The comparison of cellulose regeneration behavior in different solvents after sulfuric acid treatment.

In this study, a high solid/liquid ratio beyond the region normally explored in the conventional processes was applied in the sulfuric acid treatment of cellulose, and different solvents were employed in the cellulose regeneration process. The results showed that sulfuric acid in the swelling state was effective in disrupting the cellulose structure and breaking its internal hydrogen bonds. The crystal type of the cellulose samples regenerated in water was cellulose II, while samples generated in methanol and ethanol showed amorphous structures.

The augmentative efficacy of second-generation anti-psychotics (SGA) to anti-depressants in treating treatment-resistant depression: a network meta-regression analysis.

Background: To compare the augmentative efficacy of second-generation anti-psychotics (SGA) to anti-depressants in adult patients with treatment-resistant depression (TRD) adjusting follow-up period and explore the underlying"time window"effects of the regimens.

Methods: Databases included Embase, PubMed, Scopus, Cochrane Library and Google Scholars as well as Clinicaltrials.gov from inception to May 15, 2024, for relevant randomized controlled studies (RCTs) were retrieved.

Stereoselective Metabolism, Hepatotoxicity, and Cytotoxic Effects of Four Enantiomers of the Fungicide Propiconazole.

Propiconazole (PRO) is a chiral triazole fungicide that has been widely used for several years. However, its metabolic characteristics and hepatotoxicity in the chiral level environment remain unclear. In this study, the stereoselective behavior of PRO was investigated by using liver microsome incubation, cell viability assay, inhalation exposure, and molecular docking.

Acorus tatarinowii alleviates D-galactose-induced Alzheimer's-like disease cognitive impairment and Aβ-induced pericytes dysfunction in mice.

Pericytes regulate cerebral blood flow (CBF) and excess amyloid in the brain. Pericyte dysfunction may contribute to the pathology of Alzheimer's disease (AD). Acorus tatarinowii (AT), a Chinese medicine commonly used to treat AD, protects the central nervous system.

Rheological engineering of perovskite suspension toward high-resolution X-ray flat-panel detector.

Solution-processed polycrystalline perovskite film is promising for the next generation X-ray imaging. However, the spatial resolution of current perovskite X-ray panel detectors is far lower than the theoretical limit. Herein we find that the pixel level non-uniformity, also known as fixed pattern noise, is the chief culprit affecting the signal-to-noise ratio and reducing the resolution of perovskite detectors.

The Association Between Allostatic Load and Frailty Trajectories Among Adults Aged 50+ Years: Mediating Role of Physical Activity.

Objectives: To identify frailty trajectories and examine its association with allostatic load (AL) and mediating effect of physical activity (PA).

Methods: This study included 8,082 adults from the English Longitudinal Study of Aging over Waves 4-9. AL was calculated by 14 biological indicators, and a 53-item frailty index was used to evaluate frailty.

Percutaneous Closure vs. Surgical Repair for Postinfarction Ventricular Septal Rupture: A Systematic Review and Meta-Analysis.

Introduction: Ventricular septal rupture is an important high-mortality complication in the scope of myocardial infarctions. The effectiveness of different treatment modalities is still controversial. This meta-analysis compares the efficacy of percutaneous closure vs.

TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.

Gliomas are the highest prevalent primary central nervous system (CNS) cancers with poor overall survival rate. There is an urgent need to conduct more research into molecular therapies targeting critical elements of gliomas. This study herein targeted to assess the impact of tripartite motif protein 6 (TRIM6) on gliomas.

Mechanochemical Synthesis of High-Entropy Perovskite toward Highly Sensitive and Stable X-ray Flat-Panel Detectors.

Perovskites are attracting attention for optoelectronic devices. Despite their promise, the large-scale synthesis of perovskite materials with exact stoichiometry, especially high-entropy perovskites, has been a major challenge. Moreover, the difficulty in stoichiometry control also hinders the development of perovskite X-ray flat-panel detectors.

Dark current modeling of thick perovskite X-ray detectors.

Metal halide perovskites (MHPs) have demonstrated excellent performances in detection of X-rays and gamma-rays. Most studies focus on improving the sensitivity of single-pixel MHP detectors. However, little work pays attention to the dark current, which is crucial for the back-end circuit integration.

Age-stratified modifiable fall risk factors in Chinese community-dwelling older adults.

Background: Fall incident is one of the major causes of mortality and injury in older adults. Modifiable fall risk factors are the targets for fall prevention. Since the status of some fall risk factors can change with age, insights into age-stratified fall risk factors can be beneficial for developing tailored fall prevention strategies for older adults at different ages.

Components of Salvia miltiorrhiza and Panax notoginseng Protect Pericytes Against OGD/R-Induced Injury via Regulating the PI3K/AKT/mTOR and JNK/ERK/P38 Signaling Pathways.

Salvia miltiorrhiza (SAL) and Panax notoginseng (PNS) are widely used in treating of ischemic stroke. However, it is unknown which components of SAL and PNS protect brain microvascular pericytes after an ischemic stroke. We evaluated the protective effects and mechanisms of SAL and PNS components in pericytes subjected to oxygen-glucose deprivation/reoxygenation (OGD/R).

Preclinical evidence and possible mechanisms of β-asarone for rats and mice with Alzheimer's disease: A systematic review and meta-analysis.

Currently, there are many different drugs to improve Alzheimer's disease (AD) from different pathways. As a supplement and alternative medicine, traditional Chinese medicine (TCM) targets multiple pathways which may be different from classical Western medicine, which may be orchestrated with Western medicine to materialize multiplying efficacy in AD patients. To investigate the therapeutic effect and assess the available preclinical evidence and possible mechanisms of β-asarone which was extracted from Acorus gramineus Soland (Araceae, AGS) for AD based on rat and mouse animal models.

SETD3 Methyltransferase Regulates PLK1 Expression to Promote Hepatic Carcinogenesis.

Background: The development of a new strategy to overcome chemoresistance to hepatocellular carcinoma (HCC) treatment is a long-standing issue. We have previously found that upregulated SETD3 levels are closely correlated with HCC. This study aims to explore the mechanism underlying how upregulation of SETD3 promotes liver carcinogenesis.

Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/reperfusion injury in rats through PI3K/AKT/mTOR and RhoA/ROCK pathways.

The combined use of two or more different drugs can better promote nerve recovery and its prognosis for treatment of stroke. Salvianolate lyophilized injection (SLI) made from the aqueous extraction of salvia miltiorrhiza and Xueshuantong injection (lyophilized) (XST) made from the Panax Notoginseng extraction are two herbal standardized preparations that have been widely used in China for the treatment of ischemic stroke. In this study, we investigated the neuroprotective effects of XST combined with SLI in the recovery stage of middle cerebral artery occlusion / reperfusion (MCAO/R) injury rat.

Vertical matrix perovskite X-ray detector for effective multi-energy discrimination.

Multi-energy X-ray detection is sought after for a wide range of applications including medical imaging, security checking and industrial flaw inspection. Perovskite X-ray detectors are superior in terms of high sensitivity and low detection limit, which lays a foundation for multi-energy discrimination. However, the extended capability of the perovskite detector for multi-energy X-ray detection is challenging and has never been reported.

Chemical Potential Diagram Guided Rational Tuning of Electrical Properties: A Case Study of CsPbBr for X-ray Detection.

Controlling the carrier polarity and concentration underlies most electronic and optoelectronic devices. However, for the intensively studied lead halide perovskites, the doping tunability is inefficient. In this work, taking CsPbBr as an example, it is revealed that the coexistence of metallic Pb or CsBr /Br , rather than the precursor ratio, can provide Pb-rich/Br-poor or Br-rich/Pb-poor chemical conditions, enabling the tunability of electrical properties from weak n-type, intrinsic, to moderate p-type.

Multi-step preparation of Fe and Si modified biochar derived from waterworks sludge towards methylene blue adsorption.

A magnetic nitrogen-doped sludge-based biochar (NAlSB-Fe-Si) was prepared based on waterworks sludge for raw material and dicyandiamide for nitrogen source to adsorb methylene blue (MB) from water. And the magnetic particles loaded on the adsorbent were obtained through functionalizing iron and silicon ions which were extracted from the biochar by acid and alkali impregnation. Physicochemical properties of sludge-based biochar (SB) were analyzed by SEM, BET, FTIR, XRD, XPS and VSM.

Template directed perovskite X-ray detectors towards low ionic migration and low interpixel cross talking.

The metal halide perovskites exhibit excellent performance as the direct X-ray detectors owing to their strong absorption capability, long carrier lifetime and diffusion length, radiation ruggedness, etc. For imaging applications, the ionic migration of perovskites and charge sharing effect between the adjacent pixels have a significantly negative impact on the spatial resolution. Herein, for the first time, the porous anodic aluminum oxides (AAO) have been used as a template to grow the CsPbBrI thick film for the direct X-ray detection.

Antisolvent-assisted Crystallization of Centimeter-sized Lead-free Bismuth Bromide Hybrid Perovskite Single Crystals with X-ray Sensitive Merits.

Hybrid bismuth halides perovskites have emerged as promising candidates for X-ray detection, due to the strong absorptivity of high-energy X-ray photons, high resistivity, large carrier diffusion length and low toxicity. However, the mostly investigated hybrid bismuth iodides single crystals are usually opaque and require a harsh synthesis process. Herein, novel one-dimensional (1D) pentamethylenediamine bismuth bromide (PDA)BiBr single crystals were synthesized via an antisolvent-assisted crystallization method at room temperature.

SbSe film with grain size over 10 µm toward X-ray detection.

Direct X-ray detectors are considered as competitive next-generation X-ray detectors because of their high spatial resolution, high sensitivity, and simple device configuration. However, their potential is largely limited by the imperfections of traditional materials, such as the low crystallization temperature of α-Se and the low atomic numbers of α-Si and α-Se. Here, we report the SbSe X-ray thin-film detector with a p-n junction structure, which exhibited a sensitivity of 106.

Lead halide perovskite for efficient optoacoustic conversion and application toward high-resolution ultrasound imaging.

Lead halide perovskites have exhibited excellent performance in solar cells, LEDs and detectors. Thermal properties of perovskites, such as heat capacity and thermal conductivity, have rarely been studied and corresponding devices have barely been explored. Considering the high absorption coefficient (10~10 cm), low specific heat capacity (296-326 J kg K) and small thermal diffusion coefficient (0.

Efficient and Reabsorption-Free Radioluminescence in CsCuI Nanocrystals with Self-Trapped Excitons.

Radioluminescent materials (scintillators) are widely applied in medical imaging, nondestructive testing, security inspection, nuclear and radiation industries, and scientific research. Recently, all-inorganic lead halide perovskite nanocrystal (NC) scintillators have attracted great attention due to their facile solution processability and ultrasensitive X-ray detection, which allows for large area and flexible X-ray imaging. However, the light yield of these perovskite NCs is relatively low because of the strong self-absorption that reduces the light out-coupling efficiency.

Rubidium Doping to Enhance Carrier Transport in CsPbBr Single Crystals for High-Performance X-Ray Detection.

The direct band gap CsPbBr perovskite is regarded as a promising alternative for low-cost and high-performance X-ray radiation detectors. Despite the fact that CsPbBr nanocrystals have been shown to be good scintillators in the indirect conversion mode, the direct X-ray conversion with CsPbBr single crystals is expected to yield higher spatial resolution. Here, rubidium (Rb) doping is demonstrated to be an efficient approach to improve carrier transport and X-ray detection performance in the direct-conversion X-ray detectors based on CsRbPbBr single crystals.