Fabrication of EP@PDMS@F-SiO Superhydrophobic Composite Coating on Titanium Alloy Substrate.

In this study, a preparation method of superhydrophobic composite coating based on a titanium alloy (Ti-6Al-4V) substrate is proposed. The micro-scale pit array structure was fabricated via laser etching technology. Utilizing the synergistic effects of epoxy resin (EP), polydimethylsiloxane (PDMS), and fluorinated nanosilica (F-SiO), we successfully prepared an EP@PDMS@F-SiO composite coating.

Signal-induced NLRP3 phase separation initiates inflammasome activation.

NLRP3 inflammasome is activated by diverse stimuli including infections, intracellular and environmental irritants. How NLRP3 senses these unrelated stimuli and what activates NLRP3 remain unknown. Here we report that signal-dependent NLRP3 phase separation initiated its activation, in which the palmitoyltransferase ZDHHC7-mediated tonic NLRP3 palmitoylation and an IDR region in the FISNA domain of NLRP3 play important roles.

The shrimp NF-κB pathway is activated to mediate the antioxidant defense and apoptosis under ammonia-N stress.

Ammonia-N stress from aquaculture system can interfere physiological function in shrimp leading to constant oxidative stress and apoptosis, but little is known concerning the upstream regulators. In this study, survival analysis and Western blot was perform to determine the optimal concentration and inhibitory effect on NF-κB pathway inhibitor (PDTC). Then the influence of 30 mg/kg PDTC on the ammonia-N tolerance, antioxidation, and apoptosis in L.

Combining laser biomimetic surface microtextured and PTFE solid lubricant for improved friction property of Ti6Al4V.

Titanium alloys have limited applications due to their poor friction performance. Inspired by the scale structures on biological surfaces in nature, laser surface texturing technology was employed to fabricate diamond-shaped biomimetic micro-textures with different angles and area densities on the surface of titanium alloy (Ti6Al4V). The coupling effect of scale-like biomimetic micro-textures and polytetrafluoroethylene (PTFE) coatings on the frictional properties of Ti6Al4V were explored.

Roles of NLRC4 inflammasome in neurological disorders: Mechanisms, implications, and therapeutic potential.

The nucleotide-binding oligomerization domain-like receptor family caspase recruitment domain containing 4 (NLRC4) inflammasome, a vital component of the innate immune system, is known for defending against bacterial infections. However, recent insights have revealed its significant impact on neurological disorders. This comprehensive review discussed the mechanisms underlying the activation and regulation of the NLRC4 inflammasome, highlighting the complexity of its response to cellular stress and damage signals.

Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia-reperfusion injury via Wnt/β-catenin pathway modulation.

Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia-reperfusion injury (CIRI) are not fully understood.

Preparation of Aluminum-Based Dual-Gradient Surfaces for Directional Droplet Transport by Bioinspired Sarracenia Microstructures.

Inspired by the ultrafast directional water transport structure of Sarracenia trichomes, hierarchical textured surfaces with specific microgrooves were prepared based on laser processing combined with dip modification, in response to the growing problem of freshwater scarcity. The prepared surfaces were tested for droplet transport behavior to investigate the relationship between the surface structure and the driving force of directional water transport and their effects on the water transport distance and water transport velocity. The results showed that surfaces with a superhydrophobic background associated channels of multirib structures, and a dual-gradient surface of gradient hydrophobic background associated channels with gradient structure performed the best in terms of water transport efficiency.

Zinc homeostasis regulates caspase activity and inflammasome activation.

Inflammasome activation drives pyroptotic cell death and the release of inflammatory cytokines, and many diseases involve its overactivation. Zinc is essential for all organisms as a trace element, but its functions in innate immunity remain undefined. Here, we reported that Zn2+ inhibits caspase-1 to hinder inflammasome activation.

Preparation of Aluminum-Based Superhydrophobic Surfaces for Fog Collection by Bioinspired Sarracenia Microstructures.

Freshwater shortage is a growing problem. Inspired by the Sarracenia trichome fog-trapping and ultrafast water-transport structure, a series of hierarchical textured surfaces with high-low ribs with different wettabilities was prepared based on laser processing combined with dip modification. Through fog-collection performance tests, it was found that the samples with superhydrophobicity and low adhesion had the best fog-collection effect.

Integrated histological, physiological, and transcriptome analysis reveals the post-exposure recovery mechanism of nitrite in Litopenaeus vannamei.

Nitrite is one of the most common toxic pollutants in intensive aquaculture and is harmful to aquatic animals. Recovery mechanisms post exposure to nitrite in shrimp have rarely been investigated. This study focuses on the effect of nitrite exposure and post-exposure recovery on the histological and physiological aspects of Litopenaeus vannamei and utilizes transcriptome sequencing to analyze the molecular mechanisms of adaptation to nitrite exposure.

miR-8-3p regulates the antioxidant response and apoptosis in white shrimp, Litopenaeus vannamei under ammonia-N stress.

Exposure to excess ammonia-N (NH/NH) in aquaculture can disrupt physiological function in shrimp leading to enhanced oxidative stress and apoptosis, but little is known concerning the post-transcriptional regulation mechanism. In this study, the first miR-200 family member in crustacean was identified and characterized from Litopenaeus vannamei (designed as Lva-miR-8-3p). Lva-miR-8-3p was highly expressed in eyestalks, brainganglion, and gills.

Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study.

Background: Previous studies have indicated bidirectional associations between urate levels and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). However, it remains unclear whether the observations are causal because of confounding factors.

Aim: To investigate the causal associations between urate levels and IBD using bidirectional Mendelian randomization (MR).

Historical changes in wind-driven ocean circulation drive pattern of Pacific warming.

The tropical Pacific warming pattern since the 1950s exhibits two warming centers in the western Pacific (WP) and eastern Pacific (EP), encompassing an equatorial central Pacific (CP) cooling and a hemispheric asymmetry in the subtropical EP. The underlying mechanisms of this warming pattern remain debated. Here, we conduct ocean heat decompositions of two coupled model large ensembles to unfold the role of wind-driven ocean circulation.

Differential Toxicity Responses between Hepatopancreas and Gills in under Chronic Ammonia-N Exposure.

Ammonia nitrogen is one of the main toxic substances in aquatic cultivation environments. Chronic exposure to excessive amounts of ammonia-N creates toxic consequences, retarding the growth of aquatic organisms. This study investigated the growth performance, morphological and physiological alterations, and transcriptome changes in the hepatopancreas and gills of white shrimp .

Genome-wide association study identified genes associated with ammonia nitrogen tolerance in .

Ammonia nitrogen tolerance is an economically important trait of the farmed penaeid shrimp . To identify the genes associated with ammonia nitrogen tolerance, we performed an extreme phenotype genome-wide association study method (XP-GWAS) on a population of 200 individuals. The single nucleotide polymorphism (SNP) genotyping array method was used to construct the libraries and 36,048 SNPs were genotyped.

BPA disrupted the testis testosterone levels by interfering ER enrichments within StAR 5' flanking region in rare minnow Gobiocypris rarus.

Bisphenol A (BPA) is a widely used endocrine disruptor, which has attracted much attention due to its harmful effects on male reproduction. To investigate the interference of BPA on steroid synthesis in males, male rare minnows (Gobiocypris rarus) were exposed to 15 μg L BPA for 7, 14 and 21 d. Meanwhile, a positive control group was performed with 25 ng L 17α-ethynyl estradiol (EE2).

Research on optimal control strategy of wind-solar​ hybrid system based on power prediction.

In wind and solar power generation systems, the MPPT algorithm is often used to quantify renewable energy production power, if the light or wind changes suddenly in the algorithm search process, it is possible that the iterative algorithm will not be able to track to the maximum power point or fall into turbulence, and frequent restart of the relevant algorithm will also bring a large energy loss. In view of this situation. For the purpose of further analysis the effect of power output characteristics on the tracking ability of the system, and to enhance the reliability and energy utilization of renewable energy generation system.