Spatiotemporal changes in habitat quality and driving factors in South Hunan mining urban agglomerations, China.

The development of urban agglomerations driven by the mining industry inevitably impacts regional habitat quality. Understanding how habitat quality evolves over time and space, as well as identifying the key driving factors in mining urban agglomerations, is essential for developing sustainable policies and maintaining ecological security. This study evaluates the spatiotemporal changes in habitat quality from 1990 to 2020 via the InVEST model, forecasts habitat quality in 2040 under various development scenarios via the PLUS model, and investigates the factors contributing to these changes.

Stabilizing mechanisms enable dioecious trees to maintain synchrony in spring budburst under climate warming.

Climate change could reduce dioecious plant fitness if the phenology of males and females responds differently to temperature. However, the extent to which spring phenological responses to climate differ between sexes in wind-pollinated dioecious trees remains poorly understood. Here, we combined ground observations with climate-controlled experiments to investigate sexual differences in spring budburst in Ginkgo biloba, Fraxinus chinensis, and Eucommia ulmoides.

Tree species composition governs urban phenological responses to warming.

Urban environments are typically warmer than surrounding rural areas, providing a unique setting for studying phenological responses to climate warming. Phenological differences between urban and rural trees are driven by local climate and species composition. Yet, the extent to which species composition influences phenological responses to urbanization remains poorly understood.

Epitranscriptomic Mass Spectrometry.

Every chemical group that is added to any one of the canonical ribonucleotides in a transcript would create a specific RNA modification. Currently, 170+ RNA modifications have been identified. A specific epitranscriptome refers to all the RNA modifications in a given biological system and is considered to play an important role in the regulations of cellular activities.

Theory of Mind and Empathy in Adults With Epilepsy: A Meta-Analysis.

Mounting evidence suggests that social cognitive abilities [including theory of mind (ToM) and empathy] are impaired in adult patients with epilepsy. Although the deficits in overall ToM in epilepsy have been documented well, the effects of epilepsy on empathic ability and specific subcomponents of ToM remain unclear. The primary aim of this study was to provide the first meta-analytic integration of ToM and empathy in adult patients with epilepsy, and to decompose these constructs to clearly differentiate their distinct (cognitive ToM and affective empathy) and overlapping (affective ToM/cognitive empathy) components.

A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes.

Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers. Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA duplexes focused on selected individual epitranscriptomic variation. There are also limited development on the computational modeling of RNA duplexes containing a specific epitranscriptomic variation.

Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin.

Objective: Ribonucleic acids (RNA) are involved in many cellular functions. In general, RNA is made up by only four different ribonucleotides. The modifications of RNA (epitranscriptome) can greatly enhance the structural diversity of RNA, which in turn support some of the RNA functions.

Blood neurofilament light chain in Parkinson disease and atypical parkinsonisms: A protocol for systematic review and meta-analysis.

Background: Neurofilament light chain (NfL), an index of neuroaxonal injury, is a promising diagnostic and prognostic fluid biomarker with high translational value in many neurodegenerative disorders. Blood NfL measurement has been an exciting and active field of research in idiopathic Parkinson disease (PD) and atypical parkinsonisms. However, blood NfL levels in these parkinsonisms from existing literature were inconsistent.

Inflammatory cytokine levels in multiple system atrophy: A protocol for systematic review and meta-analysis.

Background: Multiple system atrophy (MSA) is a fatal neurodegenerative disease that progresses very rapidly and has a poor prognosis. Some studies indicate that the level of inflammatory cytokines may be related to MSA. However, no consistent conclusion has been drawn yet.

Cerebrospinal fluid and blood levels of neurofilament light chain in Parkinson disease: A protocol for systematic review and meta-analysis.

Background: Parkinson disease (PD) is a common neurodegenerative disorder. Elevations of neurofilament light chain (NfL) concentrations in the cerebrospinal fluid (CSF) and blood are a marker of neuronal/axonal injury and degeneration. However, CSF and blood NfL alterations in patients with PD from existing studies remain inconclusive.

Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.

BACKGROUND Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis. Pyroptosis, or cell death associated with sepsis, is mediated by caspase-1 activation. This study aimed to investigate the role of CO on the expression of proteins associated with intestinal mucosal pyroptosis in a rat model of sepsis induced by cecal ligation and puncture (CLP).

Long non-coding RNA GAS5 regulates human B lymphocytic leukaemia tumourigenesis and metastasis by sponging miR-222.

Accumulating evidence has shown that lncRNA GAS5 is a novel tumour-promoting RNA that contributes to tumour progression by sponging miRNAs. However, the detailed role of lncRNA GAS5 in B lymphocytic leukaemia is still unclear. A qRT-PCR assay was used to examine the levels of lncRNA GAS5 and miR-222 in leukomonocytes of patients with B lymphocytic leukaemia and in healthy donors.

Identification of key genes and pathways using bioinformatics analysis in septic shock children.

Background And Hypothesis: Sepsis is still one of the reasons for serious infectious diseases in pediatric intensive care unit patients despite the use of anti-infective therapy and organ support therapy. As it is well-known, the effect of single gene or pathway does not play a role in sepsis. We want to explore the interaction of two more genes or pathways in sepsis patients for future works.

Elevated IL-7Rα is linked to recurrence and poorer survival of gastric adenocarcinoma.

IL-7Rα expression has been suggested to be involved in the development of cancer and has been reported to be linked to poor overall survival in patients with lung cancer. However, no evidence has been reportedregarding the significance of IL-7Rα expression in gastric adenocarcinoma (GA) untilnow. In the present investigation, to understand the clinicopathological significance of IL-7Rα expression in GA, expression of IL-7Rα was evaluated using immunohistochemistry in 121 cases of paired GA and its corresponding normal controls.