Hepatoprotective effects of the active extracts from Chrysanthemi Indici Flos via regulating epigenetic networks.

Chrysanthemi Indici Flos, traditionally known for its heat-clearing, detoxifying, liver-dredging, and vision-improving properties, targets the liver meridian and has a long history of use in China. Our previous study demonstrated that extracts of Chrysanthemi Indici Flos (CIC) exert multiple effects on hepatic disorders, including anti-hepatitis B virus activity and immune modulation, particularly in liver protection. However, the exact mechanism underlying its hepatoprotective effects remains unclear.

Three-Dimensional-Printed Meat Products with Lycopene-Functionalized Yeast Pickering Emulsions as Fat Replacer.

Due to the health-driven demand for fat replacers in meat products, Lycopene (Lyc)-loaded yeast protein (YP) high internal phase Pickering emulsions (HIPPEs) were explored as fat replacers for 3D-printed meat products. HIPPEs with varying Lyc concentrations were formulated, and their encapsulation efficiency and antioxidant activity (DPPH and ABTS assays) were evaluated. The encapsulation efficiency of Lyc exceeded 90% for all samples.

Supervised contrastive loss helps uncover more robust features for photoacoustic prostate cancer identification.

Background: Photoacoustic spectral analysis has been demonstrated to be efficacious in the diagnosis of prostate cancer (PCa). With the incorporation of deep learning, its discrimination accuracy is progressively enhancing. Nevertheless, individual heterogeneity persists as a significant factor that impacts discrimination performance.

Assessment of the rat acute oral toxicity of quinoline-based pharmaceutical scaffold molecules using QSTR, q-RASTR and machine learning methods.

Quinoline is a common pharmaceutical scaffold molecule known for its wide range of biological and pharmacological activities, including antimalarial, antitumor, and antibacterial effects. With the continuous discovery of new bioactivities, there is a growing demand for the design and development of novel quinoline-based drugs. However, drug development is time-consuming and costly, and traditional toxicity testing methods such as animal experiments are resource-intensive.

TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression.

Acute myeloid leukemia is a life-threaten disease. Researches have indicated that increased expression of TKT was closely related to the progression of malignant tumors. However, the mechanism of TKT in the pathogenesis of AML need to be further elucidated.

Fluorinated Phosphates, BaMPOF (M = Mn, Fe), with One-Dimensional Channels: Structure and Magnetism.

Two transition metal fluoride phosphates, BaMPOF (M = Mn, Fe), are prepared through hydrothermal redox reactions and analyzed using XRD, XPS, Mössbauer spectroscopy, and density functional theory (DFT). The modified fluoride-rich hydrothermal routes combining two reducing sources, i.e.

A retrospective review of treatment approach and outcomes for locally advanced head and neck squamous cell cancer.

Background: We sought to provide clinicians with important insights into the best treatment plans for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) by examining the treatment trends and outcomes of the disease.

Methods: Data pertaining to 158 patients with stage III to IVB LA-HNSCC who received treatment at our hospital from October 2019 to October 2021 were examined in this study. The clinical results of various treatment approaches were compared among the patients.

Promoting collagen synthesis: a viable strategy to combat skin ageing.

Skin ageing is a complex physiological process primarily characterised by the deepening of wrinkles and the sagging of the skin. Collagen is essential for maintaining skin elasticity and firmness. As skin ages, it experiences structural and functional changes in collagen, including a decrease in collagen synthesis and an increase in collagen hydrolysis.

Natural forests vs. plantations: A meta-analysis of consequences for soil organic carbon functional fractions.

Plantations are becoming more common globally as one of the important initiatives to mitigate global climate change, but the results on whether the soil organic carbon (SOC) can reach the level of natural forests are still inconsistent. Here, we conducted a meta-analysis of 418 paired observations, comparing plantations to adjacent natural forests (primary and secondary forests), from 47 published studies to explore the global patterns and associated drivers of SOC functional fractions (particulate OC, POC; mineral-associated OC, MAOC) and their ratios (the ratio of POC to MAOC, POC:MAOC; the ratio of POC to SOC, POC:SOC; the ratio of MAOC to SOC, MAOC:SOC). We found significant reductions of POC (42.

A Multi-Scale Self-Supervision Approach for Bearing Anomaly Detection Using Sensor Data Under Multiple Operating Conditions.

Early fault detection technologies play a decisive role in preventing equipment failures in industrial production. The primary challenges in early fault detection for industrial applications include the severe imbalance of time-series data, where normal operating data vastly outnumber anomalous data, and in some cases, anomalies may be virtually absent. Additionally, the frequent changes in operational modes during machinery operation further complicate the detection process, making it difficult to effectively identify faults across varying conditions.

Synthesis, structures, and magnetic properties of alkali metal manganese(III) fluorophosphates containing low-dimensional = 2 spin structures.

Five alkali metal manganese(III) fluorophosphates, KMn(POF)F (I), RbMn(POF)F (II), RbMn(POF)(PO)F (III), RbMn(POF)(PO)F (IV), and CsMn(POF)F (V), were successfully synthesized using a hydrothermal method. The monofluorophosphate anion (POF) groups work as "chemical scissors" to promote low-dimensional spin structures with the aid of alkali metal cations. I and II had an = 2 uniform chain structure formed by corner-sharing -MnOF octahedra.

Open frameworks in the NaMn(PO)F fluoro-pyrophosphates system.

Three new sodium manganese fluoro-pyrophosphate compounds, namely, NaMn(PO)F (I), NaMn(PO)F (II), and NaMn(PO)F (III), have been synthesized by heating a mixture of NaPF, NaPOF or NaHPO with different Mn sources in NaNO and KNO fluxes. The structures of the title compounds were characterized single-crystal X-ray diffraction (XRD). II is characteristic of a shell of Na ions that encloses one [Mn(PO)F] unit, whereas I and III reveal three-dimensional (3D) frameworks that consist of MnO, Mn/NaOF octahedra or MnO octahedra and distorted MnO square pyramids with PO units, where Na cations reside in different-membered ring one-dimensional (1D) tunnels.

Thermodynamically Dependent Behavior in Gas Transport in Two-Dimensional Graphene Nanochannels.

Gas transport through nanochannels has aroused significant interest in many fields. Recently, "ballistic transport" of gas was observed through a two-dimensional graphene nanochannel, and it causes a peculiar enhancement compared to the predictions of the Knudson theory. Many studies attributed this effect to the specular reflection caused by the atomically smooth surface of the channel.

Prediction of the Remaining Useful Life of Bearings Through CNN-Bi-LSTM-Based Domain Adaptation Model.

Predicting the remaining useful life (RUL) of mechanical bearings is crucial in the industry. Estimating the RUL enables the assessment of health bearing, maintenance planning, and significant cost reduction, thereby fostering industrial development. Existing models rely on traditional feature engineering with feature changes because operating conditions pose a major challenge to the generalization of RUL prediction models.

ATP11A Promotes Epithelial-mesenchymal Transition in Gastric Cancer Cells via the Hippo Pathway.

ATP11A, a P-type ATPase, functions as flippases at the plasma membrane to maintain cellular function and vitality in several cancers. However, the role of ATP11A in gastric cancer remains unknown. This study aimed to identify ATP11A related to the biological behavior of gastric cancer, and elucidate the underlying mechanism.

[Differences and drivers of leaf stable carbon and nitrogen isotope in herbs under different vegetation types on the eastern Qinghai-Tibet Plateau].

The natural abundance of stable carbon and nitrogen isotopes (δC and δN) in leaves can provide comprehensive information on the physiological and ecological processes of plants and has been widely used in ecological research. However, recent studies on leaf δC and δN have focused mainly on woody species, few studies have been conducted on herbs in different vegetation types, and their differences and driving factors are still unclear. In this study, we focused on the herbs in subalpine coniferous forests, alpine shrublands, and alpine mea-dows on the eastern Qinghai-Tibet Plateau, and investigated the differences in leaf δC and δN of herbs and the driving factors.

Advancements in research on the association between the biological CLOCK and type 2 diabetes.

Due to the Earth's rotation, the natural environment exhibits a light-dark diurnal cycle close to 24 hours. To adapt to this energy intake pattern, organisms have developed a 24-hour rhythmic diurnal cycle over long periods, known as the circadian rhythm, or biological clock. With the gradual advancement of research on the biological clock, it has become increasingly evident that disruptions in the circadian rhythm are closely associated with the occurrence of type 2 diabetes (T2D).

Variation in photosynthetic capacity of Salvia przewalskii along elevational gradients on the eastern Qinghai-Tibetan Plateau, China.

Elevational variation in plant growing environment drives diversification of photosynthetic capacity, however, the mechanism behind this reaction is poorly understood. We measured leaf gas exchange, chlorophyll fluorescence, anatomical characteristics, and biochemical traits of Salvia przewalskii at elevations ranging from 2400 m to 3400 m above sea level (a.s.

Ferromagnetic Mn Sawtooth Chains in A(MnO)(SeO) (A = K, Rb) Quaternary Selenites.

Two quaternary manganese selenites, A(MnO)(SeO) (A = K, Rb), have been synthesized by hydrothermal reactions. They both crystallize in a complex triclinic (P-1) structure built of Jahn-Teller (JT) distorted MnO octahedra, connected into nearly isosceles [MnO] triangles, themselves arranged into so-called "sawtooth (ST) chains". The K and Rb compounds show subtle variations in the orientations of the MnO planes inside the elementary triangles.

Metal-Organic Frameworks/Heterojunction Structures for Surface-Enhanced Raman Scattering with Enhanced Sensitivity and Tailorability.

Metal-organic frameworks (MOFs), which are composed of crystalline microporous materials with metal ions, have gained considerable interest as promising substrate materials for surface-enhanced Raman scattering (SERS) detection via charge transfer. Research on MOF-based SERS substrates has advanced rapidly because of the MOFs' excellent structural tunability, functionalizable pore interiors, and ultrahigh surface-to-volume ratios. Compared with traditional noble metal SERS plasmons, MOFs exhibit better biocompatibility, ease of operation, and tailorability.

Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs.

Androgenetic alopecia (AGA) significantly impacts the self-confidence and mental well-being of people. Recent research has revealed that thyroid receptor β (TRβ) agonists can activate hair follicles and effectively stimulate hair growth. This review aims to comprehensively elucidate the specific mechanism of action of TRβ in treating AGA from various perspectives, highlighting its potential as a drug target for combating AGA.

Identification of T-cell exhaustion-related genes and prediction of their immunotherapeutic role in lung adenocarcinoma.

Lung adenocarcinoma ranks as the second most widespread form of cancer globally, accompanied by a significant mortality rate. Several studies have shown that T cell exhaustion is associated with immunotherapy of tumours. Consequently, it is essential to comprehend the possible impact of T cell exhaustion on the tumor microenvironment.

Pickering Emulsion Stabilized by Hordein-Whey Protein Isolate Complex: Delivery System of Quercetin.

As a lipophilic flavonol, quercetin has low bioavailability, which limits its application in foods. This work aimed to prepare a hordein-based system to deliver quercetin. We constructed hordein-whey isolate protein fibril (WPIF) complexes (H-Ws) by anti-solvent precipitation method at pH 2.