[Relationship between sterol carrier protein 2 gene and prostate cancer: Based on single-cell RNA sequencing combined with Mendelian randomization].

Objective： To investigate the relationship between the lipid metabolism-related gene sterol carrier protein 2(SCP2) and prostate cancer (PCa) from a multi-omics perspective using single-cell transcriptomes combined with Mendelian randomization. Methods： Single-cell transcriptome data of benign and malignant prostate tissues were obtained from GSE120716, GSE157703 and GSE141445 datasets, respectively. Integration, quality control and annotation were performed on the data to categorize the epithelial cells into high and low SCP2 expression groups, followed by further differential and trajectory analyses.

[Correlation between oxidative balance score and benign prostatic hyperplasia assessed by machine learning].

Objective: The relationship between benign prostatic hyperplasia (BPH) and the oxidative balance score (OBS) will be discussed in this study.

Methods: The clinical data on 16 dimensions of diet and 4 dimensions of lifestyle from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2008 were used to calculate OBS. We considered BPH as the outcome and investigated the linear and nonlinear relationships between the two.

Genetically Predicted 1400 Blood Metabolites in Relation to Risk of Prostate Cancer: A Mendelian Randomization Study.

Objectives: Metabolic dysregulation is common in cancer, yet evidence linking circulating metabolites to causal relationships in prostate cancer (PCa) is lacking. We performed a Mendelian randomization analysis utilizing 1400 blood metabolites to evaluate their roles in PCa.

Methods: Exposure data from genome-wide association studies (GWAS) was extracted from metabolite level GWAS involving 462,933 individuals of European descent.

Oxidative stress and inflammation mediate the association between Life's Crucial 9 and biological ageing: A secondary analysis of two observational studies.

Background: Life's Essential 8 (LE8) is known to have a negative correlation with biological aging, while the relationship between the Life's Crucial 9 (LC9) score, which includes mental health, and biological aging remains to be further investigated.

Methods: We obtained data from two national cohorts, the UK Biobank and National Health and Nutrition Examination Survey (NHANES), to analyze the association between LC9 and biological aging. Biological aging was assessed using PhenoAge and KDMAge, with gender, race, and other indicators included as covariates.

TMSB10 drives prostate cancer aggressiveness via immune microenvironment regulation.

Thymosin β10 (TMSB10) has emerged as a key player in the progression of prostate cancer, significantly influencing the tumor immune microenvironment. Pan-cancer analysis from The Cancer Genome Atlas (TCGA) revealed that TMSB10 is upregulated across multiple cancer types, particularly in prostate cancer, where high TMSB10 expression correlates with poorer patient outcomes. Functional assays using prostate cancer cell lines LNCaP and DU145 showed that TMSB10 silencing suppresses cell proliferation, migration, and invasion, while overexpression enhances these oncogenic processes.

Visible Light-Induced Arylsulfonylation/Cyclization Reactions for the Synthesis of Thiochromane 1,1-dioxide.

Simple operation, easily accessible starting materials, and short syntheses of the privileged scaffold thiochromane 1,1-dioxide that widely exist in bioactive molecules was achieved by photocatalytic divergent cyclization of α-allyl-β-ketosulfones with arylsulfonyl chlorides. Optimization and scope and limitations of this short and general pathway are described. The methodology provides an efficient strategy for the construction of a wide variety of thiochromane 1,1-dioxide derivatives.

Recent Advances in the Synthesis of Cyclic Sulfone Compounds with Potential Biological Activity.

In recent years, cyclic sulfone compounds, a subset of biologically active heterocyclic compounds, have gained considerable attention due to their potential in the development of novel active pharmaceutical ingredients. This review focuses on identifying simple, mild, environmentally friendly, and efficient synthesis methods. Various catalytic approaches for the synthesis of cyclic sulfone compounds are systematically reviewed, highlighting their advantages and potential applications in pharmaceutical development.

Microplasma radio frequency technology using stationary tips on pig skin: A histological study.

Objective: To investigate the histological properties of microplasma radiofrequency (MPRF) using a stationary tip in different treatment strategies on porcine skin.

Methods: Two Bama miniature pigs received MPRF treatment with two types of stationary tips in eight groups of parameters (power, duration, and pass) on dorsal skin. Skin samples were collected from each treatment zone immediately, at 1 week and 1, 3, and 6 months after treatment.

Effects of different processing techniques of palm kernel cake on processing quality of pellet feed, nutrient digestibility, and intestinal microbiota of pigs.

The present study was conducted to investigate the effects of extrusion, fermentation, and enzymolysis of palm kernel cake on processing quality of pellet feed, nutrient digestibility, and intestinal microbiota of pigs. First, the pretreatment parameters of extrusion, enzymolysis, and fermentation of palm kernel cake were optimized. Then, PKC after three processing techniques were used to prepare pellet feed.

Chemical Bonding in Isoelectronic NdO and SmO.

Neodymium dioxide (NdO) and samarium dioxide cation (SmO) are isoelectronic molecules. Here we used calculations of the spin-orbit-free wave functions to study and compare their geometries, spin states, and bonding. We used Kohn-Sham density functional theory with the B97-1 exchange-correlation functional to optimize the geometries and found that the two molecules have different ground spin states and structures.

Electronic Excitation of -Fluorothiophenol.

-Fluorothiophenol (-FTP) photodissociates through the well-known πσ* process. The fluorine atom of -FTP introduces a feature in the photodissociation of -FTP that does not occur in most other πσ* processes because the fluorine atom can form a hydrogen bond with the hydrogen atom of the SH group. Theoretical computations can serve as a good way to study these reactions because they usually proceed very quickly, and the current spectroscopies cannot probe the details of the processes as thoroughly as theory can.

Spin-Orbit Coupling Changes the Identity of the Hyper-Open-Shell Ground State of Ce, and the Bond Dissociation Energy of CeH Proves to Be Challenging for Theory.

Cerium (Ce) plays important roles in catalysis. Its position in the sixth period of the periodic table leads to spin-orbit coupling (SOC) and other open-shell effects that make the quantum mechanical calculation of cerium compounds challenging. In this work, we investigated the low-lying spin states of Ce and the bond energy of CeH, both by multiconfigurational methods, in particular, SA-CASSCF, MC-PDFT, CASPT2, XMS-PDFT, and XMS-CASPT2, and by single-configurational methods, namely, Hartree-Fock theory and unrestricted Kohn-Sham density functional theory with 34 choices of the exchange-correlation functional.

The valence and Rydberg states of dienes.

The molecules 1,4-cyclohexadiene (unconjugated 1,4-CHD) and 1,3-cyclohexadiene (conjugated 1,3-CHD) both have two double bonds, but these bonds interact in different ways. These molecules have long served as examples of through-bond and through-space interactions, respectively, and their electronic structures have been studied in detail both experimentally and theoretically, with the experimental assignments being especially complete. The existence of Rydberg states interspersed with the valence states makes the quantum mechanical calculation of their spectra a challenging task.

Advanced sulfide solid electrolyte by core-shell structural design.

Solid electrolyte is critical to next-generation solid-state lithium-ion batteries with high energy density and improved safety. Sulfide solid electrolytes show some unique properties, such as the high ionic conductivity and low mechanical stiffness. Here we show that the electrochemical stability window of sulfide electrolytes can be improved by controlling synthesis parameters and the consequent core-shell microstructural compositions.

A Microporous Covalent-Organic Framework with Abundant Accessible Carbonyl Groups for Lithium-Ion Batteries.

A key challenge faced by organic electrodes is how to promote the redox reactions of functional groups to achieve high specific capacity and rate performance. Here, we report a two-dimensional (2D) microporous covalent-organic framework (COF), poly(imide-benzoquinone), via in situ polymerization on graphene (PIBN-G) to function as a cathode material for lithium-ion batteries (LIBs). Such a structure favors charge transfer from graphene to PIBN and full access of both electrons and Li ions to the abundant redox-active carbonyl groups, which are essential for battery reactions.