Alpinetin protects against myocardial ischemia-reperfusion injury by inhibiting ferroptosis and apoptosis via mitochondrial ferritin.

Purpose: Ischemia-reperfusion injury remains a major problem following myocardial infarction. Alpinetin (ALPT) has been reported to exhibit cardioprotective effects as well as resistance to ischemia-reperfusion injury. However, its role and mechanism during myocardial ischemia-reperfusion injury are unknown.

Dysregulation of chromatin remodeling genes predicts clinical outcomes in acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is a malignancy of the blood system. The commonly altered regions in the genome of AML encompass a multitude of gene modifications associated with epigenetic regulation. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) as an overall indicator has yet to be assessed in AML.

The emerging role of the gut microbiome in depression: implications for precision medicine.

Major depressive disorder is a debilitating mental illness that seriously endangers human health. Its pathogenesis is highly complex, and traditional treatments face substantial challenges. A growing body of preclinical and clinical findings highlight the important role of the gut microbiome in the pathogenesis of depression and its potential as a diagnostic and therapeutic target.

Lactobacillus reuteri DSM 17,938 ameliorates LPS-induced depression-like and anxiety-like behaviors by modulating gut microbiota and brain metabolic function.

Background: Lactobacillus reuteri DSM 17,938 exhibits antidepressant and anxiolytic potential. The purpose of this study is to validate the effects of L. reuteri DSM 17,938 and preliminarily explore its underlying antidepressant and anxiolytic mechanisms, thereby providing a general direction for researching the targets of its antidepressant and anxiolytic effects.

[Sertraline hydrochloride combined with compound chamomile lidocaine gel for the treatment of premature ejaculation].

Objective: To investigate the effect of sertraline hydrochloride combined with compound chamomile lidocaine gel in the treatment of premature ejaculation (PE).

Methods: We selected 80 cases of PE treated in our hospital from June 2021 to May 2023 and equally randomized them into a control and an observation group, the former medicated with compound chamomile lidocaine gel while the latter with sertraline hydrochloride in addition, both for 6 weeks. We recorded and compared the intravaginal ejaculation latency time (IELT), the number of successful sexual intercourses per week, the Premature Ejaculation Diagnostic Tool (PEDT) scores, and the incidence of adverse reactions between the two groups of patients.

Association between organophosphorus pesticide exposure and the prevalence of kidney stones in US adults: A population-based study.

It has been demonstrated that exposure to glyphosate (GLY) may result in the development of a number of diseases. The objective of this study was to ascertain whether there is a correlation between GLY exposure and the risk of developing kidney stones in adults residing in the United States. A cross-sectional study was conducted on 4178 patients from the 2013 to 2018 National Health and Nutrition Examination Survey.

Mitochondrial Ferritin Overexpression Attenuates Ferroptosis and Mitochondrial Dysfunction by Reducing VDAC1 to Relieve MI/RI-Induced Damage.

Ischaemic cardiomyopathy is becoming one of the most prevalent cardiovascular diseases among the global elderly population. However, the underlying molecular mechanisms remain incompletely understood. Our previous study demonstrated that VDAC1 plays a significant role in MI/RI.

Multi-Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide-Induced Mouse Model of Depression.

Background: Depression is a global health concern characterized by high incidence, disability, and disease burden. Neuroimmunity, through the secretion of inflammatory mediators and mediation of neuroinflammation, plays a significant role in depression's pathogenesis. However, the underlying molecular mechanisms remain poorly understood.

The efficacy and acceptability of Lactobacillus reuteri for the treatment of depression: A systematic review and meta-analysis.

Introduction: Some preclinical and clinical studies have demonstrated the positive effect of Lactobacillus reuteri (L. reuteri) supplementation on depressive symptoms. We conducted an updated systematic review on this topic.

STAB1 Promotes Acute Myeloid Leukemia Progression by Activating the IKK/NF-κB Pathway and Increasing M2 Macrophage Polarization.

As a multifunctional scavenger receptor, stabilin-1 (STAB1) has been identified to induce chronic inflammation and promote cancer progression. Although in silico studies from multiple data sets showed that STAB1 might facilitate the progression of acute myeloid leukemia (AML) and drug resistance, the real impacts of STAB1 expression on AML patients and the detailed mechanisms remain unclear. Herein, we found that a higher expression of STAB1 is associated with a worse prognosis in AML patients.

Facile preparation of lac terpene acid based heat setting adhesive with improved performances.

As a by-product of shellac resin, the high-value utilization of lac terpene acid (LTA) is a major challenge. In this study, a novel adhesive material, designated as A-LTA, was developed through a facile synthesis reaction between LTA and melamine, demonstrating significantly enhanced performance characteristics. The A-LTA adhesive, owing to its diverse functional groups, demonstrates exceptional cross-linking and polymerization capabilities under elevated temperatures, resulting in the formation of multiple chemical bonds and a highly dense network structure.

Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1.

Despite improvements in interventional techniques leading to faster myocardial reperfusion postmyocardial infarction, there has been a significant rise in the occurrence of myocardial ischaemia/reperfusion injury (MI/RI). A deeper understanding of the underlying mechanisms of MI/RI could offer a crucial approach to reducing myocardial damage and enhancing patient outcomes. This study examined the myocardial protective properties of puerarin (PUE) in the context of MI/RI using hypoxia/reoxygenation (H/R) or ischaemia/reperfusion (I/R) injury models were employed in H9c2 cells and C57BL/6 mice.

[Clinical Analysis of Epstein-Barr Virus Infection after Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To analyze the risk factors of Epstein-Barr virus (EBV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its impact on survival.

Methods: The clinical data of 347 patients who underwent their first allo-HSCT in our hospital from January 2014 to June 2021 were retrospectively analyzed. Patients were divided into EBV ( =114) and Non-EBV ( =233) groups according to whether they were infected with EBV.

Evaluating the therapeutic effect of LIPUS in the early stage of traumatic brain injury using FA and T2 in rats.

To evaluate the protective effect of LIPUS at the early stage of brain trauma in rats, 45 rats were randomly divided into 3 groups: sham ( = 15), TBI ( = 15) and LIPUS treatment groups ( = 15). Ipsilateral and contralateral cortical and thalamic parameters obtained by diffusion tensor imaging (DTI) and fast low-angle shot magnetic resonance imaging (FLASH-MRI) were measured at different times after trauma. For fractional anisotropy (FA) and T2 values, two-way repeated measures ANOVA with Tukey's post hoc was used for intergroup comparisons.

Surface Functionalization of Bamboo via Photo-Grafting Tannic Acid for Enhanced Silver Ion Loading Properties.

Photo-grafting is a gentle, simple, and precise approach to incorporating specific functional molecules for the surface functionalization of substrates. In this work, ultraviolet (UV)-induced tannic acid (TA) grafting onto the surface of bamboo was proposed as a viable strategy for functionalizing bamboo. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) clearly indicated that TA was successfully introduced to the bamboo's surface.

An insect lac blanket-mimetic and degradable shellac hydrogel/chitosan packaging film with controllable gas permeation for fresh-cut vegetables preservation.

Fresh-cut products are extremely perishable due to the processing operations, and the atmosphere environment, especially CO, O and HO, could profoundly affect their shelf life. Herein, an insect "lac blanket"-mimetic and facile strategy was proposed for fresh-cut vegetables preservation, employing porous shellac hydrogel microparticles as gas "switches" in chitosan film to regulate CO, O and HO vapor permeability. Thus, the shellac hydrogel/chitosan hybrid film presented the controllable and wide range of gas permeability, compared with the chitosan film.

Preparation of multi-functional active packaging film of Galla chinensis waste CDs/pullulan.

In this study, multifunctional green carbon dots (CDs) have been synthesized using Galla chinensis waste (GCW) via hydrothermal method for the first time. An active packaging film has been developed in this work by combining CDs and pullulan (PL), using the solution-casting method. The microscopic morphology revealed that the CDs that were prepared using GCW exhibited good compatibility with PL.

A comprehensive analysis of the differential expression in the hippocampus of depression induced by gut microbiota compared to traditional stress.

Depression, which is a disease of heterogeneous etiology, is characterized by high disability and mortality rates. Gut microbiota are associated with the development of depression. To further explore any differences in the mechanisms of depression induced by gut microbiota and traditional stresses, as well as facilitate the development of microbiota-based interventions, a fecal microbiota transplantation (FMT) depression model was made.

Pathways and molecules for overcoming immunotolerance in metastatic gastrointestinal tumors.

Worldwide, gastrointestinal (GI) cancer is recognized as one of the leading malignancies diagnosed in both genders, with mortality largely attributed to metastatic dissemination. It has been identified that in GI cancer, a variety of signaling pathways and key molecules are modified, leading to the emergence of an immunotolerance phenotype. Such modifications are pivotal in the malignancy's evasion of immune detection.

Crystallization-induced emission from F-doped carbon dots.

Herein, F-doped CDs with bright red SSF were synthesized by a solvothermal method using trifluoroethanol as the solvent and -hydroxybenzaldehyde as the carbon source. Strong F-F interactions are vital for inducing crystallization, and solid luminescence is achieved by blocking the nonradiative energy dissipation pathways of crystalline organizations.

Maternal separation regulates sensitivity of stress-induced depression in mice by affecting hippocampal metabolism.

Depression is a serious mental illness. Previous studies found that early life stress (ELS) plays a vital role in the onset and progression of depression. However, relevant studies have not yet been able to explain the specific effects of early stress on stress-induced depression sensitivity and individual behavior during growth.

The dynamics of B-cell reconstitution post allogeneic hematopoietic stem cell transplantation: A real-world study.

Background: The immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is crucial for preventing infections and relapse and enhancing graft-versus-tumor effects. B cells play an important role in humoral immunity and immune regulation, but their reconstitution after allo-HSCT has not been well studied.

Methods: In this study, we analyzed the dynamics of B cells in 252 patients who underwent allo-HSCT for 2 years and assessed the impact of factors on B-cell reconstitution and their correlations with survival outcomes, as well as the development stages of B cells in the bone marrow and the subsets in the peripheral blood.

Multimodal evaluation of the effects of low-intensity ultrasound on cerebral blood flow after traumatic brain injury in mice.

Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide, and destruction of the cerebrovascular system is a major factor in the cascade of secondary injuries caused by TBI. Laser speckle imaging (LSCI)has high sensitivity in detecting cerebral blood flow. LSCI can visually show that transcranial focused ultrasound stimulation (tFUS) treatment stimulates angiogenesis and increases blood flow.

Modulatory Effect of Low-Intensity Transcranial Ultrasound Stimulation on Behaviour and Neural Oscillation in Mouse Models of Alzheimer's Disease.

Transcranial ultrasound stimulation (TUS) is a noninvasive brain neuromodulation technique. The application of TUS for Alzheimer's disease (AD) therapy has not been widely studied. In this study, a long-term course (28 days) of TUS was used to stimulate the hippocampus of APP/PS1 mice.

Highly efficient removal of tannic acid from wastewater using biomimetic porous materials.

To effectively remove tannic acid (TA) from wastewater, using green and natural materials has attracted increasing attention. Inspired by Galla Chinensis (GC) with high content of TA, this study synthesized a biomimetic porous adsorbent to mimic the GC structure using dialdehyde tapioca starch (DTS) and gelatin (GL). The TA adsorption performance and mechanism of synthetic porous material were investigated.