Impact of smart healthcare-based behaviors of elderly patients with chronic diseases on physicians' behavioral adaptations.

Background: This study aimed to investigate how the smart healthcare-based behaviors of elderly patients with chronic diseases influence physicians' behavioral adaptations.

Methods: Physicians providing healthcare services to elderly patients with chronic diseases between July 1, 2024, and July 31, 2024, were recruited. A total of 100 physicians and 100 of their patients were enrolled.

Dynamic Beat-to-Beat Measurements of Blood Pressure Using Multimodal Physiological Signals and a Hybrid CNN-LSTM Model.

Wearable cuffless blood pressure (BP) technology is emerging as a critical tool for monitoring hypertension, the leading risk factor of most cardiovascular diseases. However, current cuffless BP methods are not accurate enough for clinical use, because they mainly use single or dual modalities/features as inputs for estimation. To address this challenge, we propose multimodal McBP-Net, built with hybrid CNN-LSTM architecture combing two-layer convolution operations with four-layer LSTMs to capture both local signal features and temporal dependencies for continuous dynamic beat-to-beat BP estimation.

Predictive efficacy and role of 2HG in MGMT promoter methylation in gliomas: a retrospective study based on MRS and mediator variable analysis.

Background: The role of 2-hydroxyglutarate (2HG) in the methylation process of O6-methylguanine-DNA methyltransferase (MGMT) promoter remains unclear. This study aimed to investigate the predictive efficacy and role of 2HG in MGMT promoter methylation.

Methods: Patients who met the inclusion criteria were retrospectively included and divided into MGMT promoter methylation group (M) and MGMT promoter unmethylation group (UM).

Perspectives of Global Standards on Validation of Blood Pressure Measuring Devices.

Blood pressure (BP) measuring devices are essential tools across all areas of medicine, where BP is used as a vital sign for assessing cardiovascular status, guiding clinical decisions in acute medicine, critical care, and routine monitoring of hospitalized patients. International standards for BP measuring devices establish safety and accuracy criteria to ensure the reliability and usability of these instruments. The standardization of BP device validation protocols is vital to guarantee the accuracy and consistency of readings, which are crucial for effective medical decision-making.

Simulation Experimental Study on Evolution Law of Cumulative Damage in Coal under Shocks by Multiple High Pressure Air Blasting.

High pressure air blasting (HPAB) is a new type of waterless physical expansion method for enhancing coalbed methane extraction from low-permeability coal reservoirs. In order to explore the influence of shocks by multiple HPAB on the cumulative damage evolution of coal, shocks by multiple HPAB experiments were conducted using simulated coal samples and a self-developed HPAB device. During the experimental testing process, The wave velocity of coal samples under shocks by multiple HPAB was tested using an ultrasonic tester, and the time-domain signal of the ultrasonic wave was converted into a frequency-domain signal using Fourier transform theory.

Efficacy of individualized orelabrutinib-based regimens in relapsed or refractory central nervous system lymphoma.

Background: Relapsed or refractory central nervous system lymphoma (rrCNSL) lacks established preferred treatment and carries an inferior prognosis. Bruton's tyrosine kinase inhibitor (BTKi) showed promising effectiveness. Orelabrutinib is a second-generation BTKi with a high concentration in cerebrospinal fluid.

The Efficacy and Safety of Applying the Combination of Pulsed Radiofrequency and Platelet-Rich Plasma to the Gasserian Ganglion for the Treatment of Idiopathic Trigeminal Neuralgia: A Protocol for a Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study.

Background: Trigeminal neuralgia (TN) is one of the severest and most common forms of neuropathic pain, and the current standard treatments for TN still have some disadvantages and limitations. Pulsed radiofrequency (PRF) has great potential as a micro-destructive method in treating refractory TN, but the long-term outcomes of PRF have been reported to be unsatisfactory. Autologous platelet-rich plasma (PRP) can reduce inflammation and promote nerve repair and has been proven effective in a previously published case report.

Targeting the HLA-E-NKG2A axis in combination with MS-275 enhances NK cell-based immunotherapy against DMG.

Background: Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor with limited treatment options. Although natural killer (NK) cell-based immunotherapy is promising, its efficacy remains limited, necessitating strategies to enhance NK cell cytotoxicity. Histone deacetylase (HDAC) inhibition demonstrate potential to enhance NK-mediated killing.

Identification of urinary metabolic biomarkers for histone 3 lysine27-to-methionine mutation diagnosis in brainstem gliomas.

Background: Brainstem gliomas (BSGs) harboring a histone 3 lysine27-to-methionine (H3K27M) mutation represent one of the deadliest brain tumors with a dismal prognosis, as they exhibit a much worse response to therapy compared to the wildtype BSGs. Early noninvasive recognition of the H3K27M mutation is paramount for clinical decision-making in treating BSGs.

Methods: Plasma and urine samples were prospectively collected from BSG patients before biopsy or surgical resection and were chronologically divided into discovery, test, and validation cohorts.

The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma.

Glioblastoma (GBM) is one of the most lethal adult brain tumors with limited effective therapeutic options. Immunotherapy targeting B7-H3 (CD276) has shown promising efficacy in the treatment of gliomas. However, the response to this treatment varies among glioma patients due to individual differences.

High-dose methotrexate-based chemotherapy for induction remission of newly diagnosed primary CNS lymphoma: A systematic review and meta-analysis.

Background: This study aimed to comprehensively assess the optimal regimen for high-dose methotrexate (HD-MTX) in treating primary central nervous system lymphoma (PCNSL).

Methods: We have searched 8 databases, including PubMed, EMBASE, Cochrane Library, WOS, Epistemonikos, CNKI, WAN-FANG Database, and CBM, and were selected for the clinical trials about PCNSL. A total of 37 studies were included in our analysis, consisting of 6 randomized controlled trials and 31 single-arm clinical studies.

Strategies for perioperative hypothermia management: advances in warming techniques and clinical implications: a narrative review.

Perioperative hypothermia is a frequent clinical complication resulting from the cold environment of the operating room and prolonged skin exposure, leading to adverse outcomes and increased healthcare burdens. To address this issue, this narrative review discusses in detail the currently common warming strategies for perioperative hypothermia .Forced air warming (FAW) systems are widely recognized as the most effective intervention for maintaining core body temperature.

Efficacy of Preemptive Topical Lidocaine 5% Plaster in the Prevention of Post-Craniotomy Pain, a Randomized Clinical Trial.

Objective: The current landscape is characterized by a dearth of effective, safe, simple, and noninvasive methods for preventing pain following craniotomy. This clinical trial seeks to evaluate the efficacy profile of preemptive application of a topical 5% lidocaine patch in alleviating post-craniotomy pain.

Methods: This was a multi-centric, prospective randomized placebo-controlled triple-blind clinical trial.

Disease-specific suppressive granulocytes participate in glioma progression.

Glioblastoma represents one of the most aggressive cancers, characterized by severely limited therapeutic options. Despite extensive investigations into this brain malignancy, cellular and molecular components governing its immunosuppressive microenvironment remain incompletely understood. Here, we identify a distinct neutrophil subpopulation, termed disease-specific suppressive granulocytes (DSSGs), present in human glioblastoma and lower-grade gliomas.

Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial.

Introduction: Neurosurgery is a risk factor for postoperative delirium. Dexmedetomidine has a potential effect on reducing postoperative delirium. We aim to test the primary hypothesis that perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in patients undergoing neurosurgical resections of temporal glioma.

RFImageNet framework for segmentation of ultrasound images with spectra-augmented radiofrequency signals.

Computer-aided segmentation of medical ultrasound images assists in medical diagnosis, promoting accuracy and reducing the burden of sonographers. However, the existing ultrasonic intelligent segmentation models are mainly based on B-mode grayscale images, which lack sufficient clarity and contrast compared to natural images. Previous research has indicated that ultrasound radiofrequency (RF) signals contain rich spectral information that could be beneficial for tissue recognition but is lost in grayscale images.

Expression features of targets for anti-glioma CAR-T cell immunotherapy.

Objective: To investigate the expression features of common anti-glioma CAR-T targets (B7H3, CSPG4, EGFRv III, HER2 and IL-13Ra2) in gliomas with different grades and molecular subtypes, and explore the association of target expression with glioma malignant or immune phenotypes including immune evasion, stemness, antigen presentation, and tumor angiogenesis.

Methods: Opal™ Multiplex immunofluorescence staining was performed on glioma tissues to detect the expression of targets, and biomarkers related to the phenotypes.

Results: High variety of CAR-T target expression among glioma subtypes was observed.

Association between hypertension requiring medication and postoperative 30-day mortality in adult patients with tumor craniotomy: an analysis of data using propensity score matching.

Background: Reliable quantification of the association between hypertension requiring medication and postoperative 30-day mortality in adult patients who undergo craniotomy for tumor resection is limited. We aimed to explore the associations between these factors.

Materials And Methods: This work was a retrospective cohort study that used propensity score matching (PSM) among 18,642 participants from the American College of Surgeons National Surgical Quality Improvement Program database between 2012 and 2015.

Multi-omics and pharmacological characterization of patient-derived glioma cell lines.

Glioblastoma (GBM) is the most common brain tumor and remains incurable. Primary GBM cultures are widely used tools for drug screening, but there is a lack of genomic and pharmacological characterization for these primary GBM cultures. Here, we collect 50 patient-derived glioma cell (PDGC) lines and characterize them by whole genome sequencing, RNA sequencing, and drug response screening.

Spectral analysis enhanced net (SAE-Net) to classify breast lesions with BI-RADS category 4 or higher.

Early ultrasound screening for breast cancer reduces mortality significantly. The main evaluation criterion for breast ultrasound screening is the Breast Imaging-Reporting and Data System (BI-RADS), which categorizes breast lesions into categories 0-6 based on ultrasound grayscale images. Due to the limitations of ultrasound grayscale imaging, lesions with categories 4 and 5 necessitate additional biopsy for the confirmation of benign or malignant status.

NAD+ Metabolic Enzyme Inhibitor as Radiosensitizer for Malignant Meningioma and its Modulation of P53 Expression.

Surgical resection followed by radiotherapy (RT) is recommended for malignant meningioma, but poor outcome is unavoidable. To improve the efficacy of RT in malignant meningioma, a targeted radiosensitizer can be added. Nicotinamide phosphoribosyltransferase (NAMPT), highly expressed in high-grade meningiomas, may play a role in determining the radioresponse.

Ultrasound wavelet spectra enable direct tissue recognition and full-color visualization.

Traditional brightness-mode ultrasound imaging is primarily constrained by the low specificity among tissues and the inconsistency among sonographers. The major cause is the imaging method that represents the amplitude of echoes as brightness and ignores other detailed information, leaving sonographers to interpret based on organ contours that depend highly on specific imaging planes. Other ultrasound imaging modalities, color Doppler imaging or shear wave elastography, overlay motion or stiffness information to brightness-mode images.