A Study on the Low-Intensity Cracking Resistance of Drainage Asphalt Mixtures by Graphene/Rubber Powder Compound Modified Asphalt.

In order to investigate the influence of graphene/rubber powder compound modified asphalt on the low-temperature cracking resistance of drainage asphalt mixtures, graphene/rubber powder compound modified asphalt mixtures were prepared using graphene/rubber powder compound modified asphalt for drainage asphalt mixtures, and compared with SBS-modified asphalt and rubber powder-modified asphalt, and the low-temperature cracking resistance of graphene/rubber powder compound modification asphalt mixtures was investigated through the Marshall Stability Test, Semi-circular Bending Test (SCB), and Freeze-Thaw Split Test. Research was carried out. At the same time, a scanning electric microscope (SEM) was adopted to analyze the micro-mechanism of the graphene/rubber powder compound modified asphalt mixtures under the microscopic condition.

Dosing prediction of valproic acid in pediatric patients with epilepsy: population pharmacokinetic model or machine learning model?

Purpose: This study develops and compares population pharmacokinetics (PopPK) models and machine learning methods, including neural networks, to predict steady-state trough concentrations in pediatric patients and provide improved dosing recommendations.

Methods: Valproic acid concentration data were collected from 490 pediatric epilepsy patients treated at Beijing Tiantan Hospital and Beijing Children's Hospital. We developed predictive models employing PopPK, maximum a posteriori Bayesian (MAPB), multiple linear regression (MLR), machine learning (including Random Forest, XGBoost, and LightGBM for feature selection), and neural network techniques.

Comparing orthodontic pre-treatment information provided by large language models.

This study collected and screened the 50 most common pre-treatment consultation questions from adult orthodontic patients through clinical practice. Responses to these questions were generated using three large language models: Ernie Bot, ChatGPT, and Gemini. The responses were evaluated across six dimensions: Professional Accuracy (PA), Accuracy of Content(AC), Clarity and Comprehensibility (CC), Personalization and Relevance (PR), Information Completeness (IC), and Empathy and Patient-Centeredness (EHC).

Using the QRS-V Interval-based Algorithm to Optimize the Ablation Process of Outflow Tract Premature Ventricular Complexes.

Background: The choice between left- and right-sided ablation for outflow tract premature ventricular complexes (OT-PVCs) during procedures remains a topic of ongoing discussion. In this study we aim to elucidate the value of the QRS-V interval in distinguishing between left and right origins in left bundle branch block (LBBB)-type OT-PVCs, thereby optimizing the ablation process.

Methods: The QRS-V interval was measured in consecutive patients with LBBB-type OT-PVCs.

Seasonal variations in groundwater chemistry and quality and associated health risks from domestic wells and crucial constraints in the Pearl River Delta.

Groundwater quality is strongly compromised by polluted surface water recharge in rapidly developing urban regions. However, gaps still remain in the understanding of the critical contaminants controlling water quality and the health risks associated with groundwater consumption, particularly considering seasonal and climate changes in rainfall. This work focused on changes in groundwater quality and critical contaminants in domestic wells in the fast-developing Pearl River Delta (PRD) from the wet season to the dry season.

Design and validation of an alignment free adaptive joint torque measurement system.

Purpose: This study introduces a transferable alignment-free adaptive joint torque measurement (AFAJTM) system designed to resolve inconsistencies in torque measurements caused by misalignment between dynamometer and joint rotational axes, improving accuracy and reliability in joint torque assessment.

Method: This study presents the design and control methodology of an alignment free adaptive joint torque measurement system. An elbow joint torque measurement device (EJTMD) was developed, and its torque consistency and repeatability were evaluated at various misalignment positions using a joint simulation model.

A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1.

Metabolic changes are an important characteristic of vascular complications in diabetes. The accumulation of lactate in the microenvironment can promote vascular smooth muscle cell (VSMC) calcification in diabetes, although the specific mechanism remains to be fully elucidated. In this study, we explored the characteristics of lactylation in diabetic arterial calcification and the underlying molecular mechanism.

Development and Application of Flue Gas Desulfurized Gypsum and Blast-Furnace-Slag-Based Grouting Material for Cracked Silty Mudstone.

The grouting technique is an efficient method for enhancing the stability of cracked slopes through the use of grouting materials. Conventional cement-based grouting materials are costly, energy-intensive, and environmentally damaging. Additionally, cement-hardening slurry is prone to cracks between the slurry and the rock.

Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects.

Purpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) and reference formulation (R) in healthy Chinese male subjects.

Subjects And Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: a safety exploration design in lower dose (n = 14, 100 mg), part B: a pivotal comparative pharmacokinetic (PK) trial under fast condition (n = 44, 150 mg) and part C: a pivotal comparative PK trial under food condition (n = 44, 150 mg). Blood samples were collected for 72 hours and the PK parameters of C, AUC and AUC were used to evaluate PK differences.

Understanding electrical pulmonary vein antrum for paroxysmal atrial fibrillation: Further look into superhigh-density electroanatomic mapping of the left atrium.

Background: An isolation line placed at the pulmonary vein antrum (PVA) area is superior to ostium level in atrial fibrillation (AF) control. However, less is known about the electrophysiologic characteristics of the PVA.

Objective: The aim of this study was to describe the electrophysiologic properties of the PVA.

An open-label study to explore the optimal design of CYP3A drug-drug interaction clinical trials in healthy Chinese people.

A drug-drug interaction (DDI) trial of cytochrome P450 3A (CYP3A) is a necessary part of early-phase trials of drugs mainly metabolized by this enzyme, but CYP3A DDI clinical trials do not have a standard design, especially for Chinese people. We aimed to offer specific recommendations for CYP3A DDI clinical trial design. This was an open, three-cycle, self-controlled study.

Three-dimensional finite element analysis of the optimal mechanical design for maximum inward movement of the anterior teeth with clear aligners.

This study aims to refine clinical designs within clear aligner therapy, exploring the appropriate ratio of anterior tooth retraction to intrusion under maximum anchorage. Using a three-dimensional finite element model and evaluating 19 load scenarios with first premolar extraction, the research identifies the optimal force angle for anterior tooth retraction as 45 to 55°. For clinical planning, it is recommended to design a retraction of 0.

Safety and immunogenicity of the COVID-19 mRNA vaccine CS-2034: A randomized, double-blind, dose-exploration, placebo-controlled multicenter Phase I clinical trial in healthy Chinese adults.

Background: The novel coronavirus pneumonia (COVID-19) is an infectious disease caused by the infection of a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has resulted in millions of deaths. We aimed to evaluate the safety and immunogenicity of the COVID-19 mRNA vaccine (CS-2034, CanSino, Shanghai, China) in adults without COVID-19 infection from China.

Method: This is a multicenter Phase I clinical trial with a randomized, double-blinded, dose-exploration, placebo-controlled design.

Reducing Power Line Interference from sEMG Signals Based on Synchrosqueezed Wavelet Transform.

Power line interference (PLI) is a major source of noise in sEMG signals. As the bandwidth of PLI overlaps with the sEMG signals, it can easily affect the interpretation of the signal. The processing methods used in the literature are mostly notch filtering and spectral interpolation.

External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients.

Objective: Vancomycin is commonly used in the prevention and treatment of intracranial infections in postoperative neurosurgical patients with narrow therapeutic window and large pharmacokinetic variations. Several population pharmacokinetic (PPK) models of vancomycin have been established for neurosurgical patients. But comprehensive external evaluation has not been performed for almost all models.

Does multidimensional daily information predict the onset of myopia? A 1-year prospective cohort study.

Purpose: This study aimed to develop an interpretable machine learning model to predict the onset of myopia based on individual daily information.

Method: This study was a prospective cohort study. At baseline, non-myopia children aged 6-13 years old were recruited, and individual data were collected through interviewing students and parents.

LncRNA Osilr9 coordinates promoter DNA demethylation and the intrachromosomal loop structure required for maintaining stem cell pluripotency.

Nuclear reprogramming of somatic cells into a pluripotent status has the potential to create patient-specific induced pluripotent stem cells for regenerative medicine. Currently, however, the epigenetic mechanisms underlying this pluripotent reprogramming are poorly understood. To delineate this epigenetic regulatory network, we utilized a chromatin RNA in situ reverse transcription sequencing (CRIST-seq) approach to identify long noncoding RNAs (lncRNAs) embedded in the 3-dimensional intrachromosomal architecture of stem cell core factor genes.

[Research on muscle fatigue recognition model based on improved wavelet denoising and long short-term memory].

The automatic recognition technology of muscle fatigue has widespread application in the field of kinesiology and rehabilitation medicine. In this paper, we used surface electromyography (sEMG) to study the recognition of leg muscle fatigue during circuit resistance training. The purpose of this study was to solve the problem that the sEMG signals have a lot of noise interference and the recognition accuracy of the existing muscle fatigue recognition model is not high enough.

Muscle Synergy of Lower Limb Motion in Subjects with and without Knee Pathology.

Surface electromyography (sEMG) has great potential in investigating the neuromuscular mechanism for knee pathology. However, due to the complex nature of neural control in lower limb motions and the divergences in subjects' health and habits, it is difficult to directly use the raw sEMG signals to establish a robust sEMG analysis system. To solve this, muscle synergy analysis based on non-negative matrix factorization (NMF) of sEMG is carried out in this manuscript.

Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network.

Background: A specific 3-dimensional intrachromosomal architecture of core stem cell factor genes is required to reprogram a somatic cell into pluripotency. As little is known about the epigenetic readers that orchestrate this architectural remodeling, we used a novel chromatin RNA in situ reverse transcription sequencing (CRIST-seq) approach to profile long noncoding RNAs (lncRNAs) in the Oct4 promoter.

Results: We identify Platr10 as an Oct4 - Sox2 binding lncRNA that is activated in somatic cell reprogramming.