In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment.

Melanoma, a highly aggressive skin cancer, presents significant therapeutic challenges owing to its metastatic potential. Targeting deoxyhypusine synthase (DHPS), a pivotal enzyme in the activation of eukaryotic translation initiation factor 5A (eIF5A), emerges as a promising therapeutic strategy for melanoma. In this study, we designed and synthesized a series of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivatives as novel allosteric DHPS inhibitors.

Harringtonine (HT) targets PARP-1 to inhibit TS mRNA m6A modification, blocks STAT3-induced miR-4521/TS axis and attenuates 5-fluorouracil (5-FU) resistance in NSCLC.

Background: Harringtonine (HT), derived from the genus Cephalotaxus, has demonstrated anti-proliferative effects against non-small cell lung cancer (NSCLC). 5-Fluorouracil (5-FU), a cost-effective chemotherapy, faces resistance issues in NSCLC. Thus, exploring HT's mechanisms in inhibiting NSCLC proliferation and overcoming 5-FU resistance is clinically important.

Synthesis of NH·BH and Its -Alkyl Analogues: Toward the Polyhedral Azaboranes, M[NHBH] (M = Na, K).

Improved and effective methods for the synthesis of NH·BH and its -alkyl analogues have been developed with synthetically satisfying yield under mild conditions. The single-crystal structure of NH·BH was determined for the first time, although it was found decades ago. These complexes possess high stability, suggesting promising potential applications in various reactions.

Manipulating Charged Domain Wall Arrays in BiFeO Films by Asymmetric Electrical Boundary Conditions.

Charged domain walls (CDWs) in ferroelectric thin films have been identified as reconfigurable functional elements for advanced nanoelectronics, owing to their enhanced electrical conductivity and field-tunable topology. Deterministic control of stable CDWs remains a critical challenge due to insufficient understanding of their atomic-scale mechanisms. Here, we present a method for controllable introduction of CDWs in BiFeO thin films.

Controllable Preparation of Millimeter-Scale In-Plane Charged Domain Wall in a Lead-Free Ferroelectric Film.

Ferroelectric domain walls are emerging as active components in nanoelectronics, offering a transformative paradigm for non-volatile memory and logic technologies. In particular, in-plane charged domain walls stand out for their potential to support unique functionalities, such as quantum confinement and tunneling effects, unlocking new possibilities for advanced device applications. Here, a facile approach is developed for fabricating large-scale continuous in-plane charged domain walls in NaBiTiO ferroelectric films through thermally optimized growth control.

One-Step Synthesis of Co-Ni-O-S Nanohybrid with Amorphous-Nanocrystalline Interwoven Architecture for High-Energy-Density Supercapacitor-Battery Hybrids.

Transition metal sulfur oxides have emerged as promising candidates for advanced energy storage due to their multi-electron redox activity and tunable nanostructures. Among them, Co-Ni-O-S composites are particularly attractive for supercapacitors owing to their high energy storage density. However, conventional synthesis methods often require prolonged processing times (>10 h) or high-temperature treatments (>80 °C), which limit their practical applications.

Iturin A Potentiates Differentiation of Intestinal Epithelial Defense Cells by Modulating Keap1/Nrf2 Signaling to Mitigate Oxidative Damage Induced by Heat-Stable Enterotoxin B.

Intestinal stem cells (ISCs) maintain epithelial renewal through their proliferation and differentiation capabilities, responding to various intestinal insults. However, the impact of iturin A, a natural antimicrobial peptide, on ISC viability and its potential to mitigate heat-stable enterotoxin b (STb)-induced intestinal damage remains unclear. Our recent study demonstrated that oral administration of iturin A enhances tight junction protein expression, accelerates crypt-villus regeneration, and restores epithelial barrier integrity in STb-exposed mice.

Erbin Inhibited Angiogenesis in Vitro with the Inhibition on the STAT3 Pathway in Breast Cancer Cells.

Background: Angiogenesis plays an important role in progression of tumors including breast cancer, which accounts for the vast majority of women's malignant tumors globally, to meet the excessive requirement of oxygen and nutrition for growth, metastasis, and invasion of the tumor. Therefore, targeting tumor angiogenesis has turned into a significant target for cancer therapy. Erbin has a significant effect on the initiation and progression of cancer, including breast cancer, but its role in inhibiting vascular endothelial cell proliferation and angiogenesis by breast cancer cells remains unclear.

Acteoside inhibits hepatic lipid accumulation and oxidative stress in type 2 diabetic mice via the Nrf2/HO-1 Pathway.

Acteoside, a naturally occurring compound found in various plants, was found to exert antihyperlipidemic effects; however, the underlying mechanisms in nonalcoholic fatty liver disease associated with type 2 diabetes remain to be elucidated. This study aimed to examine (1) acteoside initiated hepatoprotection in diabetic mice and (2) whether the beneficial actions involved activation of Nrf2/HO-1 signaling pathway. Male mice given a high fat diet were injected with streptozotocin (STZ 50 mg/kg) to initiate type 2 diabetes mellitus (T2DM).

From Holodirected to Hemidirected Coordination Activated by Oxygenation Strategy: A Facile Route to Long Wave Infrared Birefringent Crystal.

Long wave infrared (LWIR) birefringent crystals are essential for infrared optical applications but such materials are rarely reported due to the requirements of large birefringence and wide infrared transmission range. This study proposes a facile route to create new LWIR birefringent crystal by oxygenation strategy in halides with cations containing lone pair electrons. Given the tendency of such cations to form holodirected geometry, a divalent oxygen was introduced to substitute the monovalent halogen to decrease the coordination number and activate the lone pair electrons.

Comparative outcomes of ultrasound-guided radiofrequency ablation vs. microwave ablation for patients with T1N0M0 papillary thyroid carcinoma: a retrospective cohort study.

Objective: To compare the clinical outcomes between radiofrequency ablation (RFA) and microwave ablation (MWA) for the treatment of T1N0M0 papillary thyroid carcinoma (PTC) in a large cohort.

Materials And Methods: This retrospective study included 1111 patients with solitary T1N0M0 PTC treated with RFA (n = 894) or MWA (n = 215) by experienced physicians. A propensity score matching was used to compare disease progression, including lymph node metastases (LNM), recurrent tumors and persistent tumors, recurrence-free survival (RFS), volume reduction ratio (VRR), and complications between the RFA and MWA groups.

Thermal Ablation for Papillary Thyroid Carcinoma.

Importance: Image-guided thermal ablation has been administered for patients with T1N0M0 papillary thyroid carcinoma (PTC) who elect to not undergo surgery or receive active surveillance. Considering the indolent nature of PTC, long-term outcomes of ablation are needed.

Objective: To investigate l0-year outcomes of thermal ablation in treating T1N0M0 PTC.

Inhibitory Potential of FB1-1 Cell-Free Supernatant against Carbapenem-Resistant Drug Resistance Spread.

The widespread dissemination of carbapenem-resistant (CRKP) and its drug resistance transfer poses a global public health threat. While previous studies outlined CRKP's drug resistance mechanism, there is limited research on strategies inhibiting CRKP drug resistance spread. This study investigates the potential of () FB1-1, a probiotic, in curbing the spread of drug resistance among CRKP by evaluating its cell-free supernatant (CFS) for antibacterial activity.

Outcomes of endoscopic submucosal dissection versus esophagectomy for poorly differentiated superficial esophageal squamous cell carcinoma: A 10-year cohort study.

Backgrounds: The efficacy of endoscopic submucosal dissection (ESD) to treat poorly differentiated superficial esophageal squamous cell carcinoma (SESCC) is unclear.

Aims: To exploring the efficacy and prognosis of ESD treatment poorly differentiated SESCC compared with esophagectomy.

Methods: A retrospective cohort study was conducted, the data of poorly differentiated SESCC patients who received ESD or esophagectomy from Jan 2011 to Jan 2021 were analyzed.

Targeting the chromatin structural changes of antitumor immunity.

Epigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes, which may have significant implications for the development and application of epigenetic therapy, cancer immunotherapy, and their combinations. Herein, we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes, DNA methylation, histone post-translational modification, and chromatin structure in tumor immunogenicity, and introduce these epigenetic research methods.

Preliminary investigation on the causes of red tides in Qinhuangdao coastal areas in 2022.

To explore the causes of red tides in Qinhuangdao coastal water, we conducted surveys on both water quality and red tides during April to September of 2022 and analyzed the relationships between main environmental factors and red tide organisms through the factor analysis and canonical correspondence analysis. The results showed that there were eight red tides along the coast of Qinhuangdao in 2022, with a cumulative blooming area of 716.1 km.

Influence of Tempering Temperature on Mechanical and Rotational Bending Fatigue Properties of 40CrNi2MoE Steel.

In order to examine the mechanical properties and rotational bending fatigue performance of 40CrNi2MoE steel subsequent to tempering at varying temperatures, the steel specimen was subjected to tempering within the range of 400~460 °C. SEM, EBSD, and TEM were used to analyze the microstructure as well as precipitates. The strain hardening law was studied using the modified Crussard-Jaoult method.

Discovery of (quinazolin-6-yl)benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

P-glycoprotein (P-gp) is an important factor leading to multidrug resistance (MDR) in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been a treatment strategy to overcome MDR. In recent years, tyrosine kinase inhibitor Lapatinib has been reported to reverse MDR through directly interacting with ABC transporters.

A Study on the Fault Location of Secondary Equipment in Smart Substation Based on the Graph Attention Network.

The inability to locate device faults quickly and accurately has become prominent due to the large number of communication devices and the complex structure of secondary circuit networks in smart substations. Traditional methods are less efficient when diagnosing secondary equipment faults in smart substations, and deep learning methods have poor portability, high learning sample costs, and often require retraining a model. Therefore, a secondary equipment fault diagnosis method based on a graph attention network is proposed in this paper.

Metagenomic and metaproteomic analyses of microbial amino acid metabolism during Cantonese soy sauce fermentation.

Cantonese soy sauce is an important type of traditional Chinese brewed soy sauce that was developed in southern China, mainly in Guangdong. Due to the long fermentation period and complex microbiota in Cantonese soy sauce, there are few reports on the microbial metaproteomics of Cantonese soy sauce. In this study, integrative metagenomic and metaproteomic analyzes were used to identify the changes in the dominant microbiota and amino acid synthesis-related enzymes and metabolism during Cantonese soy sauce fermentation.