Generation of guide star catalog for the all-time three-FOV star sensor applied on airborne platforms.

The guide star catalog plays a crucial role in the star sensor, impacting the system's star identification speed and attitude measurement accuracy. Currently, the generation method for the guide star catalog is well developed for star sensors used on satellites. However, the inter-FOV guide star catalog for the all-time three-FOV star sensor still faces challenges such as excessive storage requirements, non-uniform distribution of guide stars, and incompleteness.

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report.

Anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare autoimmune disorder characterized by varied neurological symptoms, often associated with limbic syndromes. We report the case of a 57-year-old female who presented with obvious ataxia, and then cognitive impairment and behavioral changes. MRI revealed cerebellar dentate nucleus and basal ganglia lesions with enhancement, which spontaneously regressed on follow-up imaging-a rare phenomenon in mGluR5 encephalitis.

Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-κB pathway.

BackgroundAlzheimer's disease (AD) causes cognitive function disorder and has become the preeminent cause of dementia. Glucagon-like peptide-1 (GLP-1) receptor agonists, semaglutide, have shown positive effects on promoting the cognitive function. However, research about the mechanism of semaglutide as a therapeutic intervention in AD is sparse.

Bilingual Dialogue Dataset with Personality and Emotion Annotations for Personality Recognition in Education.

Dialogue datasets are essential for advancing natural language processing (NLP) tasks. However, many existing datasets lack integrated annotations for personality and emotion, limiting models' ability to effectively capture these aspects and generate personalized, human-like dialogues, which ultimately impact user experience. To address this challenge, we construct bilingual dialogue datasets in Chinese and English, incorporating Big Five personality traits and emotion annotations.

Farrerol alleviates cognitive impairments in chronic cerebral hypoperfusion via suppressing NLRP3 inflammasome-mediated pyroptosis.

Background: Chronic cerebral hypoperfusion (CCH) serves as a critical pathological mechanism that contributes to the development of vascular dementia (VaD). NLRP3 inflammasome activation is a pivotal factor in promoting cognitive decline in CCH. Farrerol, a dihydroflavonoid derived from Rhododendron and other Ericaceae species, possesses anti-inflammatory, antioxidant, and neuroprotective properties.

On-orbit high-precision calibration for deep-coupled parameters of star sensor and gyroscope systems.

To enhance the dynamic performance and stability of spacecraft attitude measurement, a commonly adopted approach is to integrate a star sensor with an inertial gyroscope. While an integrated sensor system offers benefits in high-precision and high-dynamic scenarios, it also introduces errors in the extrinsic parameters of the camera and gyroscope, directly contributing to increased fixed error in attitude determination. Hence, real-time correction of integrated system parameters becomes crucial for enhancing the accuracy of attitude estimation.

Intelligent transformation, fintech, and green Growth：A general equilibrium analysis based on credit allocation perspective.

This paper conducted an in-depth study to elucidate the impact of corporate intelligence transformation and regional financial technology on green economic growth, particularly the role of credit resource allocation. We developed a multi-sector general equilibrium model, integrating the heterogeneity of intelligent transformation in production sectors and accounting for the influence of Fintech on financial institutions. Within this model framework, panel data from 2011 to 2021 at the provincial, municipal, and micro-enterprise levels in China were used to validate the theoretical model through a mixed regression approach.

In situ gel-forming oil as rectally delivering platform of hydrophobic therapeutics for ulcerative colitis therapy.

Because of their poor water-soluble properties and non-specific distribution, most hydrophobic therapeutics had limited benefit for patients with ulcerative colitis. Herein, an in-situ oil-based gel has been developed as a rectal delivery vehicle for these therapeutics. In situ gel-forming oil (BBLG) was composed of soybean phosphatidyl choline (40%, w/w), glyceryl dioleate (50%, w/w), and ethanol (10%, w/w).

miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.

Promotion of new blood vessel formation is a new strategy for treating ischemic stroke. Non-coding miRNAs have been recently considered potential therapeutic targets for ischemic stroke. miR-181b has been shown to promote angiogenesis in hypoxia and traumatic brain injury model, while its effect on ischemic stroke remains elusive.

Understanding college students' continuous usage intention of asynchronous online courses through extended technology acceptance model.

Asynchronous online learning has gained great popularity in higher education, especially due to the recent COVID-19 pandemic. However, few studies have investigated how to maintain students' continuous usage intention of asynchronous online courses in the context of higher education. This study incorporated four key factors (intrinsic motivation, extrinsic motivation, perception of multiple sources, and cognitive engagement) associated with students' continuous usage intention of asynchronous online courses into technology acceptance model (TAM) to identify the influencing factors on students' continuous usage intention.

Analyses on safety and efficacy of non-standard dose of r-tPA in intravenous thrombolysis-treated AIS patients.

Background: Intravenous 0.9 mg/kg recombinant tissue plasminogen activator (r-tPA) is one of the most effective treatments in acute ischemic stroke patients. Practically, the dose of r-tPA is still a topic that is constantly being discussed.

ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.

Diabetes mellitus is associated with cognitive impairment characterized by memory loss and cognitive inflexibility. Recent studies have revealed that ChemR23 is implicated in both diabetes mellitus and Alzheimer's disease. However, the impact of ChemR23 on diabetes-associated cognitive impairment remains elusive.

Star Sensor Denoising Algorithm Based on Edge Protection.

Single-pixel noise commonly appearing in a star sensor can cause an unexpected error in centroid extraction. To overcome this problem, this paper proposes a star image denoising algorithm, named Improved Gaussian Side Window Filtering (IGSWF). Firstly, the IGSWF algorithm uses four special triangular Gaussian subtemplates for edge protection.

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis.

Background: ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation. Reduced ADAMTS13 levels in plasma have been detected in multiple sclerosis (MS) patients. In the present study, we have determined the role of ADAMTS13 in the disease progression of MS using a mouse model of experimental autoimmune encephalomyelitis (EAE).

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1 Mouse Model of ALS by Enhancing Autophagic Flux.

Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder caused by selective degeneration of motor neurons in the brain and spinal cord. Our previous studies indicated that abnormal protein aggregation and dysfunctional autophagic flux might contribute to the disease pathogenesis. In this study, we have detected the role of the Ca dependent autophagic pathway in ALS by using the L-type channel Ca blocker, verapamil.

The effect of lithium chloride on the attenuation of cognitive impairment in experimental hypoglycemic rats.

Background: Hypoglycemia is the most common complication in the treatment of diabetes mellitus. Accumulating evidence indicated that severe hypoglycemia could induce cognitive impairment. However, the molecular mechanism of regulating this progress is largely unknown.

Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses.

Background: Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and by degrading tight junctions. Acute severe hypoglycemia induces a proinflammatory environment that may contribute to a disruption in the epithelial barrier by decreasing tight junction protein expression. Interestingly, the altered AQP4 expression has been considered to play a critical role in neuroinflammation during acute brain injury.

Clinical significance of changes in serum neuroglobin and HIF-1α concentrations during the early-phase of acute ischemic stroke.

Background: Neuroglobin (NGB) has been described as a neuroprotective agent in cerebral ischemia, hypoxia inducible factor (HIF) has shown an important role in modulating hypoxic and ischemic injury, and therefore they have the potential to impact outcomes after acute ischemic stroke (AIS). Thus, we investigated early changes in the concentrations of serum NGB and HIF-1α after AIS and evaluated the relations of both NGB and HIF-1α to stroke severity and prognosis.

Methods: We prospectively measured the serum concentrations of NGB and HIF-1α in 40 patients with AIS at 24, 48, 72, and 96h after stroke.

Uric acid is associated with vascular dementia in Chinese population.

Objective: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently.