extractors and associated extracting solutions are required to efficiently separate MPs from SS matrices. In this study, we introduced a four-stage microplastic extractor (ME) device and investigated the fractional separation efficiencies of three extracting solutions (ultrapure water, saturated NaCl, and corn oil-in-NaCl) plus aeration, magnetic stirring, and electric stirring for three kinds of SS matrices (loam soil, sandy sediment, and muddy sediment) with four types of virgin MP pellets (acrylonitrile butadiene styrene (ABS), polycarbonate (PC), polypropylene, and polystyrene).

Stabilization and Performance Enhancement Strategies for Halide Perovskite Photocatalysts.

Solar-energy-powered photocatalytic fuel production and chemical synthesis are widely recognized as viable technological solutions for a sustainable energy future. However, the requirement of high-performance photocatalysts is a major bottleneck. Halide perovskites, a category of diversified semiconductor materials with suitable energy-band-enabled high-light-utilization efficiencies, exceptionally long charge-carrier-diffusion-length-facilitated charge transport, and readily tailorable compositional, structural, and morphological properties, have emerged as a new class of photocatalysts for efficient hydrogen evolution, CO reduction, and various organic synthesis reactions.

Risk Factors and Prognostic Analysis of Gastrointestinal Stromal Tumor Recurrence-Metastasis.

Objective: Gastrointestinal stromal tumors (GISTs) are potential malignancies that occur in the digestive tract. This study aimed to investigate the risk factors and prognosis of recurrence and metastasis of gastrointestinal stromal tumor (GIST).

Methods: From January 2018 to December 2019, 422 patients with GIST who received surgery in the First Affiliated Hospital of Wenzhou Medical University were enrolled.

Maximizing friction by liquid flow clogging in confinement.

In the nanoscale regime, flow behaviors for liquids show qualitative deviations from bulk expectations. In this work, we reveal by molecular dynamics simulations that plug flow down to nanoscale induces molecular friction that leads to a new flow structure due to the molecular clogging of the encaged liquid. This plug-like nanoscale liquid flow shows several features differ from the macroscopic plug flow and Poiseuille flow: It leads to enhanced liquid/solid friction, producing a friction of several order of magnitude larger than that of Couette flow; the friction enhancement is sensitively dependent of the liquid column length and the wettability of the solid substrates; it leads to the local compaction of liquid molecules that may induce solidification phenomenon for a long liquid column.

Effects of cadmium (Cd) on fungal richness, diversity, and community structure of Haplic Cambisols and inference of resistant fungal genera.

Cadmium (Cd) is one of the most toxic and widely distributed pollutants in mining sites of Northeast China, and how Cd contamination may affect the fungal characteristics of the zonal Haplic Cambisols is still unknown. The study aims to investigate the richness and diversity of fungal community in Haplic Cambisols in response to Cd treatments and to infer Cd-resistant fungal genera. Haplic Cambisol was treated with different concentrations of CdCl·2.

Circulating tumor cells in blood as a prognostic biomarker in tongue squamous cell carcinoma.

Objective: The study aimed to evaluate the role of circulating tumor cells (CTCs) as a prognostic biomarker of tongue squamous cell carcinoma (TSCC).

Study Design: CTC levels in the peripheral blood of 50 patients with TSCC at baseline (i.e.

Efficacy of the Integrative Acupuncture and Moxibustion Treatment in Patients With Major Depressive Disorder: The Study Protocol for a Multicenter, Single-Blinded, Randomized Trial in China.

Introduction: Antidepressants are the front-line treatments for major depressive disorder (MDD), but remain unsatisfactory in outcome. An increasing number of patients are interested in acupuncture and moxibustion treatment as complementary therapies. This study aims to evaluate the efficacy and safety of integrative acupuncture and moxibustion (iAM) treatment in patients with MDD.

A multicenter, double-blind, placebo-controlled parallel study to evaluate the role of Yinhua Miyanling tablets in the prevention of bacterial biofilm formation on ureteral stents: a randomised trial.

Background: Yinhua Miyanling tablet (YMT) not only has the functions of clearing away heat and toxin, dredging drenching and diuresis, but also has antibacterial activity. The formation of bacterial biofilm in ureteral stent and its related infection have plagued the clinic. Antibacterial traditional Chinese medicine is a potential method.

Temporal Expression Profiles Reveal Potential Targets during Postembryonic Development of Forensically Important (Diptera: Sarcophagidae).

(Robineau-Desvoidy, 1830) is a species of medical and forensic importance. In order to investigate the molecular mechanism during postembryonic development and identify specific genes that may serve as potential targets, transcriptome analysis was used to investigate its gene expression dynamics from the larval to pupal stages, based on our previous -assembled genome of . Totals of 2457, 3656, 3764, and 2554 differentially expressed genes were identified.

Generalized Multiphase Dynamic Modeling and Precision Interaction Force Control of a Walking Lower Limb Hydraulic Exoskeleton.

Wearable lower limb hydraulic exoskeletons can be used to augment the human performance in heavy load transportation. Nonlinear and walking phase-dependent dynamics make the lower limb hydraulic exoskeleton become difficult to be modeled. This paper presents a generalized multiphase dynamic modeling method in which the dynamic model of each walking phase can all be solved based on a general higher dimensional dynamic model and different holonomic constraints.

Photo-Induced Ruthenium-Catalyzed Double Remote C(sp )-H / C(sp )-H Functionalizations by Radical Relay.

Distal C(sp )-H and C(sp )-H functionalizations have recently emerged as step-economical tools for molecular synthesis. However, while the C(sp )-C(sp ) construction is of fundamental importance, its formation through double remote C(sp )-H/C(sp )-H activation has proven elusive. By merging the ruthenium-catalyzed meta-C(sp )-H functionalization with an aliphatic hydrogen atom transfer (HAT) process, we, herein, describe the catalyzed twofold remote C(sp )-H/C(sp )-H functionalizations via photo-induced ruthenium-mediated radical relay.

Galvanic-Cell Deposition Enables the Exposure of Bismuth Grain Boundary for Efficient Electroreduction of Carbon Dioxide.

Metallic bismuth (Bi) holds great promise in efficient conversion of carbon dioxide (CO ) into formate, yet the complicated synthetic routes and unobtrusive performance hinder the practical application. Herein, a facile galvanic-cell deposition method is proposed for the rapid and one-step synthesis of Bi nanodendrites. Compared to the traditional deposition method, it is found that the special galvanic-cell configuration can promote the exposure of low-angle grain boundaries.

Association of Sarcopenia and Low Nutritional Status with Unplanned Hospital Readmission after Radical Gastrectomy in Patients with Gastric Cancer: A Case-Control Study.

Objective: Sarcopenia is one of the influencing factors of poor prognosis in patients with gastric cancer but the association with readmission are unknown. We aimed to explore factors associated with readmission after gastrectomy and to determine whether preoperative sarcopenia is a common outcome in readmitted patients.

Methods: In this case-control study, patients who underwent gastric resection in the First Affiliated Hospital of Wenzhou Medical University between April 2016 and September 2017 were included.

Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.

The abnormal CXCL13/CXCR5 axis is involved in many inflammatory diseases and its selective inhibitor, TAK-799 has exhibited strong anti-inflammatory potency. The sequencing of clinical specimens from interstitial cystitis/bladder pain syndrome (IC/BPS) has shown that CXCL13 and CXCR5 are highly expressed, but the role of CXCL13/CXCR5 axis in IC/BPS has not been rarely reported. Therefore, in this study, we analyzed the GSE11783 sequencing data of IC/BPS patients and investigate the role and mechanism of CXCL13/CXCR5 axis and TAK-779 in the mouse model of experimental autoimmune cystitis (EAC).