Association Between Intracranial Plaque Characteristics and Stroke Recurrence Risk Stratified by Stenosis Severity.

Rationale And Objectives: This study aims to analyze the association between plaque characteristics and stroke recurrence across different degrees of stenosis, and to evaluate the predictive value of combining culprit plaque characteristics with the modified Essen score for stroke recurrence.

Materials And Methods: This retrospective analysis included 368 intracranial atherosclerotic stenosis (ICAS) patients from two centers, categorized into mild-to-moderate stenosis (<70%, n = 155) and severe stenosis (≥70%, n = 213) groups. High-resolution vessel wall images and clinical data were analyzed.

Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome.

Background: Autoimmune liver diseases, including primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and their overlap syndrome (OS), involve immune-mediated liver injury, with OS occurring in 1.2%-25% of PBC patients. OS carries a higher risk of cirrhosis, hepatocellular carcinoma, and reduced survival.

Metabolic, transcriptomic, and proteomic adaptations in pancreatic ductal adenocarcinoma-patient derived xenograft models across serial passages.

Background: Patient-derived xenograft (PDX) models are crucial for tumor biology and therapeutic response evaluations. The metabolic, transcriptomic, and proteomic changes in PDX models derived from pancreatic ductal adenocarcinoma (PDAC) during serial passaging remain poorly understood.

Methods: We established 33 PDX models from 43 PDAC patients and collected 40 benign pancreatic tissues as controls for metabolomic analysis using H NMR spectroscopy.

Respiratory bacterial and viral pathogen spectrum among influenza-positive and influenza-negative patients.

Background: Respiratory tract infections are a significant burden on public health worldwide, with influenza being a prominent viral infection. Although influenza is known to predispose individuals to secondary bacterial infections, the precise spectrum of respiratory pathogens in influenza-positive and negative-patients remains unclear. This study aims to gain insights into the pathogenesis, epidemiology, and clinical implications of co-infections, facilitating the development of preventive and targeted interventions.

Prehistoric genomes from Yunnan reveal ancestry related to Tibetans and Austroasiatic speakers.

The human landscape in East and Southeast Asia is vastly complex, and successful retrieval of genome-wide data from prehistoric humans of southern East Asia is sparse. We successfully sampled 127 ancient human genomes from southwestern China. A 7100-year-old female individual from central Yunnan shows a previously unsampled Basal Asian ancestry related to a ghost population that contributed to Tibetan Plateau populations.

Effect of 3D-printing assisted micro-osteoperforations on the rate of canine retraction: a clinical investigation.

Objectives: More time is often needed for adult orthodontic patients compared with juvenile counterparts due to lower tissue vitality. In some cases, the prolonged orthodontic treatment may cause a series of problems, such as enamel demineralization, dental caries, periodontitis and root resorption. Therefore, we aimed to accelerate tooth movement to avoid various adverse reactions by 3D-printing assisted micro-osteoperforations (MOPs) in difficult orthodontics cases.

TGEV NSP1 enhances viral replication through antagonizing stress granule formation.

Stress granules (SGs) are membrane-less organelles that form in response to adverse external stimuli. Upon viral invasion, SGs formation can serve as a cellular defence mechanism against infection. Transmissible gastroenteritis virus (TGEV), an α-coronavirus with a large positive-sense single-stranded RNA genome, causes diarrhoea, vomiting, dehydration, and even fatality in piglets.

A prediction model based on machine learning: prognosis of HBV-induced HCC male patients with smoking and drinking habits after local ablation treatment.

Background: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major health concern globally and in China, possibly shows recurrence after ablation treatment in high-risk patients. This study investigates the prognosis of early-stage male HCC patients with chronic hepatitis virus B (HBV) infection who also have long-term smoking and drinking habits, following local ablation treatment.

Methods: Data from 257 patients treated at Capital Medical University, Beijing Youan Hospital from 2014 to 2022 were retrospectively analyzed.

GLIM consensus approach to diagnosis of malnutrition: A 5-year update.

Background: The Global Leadership Initiative on Malnutrition (GLIM) introduced an approach for malnutrition diagnosis in 2019 that comprised screening followed by assessment of three phenotypic criteria (weight loss, low body mass index [BMI], and low muscle mass) and two etiologic criteria (reduced food intake/assimilation and inflammation/disease burden). This planned update reconsiders the GLIM framework based on published knowledge and experience over the past 5 years.

Methods: A working group (n = 43 members) conducted a literature search spanning 2019-2024 using the keywords "Global Leadership Initiative on Malnutrition or GLIM.

The GLIM consensus approach to diagnosis of malnutrition: A 5-year update.

Background: The Global Leadership Initiative on Malnutrition (GLIM) introduced an approach for malnutrition diagnosis in 2019 comprised of screening followed by assessment of three phenotypic criteria: weight loss, low BMI, and low muscle mass, and two etiologic criteria: reduced food intake/assimilation, and inflammation/disease burden. This planned update reconsiders the GLIM framework based on published knowledge and experience over the past five years.

Methods: A GLIM working group (n = 43 members) conducted a literature search spanning 2019-2024 using the keywords "Global Leadership Initiative on Malnutrition or GLIM".

DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes.

Background And Hypothesis: Schizophrenia (SZ) is a severe mental disorder with high heritability. DLG2 encodes the postsynaptic scaffolding protein DLG2 (PSD93, Postsynaptic Density Protein 93), and its variants were associated with an increased risk of SZ. However, the role of DLG2 locus variation in SZ remains elusive.

A multifunctional Tb-MOF constructed with triphenylamine-based hexacarboxylate ligands for highly luminescent sensing toward antibiotics and salicylaldehydes.

Antibiotics and salicylaldehydes are major organic pollutants in the environment, and their efficient selection and sensitive detection are of great significance but also challenging. A multifunctional terbium-organic framework (Tb-MOF) with multiple π-conjugated rings and basic sites decorated nanoporous channels was constructed with triphenylamine-based hexacarboxylate ligands. Structure analysis of Tb-MOF revealed that the six carboxyl groups on the skeleton of ligand exhibit considerable degree of distortion and can be regarded as three triangular nodes, which further combined the binuclear [Tb(COO)(HO)] nodes to form a new (3,3,3,6)-connected 3D net.

Cortical morphometric similarity gradient in schizophrenia and its association with transcriptional profiles and clinical phenotype.

Background: Recent studies have increasingly utilized gradient metrics to investigate the spatial transitions of brain organization, enabling the conversion of macroscale brain features into low-dimensional manifold representations. However, it remains unclear whether alterations exist in the cortical morphometric similarity (MS) network gradient in patients with schizophrenia (SCZ). This study aims to examine potential differences in the principal MS gradient between individuals with SCZ and healthy controls and to explore how these differences relate to transcriptional profiles and clinical phenomenology.

The effect of HA380 blood adsorption on patients with acute infective endocarditis undergoing cardiac surgery: a retrospective study.

Introduction: Sepsis is a major cause of ICU admission and mortality in patients with infective endocarditis patients. This study aimed to explore the effect of intraoperative HA380 blood adsorption on surgical outcomes in infective endocarditis patients, given its ability to adsorb inflammatory factors.

Methods: We retrospectively analyzed the clinical data of patients who underwent surgical treatment for infective endocarditis at our hospital.

Visible-light photocatalytic oxygen activation by oxygen vacancies-rich BiOI for enhanced removal of bisphenol A in water.

Bisphenol A (BPA) is a persistent endocrine disruptor that poses high ecological and healthy risks. Photocatalytic oxygen (O) activation has emerged as a promising technology for water decontamination, but its efficiency is often hindered by sluggish interfacial electron transfer between photocatalysts and O molecules. In this study, a Zn/S co-doping defect engineering strategy was developed to introduce oxygen vacancies (OVs) into BiOI for enhancing visible-light photocatalytic O activation and BPA removal.

HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.

Chemical repellents against arthropods have limitations in terms of toxicity and resistance. Natural plant compounds can be utilized as alternatives for developing environmentally friendly repellents for humans and animals. A variety of plant essential oils exhibit strong repellent effects against ticks; however, the mechanisms of action against ticks remain unknown.

Clinical characteristics and outcomes of BCMA-targeted CAR-T cell recipients with COVID-19 during the Omicron wave: a retrospective study.

Patients with relapsed or refractory multiple myeloma (R/R-MM) are more susceptible to develop severe coronavirus disease 2019 (COVID-19) for their immunocompromised states. Despite good responses to B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cell therapy, deficiencies in humoral immunity following CAR-T cell infusions can still cause life-threatening complications in these patients. We conducted a comparative study to delineate the clinical characteristics and outcomes between recipients of BCMA-targeted CAR-T cell therapy who contracted COVID-19 vs.

Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia.

Background: The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescent patients with schizophrenia (AOS) has been less reported.

Methods: We recruited 124 subjects who underwent resting-state functional magnetic resonance imaging scans at baseline, using key brain regions in the prefrontal-thalamic-cerebellar circuit as seed regions, to investigate the FC in AOS versus healthy controls.

High-dose methotrexate-based chemotherapy for induction remission of newly diagnosed primary CNS lymphoma: A systematic review and meta-analysis.

Background: This study aimed to comprehensively assess the optimal regimen for high-dose methotrexate (HD-MTX) in treating primary central nervous system lymphoma (PCNSL).

Methods: We have searched 8 databases, including PubMed, EMBASE, Cochrane Library, WOS, Epistemonikos, CNKI, WAN-FANG Database, and CBM, and were selected for the clinical trials about PCNSL. A total of 37 studies were included in our analysis, consisting of 6 randomized controlled trials and 31 single-arm clinical studies.

Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC.

Background: Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous make-up of myeloid cells that influences the therapeutic response and prognosis. However, understanding the myeloid cell at both a genetic and cellular level remains a significant challenge.

Methods: Single-cell RNA sequencing (scRNA-seq) data were downloaded from t the Tumor Immune Single-cell Hub and gene expression data were retrieved from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database.

Robust bifunctionality towards hydrogen evolution and ethanol oxidation reactions catalyzed by six-element high-entropy alloys.

FeCoNiIrPtPd/NCNT exhibits 3.4- and 1.6-fold higher levels of mass activity than does commercial Pt/C in the hydrogen evolution reaction (HER) and ethanol oxidation reaction (EOR), respectively.

Mitochondria-Targeting Virus-Like Gold Nanoparticles Enhance Chemophototherapeutic Efficacy Against Pancreatic Cancer in a Xenograft Mouse Model.

Background: The dense and fibrotic nature of the pancreatic tumor microenvironment significantly contributes to tumor invasion and metastasis. This challenging environment acts as a formidable barrier, hindering effective drug penetration and delivery, which ultimately limits the efficacy of conventional cancer treatments. Gold nanoparticles (AuNPs) have emerged as promising nanocarriers to overcome the extracellular matrix barrier; however, their limited targeting precision, poor delivery efficiency, and insufficient photothermal conversion present challenges.

Transcriptome and Metabolome Analyses Reveal the Regulatory Mechanism of in the Sucrose and Starch Synthesis Pathways in .

Tumor necrosis factor receptor-associated factor (TRAF) proteins, originally identified in mammals, have since been found in most plants. TRAF proteins in plants have been shown to be involved in cellular autophagy, immunity, drought resistance, and ABA induction. However, the role in regulating sucrose and starch metabolism has not been reported.

Laboratory Evaluation of the Xpert Xpress Flu/RSV Test in Hubei, China.

Background: Early confirmation of infections with influenza virus and/or respiratory syncytial virus (RSV) is beneficial for prompt treatment and outbreak management. This study aimed to assess the Cepheid Xpert Xpress Flu/ RSV assay in Central China, using Sanger sequencing as the reference method.

Methods: Nasopharyngeal swab (NP) samples from pediatric and adult patients with influenza-like illnesses were collected by the Hubei Province Disease Control and Prevention Center.

Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies.

Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived malignancies. However, the treatment of CAR-T cells in T cell-derived malignancies has more limitations, such as fratricide, T cell aplasia, and tumor contamination, mainly because of the similarity between normal and malignant T cells.