First trimester maternal infections and offspring congenital heart defects: a meta-analysis.

Background And Aims: Maternal infections have been proposed to play a role in the development of congenital heart defects (CHD). This study aims to synthesize contemporary evidence on the association between first-trimester maternal infection and risk of offspring CHD.

Methods: This systematic review and meta-analysis (PROSPERO number: CRD42024523638) used Embase, PubMed, Web of Science, Scopus, and the Cochrane Library to identify studies investigating first-trimester maternal infection and offspring CHD, published up until 30 September 2024.

Association of Childhood Obesity Phenotypes With Cardiometabolic Outcomes in Adulthood: A Systematic Review and Meta-Analysis.

The association between different metabolic phenotypes of childhood obesity and cardiometabolic outcomes in adulthood is inconsistent. We conducted a systematic review and meta-analysis to synthesize the evidence on the association between childhood obesity phenotypes including metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and cardiometabolic outcomes in adulthood. Four cohort studies with 8446 participants were included in this review.

Maternal inflammation during the second trimester of pregnancy with adverse birth outcomes: a prospective cohort study.

Background: Distinct characteristics of maternal inflammation at midgestation related to fetal and neonatal health are not clear. This study aims to explore the associations between the maternal circulating inflammatory profile during the second trimester of pregnancy and a series of adverse birth outcomes.

Methods: The present study was a prospective cohort study based on the Born in Guangzhou Cohort Study conducted in Guangzhou, China.

GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research.

High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents and offspring. Here, we established the genomic platform of the Born in Guangzhou Cohort Study (BIGCS), named the Genome Database of BIGCS (GDBIG), which represents the first birth cohort-based genomic database in China and is designed to facilitate intergenerational genetic research. Based on the phase I results of the BIGCS, GDBIG includes low-coverage (∼ 6.

[Remediation Potential of Benth. on Farmland Soil Contaminated by Cd, As, and Pb].

This study investigated the growth, enrichment characteristics, and remediation potential of Benth. （"Hua ye ge" and "Gan ge er hao"） on cadmium （Cd）, arsenic （As）, and lead （Pb）-contaminated soils, the remediation potential of in a large field experiment under different trial fields. The results showed that the whole plant biomass （dry weight） of was 4.

Association of childhood obesity with pubertal development in boys: A systematic review and meta-analysis.

Childhood obesity leads to early puberty development in girls, but its effect in boys remains unclear. We conducted a systematic review and meta-analysis to study the association between childhood obesity and puberty development in boys. We included 14 cohort studies with 114,822 boys.

Twins and Their Risks of Cancer as Children, Teenagers or Young Adults: Updated Meta-Analysis and Retrospective Swedish Cohort Study.

We investigated whether an observed reduction in overall childhood cancer risk (<15 years of age) in twins has been sustained, and how this extends into young adulthood. We searched for English language publications reporting childhood cancer risk in twins, obtained unpublished data directly from some authors, and updated a meta-analysis. We used the Swedish Multigeneration Register to investigate the age to which the reduced overall risk of childhood cancer (observed previously using that Swedish dataset and in this and earlier meta-analyses) persisted into the teenage/young adult years, and which specific tumors accounted for the overall risk reduction beyond childhood.

Lifestyle-based subtypes of childhood obesity and their association with cardiometabolic factors: A cluster analysis.

Background: Lifestyle factors play an important role in the development and management of childhood obesity and its related cardiometabolic complications.

Objective/methods: We aimed to explore childhood obesity subtypes based on lifestyle factors and examine their association with cardiometabolic health. We included 1550 children with obesity from the National Health and Nutrition Examination Survey.

Association of common maternal infections with birth outcomes: a multinational cohort study.

Purpose: It is unclear whether common maternal infections during pregnancy are risk factors for adverse birth outcomes. We assessed the association between self-reported infections during pregnancy with preterm birth and small-for-gestational-age (SGA) in an international cohort consortium.

Methods: Data on 120,507 pregnant women were obtained from six population-based birth cohorts in Australia, Denmark, Israel, Norway, the UK and the USA.

Weight status changes from childhood to adulthood were associated with cardiometabolic outcomes in adulthood.

Aim: Few studies have assessed the association between weight changes from childhood to adulthood and cardiometabolic factors in adulthood. The aim of this study was to explore the relationships between weight changes from childhood to adulthood and cardiometabolic factors in adulthood using national Chinese data.

Methods: We included 649 participants from the China Health and Nutrition Survey from 1989 to 2009 and divided them into four groups by their body mass index from 6 to 37 years of age.

The Born in Guangzhou Cohort Study enables generational genetic discoveries.

Genomic research that targets large-scale, prospective birth cohorts constitutes an essential strategy for understanding the influence of genetics and environment on human health. Nonetheless, such studies remain scarce, particularly in Asia. Here we present the phase I genome study of the Born in Guangzhou Cohort Study (BIGCS), which encompasses the sequencing and analysis of 4,053 Chinese individuals, primarily composed of trios or mother-infant duos residing in South China.

Impact of closed-off management due to COVID-19 rebound on maternal depression during pregnancy.

Background: This study aimed to assess the impacts of closed-off measures with different strictness levels (lockdown, partial lockdown and non-lockdown) and geographic proximity to patients with coronavirus disease 2019 (COVID-19) on prenatal depression during an epidemic rebound of COVID-19.

Methods: This was a cross-sectional web-based survey including 880 pregnant women. Depressive symptoms were measured by Self-Rating Depression Scale (SDS) and geographic proximity was calculated using Geographic Information Systems.

How to enhance the applicability of a risk prediction model for term small-for-gestational-age neonates in clinical settings?

Objective: To construct a simple term small-for-gestational-age (SGA) neonate prediction model that is clinically practical.

Methods: This analysis was based on the Born in Guangzhou Cohort Study (BIGCS). Mothers who had a singleton pregnancy, delivered a term neonate, and had an ultrasonography within 30 + 0 to 32 + 6 weeks of gestation were included.

Incremental predictive value of platelet parameters for preeclampsia: results from a large prospective cohort study.

Background: Platelet parameters during pregnancy were associated with the risk of preeclampsia (PE), but the predictive value of these parameters for PE remained unclear. Our aim was to clarify the individual and incremental predictive value of platelet parameters, including platelet count (PC), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) for PE.

Methods: This study was based on the Born in Guangzhou Cohort Study in China.

Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark.

Importance: Maternal infection is common during pregnancy and is an important potential cause of fetal genetic and immunological abnormalities. Maternal infection has been reported to be associated with childhood leukemia in previous case-control or small cohort studies.

Objective: To evaluate the association of maternal infection during pregnancy with childhood leukemia among offspring in a large study.

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis.

Aims: To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age.

Methods And Results: Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis.

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood.

Importance: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population.

Objective: To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study.

Design, Setting, And Participants: This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.

The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study.

Background: Thyroid dysfunction has been reported in severe liver diseases. The aim of this study was to analyze the impact of serum thyroid-stimulation hormone (TSH) levels on the prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF).

Methods: This retrospective cohort study included 1,862 patients with HBV-related ACLF.

Associations of Cord Blood Lipids with Childhood Adiposity at the Age of Three Years: A Prospective Birth Cohort Study.

We aimed to examine the associations between cord blood lipids and childhood adiposity and to investigate whether these associations vary across birth weight categories (small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA)) in 1306 infants in the Born in Guangzhou Cohort Study, China. Adiposity outcomes at the age of three years included z-scores of weight-for-length/height (WFLZ), body mass index (BMIZ), subscapular (SSTZ) and triceps skinfold thickness (TSTZ), and the sum of skinfold thicknesses (SSFTZ). Cord blood triglycerides (TG) levels were negatively associated with WFLZ and BMIZ, whereas high density lipoprotein (HDL) levels were positively associated with WFLZ, BMIZ, TSTZ and SSFTZ.

Gestational weight gain rates in the first and second trimesters are associated with small for gestational age among underweight women: a prospective birth cohort study.

Background: Despite the well-studied effects of gestational weight gain (GWG) on offspring health, little is known about the association of trimester-specific GWG with offspring birth weight among underweight pregnant women. This study aimed to explore the association of trimester-specific GWG rate with small for gestational age (SGA) in underweight women.

Methods: The GWG rate of underweight pregnant women (pre-pregnancy body mass index [BMI] lower than 18.

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth.

Background: Birth weight is associated with cardiometabolic factors at birth. However, it is unclear when these associations occur in fetal life. We aimed to investigate the associations between fetal growth in different gestational periods and cord blood cardiometabolic factors.