Assessing the Influence of Bladder Cancer on Upper Tract Urothelial Carcinoma Prognoses Following Radical Nephroureterectomy: A Retrospective, Propensity Score-Based Multicenter Cohort Study.

Background: Bladder cancer (BCa) is relatively common in patients diagnosed with upper tract urothelial carcinoma (UTUC); however, the impact of BCa history on UTUC prognoses after radical nephroureterectomy (RNU) is unclear. This retrospective, multicenter cohort study aimed to assess this relationship and improve clinical decision making.

Materials And Methods: We conducted a comprehensive analysis of propensity score-matched (PSM) data from two Chinese centers and the Surveillance, Epidemiology, and End Results (SEER) database.

Hypoxia-Responsive Nano-Photosensitizer Anchored by PEGylated BODIPY: A Single-Laser-Driven Platform for Photo-Enhanced Synergistic Chemo/Photodynamic/Photothermal Cancer Therapy.

The integration of chemotherapeutic drugs and photosensitizers into nanocarriers holds great potential for combining chemotherapy and phototherapy while reducing systemic toxicity. However, therapeutic efficacy is hindered by the hypoxic tumor microenvironment and the insufficient drug release. This study designs a multifunctional nano-photosensitizer BAP by conjugating hydrophobic boron dipyrromethene (BODIPY) with hydrophilic poly(ethylene glycol) via hypoxia-responsive azobenzene linkers.

Polycation Engineering in Polymeric Metal Halides Enables Tunable and Multicolor Emission from Single Transition-Metals.

Zero-dimensional metal halides have emerged as a versatile platform for the development of light-emitting materials, but achieving tunable or even multicolor emission from a material containing a single type of metal has proven highly challenging. Here, we leverage the "structural tolerance" of recently-developed polymeric metal halides to integrate two distinct coordination units of a single metal into a material, thereby achieving highly tunable optical properties in single-phase metal halides. By manipulating the steric hindrance of polycations, facilely adjustable green, red or bicolor emission can be realized in manganese bromides, which originates from controllable transformation from manganese-bromine tetrahedra into octahedra.

The impact of surgery and survival prediction in patients with bladder neuroendocrine carcinoma: a novel propensity score-matched population-based cohort study.

Objective: To evaluate the effects of surgical interventions on individuals diagnosed with bladder neuroendocrine carcinoma (BNEC).

Materials And Methods: Data were gathered from the Surveillance, Epidemiology, and End Results (SEER) database for this retrospective analysis. No-surgery procedures included TURBT, cryotherapy, excisional biopsy, or partial cystectomy.

Treatment of diabetic infection wounds using novel fluoroborane dipyrrole-coated transparent patch.

Diabetic wounds complicated by bacterial infections present a significant clinical challenge, and cause a great burden to the world's health care systems. Infections by bacteria, especially drug-resistant bacteria, is the major underlying factor leading to diabetic wounds. Here, we synthesized a series of fluoroborane dipyrrole compounds that can be activated under ambient light conditions, and identified one compound with potent antibacterial action.

Optimization of sludge retention time for rapid start-up and stable operation of high-rate partial nitritation in a continuous flow reactor treating municipal wastewater.

High-rate partial nitritation (HRPN) of municipal wastewater is receiving increasing attention, but how to achieve the rapid start-up and stable operation of municipal wastewater HRPN in continuous flow reactor remains a technical challenge. In this study, a feasible and economical strategy based on optimization sludge retention time (SRT) operation was proposed to address this issue, leveraging the kinetic differences between ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB). A HRPN reactor was operated for 225 days with dissolved oxygen (DO) of 2.

Structural Variations Associated with Adaptation and Coat Color in Qinghai-Tibetan Plateau Cattle.

Structural variations (SVs) play crucial roles in the evolutionary adaptation of domesticated animals to natural and human-controlled environments, but SVs have not been explored in Tibetan cattle, which recently migrated and rapidly adapted to the high altitudes of the Qinghai-Tibetan Plateau (QTP). In this study, a de novo chromosome-level genome assembly for Tibetan cattle is constructed. It is found that using a lineage-specific reference genome significantly increased variant detection accuracy and completeness.

Membrane-enhanced methanogenesis efficiency and biomass retention in EGSB-AnMBR for food waste press filtrate treatment.

In this study, an anaerobic membrane bioreactor (AnMBR) system was integrated with the expanded granular sludge bed (EGSB) to enhance the treatment performance and stability of food waste press filtrate (FWPF) digestion. A long-term continuous experiment was conducted at organic loading rates (OLRs) of 6.7, 13.

Interfered long non-coding RNA HELLPAR or up-regulated microRNA-448 inhibits nasopharyngeal carcinoma progression via suppression of ADAM10.

Objective: Nasopharyngeal carcinoma (NPC) is a highly invasive malignancy with poor prognosis, necessitating further exploration of its molecular mechanisms. While HELLP-associated long non-coding RNA (HELLPAR), microRNA-448 (miR-448), and a disintegrin and metalloprotease 10 (ADAM10) have been implicated in other malignancies, their regulatory interplay and functional roles in NPC remain unclear. This study aimed to investigate the role of HELLPAR in NPC progression through its interaction with miR-448 and ADAM10.

Association of life's crucial 9 score with benign prostatic hyperplasia: a cross-sectional study.

Background: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are prevalent prostate diseases in aging male populations, with significant implications for quality of life and healthcare burden. While cardiovascular health (CVH) and lifestyle factors have been linked to aging and chronic diseases, their association with prostate diseases remains underexplored.

Objective: This study investigates the relationship between CVH, assessed using the Life's Crucial 9 (LC9) score, and the risk of prostate diseases, including BPH and PCa, in a large UK cohort.

Robust aeration coefficient control based on pH feedback towards stable NO-N/NH-N ratio in large pilot-scale partial nitritation reactor treating food waste digestate.

Two-stage partial nitritation/anammox (PNA) system is a promising technology for treating food waste digestate (FWD). Maintaining a stable NO-N/NH-N ratio in partial nitritation (PN) is essential for the successful implementation of two-stage PNA. Although the aeration coefficient (AC) is a key regulatory parameter, its stability is challenged by fluctuations in chemical oxygen demand (COD).

Intelligent FA/FNA alternating strategy for nitrite-oxidizing bacteria inhibition: Data-driven prediction and process control.

Alternating treatment with free ammonia (FA) and free nitrous acid (FNA) is an effective strategy to inhibit nitrite-oxidizing bacteria (NOB) in partial nitrification (PN) process. However, the current alternating treatment relies on manual assessment of nitrite accumulation rate (NAR), which poses challenges for automation. This study proposed an intelligent control system for automatic real-time switching between FA/FNA inhibition strategy and real-time control of inhibition concentration to realize stable NOB inhibition.

Oxidative stress and inflammation mediate the association between Life's Crucial 9 and biological ageing: A secondary analysis of two observational studies.

Background: Life's Essential 8 (LE8) is known to have a negative correlation with biological aging, while the relationship between the Life's Crucial 9 (LC9) score, which includes mental health, and biological aging remains to be further investigated.

Methods: We obtained data from two national cohorts, the UK Biobank and National Health and Nutrition Examination Survey (NHANES), to analyze the association between LC9 and biological aging. Biological aging was assessed using PhenoAge and KDMAge, with gender, race, and other indicators included as covariates.

Central obesity and its association with benign prostatic hyperplasia: insights from a cross-sectional study of NHANES 2001-2008.

Background: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated.

Methods: In this study, we included a total of 4,625 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2008. We calculated indices related to central obesity for each participant and then employed univariate logistic regression, multivariate logistic regression, restricted cubic splines (RCS), and Akaike's Information Criterion (AIC) analysis.

The carrier dynamics for self-assembled black phosphorus and perovskite nanocrystals enable photocatalytic conversion.

Few-layer black phosphorus (BP) becomes an ideal self-assembled material with perovskite nanocrystals (NCs) for photoluminescence (PL) and photocatalysis, due to the feasible control of photogenerated charge carriers. Until now, it is still a challenge to figure out the intrinsic carrier dynamics for multifunctional photodegradation in water. In this work, a series of few-layer BP components were successfully incorporated into CsPbBr NCs to achieve apparent PL quenching and ˙O-dominated photocatalytic degradation of rhodamine B in aqueous solution.

Epigenetic regulation of physiological resilience to ammonia nitrogen stress in the Pacific whiteleg shrimp Penaeus vannamei: Evidence from genome-wide DNA methylation dynamics.

Although DNA methylation has emerged as an essential epigenetic mechanism modulating organismal responses to abiotic stresses, its involvement in the physiological resilience of marine invertebrates like shrimp to ammonia nitrogen toxicity remains enigmatic. Here, we performed the first comprehensive dissection of genome-wide DNA methylation dynamics in the Pacific whiteleg shrimp Penaeus vannamei exposed to ammonia nitrogen, based on whole-genome bisulfite sequencing and transcriptome analyses. In the genome of P.

MED10 Increases Cisplatin Resistance by Promoting PTEN Ubiquitination of Hepatocellular Carcinoma.

Objective: Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor, ranking as the third leading cause of cancer-related deaths worldwide. Despite advances in chemotherapy, many patients exhibit limited therapeutic efficacy, ultimately leading to cisplatin resistance. Thus, an in-depth investigation into the molecular mechanisms underlying cisplatin resistance is critically needed.

The shrimp NF-κB pathway is activated to mediate the antioxidant defense and apoptosis under ammonia-N stress.

Ammonia-N stress from aquaculture system can interfere physiological function in shrimp leading to constant oxidative stress and apoptosis, but little is known concerning the upstream regulators. In this study, survival analysis and Western blot was perform to determine the optimal concentration and inhibitory effect on NF-κB pathway inhibitor (PDTC). Then the influence of 30 mg/kg PDTC on the ammonia-N tolerance, antioxidation, and apoptosis in L.

Corrigendum: A simplified frailty index and nomogram to predict the postoperative complications and survival in older patients with upper urinary tract urothelial carcinoma.

[This corrects the article DOI: 10.3389/fonc.2023.

An ab initio deep neural network potential to study the effect of density on the thermal decomposition mechanism of FOX-7.

Condensed phase explosives typically contain defects such as voids, bubbles, and pores; this heterogeneity facilitates the formation of hot spots and triggers decomposition reaction at low densities. The study of the thermal decomposition mechanisms of explosives at different densities has thus attracted considerable research interest. Gaining a deeper insight into these mechanisms would be helpful for elucidating the detonation processes of explosives.

Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China.

Background: Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of the region have collectively contributed to shaping the distinctive germplasm characteristics observed in Yunnan indigenous cattle through prolonged domestication. The different breeds of Yunnan cattle exhibit distinct advantageous characteristics and traits, which are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. However, a comprehensive genomic landscape of genetic resources has yet to be delineated.

Preparation and characterization of electrically conductive nano-ZnO-doped Ti/Zr composite conversion coating on aluminum alloy.

The integration of semiconductive nano-ZnO into a Ti/Zr-based solution has facilitated the development of a conductive coating on aluminum alloy surfaces. A comprehensive characterization of the coating's morphology, microstructure, electrical conductivity, and corrosion resistance was conducted utilizing a suite of analytical techniques, including SEM, FIB-SEM, EDS, XPS, UV-vis, FTIR, and an electrochemical workstation. Significantly, the electrical contact resistance (ECR) of the coating experienced a substantial decrease when subjected to a pressure of 200 psi, plummeting from 0.

Theoretical Study on the Key Influence of Ionic Liquid on the Synthesis Method of HMX by DPT.

The role of ionic liquids in the nitration synthesis of HMX from DPT is explored in this study by using quantum chemical calculations and AIMD-metadynamics methods. The findings reveal that the formation of NO and NO is enhanced by ionic liquids while significantly lowering the energy barriers of critical reaction pathways, such as nitration, nitrosation, and hydroxylation, through supramolecular structure. Moreover, the research results further demonstrate the catalytic role and environmentally friendly green characteristics of ionic liquids in this synthesis reaction and the influence of appropriate acidity of ionic liquids on the synthesis of HMX.

A chemically enhanced primary treatment and anammox-based process for sustainable municipal wastewater treatment: The advantage and application prospects.

Low-carbon nitrogen removal, bioenergy production, and phosphorus recovery are key goals for sustainable municipal wastewater treatment. Traditional activated sludge processes face an energy demand conflict. Anaerobic ammonium oxidation (Anammox) offers a solution to this issue, with the A-B process providing a sustainable approach.