Optimized multi-stage network with multi-dimensional spatiotemporal interactions for septal and apical hypertrophic cardiomyopathy classification using 12-lead ECGs.

Abstract: Hypertrophic cardiomyopathy (HCM) is a common hereditary heart disease and is the leading cause of sudden cardiac death in adolescents. Septal hypertrophy (SH) and apical hypertrophy (AH) are two common types. The former is characterized by abnormal septal myocardial thickening and the latter by left ventricular apical hypertrophy, both of which significantly increase the risk of heart failure, arrhythmias, and other serious complications.

Artificial intelligence electrocardiogram as a novel screening tool to detect and longitudinally monitor high-risk echocardiographic features in hypertrophic cardiomyopathy.

Background: Current practice protocols for hypertrophic cardiomyopathy (HCM) recommend integrating crucial high-risk echocardiographic features associated with adverse prognosis into patient management. However, echocardiography is resource-limited and few powerful screening tools are available for risk assessment in the community. We aimed to devise an artificial intelligence (AI)-electrocardiogram (ECG) to identify high-risk echocardiographic features and monitor feature changes during long-term follow-up.

Highly Selective Electrocatalytic 1,4-NADH Regeneration Based on Host-Guest Recognition Mediated by Cucurbit[8]uril on NiO.

Efficient regeneration of nicotinamide adenine dinucleotide (NADH) cofactors, particularly 1,4-NADH, is crucial for advancing oxidoreductase catalysis. Electrocatalysis provides a promising route for 1,4-NADH regeneration, but an expensive catalyst, typically a rhodium organometallic complex, is frequently required to guarantee the high selectivity of 1,4-NADH, significantly limiting its large-scale application. Herein, inspired by the catalytic pocket and enzyme-substrate interaction in nature, a direct electrochemical 1,4-NADH regeneration route was designed by modification of the surface of nickel oxide (NiO) with cucurbit[8]uril (CB[8]) (denoted as CB[8]-NiO).

ECGEFNet: A two-branch deep learning model for calculating left ventricular ejection fraction using electrocardiogram.

Left ventricular systolic dysfunction (LVSD) and its severity are correlated with the prognosis of cardiovascular diseases. Early detection and monitoring of LVSD are of utmost importance. Left ventricular ejection fraction (LVEF) is an essential indicator for evaluating left ventricular function in clinical practice, the current echocardiography-based evaluation method is not avaliable in primary care and difficult to achieve real-time monitoring capabilities for cardiac dysfunction.

Bio-inspired Catalyst-Modified Photocathode for Bias-Free Photoelectrochemical NADH Regeneration.

Cofactors such as nicotinamide adenine dinucleotide (NADH) and its phosphorylated form (NADPH) play a crucial role in natural enzyme-catalyzed reactions for the synthesis of chemicals. However, the stoichiometric supply of NADH for artificial synthetic processes is uneconomical. Here, inspired by the process of cofactor NADPH regeneration in photosystem I (PSI), catalyst-modified photocathodes are constructed on the surface of polythiophene-based semiconductors (PTTH) via self-assembly for photoelectrochemical catalytic NADH regeneration.

CMR-BENet: A confidence map refinement boundary enhancement network for left ventricular myocardium segmentation.

Background And Objective: Left ventricular myocardium segmentation is of great significance for clinical diagnosis, treatment, and prognosis. However, myocardium segmentation is challenging as the medical image quality is disturbed by various factors such as motion, artifacts, and noise. Its accuracy largely depends on the accurate identification of edges and structures.

A Mechanistic Insight into the Acidic-stable MnSbO for Electrocatalytic Water Oxidation.

The abundant, active, and acidic-stable catalysts for the oxygen evolution reaction (OER) are rare to proton exchange membrane-based water electrolysis. Mn-based materials show promise as electrocatalysts for OER in acid electrolytes. However, the relationship between the stability, activity and structure of Mn-based catalysts in acidic environments remains unclear.

Promoting Water Oxidation by Proton Acceptable Groups Surrounding Catalyst on Electrode Surface.

Large-scale hydrogen production through water splitting represents an optimal approach for storing sustainable but intermittent energy sources. However, water oxidation, a complex and sluggish reaction, poses a significant bottleneck for water splitting efficiency. The impact of outer chemical environments on the reaction kinetics of water oxidation catalytic centers remains unexplored.

Topology-sensitive weighting model for myocardial segmentation.

Accurate myocardial segmentation is crucial for the diagnosis of various heart diseases. However, segmentation results often suffer from topology structural errors, such as broken connections and holes, especially in cases of poor image quality. These errors are unacceptable in clinical diagnosis.

A signal-amplification electrochemiluminescence sensor based on layer-by-layer assembly of perylene diimide derivatives for dopamine detection at low potential.

Perylene diimide derivatives (PDIs) are suitable ECL luminophore candidates with low triggering potentials and strong ECL signals for fundamental studies and practical applications. However, PDIs tend to aggregate, which affects their optical properties and limits their application in bio-imaging and bio-sensing fields. In this study, an ECL sensor is fabricated based on the layer-by-layer (LBL) assembly of N, N-bis(phosphonomethyl)-3,4,9,10-perylene diimide (PMPDI) and Zr ions on the surface of a mesoporous indium tin oxide (ITO) substrate.

Neuropeptide S and its receptor NPSR enhance the susceptibility of hosts to pseudorabies virus infection.

The neuropeptide S (NPS) and its receptor (NPSR) represent a signaling system in the brain. Increased levels of NPS and NPSR have been observed in PK15 cells and murine brains in response to pseudorabies virus (PRV) infection, but it remains unclear whether elevated levels of NPS and NPSR are involved in the pathogenic process of PRV infection. In this study, the activities of both NPS and NPSR during PRV pathogenesis were explored in vitro and in vivo by reverse transcription polymerase chain reaction (RT-PCR), PCR, real-time quantitative RT-PCR (qRT-PCR), qPCR, TCID, and Western blotting methods.

Determination of aortic pulse transit time based on waveform decomposition of radial pressure wave.

Carotid-femoral pulse transit time (cfPTT) is a widely accepted measure of central arterial stiffness. The cfPTT is commonly calculated from two synchronized pressure waves. However, measurement of synchronized pressure waves is technically challenging.

The Evaluation of Longitudinal Strain of Large and Small Abdominal Aortic Aneurysm by Two-Dimensional Speckle-Tracking Ultrasound.

Objectives: Abdominal aortic aneurysm (AAA) is a dangerous and lethal vascular disease. Non-invasive two-dimensional speckle-tracking imaging (2D STI) plays an important role in assessing aortic biomechanical properties. Our study aimed to evaluate the alterations of biomechanical characteristics using 2D STI in 91 AAA patients with different size.

Assessment of the Global and Regional Circumferential Strain of Abdominal Aortic Aneurysm with Different Size by Speckle-Tracking Echocardiography.

Objectives: We aimed to use speckle-tracking echocardiography (STE) to quantify circumferential aortic strain of abdominal aortic aneurysms (AAA) with different size.

Methods: A total of 87 AAA patients were included. The morphological variables, including aortic maximum diameter (MD), end systolic area (ESA), end diastolic area (EDA), and thickness and area of intraluminal thrombus (ILT), were measured by ultrasound.

Association of Toll-Like Receptor 4 Gene Polymorphisms with Acute Aortic Dissection in a Chinese Han Population.

Background: Inflammation may be involved in the pathogenesis of acute aortic dissection (AAD). Toll-like receptor 4 () is known to play a critical role in regulating the immune and inflammatory processes. To date, the relationship between genetic variation of and AAD is far from clear.

Right atrial function for the prediction of prognosis in connective tissue disease-associated pulmonary arterial hypertension: a study with two-dimensional speckle tracking.

Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue disease (CTD). Right atrial (RA) function is essential to maintaining adequate total right heart function in PAH. However, little is known about prognostic utility of RA function in CTD-PAH.

Comparative performance of electrochemiluminescence immunoassay and EIA for HIV screening in a multiethnic region of China.

Background: The recent approval of 4th generation HIV tests has forced many laboratories to decide whether to shift from 3rd to these tests. There are limited published studies on the comparative evaluation of these two different assays. We compare the performance of fourth-generation electrochemiluminescence immunoassay (ChIA) and third-generation enzyme linked immunosorbent assay (EIA) for human immunodeficiency virus (HIV) screening and gauge whether the shift from EIA to ChIA could be better in a multiethnic region of China.