Preparation and Performance Evaluation of a High Temperature Stable Magnetorheological Fluid with Shear-Thinning Resistance.

Magnetorheological fluid exhibits shear-thinning behavior when subjected to high temperature environments exceeding 100 °C, which will significantly compromise the operational stability and reliability of the associated mechanical systems. To enhance the performance of magnetorheological fluid, this study selects soft magnetic particles, base carrier fluid, and surfactants based on their resistance to high temperatures and shear-thinning effects. A novel magnetorheological fluid with enhanced thermal stability and shear stability is subsequently developed by carefully selecting flake-shaped carbonyl iron powder, dimethyl silicone oil, and surfactant exhibiting both sedimentation stability and high temperature resistance.

Lactylation-Related Gene LILRB4 Predicts the Prognosis and Immunotherapy of Prostate Cancer Based on Machine Learning.

Lactylation plays a pivotal role in the metabolic reprogramming, proliferation, migration and immune evasion of tumour cells. However, its specific impact on prostate cancer (PCa) remains poorly understood. This study aimed to investigate the role of lactylation related genes (LRGs) in PCa.

Advances in ERK Signaling Pathway in Traumatic Brain Injury: Mechanisms and Therapeutic Potential.

Traumatic brain injury (TBI) stands as one of the leading global causes of disability and mortality. Its pathological progression involves intricate secondary injury mechanisms, including oxidative stress, neuroinflammation, apoptosis, and ferroptosis. Current clinical treatments primarily focus on symptom management, yet lack effective intervention strategies targeting core pathological pathways.

Expert-guided StyleGAN2 image generation elevates AI diagnostic accuracy for maxillary sinus lesions.

Background: The progress of artificial intelligence (AI) research in dental medicine is hindered by data acquisition challenges and imbalanced distributions. These problems are especially apparent when planning to develop AI-based diagnostic or analytic tools for various lesions, such as maxillary sinus lesions (MSL) including mucosal thickening and polypoid lesions. Traditional unsupervised generative models struggle to simultaneously control the image realism, diversity, and lesion-type specificity.

VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7.

Extrachromosomal circular DNAs (eccDNAs) are circular, double-stranded DNA molecules ubiquitously present across various organisms, playing a critical role in tumorigenesis and tumor progression. However, their precise contribution to prostate cancer (PCa) remains incompletely understood. To elucidate the function of eccDNAs in PCa, eccDNA sequencing and annotation were performed in PCa tissues and cell lines using Circle-seq.

Time-Varying Effects of Glucocorticoid Treatment in Critically III Patients with Severe Fever with Thrombocytopenia Syndrome: An Inverse Probability of Treatment Weighting Analysis.

Purpose: To evaluate the efficacy of glucocorticoid treatment in critically ill patients with severe fever with thrombocytopenia syndrome (SFTS) and to assess whether glucocorticoid use increases the risk of fungal infections.

Patients And Methods: A retrospective cohort study was conducted involving confirmed SFTS patients from a tertiary hospital. After applying the Inverse Probability of Treatment Weights (IPTW), multivariable Cox regression and logistic regression analyses were utilized to assess the impact of glucocorticoids on the 28-day mortality rate and the risk of fungal infections.

Genome-Wide Identification and Functional Characterization of New Serotonin N-Acetyltransferases in Soybean.

Melatonin is recognized as a crucial plant hormone due to its significant role in plant development, growth promotion, enhancing antioxidant activity, and stress resistance. Soybean is one of the most important crops globally. To date, three SNAT genes have been cloned in Arabidopsis and rice; however, only one gene, , has been characterized in soybeans.

A laboratory-less nomogram predicting survival rates for hospice patients with advanced cancer.

Introduction: Cancer is the leading cause of death globally(1). According to the WHO's 2020 Global Cancer Report(2), China represented 23.7% of new cancer cases and 30.

Extreme pH Tolerance in Peptide Coacervates Mediated by Multivalent Hydrogen Bonds for Enzyme-Triggered Oral Drug Delivery.

Biopolymer-based complex coacervates hold promising prospects in the field of biomedicine. However, their low stability in environments with extreme pH and high salt concentrations, largely due to weakly charged biomacromolecules and insufficient understanding of their assembly processes, has hindered their practical applications in oral drug delivery. Here, we have developed Dopa-containing peptide-based complex coacervates that are stable across a wide range of pH (1-11) and salt concentrations.

Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis.

Exosomal microRNAs produced from mesenchymal stem cells (MSCs) are crucial in the management of acute lung injury (ALI). In this work, mMSCs separated from bone marrow were used to extract exosomes (MSC-Exos). MSC-Exos treatment attenuated pathological changes and scores, and edema in ALI mice.

Quantitative relationships between elastic modulus of rod and biomechanical properties of transforaminal lumbar interbody fusion: a finite element analysis.

Background: Currently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).

Pharmacovigilance insights into medication-induced risk of dural arteriovenous fistula.

Background: Dural arteriovenous fistulas (DAVFs) pose a significant health threat owing to their high misdiagnosis rate. Case reports suggest that DAVFs or related acute events may follow medication use; however, drug-related risk factors remain unclear. In clinical practice, the concomitant use of multiple drugs for therapy is known as "polypharmacy situations," further increasing the risk of drug-induced DAVF.

Association between the composite dietary antioxidant index and all-cause mortality in individuals with osteoarthritis via NHANES data.

The impact of antioxidant intake on the prognosis of osteoarthritis (OA) patients remains unclear. The aim of this study was to investigate the relationship between the composite dietary antioxidant index (CDAI) and all-cause mortality in OA patients. A total of 35,590 participants with OA from the National Health and Nutrition Examination Survey (1999-2020) were included in this study.

Study on the Predictive Value of Renal Resistive Index Combined with β2-Microglobulin in Patients with Urosepsis Complicated with Acute Kidney Injury.

Purpose: This study aims to evaluate the predictive value of the renal resistive index (RRI) and β2-microglobulin (β2-MG) for acute kidney injury (AKI) in urosepsis patients and to develop a clinical prediction model for AKI risk.

Methods: Data from 108 urosepsis patients at Tongji Hospital were analyzed. Patients were divided into AKI (67 patients) and non-AKI (41 patients) groups based on KDIGO guidelines.

LncRNA promotes prostate cancer progression by regulating the miR-512-3p/HK-2 axis.

Objective: Long non-coding RNAs (lncRNAs) play an important role in tumor progression. Numerous studies show that lncRNAs are strongly associated with prostate cancer (PCa) progression. The aim of this study was to investigate the pathway through which lncRNA regulates PCa progression by bioinformatics analysis and experiments.

Intravenous immunoglobulin‑based adjuvant therapy for severe fever with thrombocytopenia syndrome: A single‑center retrospective cohort study.

Intravenous immunoglobulin (IVIG) is frequently administered to patients with severe fever with thrombocytopenia syndrome (SFTS), particularly those with severe manifestations, although its efficacy remains controversial. The study retrospectively analyzed the effects of IVIG administration on SFTS patients in both mild and severe groups. The primary outcome measure was 28-day mortality.

Extrachromosomal circular DNA-related SPOCK1 contributes to development and enzalutamide resistance of prostate cancer by regulating epithelial mesenchymal transition.

Prostate cancer is a significant contributor to cancer-related mortality, and the tumor typically develops into castration-resistant prostate cancer (CRPC). Hence, few effective clinical strategies are available to patients with advanced disease. Extrachromosomal circular DNA (eccDNA) is a type of circular DNA originating from the chromosomes but is likely independent of them.

Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression.

This study aims to investigate the effect of adipose-derived stem cells (ADSCs) transplantation on progranulin (PGRN) expression and functional recovery in rats with spinal cord injury (SCI). ADSCs were isolated from the inguinal adipose tissue of rats. A SCI model was created, and ADSCs were injected into the injured area.

Engineered protein elastomeric materials.

Natural evolution endows some insects and marine organisms with a special class of protein-based elastic tissues that possess energy feedback characteristics, providing them with the foundation for jumping and flying, and protecting them from the damage caused by movements or waves. However, the design and fabrication of such protein-based elastomeric materials that can function in human society through biomimetic strategies still remains challenging. Recombinant proteins designed by synthetic biology can mimic the advantageous structures in natural proteins and can be biosynthesized without the requirements for harsh conditions such as high temperatures and cytotoxic agents, which provides a great opportunity to prepare protein-based elastomeric materials.