A Novel Open-Loop Current Sensor Based on Multiple Spin Valve Sensors and Magnetic Shunt Effect with Position Deviation Calibration.

To address the demands for wide-range and high-precision current measurement, this paper proposes a novel current sensor design that integrates spin sensing technology, magnetic shunt effect, and a multi-sensor data fusion algorithm. The spin valve sensors accurately detect the magnetic field generated by the signal current, while the soft magnetic shunt structure attenuates the magnetic field to a level suitable for the spin valve sensors. Consequently, the detection current range can be extended by 6.

Circulated echovirus 18 strains in Guangdong Province and worldwide: A novel perspective on genetic diversity and recombination patterns.

Echovirus 18 (E18) has re-emerged as a global public health concern in recent years because of its association with severe neonatal systemic diseases that pose a risk of high mortality. The lack of effective intervention strategies for E18 infections is largely attributed to limited knowledge regarding molecular epidemiology and recombination patterns. In this study, we obtained seven full-length E18 sequences from infants in Guangdong Province and combined them with representative sequences from GenBank.

Characteristics of Cerebral Cortical Structural Alterations in Female Patients with Systemic Lupus Erythematosus Without Major Neuropsychiatric Manifestations Accompanied by Anxiety and Depression.

Background: This study investigated cortical morphological changes in systemic lupus erythematosus (SLE) patients diagnosed with anxiety and/or depression, all of whom exhibited no major neuropsychiatric symptoms and had normal conventional magnetic resonance imaging (MRI) findings. We also further examined the correlation between these morphological alterations and clinical characteristics.

Methods: Employing advanced structural MRI (sMRI) techniques, we implemented a dual analytical approach combining voxel-based morphometry (VBM) and surface-based morphometry (SBM) to assess structural differences across three cohorts comprising 59 SLE patients with anxiety and/or depression (SLE-AD), 35 SLE patients with no anxiety and/or depression (SLE-NAD), and 48 age-matched healthy controls (HCs).

Constructing Stimuli-Responsive Luminescent Systems with High-Contrast Fluorescence and Phosphorescence Through a Host-Guest Strategy.

Organic room-temperature phosphorescence (RTP) materials have attracted significant attention because of their potential applications in information storage, bioimaging, sensors, among others. However, the design of high-performance stimulus-responsive RTP materials remains challenging. In this work, multi-stimuli-responsive RTP systems are constructed by utilizing the acid-base responsive properties of the pyridine group, the heavy-atom effect of halogen and sulfur atoms, and d-pπ bonds.

HTD1801 demonstrates promising potential for histologic improvements in metabolic dysfunction-associated steatohepatitis in both a preclinical and phase 2 study.

Background/aims: Berberine ursodeoxycholate (HTD1801) has been shown to significantly reduce liver fat content (LFC) in an 18-week, placebo-controlled Phase 2 study in patients with metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus. The purpose of this assessment was to establish proof of concept in liver histologic improvement with HTD1801 treatment based on preclinical and clinical evidence.

Methods: The efficacy of HTD1801 was evaluated in a preclinical MASH/dyslipidemia model (golden hamsters fed a high fat diet, eight/group) after six weeks of daily treatment.

[Brief Discussion on the General Requirements of Quality Management System of Diagnostic Reagents Developed by Medical Institutions].

On March 19, 2021, the National Medical Products Administration(NMPA) issued the (Order No. 739 of the State Council of the People's Republic of China), which clearly stipulated in Article 53 the basic definition and scope of use of diagnostic reagents developed by medical institutions. It also pointed out that the relevant administrative measures shall be formulated by the Drug Regulatory Department of the State Council in conjunction with the Health Department of the State Council.

Knowledge, Attitudes, and Practices of Chinese Breast Cancer Patients Towards Comprehensive Postoperative Self-Management: a Cross-Sectional Study.

Purpose: To comprehensively assess the knowledge, attitudes, and practices (KAP) of Chinese breast cancer (BC) patients regarding postoperative self-management (POSM) and identify factors influencing self-management behaviors.

Methods: Questionnaire surveys were administered to BC patients who underwent surgery. A total of 566 participants (98.

Abnormal brain functional networks in systemic lupus erythematosus: a graph theory, network-based statistic and machine learning study.

Systemic lupus erythematosus patients' brain functional network impairments are incompletely clarified. This study investigates the brain functional network topological alterations in systemic lupus erythematosus and the application of machine learning to the classification of systemic lupus erythematosus and healthy controls. Resting-state functional MRI data from 127 systemic lupus erythematosus patients and 102 healthy controls were used.

Predictive modeling of pregnancy outcomes utilizing multiple machine learning techniques for in vitro fertilization-embryo transfer.

Objective: This study aims to investigate the influencing factors of pregnancy outcomes during in vitro fertilization and embryo transfer (IVF-ET) procedures in clinical practice. Several prediction models were constructed to predict pregnancy outcomes and models with higher accuracy were identified for potential implementation in clinical settings.

Methods: The clinical data and pregnancy outcomes of 2625 women who underwent fresh cycles of IVF-ET between 2016 and 2022 at the Reproductive Center of the Affiliated Hospital of Inner Mongolia Medical University were enrolled to establish a comprehensive dataset.

AI-Assisted Passive Magnetic Distance/Position Sensor.

Magnetic sensing technology is crucial for non-contact distance and position measurement. Due to the nonlinear characteristics of the magnetic fields from permanent magnets, conventional magnetic sensors struggle with accurate distance and position determination. To address this, we propose a distance/position sensor that employs a customized back propagation (BP) neural network.

An Oxidative Stress Nanoamplifier to Enhance the Efficacy of Cisplatin in Head and Neck Cancer.

Cisplatin (CP) is a first-line platinum-based drug used for the treatment of head and neck cancer. However, tumor cells can diminish the therapeutic effects of CP through the detoxification system mediated by glutathione (GSH) and the nucleotide excision repair (NER) pathway. Herein, we present a light-activable and pH-responsive oxidative stress nanoamplifier (FPLC@IR OSNA), comprising an amphiphilic compound (FPLC) with Fmoc-lysine acting as a connector between a nitroimidazole derivative and a pH-responsive cinnamaldehyde (CA) derivative, loaded with photosensitizer IR780.

Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus.

Objective: The study aimed to investigate the damage of white matter (WM) microstructure and structural network in patients with systemic lupus erythematosus (SLE) using diffusion tensor imaging.

Methods: Tract-based spatial statistics (TBSS) were used to compare the difference in WM fractional anisotropy (FA) between SLE and HCs groups. The differences in WM networks between groups are compared using graph theory.

Do Boys and Girls Display Different Levels of Depression in Response to Mobile Phone Addiction? Examining the Longitudinal Effects of Four Types of Mobile Phone Addiction.

Purpose: Prior research has indicated that mobile phone addiction (MPA) significantly contributes to depression. However, there is a research gap in exploring the distinct impacts of various types of MPA on depression, along with the potential moderating effect of gender. The current study investigated whether the relationship between MPA and depression varies depending on the types of MPA and gender.

Hydrogel-Mediated Jamming of Exosome Communications That Counter Tumor Adaption in the Tumor Immune Microenvironment.

Hypoxia, a common occurrence within solid tumors, can stimulate the dissemination of deceptive tumor exosomes, which function as communicative bridges and orchestrate the recruitment of various supportive cell types for enhanced tumor adaptability in a tumor immune microenvironment. Current nanotechnology provides us intelligent strategies to combat the hypoxic tumor microenvironment. However, once exposed to external stimuli, such as chemotherapy, tumor cells simultaneously release malignant signals to develop tumor migration and immunosuppression, posing challenges to clinical practice.

Nanomaterials: Recent Advances in Knee Osteoarthritis Treatment.

Osteoarthritis (OA) of the knee is the most prevalent degenerative joint condition that places a substantial financial and medical burden on society. However, due to drawbacks such as inefficiency, adverse effects, and brief duration of action, the clinical efficacy of the current major therapies for knee OA is largely restricted. Therefore, novel medication development is highly required to address these issues.

Electrical Kinetic Model of a Hydroxylated Graphene FET Gas Sensor.

Graphene transistor sensors, with advantages such as facile surface functionalization and high sensitivity, have gained extensive research interest in gas detection applications. This study fabricated back-gated graphene transistors and employed a hydroxylation scheme for the surface functionalization of graphene. On the basis of the interaction mechanisms between gas molecules and graphene's electrical properties, a compact electrical kinetics model considering the gas-solid surface reaction of graphene transistors is proposed.

Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species.

Spatial and temporal associations between sympatric species underpin biotic interactions, structure ecological assemblages, and sustain ecosystem functioning and stability. However, the resilience of interspecific spatiotemporal associations to human activity remains poorly understood, particularly in mountain forests where anthropogenic impacts are often pervasive. Here, we applied context-dependent Joint Species Distribution Models to a systematic camera-trap survey dataset from a global biodiversity hotspot in eastern Himalayas to understand how prominent human activities in mountain forests influence species associations within terrestrial mammal communities.

Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic.

Human adenovirus type 41 (HAdV-F41) usually causes pediatrics gastroenteritis. However, it was reported to be associated with the outbreaks of severe acute hepatitis of unknown aetiology (SAHUA) in pediatrics during COVID-19 pandemic. In this study, we investigated the prevalence of enteric HAdV-F41 in 37,920 paediatric gastroenteritis cases from 2017 to 2022 in Guangzhou, China.

Phase division and recognition of crystal HRTEM images based on machine learning and deep learning.

The High Resolution Transmission Electron Microscope (HRTEM) images provide valuable insights into the atomic microstructure, dislocation patterns, defects, and phase characteristics of materials. However, the current analysis and research of HRTEM images of crystal materials heavily rely on manual expertise, which is labor-intensive and susceptible to subjective errors. This study proposes a combined machine learning and deep learning approach to automatically partition the same phase regions in crystal HRTEM images.

Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.

Gastrointestinal stromal tumors (GISTs) are predominately induced by KIT mutants. In this study, we found that four and a half LIM domains 2 (FHL2) was highly expressed in GISTs and KIT signaling dramatically increased FHL2 transcription while FHL2 inhibited KIT transcription. In addition, our results showed that FHL2 associated with KIT and increased the ubiquitination of both wild-type KIT and primary KIT mutants in GISTs, leading to decreased expression and activation of KIT although primary KIT mutants were less inhibited by FHL2 than wild-type KIT.

[Development and Clinical Application of Multifunctional Inflation-Free Lumpectomy Aid].

To investigate the value of self-developed air-free laparoscopic auxiliary instruments in the clinical application of thyroid diseases. The clinical data of 70 transaxillary and 45 transareolar air-free laparoscopic surgeries for thyroid cancer and 40 conventional open surgeries were retrospectively compared. The transaxillary and transareolar laparoscopic groups had significantly longer operative times than the open group, while the postoperative satisfaction was higher in the endoscopic group than in the open group.

Clinical analysis of a new multifunctional instrument set for gasless endoscopic thyroidectomy with two different approaches.

Background: Following the rapid development of endoscopic thyroidectomy techniques, various surgical procedures have been developed (e.g., transoral, submandibular, areolar, axillary, retroauricular, and combined procedures), and each of these procedures has its own advantages.