Antibiotic resistance genes in multi-matrices of Chaohu Lake: Spatiotemporal variation and correlation with pesticides and PPCPs.

This study explored the spatiotemporal distributions of microorganisms and antibiotic resistance genes (ARGs) in the surface water, sediments, and fish intestinal contents (IC) of Chaohu Lake, and further revealed the pharmaceuticals and personal care products (PPCPs), pesticides in lake water and their relationships with ARGs. 53 types of pesticides and 25 types of PPCPs were identified in the river-lake system basin, with the highest concentrations observed for tebuconazole (1142.36 ng/L) and amantadine (851.

Therapeutic effect of fecal microbiota transplantation on hyperuricemia mice by improving gut microbiota.

Objective: The primary objective of this study was to assess the impact of fecal microbiota transplantation (FMT) on serum biochemical parameters, renal injury, and gut microbiota in hyperuricemia (HUA) mice.

Methods: Six-week-old male C57BL/6 J mice were given a high-purine diet and potassium oxonate injections to induce HUA, followed by a two-week FMT treatment. Regular body weight checks, serum biochemical analyses, and fecal sampling for 16S rRNA gene sequencing were conducted to evaluate the treatment's impact on gut microbiota.

Palladium-Catalyzed Silylation of 1-(2-Iodophenyl)-1-indoles via Intramolecular C-H Activation.

An efficient palladium-catalyzed C-H silylation of 1-(2-iodophenyl)-1-indoles has been developed. The reaction exhibits an obvious electronic effect. This protocol uses Pd(OAc) as a catalyst with hexamethyldisilane as the trimethylsilyl source.

Pd-Catalyzed Selective -C-H Silylation of Benzaldehydes Using Transient Directing Group.

An efficient and convenient palladium(II)-catalyzed selective -C-H silylation of benzaldehydes was developed for the synthesis of arylsilanes. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The kinetic experiments demonstrate that C-H activation is the rate-determining step in this transformation.

Synthesis of cyclopropanes palladium-catalyzed [2+1] annulations of sulfoxonium ylides and norbornenes.

A novel and efficient cyclopropanation reaction of sulfoxonium ylides with norbornene (NBE) derivatives catalyzed by a palladium catalyst has been realized. Such a conversion provides access to a range of cyclopropane-fused norbornene skeletons with exclusive selectivity using sulfoxonium ylides as the carbene precursors.

A causal association between serum mitochondrial-related proteins and the risk of chronic kidney disease.

Purpose: Previous studies have extensively reported some alterations in mitochondrial-related proteins in patients with chronic kidney disease (CKD). Herein, we used a two-sample Mendelian randomization (MR) to investigate the potential causal relationship between serum mitochondrial-related protein function and CKD.

Methods: The data related to CKD and mitochondrial 2,4-dienoyl CoA reductase 1 were obtained from the genome-wide association studies (GWAS) database; data on other mitochondrial-related proteins were sourced from the IEU (Integrative Epidemiology Unit) database.

Palladium-catalyzed dual C-H activation for the synthesis of indolo[1,2-]phenanthridines.

An efficient palladium-catalyzed strategy for the synthesis of indolo[1,2-]phenanthridine derivatives has been developed. The current strategy delivers a range of indolo[1,2-]phenanthridines by utilizing readily available -(2-halophenyl)-indoles and commercially available iodobenzenes as the starting materials. The reaction features the formation of two C-C bonds through Pd-catalyzed dual C-H bond activation.

Ni(II)-Catalyzed Site- and Regioselective α-Alkenylation of Cyclic Ketones with Alkenes.

Herein, a nickel-catalyzed α-alkenylation reaction of asymmetric cyclic ketones at the sterically hindered α-position with alkenes is disclosed. The high regioselectivity might originate from the acid-catalyzed enolization reaction, selectively generating the thermodynamically favored enol. The nickel catalyst facilitates the preferential alkenylation of polysubstituted enolates rather than monosubstituted enolates, thereby reversing the conventional regioselectivity of alkenylation at the α-position of ketones.

An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models.

An overwhelming burden to clinics, herpes zoster (HZ), or shingles, is a painful disease that occurs frequently among aged individuals with a varicella-zoster virus (VZV) infection history. The cause of shingles is the reactivation of dormant VZV in the dorsal root ganglia/cranial nerves of the human body. Patients with HZ experience sharp, intense, electric shock-like pain, which makes their health-related quality of life (HRQoL) extremely low.

Association between ZJU index and kidney stone prevalence in the Chinese adult population: a retrospective propensity score-matched analysis.

The study aimed to explore the association between the ZJU (Zhejiang University) index and the prevalence of kidney stones in Chinese adults. Electronic health records of individuals undergoing routine physical examinations at Wuhu Second People's Hospital between January 2021 and June 2024 were retrospectively analyzed. Participants were divided into kidney stone recurrence and non-recurrence groups.

Long-term exposure to dust in fine particulate matter and post-stroke functional impairment-Findings from the China National Stroke Screening Surveys.

The dust component of particulate matter (PM) warrants more attention in the era of climate change and increased frequency of dust event, yet rarely are studies focused exclusively on the long-term health effects of dust PM. This study aims to assess the relative toxicity of dust and non-dust PM on the long-term functional impairment after stroke. We utilized data from a multicenter, national survey in China from 2013 to 2019 and selected participants with repeated assessments of the functional impairment outcomes, the modified Rankin scale (mRS) score, to form a longitudinal dataset.

Meta-analysis of gut microbiota alterations in patients with irritable bowel syndrome.

Introduction: Irritable bowel syndrome (IBS) is a common chronic disorder of gastrointestinal function with a high prevalence worldwide. Due to its complex pathogenesis and heterogeneity, there is urrently no consensus in IBS research.

Methods: We collected and uniformly reanalyzed 1167 fecal 16S rRNA gene sequencing samples (623 from IBS patients and 544 from healthy subjects) from 9 studies.

Palladium-catalyzed annulation and intermolecular hydroamination involving norbornene derivatives: synthesis of indanones and -alkylamines.

A palladium-catalyzed divergent reaction of primary benzamides using norbornene (NBE) derivatives as a controlled switch is reported. When NBE is used as a mediator, indanones are synthesized with moderate to good yields a Catellani reaction that involves sequential -C-H alkylation and -C-N bond cleavage annulation of primary benzamides. Employing norbornadiene (NBD) instead of NBE enables the assembly of -alkylamines by an intermolecular hydroamination reaction.

The pro-tumor activity of INTS7 on lung adenocarcinoma via inhibiting immune infiltration and activating p38MAPK pathway.

Lung adenocarcinoma (LUAD) is the most common lung cancer, accounting for 19.4% of all cancer deaths. Our previous study discovered that INTS7 expression was upregulated in LUAD, while the precise mechanism by which INTS7 exerts pro-cancer effects remains unknown.

Association between exposure to greenspace and ECG abnormalities in China: a nationwide longitudinal study.

Background: Greenspace is an important modifiable environmental factor that is associated with health and well-being. Although previous research has shown that exposure to greenspace is beneficial for cardiovascular diseases, studies have rarely focused on early subclinical health outcomes such as electrocardiogram (ECG) abnormality.

Methods: We developed a longitudinal study using data from the China National Stroke Screening Survey (2013-2019).

Possible Mechanism of Sucrose and Trehalose-6-Phosphate in Regulating the Secondary Flower on the Strong Upright Spring Shoots of Blueberry Planted in Greenhouse.

Secondary flowering is the phenomenon in which a tree blooms twice or more times a year. Along with the development of blueberry ( L.) fruits in spring, a large number of secondary flowers on the strong upright spring shoots were noticed in blueberries planted in the greenhouse.

Efficacy of Donor-Recipient-Matched Faecal Microbiota Transplantation in Patients with IBS-D: A Single-Centre, Randomized, Double-Blind Placebo-Controlled Study.

Introduction: The imbalance in gut microbiota is contributing to the development and progression of IBS. FMT can improve the gut microbiota, and donor-recipient-matched FMT can help develop individualized treatment plans according to different enterotypes. This study aimed to explore the efficacy of donor-recipient-matched FMT in IBS with predominant diarrhoea (IBS-D) and evaluate its effects on gut microbiota.

Palladium(II)-Catalyzed Norbornene-Mediated Selective -C-H Silylation for the Synthesis of Arylsilanes from Primary Benzamides.

A palladium(II)-catalyzed norbornene-mediated remote selective -C-H silylation of primary benzamides was developed for the synthesis of arylsilanes. Such a conversion provides access to a range of arylsilanes with exclusive selectivity using norbornene (NBE) as the -C-H activator. The amide directing group can be detached simultaneously through C-C bond cleavage or undergo a dehydration reaction pathway to form nitriles.

The impact of retirement on blood pressure: evidence from a nationwide survey in China.

Introduction: The health impact of retirement is controversial. Most previous studies have been based on self-reported health indicators or the endpoints of some chronic diseases (e.g.

Tandem Vinylogous Aldol and Intramolecular [2 + 2] Cycloaddition toward Benzocyclobutenes by UV Light Photocatalysis.

A facile and efficient radical tandem vinylogous aldol and intramolecular [2 + 2] cycloaddition reaction for direct synthesis of cyclobutane-containing benzocyclobutenes (BCBs) under extremely mild conditions without using any photocatalysts is reported. This approach exhibited definite compatibility with functional groups and afforded new BCBs with excellent regioselectivity and high yields. Moreover, detailed mechanism studies were carried out both experimentally and theoretically.

[A Review of Comparative Studies on Exposure Levels of Air Pollutants Among Different Modes of Transportation in China's Cities].

Urban traffic is closely related to the daily life of the public,and air pollution in the traffic microenvironment has become a public health problem that cannot be ignored.This paper reviews the comparative studies of air pollutant exposure levels among different modes of transportation in multiple cities in China.By comparing the exposure levels of pollutants among different modes of transportation,this paper provides a reference for protecting the health of the public in daily transportation and selecting targeted control measures.

Palladium/NBE-Catalyzed Regioselective C-H Silylation: Access to Divergent Silicon-Containing Indoles.

A palladium/norbornene (NBE)-catalyzed regioselective C-H silylation of free NH-indoles is reported. This protocol uses Pd(OAc) as the catalyst and Cu(OAc) as the oxidant, and the reaction relies on the control of NBE as a switch. The reaction tolerates various functional groups, and a series of silicon-containing indoles were directly synthesized in 30%-94% yields.

When and how is team cognitive diversity beneficial? An examination of Chaxu climate.

The workforce is becoming increasingly heterogeneous in terms of age, gender, race/ethnicity, education, values, cognition, and culture. Thus, team diversity management is regarded as an important development strategy that organizations can use to gain advantages. However, in the diversity literature, empirical studies investigating the effects of cognitive diversity on creativity have not yielded conclusive findings.

The Association Between Urbanization and Electrocardiogram Abnormalities in China: a Nationwide Longitudinal Study.

The health effects of urbanization are controversial. The association between urbanization and reversible subclinical risks of cardiovascular diseases (e.g.