Construction of a prognostic model for endometrial cancer related to programmed cell death using WGCNA and machine learning algorithms.

Background: Programmed cell death (PCD) refers to a regulated and active process of cellular demise, initiated by specific biological signals. PCD plays a crucial role in the development, progression, and drug resistance of uterine corpus endometrial carcinoma (UCEC), making the exploration of its relationship with UCEC prognosis highly clinically relevant.

Methods: Data from UCEC patients and control cohorts were obtained from The Cancer Genome Atlas (TCGA) database.

Do multiple reconstructive surgeries increase loss of cervical lordosis in patients with multilevel degenerative cervical diseases? A retrospective cohort study.

Study Design: A retrospective cohort study.

Background And Objective: There are no data on changes in cervical sagittal alignment and curvature after second and third surgeries in patients with multilevel cervical degenerative diseases (CDD). This study aimed to explore these changes following multiple decompression and reconstruction surgeries.

Advancing digital cognitive rehabilitation: the role of adaptive serious games in enhancing elderly cognitive health.

As individuals age, cognitive decline increases the cognitive load, adversely affecting their ability to perform daily activities. Recently, serious games have emerged as practical digital rehabilitation tools to mitigate cognitive load in older adults. These games are categorised into task-oriented, adaptive, and multimodal types.

Enhancing MaaS user satisfaction through strategic marketing: The synergy of sustainability and service experience.

As urbanization intensifies and the need for sustainable transportation grows, Mobility as a Service (MaaS) emerges as a promising solution to urban mobility challenges. This study seeks to explore the underlying mechanisms of MaaS from a sustainability perspective and to assess its impact on service experience and user satisfaction. Additionally, it examines how user satisfaction influences the broader adoption of MaaS.

Effects of "fixation-fusion" sequence of lumbar surgery on surgical outcomes for patients with lumbar spinal stenosis: study protocol for a multicenter randomized controlled trial.

Background: New-onset neurological symptoms such as numbness and pain in lower extremities might appear immediately after conventional lumbar interbody fusion (LIF) surgery performed in patients with lumbar spinal stenosis.

Methods And Analysis: This is a multicenter, randomized, open-label, parallel-group, active-controlled trial investigating the clinical outcomes of modified LIF sequence versus conventional LIF sequence in treating patients with lumbar spinal stenosis. A total of 254 eligible patients will be enrolled and randomized in a 1:1 ratio to either modified LIF sequence or conventional LIF sequence group.

Self-wavelength shifting in two-dimensional perovskite for sensitive and fast gamma-ray detection.

Lead halide perovskites have recently emerged as promising X/γ-ray scintillators. However, the small Stokes shift of exciton luminescence in perovskite scintillators creates problems for the light extraction efficiency and severely impedes their applications in hard X/γ-ray detection. Dopants have been used to shift the emission wavelength, but the radioluminescence lifetime has also been unwantedly extended.

Reduction of Adolescent Idiopathic Scoliosis and Improved -Axis Alignment of the Entire Spine When Treating a Symptomatic Patient Using a Multidisciplinary Approach: A Case Report.

Background: This study presents findings on improvements of both the X-axis and Z-axis posture in a young female with adolescent idiopathic, scoliosis suffering from pain complaints who was treated with a multidisciplinary approach.

Case Presentation: The 15-year-old patient reported low back pain for several months. Full spine radiographic assessment revealed a cervical kyphosis, forward head translation, a right ribcage translation, a left higher shoulder, and a dextroconvex lumbar scoliosis with a Cobb angle of 23°.

MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion.

Background: Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be significantly upregulated in SA-associated villus tissues, yet the function it plays in this context has yet to be clarified. This study explored the function of miR-135a-5p and its potential as a biomarker for unexplained SA.

Chemical Potential Diagram Guided Rational Tuning of Electrical Properties: A Case Study of CsPbBr for X-ray Detection.

Controlling the carrier polarity and concentration underlies most electronic and optoelectronic devices. However, for the intensively studied lead halide perovskites, the doping tunability is inefficient. In this work, taking CsPbBr as an example, it is revealed that the coexistence of metallic Pb or CsBr /Br , rather than the precursor ratio, can provide Pb-rich/Br-poor or Br-rich/Pb-poor chemical conditions, enabling the tunability of electrical properties from weak n-type, intrinsic, to moderate p-type.

MYB43 as a novel substrate for CRL4 E3 ligases negatively regulates cadmium tolerance through transcriptional inhibition of HMAs in Arabidopsis.

Controlled stability of proteins is a highly efficient mechanism to direct diverse processes in plants. A key regulatory system for protein stability is given by the CULLIN-RING E3 ligases (CRLs). In this work, MYB43 is identified as a novel target of a CUL4-DDB1-PRL1 (PLEIOTROPIC REGULATORY LOCUS 1)-RING E3 ligase (CRL4 E3 ligase).

Template directed perovskite X-ray detectors towards low ionic migration and low interpixel cross talking.

The metal halide perovskites exhibit excellent performance as the direct X-ray detectors owing to their strong absorption capability, long carrier lifetime and diffusion length, radiation ruggedness, etc. For imaging applications, the ionic migration of perovskites and charge sharing effect between the adjacent pixels have a significantly negative impact on the spatial resolution. Herein, for the first time, the porous anodic aluminum oxides (AAO) have been used as a template to grow the CsPbBrI thick film for the direct X-ray detection.

Lead halide perovskite for efficient optoacoustic conversion and application toward high-resolution ultrasound imaging.

Lead halide perovskites have exhibited excellent performance in solar cells, LEDs and detectors. Thermal properties of perovskites, such as heat capacity and thermal conductivity, have rarely been studied and corresponding devices have barely been explored. Considering the high absorption coefficient (10~10 cm), low specific heat capacity (296-326 J kg K) and small thermal diffusion coefficient (0.

The effect of ABRE BINDING FACTOR 4-mediated FYVE1 on salt stress tolerance in Arabidopsis.

FYVE1 encodes a protein that is localized to the peripheral membrane of late endosomal compartments, and is involved in the regulation of mulitivesicular/prevacuolar compartment protein sorting. It was found that FYVE1 attenuates ABA signaling through degrading ABA receptors PYR1 and PYL4 by ESCRT pathway, and also interacts with transcription factors ABF4 and ABI5 to transcriptionally inhibit ABA signaling pathway by reducing their binding to the cis-regulatory sequences of their downstream genes. However, the mechanisms underlying the transcriptional regulation of FYVE1 and its biological function in salt stress are largely unknown.

Hot-Pressed CsPbBr Quasi-Monocrystalline Film for Sensitive Direct X-ray Detection.

An X-ray detector with high sensitivity would be able to increase the generated signal and reduce the dose rate; thus, this type of detector is beneficial for applications such as medical imaging and product inspection. The inorganic lead halide perovskite CsPbBr possesses relatively larger density and a higher atomic number in contrast to its hybrid counterpart. Therefore, it is expected to provide high detection sensitivity for X-rays; however, it has rarely been studied as a direct X-ray detector.

Effect of age at first use of oral contraceptives on breast cancer risk: An updated meta-analysis.

Background: We evaluated the relationship between the age at first use of oral contraceptives (OC) and breast cancer (BC) risk.

Methods: We searched PubMed, Embase, and related reviews published through June 28, 2018, and used summary relative risk (RR) and 95% confidence intervals (CIs) to evaluate the cancer risks, and fixed-effects dose-response meta-analysis to assess potential linear and non-linear dose-response relationships.

Results: We included 10 studies, with 8585 BC cases among 686,305 participants.

Heteroepitaxial passivation of CsAgBiBr wafers with suppressed ionic migration for X-ray imaging.

X-ray detectors are broadly utilized in medical imaging and product inspection. Halide perovskites recently demonstrate excellent performance for direct X-ray detection. However, ionic migration causes large noise and baseline drift, limiting the detection and imaging performance.

Photophysical Pathways in Highly Sensitive Cs AgBiBr Double-Perovskite Single-Crystal X-Ray Detectors.

The sensitive detection of X-rays embodies an important research area, being motivated by a common desire to minimize the radiation doses required for detection. Among metal halide perovskites, the double-perovskite Cs AgBiBr system has emerged as a promising candidate for the detection of X-rays, capable of high X-ray stability and sensitivity (105 μC Gy cm ). Herein, the important photophysical pathways in single-crystal Cs AgBiBr are detailed at both room (RT) and liquid-nitrogen (LN T) temperatures, with emphasis made toward understanding the carrier dynamics that influence X-ray sensitivity.

RNA binding protein HuR promotes osteosarcoma cell progression via suppressing the miR-142-3p/HMGA1 axis.

The present study aimed to study the roles and underlying mechanisms of human antigen R (HuR) in osteosarcoma (OS) cell progression. It was determined that the HuR mRNA and protein levels were significantly upregulated in OS tissues, compared with that in normal adjacent tissues. HuR expression was negatively associated with miR-142-3p expression, but positively with High Mobility Group AT-Hook 1 (HMGA1).

RNA binding protein Lin28A promotes osteocarcinoma cells progression by associating with the long noncoding RNA MALAT1.

Objectives: To explore the effects of Lin28A on progression of osteocarcinoma (OS) cells.

Results: Lin28A mRNA and protein expressions were significantly increased in OS tissues compared with that in normal adjacent tissues. Expressions of Lin28A and long noncoding RNA MALAT1 were positively correlated.

High-Pressure Band-Gap Engineering in Lead-Free Cs AgBiBr Double Perovskite.

Novel inorganic lead-free double perovskites with improved stability are regarded as alternatives to state-of-art hybrid lead halide perovskites in photovoltaic devices. The recently discovered Cs AgBiBr double perovskite exhibits attractive optical and electronic features, making it promising for various optoelectronic applications. However, its practical performance is hampered by the large band gap.

1-Carboxymethyl-1'-carboxylatomethyl-3,3'-[p-phenylenebis(oxymethylene)]dipyridinium bromide dihydrate.

In the crystal structure of the title salt, C(22)H(21)N(2)O(6) (+)·Br(-)·2H(2)O, pairs of betaine mol-ecules are bridged by protons (the bridging proton is disordered), forming strong and symmetrical O-H⋯O hydrogen bonds, leading to an infinite chain along the b axis. The water mol-ecules are linked to the betaine mol-ecule and the bromide ion through O-H⋯O and O-H⋯Br inter-actions. The central ring, located on an inversion centre, makes dihedral angles of 1.

catena-Poly[[[tetra-aqua-cadmium(II)]-μ-3,3'-[p-phenyl-enebis(oxymethyl-ene)]bis-(1-pyridinioacetate)] dinitrate hemihydrate].

In the title polymeric coordination complex, {[Cd(C(22)H(20)N(2)O(6))(H(2)O)(4)](NO(3))(2)·0.5H(2)O}(n), obtained from the self-assembly of the flexible double betaine 3,3'-[p-phenyl-enebis(oxymethyl-ene)]bis-(1-pyridinioacetate) with cadmium nitrate, both the octa-hedrally coordinated Cd(II) cation and the substituted betaine ligand lie on inversion centres. The chains constructed through the trans-related acetate groups of the ligand are inter-connected via O-H⋯O hydrogen bonds involving coordinated aqua ligands, the nitrate anions and the partial-occupancy (0.

catena-Poly[[[diaqua-copper(II)]-μ-2,2'-{[p-phenyl-enebis(oxymethyl-ene)]bis-(pyridinium-3,1-di-yl)}diacetate] dibromide].

The title centrosymmetric coordination polymer, {[Cu(C(22)H(20)N(2)O(6))(H(2)O)(2)]Br(2)}(n), formed by the reaction of the flexible double betaine ligand 2,2'-{[p-phenyl-enebis(oxymethyl-ene)]bis-(pyridine-3,1-di-yl)}diacetic acid with CuBr(2), contains a Cu(II) atom ( symmetry) which is surrounded by two water molecules and bridged by two anions in a square-planar coordination. In the crystal, polymeric zigzag chains are linked via O-H⋯Br inter-actions, forming a two-dimensional network extending parallel to (011).