A novel fluorescent probe for the detection of HO in multiple food matrices and biological samples.

To address the risk of hydrogen peroxide (H₂O₂) abuse during food processing, this paper developed a naphthylimine fluorescent probe, DN-H₂O₂, based on the intramolecular charge transfer mechanism (ICT). Activation of the ICT mechanism through the interaction of boronic acid groups with HO enables HO fluorescence detection. The probe has a low detection limit (3.

Nucleus-Targeted Sonosensitizer Activates the cGAS-STING Pathway for Tumor Sonodynamic Immunotherapy.

A nucleus is crucial for both sonodynamic therapy (SDT) and antitumor immunity. However, how to burst ROS generation , accurately damage a nucleus, and meanwhile activate a cGAS-STING pathway-induced innate immune response are still a great challenge. Here, we present TBzT-CPi, a small molecule with a D-A-π-A1 structure that simultaneously amplifies nucleus-targeted SDT and cGAS-STING pathway-dependent immune stimulation.

High-Conductivity and Ultrastretchable Self-Healing Hydrogels for Flexible Zinc-Ion Batteries.

Aqueous zinc-ion batteries are promising candidates for flexible energy storage devices due to their safety, economic efficiency, and environmental friendliness. However, the uncontrollable dendrite growth and side reactions at the zinc anode hinder their commercial application. Herein, we designed and synthesized a dual network self-healing hydrogel electrolyte with zwitterionic groups (PAM-PAAS-QCS), which can be used for the large deformations of flexible devices due to its excellent stretchability (ε = 5100%).

A benzothiophene-based fluorescent probe with dual-functional to polarity and cyanide for practical applications in living cells and real water samples.

Polarity is a significant intracellular environmental parameter associated with cancer, while cyanide (CN) is known to be highly toxic to humans. In this work, we designed a dual-functional fluorescent probe (TPABT) for simultaneous detection of polarity and CN. As a polarity sensor, the probe exhibits NIR emission at 766 nm in 1,4-dioxane (non-polar solvent), whose emission intensity is 71-fold stronger than that in water (polar solvent).

NIR-II Emissive Superoxide Radical Photogenerator for Photothermal/Photodynamic Therapy against Hypoxic Tumor.

Due to the "Achilles' heels" of hypoxia, complicated location in solid tumor, small molecular photosensitizers with second near-infrared window (NIR-II) fluorescence, type-I photodynamic therapy (PDT), and photothermal therapy (PTT) have attracted great attention. However, these photosensitizers are still few but yet challenging. Herein, an "all in one" NIR-II acceptor-donor-acceptor fused-ring photosensitizer, Y6-Th, is presented for the in-depth diagnosis and efficient treatment of cancer.

Colorimetric and fluorescent dual-signals probes for naked-eye detection of hydrogen peroxide and applications in milk samples and in vivo.

Excessive residual hydrogen peroxide (HO) disinfectant in food is harmful to human health. Therefore, it is necessary to develop efficient detection methods for HO detection. In this work, we designed and synthesized five D-A molecules 3a-3e by introducing electron-donor substituents (-OCH and -CH) to the electron-acceptor dicyanoisophorone skeleton in order to find out the suitable probes for HO detection.

Copperphosphotungstate Doped Polyanilines Nanorods for GSH-Depletion Enhanced Chemodynamic/NIR-II Photothermal Synergistic Therapy.

Introduction: The high concentration of glutathione (GSH) and hydrogen peroxide (HO) levels within the tumor microenvironment (TME) are the major obstacle to induce the unsatisfactory anticancer treatment efficiency. The synergistic cancer therapy strategies of the combination the GSH depletion enhanced chemodynamic therapy (CDT) with photothermal therapy (PTT) have been proved to be the promising method to significantly improve the therapeutic efficacy.

Methods: The copperphosphotungstate was incorporated into polyanilines to design copperphosphotungstate doped polyaniline nanorods (CuPW@PANI Nanorods) via chemical oxidant polymerization of aniline.

Inhibition of Q235 corrosion in sodium chloride solution by chitosan derivative and its synergistic effect with ZnO.

A novel chitosan Schiff base derivative (CVZ) doped with ZnO nanoparticles (ZnONPs) was synthesized and investigated. The corrosion protection performance was evaluated via electrochemical measurements and surface analyses. Compared to the undoped derivative (CV), the results show that the corrosion inhibition efficiency of CVZ sharply increases from 67.

Conductive Hydrogels with Ultrastretchability and Adhesiveness for Flame- and Cold-Tolerant Strain Sensors.

Hydrogel strain sensors with extreme temperature tolerance have recently gained great attention. However, the sensing ability of these hydrogel strain sensors changes with temperature, resulting in the variety of output signals that causes signal distortion. In this study, double-network hydrogels comprising SiO nanoparticles composed of polyacrylamide and phytic acid-doped polypyrrole were prepared and applied on strain sensors with a wide sensing range, high adhesiveness, and invariable strain sensitivity under flame and cold environments.

Two cyanoethylene-based fluorescence probes for highly efficient cyanide detection and practical applications in drinking water and living cells.

Cyanide detection methods are urgently needed due to the highly lethal to human beings. Herein, we report two fluorescence probes (Probe 1 and Probe 2) based on cyanoethylene group for cyanide anion (CN) detection. The selective recognition for CN was confirmed by the completely opposite green fluorescence of Probe 1 and red fluorescence of Probe 2 observed by fluorescence spectra and naked eyes.

Chitosan derivative corrosion inhibitor for aluminum alloy in sodium chloride solution: A green organic/inorganic hybrid.

A novel and eco-friendly chitosan derivative was synthesized as green corrosion inhibitors on C3003 aluminum alloy in 3.5 wt.% NaCl solution.

Metallohydrogel with Tunable Fluorescence, High Stretchability, Shape-Memory, and Self-Healing Properties.

Aiming at the problem that the reported smart optical metallohydrogels were limited with poor mechanical properties, we reported here a novel smart optical metallohydrogel (Al-hydrogel) with excellent elongation, shape-memory ability, self-healing property, and controllable fluorescence intensity. The Al-hydrogel was obtained by the HHPMA-Al and carboxylate-Al coordination after one-pot micellar copolymerization of acrylic acid (AAc), acrylamide (AAm), and hydrophobic arylhydrazone-based ligand (HHPMA). This hydrogel was able to extend up to 5000% of its original length without fracture.

A nucleic acid-specific fluorescent probe for nucleolus imaging in living cells.

Nucleus imaging is of great importance for understanding cellular processes of genetic expression, proliferation and growth, etc. Although many nucleic-acid selective dyes for nucleus staining are available, few of them meet multiple standards. Herein, we report a cationic fluorescence dye FTI that possesses visible light excitation (436 nm), orange emission (571 nm) and a large Stokes shift (~135 nm) for nucleic-acid staining.

Precise design and synthesis of an AIE fluorophore with near-infrared emission for cellular bioimaging.

Organic fluorophores emerge as important stains for bioimaging and biosensing, especially for fluorophores with aggregation-induced emission characters. However, the development of organic fluorophores with efficient AIE properties expand to far-red and/or near-infrared is still a great challenge. Herein, we precisely design and synthesize a novel D-π-A type of near-infrared AIE fluorophore (TPE-PTZ-R) by introducing phenothiazine (PTZ) to modify the typical AIE unit (tetraphenylethylene, TPE).

Self-Healing and Multistimuli-Responsive Hydrogels Formed via a Cooperation Strategy and Their Application in Detecting Biogenic Amines.

We reported here a new platform of supramolecular hydrogels cross-linked by the cooperation of metal-ligand coordination and hydrophobic interaction. A salicylaldehyde benzoyl hydrazone-terminal poly(ethylene glycol) (2SBH-PEG) was synthesized and formed small micelles in an aqueous environment. Addition of Ni connected the low-molecular-weight 2SBH-PEG into a metallopolymer via metal-ligand coordination and led to micelle aggregation, resulting in gelation due to the enhancement of hydrophobic interaction.

Aggregation-Induced Emission-Active Near-Infrared Fluorescent Organic Nanoparticles for Noninvasive Long-Term Monitoring of Tumor Growth.

Effective long-term monitoring of tumor growth is significant for the evaluation of cancer therapy. Aggregation-induced emission-active near-infrared (NIR) fluorescent organic nanoparticles (TPFE-Rho dots) are designed and synthesized for long-term in vitro cell tracking and in vivo monitoring of tumor growth. TPFE-Rho dots display the advantages of NIR fluorescent emission, large Stokes shift (∼180 nm), good biocompatibility, and high photostability.

Real-time imaging of cancer cell generations and monitoring tumor growth using a nucleus-targeted red fluorescent probe.

Real-time and long-term nucleus labeling is of great significance for understanding and elucidating cellular and molecular processes in the life sciences, such as gene expression, replication, recombination, and repair, but remains challenging because of the lack of ideal imaging probes. Traditional commercial DNA stains for live-cell imaging either suffer from low water solubility, high cytotoxicity and photobleaching or have small Stokes shifts and low ultraviolet (UV) light excitation; these intrinsic drawbacks limit their utility. Here, a far-red DNA stain (PTB) is explored for in vitro long-term nucleus tracking and in vivo tumor growth monitoring.

Investigation on the mechanical properties of polyurea (PU)/melamine formaldehyde (MF) microcapsules prepared with different chain extenders.

There is lack of understanding on controlling of mechanical properties of moisture-curing PU/MF microcapsules which limited its further application. PU/MF microcapsules containing a core of isophorone diisocyanate (IPDI) were prepared with different chain extenders, polyetheramine D400, HO, triethylenetetramine and polyetheramine (PEA) D230 by following a two-step synthesis method in this study. Fourier transform infra-red (FTIR) spectroscopy, Malvern particle sizing, scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

A photostable cationic fluorophore for long-term bioimaging.

Fluorophores for efficient long-term bioimaging are of great importance to fully understand the cellular and molecular processes of disease. In this study, a bright and photostable cationic fluorophore (PPB) was successfully developed as a long-term tracer. The PPB displayed advanced properties such as high fluorescence efficiency, large Stokes shift, low cytotoxicity, and good biocompatibility.

A novel fluorescence probe based on triphenylamine Schiff base for bioimaging and responding to pH and Fe.

A novel fluorescence probe 1 based on triphenylamine was synthesized and characterized by NMR, IR, high resolution mass spectrometry and elemental analysis. Its fluorescence was quenched when pH below 2. There was a linear relationship between the fluorescence intensity and pH value ranged from 2 to 7.

Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable core fraction were prepared. The structure, morphology, particle size and distribution were studied with Fourier transform infra-red spectroscopy, optical microscopy, scanning electron microscopy and Mastersizer 3000.

Fluorescent probe based on heteroatom containing styrylcyanine: pH-sensitive properties and bioimaging in vivo.

A novel fluorescent probe based on heteroatom containing styrylcyanine is synthesized. The fluorescence of probe is bright green in basic and neutral media but dark orange in strong acidic environments, which could be reversibly switched. Such behavior enables it to work as a fluorescent pH sensor in the solution state and a chemosensor for detecting acidic and basic volatile organic compounds.

Fluorescent sensors based on quinoline-containing styrylcyanine: determination of ferric ions, hydrogen peroxide, and glucose, pH-sensitive properties and bioimaging.

A novel styrylcyanine-based fluorescent probe 1 was designed and synthesized via facile methods. Ferric ions quenched the fluorescence of probe 1, whereas the addition of ferrous ions led to only small changes in the fluorescence signal. When hydrogen peroxide was introduced into the solution containing probe 1 and Fe(2+) , Fe(2+) was oxidized to Fe(3+), resulting in the quenching of the fluorescence.

A naked-eye chemosensor for fluoride ions: a selective easy-to-prepare test paper.

A new naked-eye chromogenic chemosensor based on 2-thiohydantoin shows high selectivity for fluoride ions and is used to develop a test paper for detection of fluoride ions in the solid state.