[Clinical characteristics and influencing factors of vestibular migraine patients with sleep disorders].

To investigate the sleep characteristics and clinical features of patients with vestibular migraine（VM）, and to explore the influencing factors of sleep disorder in VM patients. A cross-sectional study method was adopted to collect VM patients from Otolaryngology department and neurology department of our hospital from June 2022 to June 2024（divided into sleep disorder group and non-sleep disorder group according to whether there is sleep disorder） as the experimental group, and recruit non-VM volunteers with clinical characteristics matching with the experimental group during the same period as the control group. The clinical data of the subjects were collected, and the sleep quality of the subjects was assessed using the Pittsburgh Sleep Quality Index（PSQI）.

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma: survival outcomes and prognostic factors from a systematic review and meta-analysis.

Background: Advanced hepatocellular carcinoma (HCC) poses significant treatment challenges, with limited options and poor prognosis. Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising therapy, potentially offering superior outcomes compared to transarterial chemoembolization (TACE). This study aimed to systematically compare the survival outcomes and safety profiles of HAIC versus TACE in patients with advanced HCC, and to identify key prognostic factors influencing treatment efficacy to guide personalized therapeutic strategies.

A model for epileptic EEG detection and recognition based on Multi-Attention mechanism and Spatiotemporal.

In the field of neuroscience, epilepsy is a chronic non-communicable brain disease that affects approximately 50 million people worldwide. Electroencephalography (EEG) has become a key tool in detecting and characterizing human neurological diseases such as epilepsy. This rapid and accurate diagnosis allows doctors to provide timely and effective treatment to patients, significantly reducing the frequency of future seizures and the risk of related complications, which is crucial for ensuring the long-term health and quality of life of patients.

Single-Particle Imaging Reveals Charge Redistribution on TiO: Engineering Facets and Oxygen Vacancies for Photocatalytic Toluene Oxidation.

The manipulation of exposed anisotropic facets and surface microstructures facilitates the directional migration of photoinduced charge carriers, offering a promising strategy for enhancing the photocatalytic activity. However, the charge dynamics behavior associated with facet engineering remains unclear and elusive. Herein, the critical role of the {001}/{101} facet ratio on carrier lifetime was determined by precisely monitoring the charge redistribution in the micronano regions of individual TiO microcrystals via single-particle fluorescence spectroscopy .

Patient-derived organoids as a model to study tubo-ovarian carcinoma: a pathologist's perspective.

Background: Tubo-ovarian carcinoma, a leading cause of gynaecological-related mortality, holds substantial biological and clinical heterogeneity. Despite advancements in drug development, predicting therapeutic efficacy remains challenging, partly due to the limited availability of in vitro models that accurately replicate tumour behaviour. We present a concise overview of the intrahospital workflow for establishing patient-derived organoids and analyse the morphological and immunophenotypical features of high-grade serous carcinoma (HGSC), serous borderline tumour (SBT)/low-grade serous carcinoma (LGSC), and normal fallopian tube (FT) organoids.

Determinants of chronic disease patients' intention to use Internet diagnosis and treatment services: based on the UTAUT2 model.

Background: Chronic diseases are a significant public health concern. Internet diagnosis and treatment services can effectively monitor chronic diseases and are vital for alleviating the healthcare system burden caused by these conditions. Distinguishing itself from prior investigations, this study focuses on the critical cohort of chronic disease patients and, building upon the UTAUT2 framework, introduces additional constructs such as trust and medical habits.

Metabolic Activity Profiling of High-Temperature Microbiota Using Single-Cell Raman Spectroscopy and Deuterium Isotope Probing.

The microbial metabolic activity of , a key factor in production, varies due to environmental and raw material diversity. Quality differences exist among batches, even within the same fermentation room, and continue to change during storage. An accurate assessment of 's microbial activity is crucial for enhancing quality and production consistency, yet an in situ, nondestructive detection method remains elusive.

A Rapid and Simple Reversed-Phase HPLC-MS/MS Determination of Baloxavir in Rat Plasma and Its Application in Pharmacokinetic Study.

In this study, a novel RP-HPLC-MS/MS method was developed for the accurate quantification of baloxavir in rat plasma. The analytes were retained and separated on a C18 column, and a triple-quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source was applied for quantification. Baloxavir could be well retained in the C18 column under the appropriate chromatographic conditions.

Hepatic arterial infusion chemotherapy versus systemic chemotherapy for advanced intrahepatic cholangiocarcinoma: a meta-analysis of survival outcomes.

Background: Intrahepatic cholangiocarcinoma (iCC) is an aggressive hepatobiliary malignancy with limited therapeutic options and poor survival outcomes. Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising treatment alternative to systemic chemotherapy, but its clinical benefits require comprehensive evaluation.

Methods: A systematic review and meta-analysis were conducted, including 10 studies with 1,493 patients.

The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant.

This case report describes a 5-year-and-10-month-old female patient who developed sleep-related hypermotor epilepsy, at the age of 2, exhibiting various forms of seizures since the age of 2. Initially, the seizures were controlled for one year with multiple anti-seizure medications; however, symptoms recurred when the patient was 3 years and 5 months old, leading to an increased seizure frequency and a poor response to combined drug therapy. Long-term video-EEG revealed discharges originating from the frontal lobe, while MRI and PET-CT scans indicated FCD in the left frontal region.

Multi-objective optimization of daylighting performance and solar radiation for building geometry using a hybrid evolutionary algorithm.

Optimizing solar radiation and daylighting performance is a fundamental concern in architectural design, as these factors are directly linked to enhancing building energy efficiency and environmental comfort. This study seeks to balance solar radiation and daylighting performance through architectural geometry optimization, includes building's length, width, height, orientation, and mass distribution. Parametric modeling based on the additive and subtractive design generation algorithms included in EvoMass on the Grasshopper platform, with the goal of minimizing the solar radiation variation between summer and winter on building envelopes and maximizing useful daylight illuminance (UDI).

Exploring the combined impact of hepatitis B antibody status and systemic immune-inflammation index on mortality risk: A population-based study.

Background: Chronic hepatitis B virus (HBV) infection is a significant global health issue, leading to liver-related morbidity and mortality. The systemic immune-inflammation index (SII), a marker of systemic inflammation and immune response, may predict disease outcomes. However, its role in HBV infection and its relationship with HBV surface antibody (HBsAb) status is not well understood.

Behavior of Chiral Paclobutrazol in Soils: Enantioselective Degradation, Transformation Products, and Effects on Soil Microorganisms and Their Metabolic Functions.

Paclobutrazol, a triazole chiral plant growth regulator, has been widely applied as a racemic mixture in crop and fruit tree production. However, the enantioselective fate and effects of chiral paclobutrazol in the soil ecosystem are still unclear. In this study, systemic assessments of dissipation dynamics, transformation products (TPs) and pathways, and interactions between soil microorganisms and related metabolites are first carried out using suspect and nontarget screening, high-throughput sequencing, and soil metabolomics.

Deep learning-assisted Raman spectroscopy for rapid lactic acid bacteria identification at the colony level.

To achieve rapid and accurate identification at the colony level and improve the efficiency of colony selection, we proposed an adaptive colony Raman acquisition method based on signal-to-noise ratio screening (ACRA-SNR). This method enables in situ spectral acquisition of colonies, effectively mitigating the impact of spatial heterogeneity within colonies on classification and identification. By combining this acquisition method with the Raman Swin Transformer (Ra-ST) model, we achieved fast and accurate classification and identification of colonies.

The correlation between high temperature and cognitive function: a CHARLS 2018 cross-sectional study.

Background: Extreme temperature-related events can have a negative impact on the health of populations, especially the elderly. However, there is a lack of research on the relationship between heat exposure and cognitive function in older adults. We aim to explore the association between temperature and cognitive function through a national study of middle-aged and older adults.

Trends and determinants of female genital mutilation prevalence among women of reproductive age in Tanzania and Kenya: a demographic and health survey analysis (2008-2022).

Background: Female genital mutilation (FGM) remains a critical global public health challenge, with over 230 million affected women and girls, predominantly in Sub-Saharan Africa. Despite the reduction in FGM in both countries, the proportion of women who had FGM are still considerably high. Therefore, the study seeks to examine the socio-economic/demographic determinants of FGM in Kenya and Tanzania to inform more targeted interventions.

A proposed staging system for intrahepatic cholangiocarcinoma involving the hilar.

Background: Intrahepatic cholangiocarcinoma involving the hepatic hilum (h-ICC) is a rare and aggressive malignancy with heterogeneous clinical outcomes. Current staging systems are often inadequate for prognostic prediction in this subgroup. This study aimed to identify key prognostic factors and develop a novel, clinically applicable survival classification model for patients with h-ICC undergoing surgery.

Dye-doped fluorescent polypyrrole nanotherapeutic probe as a versatile platform for ratiometric pH-sensing-guided and self-monitored photothermal therapy of tumors.

A multifunctional fluorescent polypyrrole nanotherapeutic probe (denoted as PPy@RhB-PAA-FITC) was constructed for pH-sensing-guided photothermal therapy (PTT) of cancer and self-monitoring temperature variations during PTT. Temperature-responsive rhodamine B (RhB) and pH-sensitive fluorescein isothiocyanate (FITC) fluorescent dyes were linked to polypyrrole (PPy) nanoparticles, which served as the photothermal therapy material matrix, through encapsulation and electrostatic interaction, respectively. The fluorescence intensity of FITC increased dramatically with increasing pH, while little variation was observed in the emission intensity of RhB, enabling ratiometric fluorescent pH sensing performance.

Copper Single Atoms on N-Doped Hollow Nanocubes for Efficient Electromagnetic Wave Attenuation.

Rational design of unique nanostructures and suitable compositions is essential for highly-efficient electromagnetic wave (EMW) absorbing materials. Metal single-atoms (M-SAs) anchored on hollow-structured carbon-based materials have emerged as promising absorbers owing to their unique nanostructures and tunable electronic configurations. However, the synergistic coupling mechanism between hollow structure and M-SAs still remains poorly understood.

Prognostic factors in gallbladder cancer: a comprehensive systematic review and meta-analysis.

Background: Gallbladder cancer (GBC) is one of the most common biliary cancers and is characterized by its high malignancy. Moreover, the incidence of GBC has been increasing over the decades, partly due to advancements in diagnostic techniques and devices. The purpose of this systematic review is to provide a comprehensive assessment of factors influencing the prognosis of GBC.

Surgery-related factors for pancreatic fistula after pancreatectomy: an umbrella review.

Background: Multiple risk or protective factors for postoperative pancreatic fistula (POPF) have been suggested in the literature of surgical specialities. We aimed to map existing evidence regarding the risk factors for POPF to help guide future clinical treatment.

Methods: We performed an umbrella review by searching the Web of Science, PubMed, Embase, and Cochrane databases until June 19, 2023.

Carbon-Encapsulated Nickel via Cellulose Acetate Coordination for Efficient Hydrogen Evolution Reactions.

Developing efficient and stable electrocatalysts for hydrogen evolution reactions (HERs) is critical for sustainable green hydrogen production. Carbon-coated metal materials are highly promising HER electrocatalysts, offering excellent conductivity, stability, and abundant catalytic sites. However, the synthesis of carbon-coated materials frequently requires expensive precursors or catalysts and may encounter challenges such as poor uniformity in the distribution of the carbon layer.

A spatially organized / stem cell core governs postnatal tooth establishment.

Mineralized tissues are fundamental in mechanical support and protection in vertebrates. Their formation by progenitor cells during development remains elusive. Here, we show that the postnatal establishment of the molar teeth was governed by a spatially organized core of / progenitors that persisted into adulthood.

PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases.

Dysregulated lipid metabolism in microglia represents a hallmark of neuroinflammation and is often observed in a variety of neurodegenerative diseases. The exact molecular mechanisms underlying the induction of altered lipid homeostasis and how it contributes to neurodegeneration remain to be deciphered. Progranulin (PGRN) is a lysosomal glycoprotein encoded by GRN.

Innovative Electrochemical Sensors for Pesticide Residue Detection: Nanomaterials, Miniaturization, and Intelligent Data Analysis.

The increasing use of pesticides in agriculture has raised concerns over their residues in food products, necessitating the development of effective detection methods to ensure consumer safety and environmental sustainability. This review covers cutting- edge advances in electrochemical sensors for pesticide residue detection, emphasizing their significance in addressing the limitations of traditional methods. The authors summarize recent progress in sensor materials for enhancing detection sensitivity and selectivity, including metal-organic frameworks, single-atom materials, MXene-based materials, and conductive polymers and so on.