EDTA-Masked Tl Detection Using a Pair of Non-G-Quadruplex Aptamers with Opposite Fluorescence Responses.

Thallium (Tl) is a highly toxic trace heavy metal that poses significant environmental and ecological risks. Current analytical methods for its detection are limited to instrumentation. In this study, we employed a library-immobilized SELEX (systematic evolution of ligands by exponential enrichment) technique and isolated a pair of non-G-quadruplex DNA aptamers that can specifically recognize Tl.

Dimethoate-induced inflammation results in neurodevelopmental toxicity in zebrafish larvae.

Dimethoate (DMT), a widely used organophosphorus insecticide and recognized endocrine disruptor, has emerged as a significant contaminant in aquatic ecosystems. While its environmental prevalence is well-documented, limited research exists on its neurodevelopmental toxicity in aquatic organisms. This study investigated the adverse effects of DMT exposure on zebrafish larvae, focusing on neurobehavioral impairments and underlying molecular mechanisms.

Prognostic scores of extracorporeal membrane oxygenation: a scoping review.

Background: Extracorporeal membrane oxygenation (ECMO) is an effective measure for saving the lives of critically ill patients. Prompt identification of the risk factors for mortality among patients receiving ECMO and comprehensive analysis of the long-term prognosis of survivors are vital. This scoping review summarized the representative prognostic scoring systems, aiming to help clinicians in selecting an appropriate scoring system to avoid unnecessary medical resource consumption and reduce ECMO-associated mortality.

Stimuli-Responsive Organic Agents for Photoacoustic Imaging and Photothermal Therapy.

Owing to their inherent biocompatibility, organic agents (OAs) have been extensively exploited for phototheranostics, such as photoacoustic imaging (PAI) and photothermal therapy (PTT). However, most existing OAs are inert to the surrounding microenvironment with limited phototheranostic outcomes. Emerging smart OAs that are stimuli-responsive can readily amplify phototheranostic effects under a variety of physiological and pathological stimuli, such as hypoxia, pH, reactive oxygen species, and ions.

Commando procedure in cardiac surgery: a narrative review.

Objective: The Commando procedure is a technically demanding, high-risk cardiac operation. This review synthesizes advancements in the Commando procedure, with emphasis on technical modifications, broadening clinical applications, and associated clinical outcomes.

Methods: The study employed a systematic literature search in PubMed, utilizing the term "Commando Procedure," covering all publication dates, yielding 178 identified articles.

An aptazyme driven dual-FRET nanoplatform for simultaneous detection of chlorpyrifos and lead ions.

The co-occurrence of pesticides and heavy metal ions in water resources poses significant health risks, necessitating the development of advanced detection methods capable of simultaneously monitoring these contaminants. Sometimes, traditional biosensors for multiple target detection may face challenges in detecting chemically distinct analytes due to their signal interference and interdependent detection mechanisms. To overcome these challenges, a simple dual-target optical biosensor was fabricated for sensitive and efficient measurement of chlorpyrifos and lead ions (Pb) by utilizing a Förster resonance energy transfer (FRET) based dual recognition enzyme beacon (DRAB) nano-machine.

Postmarketing safety evaluation of pemetrexed using FAERS and JADER databases.

Pemetrexed, a multi-target antifolate chemotherapeutic widely used in non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM), is associated with various adverse drug events (ADEs), some of which may be underrecognized in clinical trials. This study conducted a comprehensive pharmacovigilance analysis using two major spontaneous reporting systems-FAERS (2004Q1-2024Q3) and JADER (2007Q1-2024Q3)-to evaluate pemetrexed-related ADEs. Disproportionality analysis was performed using four algorithms: Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS).

Neurodevelopmental toxicity and mechanism of chlorinated polyfluoroalkyl ether sulfonate alternative F-53B in pubertal male rats.

F-53B, a substitute for perfluorooctane sulfonate (PFOS), has attracted considerable concerns due to its frequent detection in environment matrices. However, the potential health risks to mammals, especially neurodevelopmental toxicity, remain unclear. In this study, 3-week-old pubertal male rats were exposed to F-53B at concentrations of 0, 0.

Dexrazoxane Attenuates Blood-Brain Barrier Injury During Venoarterial Extracorporeal Membrane Oxygenation.

Intracerebral hemorrhage during extracorporeal membrane oxygenation (ECMO) is one of the main causes of death and disability, with blood-brain barrier (BBB) disruption playing a key role. Dexrazoxane (DEX) is a Food and Drug Administration (FDA)-approved cardioprotective agent and iron chelator. The aim of this study was to investigate the effect of dexrazoxane on the BBB during venoarterial ECMO (VA ECMO).

Antibiotic-Induced Gut Microbiome Dysbiosis Aggravates Cerebral Injury During Extracorporeal Membrane Oxygenation.

Background: Extracorporeal membrane oxygenation (ECMO) is an effective treatment for cardiopulmonary failure. However, it is associated with severe complications, including cerebral injury, which contribute to elevated mortality and disability rates. The administration of antibiotics may lead to gut microbiome dysbiosis among critically ill patients.

Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway.

Typical plasticizer dibutyl phthalate (DBP) has been demonstrated to induce hepatotoxicity in zebrafish, but the underlying molecular mechanisms remain incompletely elucidated. Numerous studies have shown that ferroptosis is involved in the pathophysiological progression of hepatic disease. However, it remains unclear whether ferroptosis is involved in the DBP-induced hepatotoxicity in zebrafish.

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity.

The stimulator of interferon genes (STING)-mediated type I interferon (IFN) response is critical for mounting anti-tumor immunity and sensitizing chemotherapy by remodeling the tumor immune microenvironment. However, no clinically available drugs have been applied for STING activation. Based on high-throughput screening of small-molecule microarrays, we found that carvedilol, an adrenergic receptor blocker used to treat essential hypertension and symptomatic heart failure, is a STING activator.

Dinotefuran exposure induces immunotoxicity in zebrafish embryos.

As a typical neonicotinoid insecticide, dinotefuran (DIN) has immunotoxicity, but its immunotoxicity effects on aquatic organisms and its molecular mechanisms are not known. In this study, zebrafish embryos were used as model to reveal its immunotoxicity and its mechanism from the perspective of inflammatory response. Zebrafish larvae were exposed to DIN at environmentally relevant concentrations (0, 2, 200, and 2000 mg/L) for 120 h, followed by comprehensive analyses of immune cell populations, immune marker activities, oxidative stress levels, and gene expression profiles.

AI-enhanced cancer radiotherapy quality assessment: utilizing daily linac performance, radiomics, dosimetrics, and planning complexity.

Objective: This study aimed to develop and validate an Informer- Convolutional Neural Network (CNN) model to predict the gamma passing rate (GPR) for patient-specific quality assurance in volumetric modulated arc therapy (VMAT), enhancing treatment safety and efficacy by integrating multiple data sources.

Methods: Analyzing 465 VMAT treatment plans covering head & neck, chest, and abdomen, the study extracted data from 31 complexity indicators, 123 radiomics features, and 123 dosimetrics indices, along with daily linac performance data including 141 key performance indicators. A hybrid Informer-CNN architecture was used to handle both temporal and non-temporal data for predicting GPR.

Dexmedetomidine alleviates acute kidney injury in a rat model of veno-arterial extracorporeal membrane oxygenation.

Background: Although extracorporeal membrane oxygenation (ECMO) is an effective technique for life support, the incidence of acute kidney injury (AKI) during ECMO support remains high. Dexmedetomidine (DEX), which has been widely used for sedation during ECMO, possesses several properties that help reduce the occurrence of AKI. This study aimed to investigate the protective effect of DEX on kidney function during ECMO.

Extracorporeal membrane oxygenation in pregnancy and the post-partum period: a systematic review and meta-analysis.

Objective: There is an increase in the application data of Extracorporeal Membrane Oxygenation (ECMO) in perinatal women, particularly since the outbreak of coronavirus disease 2019. Therefore, we reviewed publications on the use of ECMO in pregnant and postpartum women and analyzed the maternal and fetal outcomes, updated the progress of ECMO in perinatal women.

Methods: We conducted a systematic literature search across PubMed, EMBASE, Cochrane Library, and the International Clinical Trials Registry (ICTRP), yielding 30 eligible clinical studies that investigated the application of ECMO during pregnancy.

CD155 promotes the advancement of hepatocellular carcinoma by suppressing the p53-mediated ferroptosis via interacting with CD96.

This work researched the influence and mechanism of CD155 on hepatocellular carcinoma advancement. CD155 expression and its effect on survival of hepatocellular carcinoma patients were analyzed based on the GEPIA2 database. String software predicted the interacting between CD155 and CD96, which was further verified by co-immunoprecipitation experiment.

Advances in understanding the effects of cardiopulmonary bypass on gut microbiota during cardiac surgery.

Cardiopulmonary bypass (CPB) is an indispensable technique in cardiac surgery; however, its impact on gut microbiota and metabolites remains insufficiently studied. CPB may disrupt the intestinal mucosal barrier, altering the composition and function of gut microbiota, thereby triggering local immune responses and systemic inflammation, which may lead to postoperative complications. This narrative review examines relevant literature from PubMed, Web of Science, Google Scholar, and CNKI databases over the past decade.

Smith-Magenis syndrome with Dandy-Walker malformation in a 2-year-old girl: A case report.

Smith-Magenis syndrome (SMS) and Dandy-Walker malformation (DWM) are uncommon genetic conditions with nonspecific clinical features, which makes reaching a definitive diagnosis challenging. We describe here, a 2-year-old girl who was diagnosed with SMS at the age of 12 months due to delayed growth and development. The child presented to hospital with acute heart failure and respiratory failure.

Neurodevelopmental toxicity and mechanism of action of monoethylhexyl phthalate (MEHP) in the developing zebrafish (Danio rerio).

Monoethylhexyl phthalate (MEHP) is the primary metabolite of di(2-ethylhexyl) phthalate (DEHP), the most prevalent phthalate plasticiser globally. It has been demonstrated that MEHP exerts more potent toxic effects than DEHP. Nevertheless, the full extent of the toxicity of MEHP to neurodevelopmental organisms remains unclear.

Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support.

Background: In recent years, dexamethasone (Dex) has been used to treat acute respiratory distress syndrome (ARDS) in patients with COVID-19 and achieved promising outcomes. Venovenous extracorporeal membrane oxygenation (VV ECMO) support for patients with ARDS has increased significantly worldwide. However, it remains unknown whether Dex could improve the efficiency of VV ECMO to reduce lung injury.

Assessing the correlation between Gamma passing rate and clinical dosimetric variations in breast cancer IMRT plans with multi-leaf collimator errors: perspectives from the ArcCHECK QA system.

This study aimed to comprehensively investigate the influence of multi-leaf collimator (MLC) position errors on both the clinical absolute dose distribution and Gamma passing rate (%GP) in intensity-modulated radiation therapy (IMRT) plans for breast cancer. Additionally, the correlation between %GP and the clinical absolute dose relative difference (%DE) caused by MLC position errors was analysed. Ten IMRT plans for breast cancer were randomly selected.

Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth.

Deeper understanding of the crosstalk between host cells and (Mtb) provides crucial guidelines for the rational design of novel intervention strategies against tuberculosis (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as a critical component. AG has been identified as a virulence factor of Mtb which is recognized by host galectin-9.

A StarGAN and transformer-based hybrid classification-regression model for multi-institution VMAT patient-specific quality assurance.

Background: The field of artificial intelligence (AI)-based patient-specific quality assurance (PSQA) for volumetric modulated arc therapy (VMAT) faces challenges in terms of developing general models across institutions due to the prevalence of multi-institution data collection and multivariate heterogeneity. Building a general model that is capable of handling diverse multi-institution data is critical for enabling large-scale integration and analysis.

Purpose: This study aims to develop a star generative adversarial network (StarGAN) and transformer-based hybrid classification-regression PSQA framework to address unification of heterogeneous data from different institutions.