Identifying plasma proteins and immunocyte phenotypes as risk factors in rheumatoid arthritis: The role of EPHA3 and CD28 CD45RA CD8 treg cells.

Objectives: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease whose pathogenesis involves the participation of numerous plasma proteins and immune cells, but their relationships are unclear. So we set out to thoroughly examine the causal link between 4907 plasma proteins and RA and to identify the involvement of 731 immunocyte phenotypes as potential mediators.

Methods: Using publicly available genome-wide association studies (GWAS) data, 5 Mendelian randomization (MR) methods (inverse variance weighted (IVW), weighted median, MR-Egger, simple mode, weighted mode) were applied for analysis, along with sensitivity analyses.

Platinum Nanoparticles Loaded in Polydopamine-Modified Porous Coordination Network-224 with Peroxidase-Like Activity for Sensitive Glutathione Detection.

The content of glutathione in the human body is crucial to human health, so a convenient and efficient method is needed to detect it. Herein, porous coordination network-224 (PCN-224) was modified by polydopamine to prepare polydopamine-modified PCN-224 (PCN-224-PDA) to improve the water dispersibility of the PCN-224. Monodispersed platinum nanoparticles were loaded into the PCN-224-PDA to prepare PCN-224-PDA-Pt.

Design and synthesis strategies of carbon nanospheres and their biomedical applications.

Carbon nanospheres (CNSs), featuring unique nanostructures and remarkable physicochemical properties, offer significant advantages such as high surface-to-volume ratio and tunable surface chemistry. They have generated extensive research interest in various fields, and great progress has been made in recent years. This review summarizes the main synthesis and design strategies for the preparation and functionalization of carbon nanospheres.

Dye-doped fluorescent polypyrrole nanotherapeutic probe as a versatile platform for ratiometric pH-sensing-guided and self-monitored photothermal therapy of tumors.

A multifunctional fluorescent polypyrrole nanotherapeutic probe (denoted as PPy@RhB-PAA-FITC) was constructed for pH-sensing-guided photothermal therapy (PTT) of cancer and self-monitoring temperature variations during PTT. Temperature-responsive rhodamine B (RhB) and pH-sensitive fluorescein isothiocyanate (FITC) fluorescent dyes were linked to polypyrrole (PPy) nanoparticles, which served as the photothermal therapy material matrix, through encapsulation and electrostatic interaction, respectively. The fluorescence intensity of FITC increased dramatically with increasing pH, while little variation was observed in the emission intensity of RhB, enabling ratiometric fluorescent pH sensing performance.

The relationship between job burnout and presenteeism among Chinese primary public health physicians: a moderated mediation model.

Background: Public health physicians are experiencing increased work stress and workload, leading to heightened negative emotions and presenteeism. This study investigates the relationship between job burnout and presenteeism among primary public health physicians in China and explores the potential mediating effect of depressive symptoms, and moderating effects of coping styles and organizational support on these associations.

Methods: 955 primary public health physicians were surveyed from September to December 2022 in China.

Effect of Potential-Determining Ions on Rheological Properties of Calcite Paste.

The mechanical properties of calcite suspension are predominantly affected by different ions dissolved in solution. In this work, natural and synthetic calcites were employed to investigate the influence of potential-determining ions (PDIs) (Ca, Mg, OH, CO and SO) on the zeta potential and rheological behavior of calcite paste. Electric double layer (EDL) models were proposed to further interpret the ionic adsorption mode and zeta potential evolution.

Global burden of depression and anxiety disorders in older adults, 1990-2019: An analysis of age-period-cohort and temporal-spatial patterns.

Background: Mental disorders are the leading causes of the global health-related burden and account for 10.6% of total disability (in disability adjusted life years, DALYs) among older adults, with depression and anxiety disorders being the most common contributors to this burden. This study provided a comprehensive epidemiological update on their global burden in older populations, analyzing evolving temporal trends, spatial distribution shifts, and identifying high-risk subgroups and geographic regions.

Palladium-gold bimetallic nanoparticles stabilized by daptomycin for sensitive colorimetric detection of sulfide ions.

Background: Sulfide ion is an important form of sulfur element, which is widely present in nature and has wide applications in industrial production and medicine. However, excessive sulfur ions may cause water acidification, harm aquatic organisms and destroy the balance of the ecological environment. In addition, long-term exposure to polluted water also poses a threat to human health, such as respiratory diseases or central nervous system symptoms.

A functional study of the trehalase genes in Tribolium castaneum and their application in the construction of RNAi engineering bacteria.

Tribolium castaneum, belonging to the order Coleoptera, family Tenebrionidae, is a global grain storage pest. The enzyme trehalase can catalyze trehalose decomposition and participate in chitin synthesis, which is of great significance in insect physiology and may be a key target for T. castaneum pest prevention and control.

Pinnatifone A, isolated from Syringa pinnatifolia (Oleaceae), exhibits inhibitory activity against phytopathogenic fungi and can be employed to formulate a soluble concentrate agent.

Background: In the realm of plant diseases, those caused by fungi and oomycetes are particularly challenging to manage, resulting in significant economic losses. There exist diverse active substances in natural products and developing them into fungicides holds great significance. At the initial phase of our research, we discovered that Syringa pinnatifolia extract demonstrates broad-spectrum inhibitory activity against phytopathogenic fungi.

Stable Leonurus cardiaca L. polysaccharide-stabilized palladium nanoparticles for sensitive colorimetric detection of acetylcholine.

Imbalances in acetylcholine levels within the human body readily precipitate neurological disorders. Hence, establishing a highly efficient and sensitive acetylcholine detection platform is of paramount importance. Palladium-based nanoparticles have high catalytic performance, which is of profoundly important in the development of nanozyme technology.

Coordinated analysis of groundwater spatiotemporal chemical characteristics, water quality, and potential human health risks with sustainable development in semi-arid regions.

The emergence of large-scale time-series data and advancements in computational power have opened new avenues for analyzing the spatiotemporal evolution of groundwater chemistry, water quality, and human health risks. This paper utilizes hydrogeochemical methods to elucidate the controlling factors of water chemical components based on the test results of 124 groundwater samples collected from 31 monitoring wells in Fuxin City, Liaoning Province, China, from 2018 to 2021. By integrating the Random Forest and Enhanced Water Quality Index methods for water quality assessment and employing the Human Health Risk Assessment (HHRA) model to analyze human health risks, our findings indicate that the groundwater is mildly alkaline, with SO·Cl-Ca·Mg and HCO-Ca·Mg as the dominant hydrochemical types, primarily derived from the dissolution of carbonate and silicate minerals such as dolomite, limestone, and andesite, and cation exchange reactions.

The relationship between family functioning and social media addiction among university students: a moderated mediation model of depressive symptoms and peer support.

Background: Social media addiction (SMA) is an increasing problem, especially among young adults. Little is known about university students' SMA and family functioning. This study aimed to explore the mediating effect of depressive symptoms and the moderating effect of peer support in the relationship between family functioning and SMA among young adults.

Global burden of self-harm and interpersonal violence and influencing factors study 1990-2019: analysis of the global burden of disease study.

Introduction: Widespread concern exists in today's world regarding self-harm and interpersonal violence. This study to analyze the changes in temporal trends and spatial patterns of risk factors and burdens of self-harm and interpersonal violence using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.

Methods: Temporal trends in self-harm and interpersonal violence were initially summarized using the estimated annual percentage change (EAPC).

Regulation of nitrogen transformation and microbial community by inoculation during livestock manure composting.

This study examined the effects of three Bacillus strains and one Saccharomyces cerevisiae strain on nitrogen transformation and microbial communities in pig and chicken manure compost. The findings revealed that the use of compound microbial inoculants increased the compost temperature, accelerated moisture reduction, enhanced cellulase activity, and stimulated the accumulation of NH -N, NO -N, and total nitrogen (TN), resulting in a 9% increase in TN content. The abundance of Firmicutes decreased by 3.

Silver-palladium bimetallic nanoparticles stabilized by elm pod polysaccharide with peroxidase-like properties for glutathione detection and photothermal anti-tumor ability.

Noble metal nanoparticles show good application prospects in biosensors and anti-tumor drug research. Herein, the near-spherical silver‑palladium bimetallic nanoparticles supported by elm pod polysaccharide (EPP-AgPd NPs) were prepared by using the elm pod polysaccharide (EPP). EPP acts as a stabilizer and reducing agent due to its water solubility and weak reducing ability.

How health risk factors affect inpatient costs among adults with stroke in China: the mediating role of length of stay.

Background: As stroke has become the leading cause of death and disability in China, it has induced a heavy disease burden on society, families, and patients. Despite much attention within the literature, the effect of multiple risk factors on length of stay (LOS) and inpatient costs in China is still not fully understood.

Aim: To analyse the association between the number of risk factors combined and inpatient costs among adults with stroke and explore the mediating effect of LOS on inpatient costs.

State-of-the-art electrochemical biosensors based on covalent organic frameworks and their hybrid materials.

As the development of global population and industry civilization, the accurate and sensitive detection of intended analytes is becoming an important and great challenge in the field of environmental, medical, and public safety. Recently, electrochemical biosensors have been constructed and used in sensing fields, such as antibiotics, pesticides, specific markers of cancer, and so on. Functional materials have been designed and prepared to enhance detection performance.

Platinum nanoflowers stabilized with aloe polysaccharides for detection of organophosphorus pesticides in food.

Organophosphorus pesticides can inhibit the activity of acetylcholinesterase and cause neurological diseases. Therefore, it is crucial to establish an efficient and sensitive platform for organophosphorus pesticide detection. In this work, we extracted aloe polysaccharide (AP) from aloe vera with the number average molecular weight of 27760 Da and investigated its reducing property.

An electrochemical impedimetric platform formed by a CNT@UiO-66 nanocomposite for quantitative analysis of oxytetracycline.

Functional materials are considered one of the most critical factors in constructing high-performance electrochemical aptasensors in the sensing field. In this work, the microporous Zr-MOF UiO-66 (UiO = Universitetet i Oslo) is selected for assembly with carbon nanotubes (CNTs) to prepare a CNT@UiO-66 composite. The as-synthesized CNT@UiO-66 composite has a high surface area, excellent stability, good electrical conductivity, and abundant Zr(IV) sites, conferring it great potential for application in fabricating high-performance electrochemical aptasensors.

Biocompatible Palladium Nanoparticles Prepared Using Vancomycin for Colorimetric Detection of Hydroquinone.

Hydroquinone poses a major threat to human health and is refractory to degradation, so it is important to establish a convenient detection method. In this paper, we present a novel colorimetric method for the detection of hydroquinone based on a peroxidase-like Pd nanozyme. The vancomycin-stabilized palladium nanoparticles (Van-Pd NPs, n = 0.

The role of effort-reward imbalance and depressive symptoms in the relationship between long working hours and presenteeism among Chinese village doctors: a moderated mediation model.

Background: Long working hours and effort-reward imbalance (ERI) among medical workers may contribute to poor mental health and reduced productivity. However, the potential mechanisms among them are not well understood. This study aimed to explore the role of depressive symptoms and ERI in the relationship between long working hours and presenteeism among village doctors.

[Foodborne disease outbreaks in China from 2011 to 2020].

Objective: To analyze the epidemiological characteristics of foodborne disease outbreaks in China and to provide references for formulating prevention strategies of foodborne diseases in China.

Methods: Collect the monitoring data reported in China's foodborne disease outbreak monitoring system from 2011 to 2020, and calculate relevant indicators.

Results: During 2011 and 2020 in 30 provinces(autonomous region, municipality), a total of 35 806 foodborne disease outbreaks were reported, which caused 266 968 illnesses.