Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis.

This study aimed to investigate the underlying mechanisms by which dandelion extract inhibits the proliferation of breast cancer MDA-MB-231 cells. Dandelion root and leaf extracts were prepared using a heat reflux method and subjected to solvent gradient extraction to obtain fractions with different polarities. MTT assays revealed that the ethyl acetate fraction exhibited the strongest inhibitory effect on cell proliferation.

Chromosome-level genome assembly from a single green slender planthopper Saccharosydne procerus.

The green slender planthopper (Saccharosydne procerus) is a significant pest for water bamboo (Zizania latifolia), which is an economically important aquatic vegetable cultivated in East Asia for its edible swollen shoot. Despite its agricultural impact, the molecular basis of S. procerus's ecological adaptations remains poorly understood.

Crystal Structure, Mutations, and Catalytic Properties of 3-Hexulose-6-phosphate Synthase from .

3-Hexulose-6-phosphate synthase, a key enzyme in the ribulose monophosphate pathway, plays a central role in formaldehyde assimilation and detoxification, offering great potential for third-generation green biomanufacturing. In this study, we determined the crystal structure of HPS from at a 2.64 Å resolution.

Applicability of cCR assessment criteria in pmmr rectal cancer patients treated with neoadjuvant chemoradiotherapy combined with immunotherapy.

Background: This study aimed to assess whether clinical complete response (cCR) criteria developed for neoadjuvant chemoradiotherapy (NACRT) are applicable to patients with proficient mismatch repair locally advanced rectal cancer (LARC) who are treated with NACRT combined with immunotherapy (NAICRT).

Methods: This retrospective study included 49 LARC patients who received NAICRT and 128 who received NACRT. Clinical response was assessed using two established criteria: the Memorial Sloan Kettering Cancer Center (MSKCC) criteria and the Chinese Watch-and-Wait Database (CWWD) criteria.

A small-molecular photoacoustic probe for reversible and ratiometric imaging oxidative stress dynamics in acute liver injury mice.

Visualization of oxidative stress dynamics during acute liver injury is crucial for revealing its pathogenesis. However, developing reversible probes to monitor oxidative stress dynamics in vivo continues to pose a challenge. Herein, we reported the design of small-molecular photoacoustic (PA) probes (PA1-4) based on the meso-amino-BODIPY skeleton.

A CRISPR/Cas9-induced point mutation on the GABA receptor subunit RDL confers high resistance to phenylpyrazole insecticides in the rice planthopper Laodelphax striatellus.

The Delphacidae planthopper Laodelphax striatellus (Order: Hemiptera) is one of the most damaging insect pests of rice crops in Asia. The phenylpyrazole insecticide fipronil was introduced in China in the mid-1990s to control these pests, but its widespread use has led to the development of high levels of resistance. Field sampling coupled with in vitro assays indicated that an A2'N-point mutation in the gamma-aminobutyric acid receptor RDL has been linked to fipronil resistance; however, genetic evidence supporting this association has been lacking.

A plasma metabolomic analysis revealed the metabolic regulatory mechanism of the water extract of Dendrobium huoshanense in improving streptozotocin-induced type 1 diabetes model rats.

D. huoshanense is a traditional Chinese medicine with antidiabetes effects, but the underlying metabolic regulatory mechanism remains unknown. Plasma metabolomic analysis was applied to assess the metabolic regulatory mechanism underlying the alleviation of streptozotocin-induced type 1 diabetes (STZ-T1D) by D.

Study on the properties and mechanism of magnesium alloy and Ni-plating stainless-steel by ultrasonic-laser welding-brazing.

This study aims to provide a new process to improve the welding performance of steel/magnesium dissimilar materials, using an ultrasonic-laser welding-brazing method to joints AZ31B magnesium alloy on 304 stainless steel. The relationship between laser power, Ni-plating and element distribution, microstructure, and mechanical properties of welded joints was studied, and the formation mechanism of the interface zone between AZ31B and 304 joint was analyzed. The research results indicate that the best welding-brazing effect is achieved when the laser power is 2000 W, the minimum wetting angle is 45° and continuous joints without obvious defects.

BODIPY-Coumarin Triad as Acceptor for Ternary Nonfullerene Solar Cells with over 15% Efficiency.

Herein, a new nonfused fullerene-free acceptor is synthesized based on the BODIPY-coumarin triad, BDP-2C, which exhibits a medium optical bandgap of about 1.51 eV, and HOMO and LUMO energy levels of about -5.50 and -4.

Genetic Analysis and Fingerprint Construction for Fort. Using SSR Markers.

Fort. is a traditional medicinal plant, which has anti-inflammatory, antioxidant, and antiviral properties. Despite the development and licensing of several cultivars in recent years, morphological similarity among cultivars complicates their identification.

A ratiometric turn-on fluorescent probe for the detection of BF based on imidazole-quinoline.

In this study, a novel ratiometric fluorescent sensor SYW for the detection of BF was successfully synthesized based on imidazole-quinoline. The sensor showed noticeable fluorescence enhancement after binding to BF with remarkable color change observed by naked eye in a short response time (within 30 s). Additionally, the probe had an extremely low detection limit (1.

Thieno[3,2-]thiophene-based bridged BODIPY dimers: synthesis, electrochemistry, and one- and two-photon photophysical properties.

Four BODIPY dyes (6a-6d) with electron-donating or electron-withdrawing groups at the -position were synthesized by the Sonogashira coupling reaction of 2,5-diethynylthieno[3,2-]thiophene with mono-iodo-BODIPY moieties. All compounds were fully characterized by H NMR and MALDI-TOF MS. Their photophysical and electrochemical properties were studied by UV-visible absorption spectroscopy, steady-state and time-resolved fluorescence spectroscopy, two-photon excitation spectroscopy and cyclic voltammetry.

SPE-YOLO: A deep learning model focusing on small pulmonary embolism detection.

Objectives: By developing the deep learning model SPE-YOLO, the detection of small pulmonary embolism has been improved, leading to more accurate identification of this condition. This advancement aims to better serve medical diagnosis and treatment.

Methods: This retrospective study analyzed images of 142 patients from Tianjin Medical University General Hospital using YOLOv8 as the foundational framework.

Molecular Engineering L-Aspartate-Alpha-Decarboxylase to Enhance Catalytic Stability and Performance.

L-aspartate-alpha-decarboxylase (ADC) catalyzes the decarboxylation of L-aspartate to produce β-alanine, which is the decisive step in the biosynthesis of β-alanine. However, the low catalytic stability and efficiency of ADC limit its industrial applications. In this study, a variant of ADC from Bacillus subtilis were used as a starting point for engineering.

P-Block Aluminum Single-Atom Catalyst for Electrocatalytic CO Reduction with High Intrinsic Activity.

Atomically dispersed transition metal sites on nitrogen-doped carbon catalysts hold great potential for the electrochemical CO reduction reaction (CORR) to CO due to their encouraging selectivity. However, their intrinsic activity is restricted by the hurdle of the high energy barrier of either *COOH formation or *CO desorption due to the scaling relationship. Herein, we discover a p-block aluminum single-atom catalyst (Al-NC) featuring an Al-N site that enables disentangling this hurdle, which endows a moderate reaction kinetic barrier for *COOH formation and *CO desorption, as validated by in situ attenuated total reflection infrared spectroscopy and theoretical simulations.

Ampere-Level Hydrogen Generation via 1000 H Stable Seawater Electrolysis Catalyzed by Pt-Cluster-Loaded NiFeCo Phosphide.

Seawater electrolysis can generate carbon-neutral hydrogen but its efficiency is hindered by the low mass activity and poor stability of commercial catalysts at industrial current densities. Herein, Pt nanoclusters are loaded on nickel-iron-cobalt phosphide nanosheets, with the obtained Pt@NiFeCo-P electrocatalyst exhibiting excellent hydrogen evolution reaction (HER) activity and stability in alkaline seawater at ampere-level current densities. The catalyst delivers an ultralow HER overpotential of 19.

Poor/rich dual electron reaction centers promoting photo-Fenton synergistic removal of organic pollutants: Graphite carbon-modified copper ferrite.

Controlling high recombination of photogenerated carriers and optimizing low cycling of metal valence states are the two key control steps in enhancing photo-Fenton oxidation. To achieve multiscale synergy of photo-Fenton degradation, graphite carbon-modified copper ferrite composites (C/CFO) with poor/rich dual electron reaction centers were synthesized through direct carbonization of Fe/Cu bimetallic organic frameworks. A novel photo-Fenton catalytic system was constructed by irradiating the Fenton reaction with visible light.

Photophysics and photochemistry of thermally activated delayed fluorescence emitters based on the multiple resonance effect: transient optical and electron paramagnetic resonance studies.

The photochemistry of two representative thermally activated delayed fluorescence (TADF) emitters based on the multiple resonance effect (MRE) (DABNA-1 and DtBuCzB) was studied. No significant TADF was observed in fluid solution, although the compounds have a long-lived triplet state ( 30 μs). We found that these planar boron molecules bind with Lewis bases, , 4-dimethylaminopyridine (DMAP) or an -heterocyclic carbene (NHC).

Small molecular donor materials based on --bridged BODIPY dimers with a triphenylamine or carbazole unit for efficient organic solar cells.

Herein, we have designed and synthesized two novel BODIPY dimer-based small molecules, denoted as ZMH-1 and ZMH-2, covalently linked and functionalized with triphenylamine (TPA) (ZMH-1) and carbazole (C) (ZMH-2) units as the electron donor at the 3- and 5-positions of the BODIPY core, respectively. Their optical and electrochemical properties were investigated. We have fabricated all small molecule bulk heterojunction organic solar cells using these BODIPY-based small molecules as electron donors along with fullerene derivative (PCBM) and medium bandgap non-fullerene acceptor IDT-TC as electron acceptors.

Beneficial In Vitro Effects of Polysaccharide and Non-Polysaccharide Components of on Gut Microbiota of Rats with Type 1 Diabetes as Opposed to Metformin.

The extract of , a traditional Chinese medicinal and food homologous plant belonging to the family Orchidaceae, was previously reported to have hypoglycemic and antioxidant effects. In this study, the direct effects of polysaccharide (DHP) and non-polysaccharide (NDHP) components of , as well as its water extract (DHWE) were compared with that of metformin (an antidiabetic drug) on the gut microbiota (collected from fecal flora) of rats with streptozotocin-induced type 1 diabetes (T1D) using an in vitro fermentation method. The results showed that DHWE, DHP, and NDHP reduced pH and increased bacterial proliferation and short-chain fatty acid (SCFA) content in fermentation broth.

Chromosome-level genome assembly of the bethylid ectoparasitoid wasp Sclerodermus sp. 'alternatusi'.

The Bethylidae are the most diverse of Hymenoptera chrysidoid families. As external parasitoids, the bethylids have been widely adopted as biocontrol agents to control insect pests worldwide. Thus far, the genomic information of the family Bethylidae has not been reported yet.

Effect of S-Ketamine on Postoperative Nausea and Vomiting in Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.

Purpose: Postoperative nausea and vomiting (PONV) frequently occur in patients after surgery. In this study, the authors investigated whether perioperative S-ketamine infusion could decrease the incidence of PONV in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy.

Patients And Methods: This prospective, randomized, double-blinded, controlled study was conducted a total of 420 patients from September 2021 to May 2023 at Xuzhou Central Hospital in China, who underwent elective VATS lobectomy under general anesthesia with tracheal intubation.