Reduction of maximal false lumen area ratio by interactive cannulation perfusion in DeBakey type I acute aortic dissection repair.

Introduction: Acknowledging lacking of recognition on postoperative aortic remodeling by intraoperative transition of cannulation perfusion mode during the open repair surgery of DeBakey type I acute aortic dissection (AAD), this study aims to investigate the effect of interactive cannulation strategy on the maximum false lumen area (MFLA) ratio.

Methods: A total of 321 AAD patients were retrospectively reviewed from March 2017 to March 2023, of which 166 patients receiving peripheral cannulation (PC, right axillary and femoral artery) and 155 patients receiving peripheral-to-centric cannulation (PCC, transition from right axillary and femoral artery to one branch of the tetrafurcated graft). The primary outcome was postoperative MFLA ratio in descending thoracic aorta.

[Cloning and functional analysis of involved in disease resistance].

The plant F-box protein more axillary growth 2 (MAX2) is a key factor in the signal transduction of strigolactones (SLs) and karrinkins (KARs). As the main component of the SKP1-CUL1-FBX (SCF) complex ubiquitin ligase E3, MAX2 is responsible for specifically recognizing the target proteins, suppressor of MAX2 1/SMAX1-like proteins (SMAX1/SMXLs), which would be degraded after ubiquitination. It can thereby regulate plant morphogenesis and stress responses.

Adult hippocampal neurogenesis-mediated cognitive behavior participates in stress resilience to anxiety and depression-like behaviors in postpartum dams.

Postpartum period being a critical phase affecting women's health recovery, and stressful events during this period are major risk factors for postpartum depression. Pup separation (PS) serves as a natural model of postpartum maternal care. However, the effects of different PS (no separation, NPS; 15 min/day, PS15, brief PS; 180 min/day, PS180, long PS) during lactation on stress-induced behavioral deficits in dams, along with the underlying mechanisms of resilience remain unclear.

Hepatotoxicity associated with statins: A retrospective pharmacovigilance study based on the FAERS database.

Background: Statins are commonly prescribed in clinical practice and are associated with a high risk of drug-induced liver injury (DILI). This study aims to examine the real-world data on statin-induced liver injury to assess medication safety.

Methods: All DILI cases reported with statins as primary suspected drugs were extracted based on the US Food and Drug Administration adverse event reporting system (FAERS) from 2004 to 2023.

The Need for Peer Support and Codesigned Services: A Qualitative Study to Understand Diabetes Education Program Needs of Adolescents With Type 1 Diabetes.

Developmental challenges of adolescence, such as puberty and social pressures, exacerbate the complexity of managing type 1 diabetes (T1D) as they transition from pediatric to adult care. However, there is a paucity of codesigned, evidence-based diabetes education and support programs and services to guide adolescents through this transition. This study aimed to explore the experiences, perspectives, facilitators, and barriers faced by adolescents with T1D in diabetes education and program services and to identify feasible approaches to support them as they transition from pediatric to adult care.

US Public Health Gains from Improved Treatment of Hypercholesterolemia: A Simulation Study of NHANES Adults Treated to Guideline-Directed Therapy.

Importance: Hypercholesterolemia is widely undertreated.

Objective: To project anticipated improvements in treatment and outcomes under full implementation of US and European pharmacologic treatment recommendations.

Design, Setting, And Participants: The study sample included a total of 4980 adults aged 40-75 years from the 2013 through March 2020 US National Health and Nutrition Examination Survey (NHANES).

An Integrated Analysis of Transcriptomic and Metabolomic Effects Reveals Insights into Stress Responses in Largemouth Bass () Under MS-222 (Tricaine Methanesulfonate) Exposure.

Background/objectives: MS-222 is a commonly used anesthetic for fish. Research on the anesthetic mechanism of MS-222 is scarce, especially in largemouth bass. Therefore, this study investigated the tissue-specific transcriptomic and metabolomic effects of MS-222 anesthesia on largemouth bass ().

Construction of a prognostic model for endometrial cancer related to programmed cell death using WGCNA and machine learning algorithms.

Background: Programmed cell death (PCD) refers to a regulated and active process of cellular demise, initiated by specific biological signals. PCD plays a crucial role in the development, progression, and drug resistance of uterine corpus endometrial carcinoma (UCEC), making the exploration of its relationship with UCEC prognosis highly clinically relevant.

Methods: Data from UCEC patients and control cohorts were obtained from The Cancer Genome Atlas (TCGA) database.

Unraveling the local coordination effect of Cu-N-C single-atom catalysts towards CO adsorption a gas-phase cluster model approach.

The current understanding regarding how the coordination environment of single-atom catalysts supported on nitrogen-doped carbon (M-N-C SACs) regulates their reactivity remains controversial, due to the complicated surface chemistry and lack of atomic-level insights. Here we introduce an experimental modeling approach to unambiguously identify the individual contribution of the local environment to the adsorption activity of CO on Cu-N-C systems. The fundamental intrinsic activities of Cu-N-C systems with different N coordination numbers, N coordination geometries (, pyrrolic N and pyridinic N), defect sites (, armchair and zig-zag), as well as S and P dopants, towards CO adsorption can be explicitly obtained and compared at the strictly atomic level, which would be challenging to access conventional techniques in SACs research.

Mechanisms of drug resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, associated with high morbidity and mortality worldwide. Despite advancements in diagnostic methods and systemic treatments, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), the development of drug resistance remains a significant challenge in HCC management. Traditional treatments such as surgical resection and transarterial chemoembolization offer limited efficacy, especially in advanced stages.

GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research.

High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents and offspring. Here, we established the genomic platform of the Born in Guangzhou Cohort Study (BIGCS), named the Genome Database of BIGCS (GDBIG), which represents the first birth cohort-based genomic database in China and is designed to facilitate intergenerational genetic research. Based on the phase I results of the BIGCS, GDBIG includes low-coverage (∼ 6.

Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning.

Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular demise. However, the role of pyroptosis in sepsis remains to be further explored.

Innovative Cardiac Rehabilitation: Effects of Adaptive Postural Balance Exercise on Coronary Artery Disease and Type 2 Diabetes.

Purpose: This study aimed to evaluate the effects of Adaptive Postural Balance Cardiac Rehabilitation Exercise (APBCRE) on glycolipid metabolism and exercise endurance in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).

Patients And Methods: This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group.

HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis.

Ferroptosis is an apoptosis-independent cell death pathway characterized by heightened lipid peroxidation, which shows promise for tumor suppression. Despite extensive research on long non-coding RNAs (LncRNAs) in ferroptosis, their role in colorectal cancer (CRC) remains underexplored. We investigated the upregulation of AC145207.

ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target.

Background: Hepatocellular carcinoma (HCC) remains a major therapeutic challenge due to its immunosuppressive tumor microenvironment (TME) and resistance to immune checkpoint inhibitors (ICIs). Pyroptosis is a form of cell death with complex dual functions in tumor immunity. However, the precise regulatory mechanisms and interactions between pyroptosis and immune evasion in HCC remain poorly understood.

Qualitative study of spousal emotional experiences of taking care of dying patients.

Background: Spouses caring for cancer patients in the terminal phase often grapple with significant physical distress when faced with the impending death of their partners. Regrettably, the personal emotions and mental health challenges of caregiving spouses are commonly overlooked. This study utilized qualitative research methodologies to delve into the emotional experiences of spouses as they provide care to dying patients.

Biodegradation of p-nitrophenol by Rhodococcus sp. 21391 unveils a two-component p-nitrophenol monooxygenase with broad substrate specificity.

Background: Bioremediation relying on highly efficient degrading bacteria constitutes a promising and sustainable avenue for controlling and reducing nitrophenol contamination in the environment. A thorough understanding of the bacterial degradation mechanism of nitrophenol is of paramount importance for supporting the development of efficient microbial remediation technology.

Results: In this study, a new bacterium, Rhodococcus sp.

Changes of food-cue processing in major depressive disorder patients with decreased appetite: An event-related potential study.

Appetite decrease is a common symptom in major depressive disorder (MDD). However, published research discussing the cognitive process to food stimuli in MDD patients with decreased appetite is lacking, as are objective indicators to assess their degree of appetitive loss. The current study evaluated the disparities in food-related cognition between healthy controls and MDD patients, explored the brain regions contributing to these changes, and evaluated the potential of event-related potentials for assessing appetite loss severity.

Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review.

This review is to systematically explore the relationship between muscle dysfunction and diabetes in adults, and to examine the impact of glycemic variability on muscle health and the development of diabetes-related complications. The review was conducted using three databases: MEDLINE, Scopus, and EMBASE, targeting peer-reviewed journal articles written in English and published from January 2014 to September 2024. The methodological quality assessment of the eligible studies was conducted using Joanna Briggs Institute Critical Appraisal Checklists.

Cultivating cultural empathy among diabetes educators: A pre-post evaluation of a digital story intervention.

Indigenous Australians are disproportionately affected by diabetes, with a diagnosis rate nearly four times higher than people from a non-Indigenous background. This health disparity highlights the urgent need for healthcare providers to develop cultural empathy - a critical competency for delivering culturally safe and person-centered care. Cultural empathy is essential for building trust and effective communication in diabetes education and management within Indigenous people.

Identification and Expression Analysis of Gene in Bitter Gourd ().

Background: Lipoxygenases (LOXs) are key enzymes in the unsaturated fatty acid oxidation reaction pathway and play an important regulatory role in the synthesis of fruit aroma volatiles.

Methods: gene family members were identified in the whole genome database of bitter gourd and analyzed bioinformatically. An RT-qPCR was used to analyze the expression differences in different tissues.

The outcome of thrombotic microangiopathy in kidney transplant recipients.

Background: The outcome of kidney transplant recipients with a history of complement-mediated thrombotic microangiopathy (cTMA) and those who develop post-transplant de novo TMA (dnTMA) is largely unknown.

Methods: We retrospectively studied all kidney transplant recipients with end-stage kidney disease secondary to cTMA and those who developed dnTMA, between Jan 2000 and Dec 2020 in our center.

Results: We identified 134 patients, 22 with cTMA and 112 had dnTMA.

Enhancement of the reactivation process of long-term starved anammox granular sludge with gravel balls: Microbial succession and metabolic impact.

Anaerobic ammonium oxidation (Anammox) process is an economical and energy-efficient method of wastewater nitrogen removal. However, they are highly susceptible to starvation stress caused by sudden environmental changes. Rapid reactivation of starved anammox sludge is a crucial method to address seed sludge shortages and expand practical applications.

Impact of Multiarterial versus Single Arterial Coronary Bypass Graft Surgery on Postoperative Atrial Fibrillation.

The effect of multiarterial (MA) versus single arterial (SA) coronary bypass graft surgery on postoperative atrial fibrillation (POAF) was not investigated. From May 2017 to May 2024, the patients with CYP2C19*2 or *3 allele receiving coronary artery grafting and postoperational aspirin 100 mg/day and clopidogrel 75 mg/day were retrospectively reviewed and assigned to the MA or SA group. The primary end point was the incidence rate of POAF in the first week.