Variations in executive function in toddlers after exposure to pre-pregnancy overweight and obesity and the mediating role of inflammation in a longitudinal pregnancy cohort study.

Objective: This study aimed to determine the association between pre-pregnancy overweight and obesity status in pregnant women and executive function (EF) development in toddlers and establish whether inflammatory biomarkers mediate this association.

Methods: This prospective cohort included 1,126 mother-infant pairs. Pre-pregnancy body mass index (ppBMI) was obtained from medical records, and the participants categorized into normal weight, overweight and obese groups according to standard ppBMI classifications.

Intimate Partner Violence During Pregnancy and Early Offspring Development: A Prospective Birth Cohort Study.

Background: Intimate partner violence (IPV) during pregnancy is linked to several unfavorable outcomes for both mothers and babies. However, few studies have examined its connections to early infant neurodevelopment, and the underlying processes of these connections remain unclear.

Methods: Our research was conducted within a prospective birth cohort of 3007 mother-child pairs from March 2018 to July 2023.

Anti-inflammatory diet mitigate cardiovascular risks due to particulate matter exposure in women during pregnancy: A perspective cohort study from China.

Background: Particulate matter (PM) exposure during pregnancy may increase cardiovascular risk (CVR). However, the specific time windows of exposure contributing to this association and the potential biological mechanisms underlying it remain unclear.

Objective: To determine the sensitive time window for CVR related to PM exposure.

Associations between particulate matter exposure during pregnancy and executive function of toddlers in a prospective cohort study.

Background: Exposure to particulate matter (PM) has been found to be associated with impaired cognitive function. However, limited evidence is available on the relationship between PM exposure in the prenatal period and toddler executive function (EF), and the potential influence of breastfeeding.

Methods: The study included 1106 mother-toddler pairs recruited between 2015 and 2019.

Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis.

Purpose Of Review: Pregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.

Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Gestational Diabetes Mellitus Risk.

Context: The putative association between pro-inflammatory and hyperinsulinemic dietary patterns and susceptibility to gestational diabetes mellitus (GDM) remains unclear.

Objective: We aimed to compare the risk associated with the Mediterranean diet, as well as insulinemic and pro-inflammatory dietary patterns, in relation to the occurrence of GDM, and evaluate their predictive value.

Methods: We prospectively followed 8495 women from the Maternal and Infant Health cohort in Hefei, China (2015-2021).

Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study.

Background: Outdoor artificial light at night (ALAN) has been linked to an elevated risk of diabetes, but the available literature on the relationships between ALAN and glucose homeostasis in pregnancy is limited.

Methods: A prospective cohort study of 6730 pregnant women was conducted in Hefei, China. Outdoor ALAN exposure was estimated using satellite data with individual addresses at a spatial resolution of approximately 1 km, and the average ALAN intensity was calculated.

Association between the Maternal Mediterranean Diet and Perinatal Outcomes: A Systematic Review and Meta-Analysis.

The Mediterranean diet is a global, well-known healthy dietary pattern. This review aims to synthesize the existing evidence on the relationship between the maternal Mediterranean diet during pregnancy and perinatal outcomes, including randomized controlled trials (RCTs) and cohort studies. PubMed, Web of Science, and the Cochrane Library were searched from inception to 10 March, 2023, supplemented by manual screening.

Association between exposure to air pollution during preconception and risk of gestational diabetes mellitus: The role of anti-inflammatory diet.

Background: Regarding the association between the sensitive time-windows of air pollution (AP) exposure and gestational diabetes mellitus (GDM), epidemiological findings are inconsistent. The dietary inflammatory potential has been implicated in the development of GDM, but it is unclear whether an anti-inflammatory diet during pregnancy reduces the association between AP and GDM.

Objective: We aimed to characterize the sensitive time-windows of AP to GDM risk.

Differences in initial versus recurrent diabetic foot ulcers at a specialized tertiary diabetic foot care center in China.

Objective: To investigate the characteristics of diabetic foot ulcer (DFU) recurrence.

Methods: A total of 573 patients with DFUs were recruited and divided into an initial group (395 patients) and a recurrence group (178 patients). The factors related to recurrence were analyzed using multivariate regression.

The effect of family doctor policy practice on primary health-care workers' health in Hongkou District of Shanghai, China: varied by occupational divisions?

Background: A key component of the 2009 medical reform in China was the change to family doctor (FD) policy practice. However, this led to an increased workload for primary health-care workers (PHCWs) at community health service centres. Their increasing workload may play a significant role in affecting PHCWs' health.

Gender- and puberty-dependent association between physical activity and depressive symptoms: national survey among Chinese adolescents.

Background: The study aims to understand the possible gender difference in the associations between physical activity and depressive symptoms during pubertal transition.

Methods: Participants were 30,399 children and adolescents of Han ethnicity from urban and rural areas in 8 cities in China. Physical activity (PA) and depressive symptom was assessed by adapted Youth Risk Behavior Survey and Children Depression Inventory (CDI), respectively.

Changes in BMI and waist circumference among primary and secondary school students from 2005 to 2010 in Anhui, China.

Aim: To examine the change in Body Mass Index (BMI) and waist circumference (WC) among primary and secondary school students aged 7-18 in Anhui Province between 2005-2010.

Subjects And Methods: A total of 15 812 primary and secondary school students aged 7-18 were included in two national surveys on students' constitution and health in 2005 and 2010 in Anhui Province. Measurements of height, weight and WC were taken by trained investigators.

[Correlation of resistance to peer pressure and risky decision-making with adolescent health risk behaviors].

Objective: To explore possible interrelationships among resistance to peer pressure, risky decision-making and health risk behaviors among young adolescents.

Methods: Based on the cluster sampling method, the participants who were recruited from 5 junior middle schools in Guangzhou and 3 junior middle schools in Shenyang city on October, 2010, were administered to complete the questionnaire concerned with their experiences with drinking and smoking during the past 30 days preceding the survey, and the hours using computer daily both in weekdays and in weekend. The level of resistance to peer influence and risky decision-making were assessed by Resistance to peer influence scale (RPIS) and Youth decision-making questionnaire (YDMQ).

Effects of emotional symptoms and life stress on eating behaviors among adolescents.

The aim of this study was to explore possible effects of emotional symptoms (depressive symptoms and anxiety symptoms) and life stress on eating behaviors (restrained, emotional and external eating behaviors) among junior and high school students in China. A total of 5473 students in Xuzhou, Jiangsu Province were sampled to participate in this survey based on a clustering sampling approach. The survey collected sociodemographic data, emotional symptoms, life stress and eating behaviors of adolescents.

[Association between body mass index and physical fitness index among children and adolescents].

Objective: To explore the relationship between body mass index (BMI) and physical fitness index (PFI) among children and adolescents.

Methods: The study sample included 8941 students aged 7 to 18 years in Anhui who attended the Physical Fitness and Health Surveillance program of Chinese School Students, in 2010. Within each sex- and age-specific group, students were classified into five BMI categories which were: very low, BMI<5th percentile; low, BMI≥5th but <15th percentiles; normal, BMI≥15th but <85th percentiles; high, BMI≥85th but <95th percentiles; and very high, BMI≥95th percentiles.

[Psychopathological sub-healthy status as predictor on self-or unintentional injuries among Chinese adolescents: a school-based follow-up study].

Objective: To investigate the association between psychological sub-healthy status and risks on injuries and related predictors among adolescents in China, in order to develop reasonable intervention programs.

Methods: Adolescents were selected from middle schools and colleges in eight cities. Baseline status on sub-healthy that related to psycho-pathology was measured using the Multidimensional Sub-health Questionnaire of Adolescents (MSQA).

[Association between self-assessed somatotypes and symptom depression among children and adolescents].

Objective: To examine the association between self-assessed somatotypes and depression related symptoms.

Methods: The study sample included 5555 students aged 9 to 18 years who had attended the Physical Fitness and Health Surveillance of Chinese School Students (2010) in Chizhou city, Anhui province. Association between self-assessed somatotypes, body mass index (BMI) and depression symptom were examined.

[A technique for investigating the component of cantharidin blisters by flow cytometry].

Objective: Cantharidimide cause blister. The effect of blister on immunoregulation was investigated.

Methods: Cantharidimide was placed on the skin, 48h later, the blister was analyzed by flow cytometry.

[Relationships between thiopurine methyltransferase gene polymorphisms and its enzymatic activity].

Objective: To investigate the relationship between the thiopurine methytransferase (TPMT) gene polymorphisms and its enzymatic activity, and to clarify the significance of TPMT activity and gene polymorphisms on individualized therapy with thiopurines.

Methods: The TPMT activity and gene polymorphisms were determined in an unrelated population of 250 Chinese healthy blood donors, 100 cords blood and 280 patients with acute leukemia. The TPMT genotyping assay was based on polymerase chain reaction (PCR), restriction digestion of PCR products, denaturing high-performance liquid chromatography (DHPLC) and SNaPshot sequencing and direct DNA sequencing in the TPMT exon 5 (G238C), TPMT exon7 (G460A) and TPMTexon10 (A719G).

[Exploration of methodology for assay of single nucleotide polymorphism in thiopurine methyltransferase gene].

The aim of the present study was to gain an insight into the thiopurine methytransferase (TPMT) genotyping assay, which was based on polymerase chain reaction (PCR), allele-specific PCR, restriction digestion of PCR products, denaturing high-performance liquid chromatography (DHPLC) and SNaPshot sequencing and in combination with direct DNA sequencing. Among the f our methods to test TPMT genetic SNPs based on PCR, allele specific PCR was not able to differentiate wild type from varied type. BsiYI, MwoI and AccI to digest PCR products were used so that SNP in TPMT exon 5, 7 and 10 tested.