Knowledge, Attitudes and Practices Toward Hypotension During Hemodialysis Among Nephrology and Hemodialysis Medical Staff: A Multi-Center Cross-Sectional Study.

Objective: To explore the knowledge, attitudes, and practices (KAP) of nephrology and hemodialysis medical staff regarding hypotension in hemodialysis patients.

Methods: This cross-sectional study was conducted between March and May 2024 across nine hospitals in China. The KAP scores were collected using a structured questionnaire including demographic characteristics, knowledge, attitudes, and practices.

Psychometric properties of screening tools for mild cognitive impairment in older adults based on COSMIN guidelines: a systematic review.

Background: The prevalence of mild cognitive impairment in older adults is understood to be as high as 40%, and early screening for MCI may slow the progression of Alzheimer's disease. However, no systematic review has summarized the psychometric properties of instruments.

Objective: This systematic review aimed to assess the psychometric properties of existing scales for screening older adults for mild cognitive impairment and to provide an evidence-based basis for selecting the most appropriate assessment tool for older adults.

The Pharmacological Effects of Gastrodin and the Progress in the Treatment of Neurological Disorders.

Blume, a traditional medicinal herb primarily used in Asian countries such as China, has long been valued for treating headaches, dizziness, spasms, epilepsy, strokes, forgetfulness, and other ailments. Gastrodin, a glycoside analog and major bioactive component of , has garnered significant scientific attention owing to its extensive pharmacological effects. It is commonly obtained through plant extraction, chemical synthesis, and biosynthesis.

Canonical Wnt Pathway Enhanced Dental Pulp Mesenchymal Stem Cells-Mediated Cementum Regeneration.

Background: Cementum is a mineralised tissue that is essential for maintaining periodontal tissue homeostasis. Our previous research has shown that dental pulp mesenchymal stem cells (DPSCs) can regenerate periodontal tissues. However, the regeneration efficiency and the specific molecular mechanism remain unclear.

Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese.

Background: Non-small cell carcinoma is the main pathologic type of lung cancer, and a large number of clinical trials have shown that epidermal growth factor receptor tyrosinase inhibitors exhibit superior clinical efficacy and lower toxicity compared with chemotherapy. FHND9041 is a new irreversible EGFR T790M mutation-selective small molecule kinase inhibitor, a third-generation EGFR inhibitor developed by Nanjing Chuangte Pharmaceutical Technology Co., Ltd.

Insecticidal effect and mechanism of Metarhizium anisopliae ZHKUJGZ1 against Solenopsis invicta (Hymenoptera: Formicidae).

The red imported fire ant (RIFA), Solenopsis invicta Buren, poses threats to biodiversity, public safety, agriculture, and the economy, especially as global trade expands its reach into China. To address this, researchers screened fungal isolates from soil in Dongguan City, Guangdong Province, aiming to develop a biopesticide against RIFA. Metarhizium anisopliae, known for its biocontrol potential, was identified as a candidate.

WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway.

Background: Dental pulp stem cells (DPSCs) possess capability of multidirectional differentiation, and their cementogenic differentiation potential enables them to participate in cementum repair and regeneration. The molecular mechanisms underlying cementogenic differentiation of DPSCs remain unclear.

Methods: DPSC data set GSE138179 was retrieved from gene expression omnibus (GEO) database.

Effects of Exposure to Different Types of Metal-Organic Framework Nanoparticles on the Gut Microbiota and Liver Metabolism of Adult Zebrafish.

Metal-organic framework nanoparticles (MOF NPs) have received much attention for their potential use in nanopesticides. However, little is known about the potential health and environmental risks associated with these materials. In this study, the toxicological responses of zebrafish exposed to five MOF NPs for short and long periods of time were evaluated.

Ecological risk assessment of castor oil based waterborne polyurethane: Mechanism of anionic/cationic state selective toxicity to Eisenia fetida.

Cationic and anionic castor oil-based waterborne polyurethanes (C-WPU/A and C-WPU/C) have great potential for development in agriculture. However, it is still unclear whether these polyurethanes are harmful or toxic to soil fauna. Based on multilevel toxicity endpoints and transcriptomics, we investigated the effects of C-WPU/A and C-WPU/C on earthworms (Eisenia fetida).

A comparative evaluation of bioequivalence of Gan & Lee glargine U300 and Toujeo in Chinese healthy male participants.

Background: To assess the bioequivalence between Gan & Lee (GL) glargine U300 and Toujeo regarding pharmacokinetics (PK), pharmacodynamics (PD), and safety in Chinese healthy male participants.

Methods: A single-center, randomized, double-blind, single-dose, two-preparation, two-sequence, four-cycle repeated crossover design study was performed to compare GL glargine U300 and Toujeo in 40 healthy participants. The primary PK endpoints were the area under the curve of glargine metabolites, M1 concentration from 0 to 24 hours (AUC), and the maximum glargine concentration within 24 hours post-dose (C).

O-Carboxymethyl chitosan nanoparticles: A novel approach to enhance water stress tolerance in maize seedlings.

Water stress, a significant abiotic stressor, significantly hampers crop growth and yield, posing threat to food security. Despite the promising potential of nanoparticles (NPs) in enhancing plant stress tolerance, the precise mechanisms underlying the alleviation of water stress using O-Carboxymethyl chitosan nanoparticles (O-CMC-NPs) in maize remain elusive. In this study, we synthesized O-CMC-NPs and delved into their capacity to mitigate water stress (waterlogging and drought) in maize seedlings.

Inhibition mechanism of Rhizoctonia solani by pectin-coated iron metal-organic framework nanoparticles and evidence of an induced defense response in rice.

Nanocrop protectants have attracted much attention as sustainable platforms for controlling pests and diseases and improving crop nutrition. Here, we reported the fungicidal activity and disease inhibition potential of pectin-coated metal-iron organic framework nanoparticles (Fe-MOF-PT NPs) against rice stripe blight (RSB). An in vitro bacterial inhibition assay showed that Fe-MOF-PT NPs (80 mg/L) significantly inhibited mycelial growth and nucleus formation.

Effect of Oil on the Toxicity of β-Cypermethrin Emulsifiable Concentrate Formulation.

Enhancing the performance of traditional pesticide formulations by improving their leaf surface wetting capabilities is a crucial approach for maximizing the pesticide efficiency. This study develops an emulsifiable concentrate (EC) of 4.5% β-cypermethrin containing oil (BJO).

Pectin-Coated Iron-Based Metal-Organic Framework Nanoparticles for Enhanced Foliar Adhesion and Targeted Delivery of Fungicides.

Conventional agrochemicals are underutilized due to their large particle sizes, poor foliar retention rates, and difficult translocation in plants, and the development of functional nanodelivery carriers with high adhesion to the plant body surface and efficient uptake and translocation in plants remains challenging. In this study, a nanodelivery system based on a pectin-encapsulated iron-based MOF (TF@Fe-MOF-PT NPs) was constructed to enhance the utilization of thifluzamide (TF) in rice plants by taking advantage of the pectin affinity for plant cell walls. The prepared TF@Fe-MOF-PT NPs exhibited an average particle size of 126.

Caregiving experiences of caregivers of children with rare diseases: A qualitative meta-synthesis.

Problem: Most rare diseases occur in childhood and are difficult to diagnose and treat. The caregivers are faced with the challenge of providing care to the children afflicted with these rare diseases, resulting in a significant burden of care and an altered family dynamic.

Eligibility Criteria: A meta-synthesis review was conducted to explore the caregivers' experience of children with rare diseases using eight electronic databases PubMed, Web of Science, the Cochrane Library, EMBASE, VIP database, Wan Fang, Chinese BioMedical Literature Database, and China National Knowledge Infrastructure from each database's inception to October 5, 2023.

Evaluation of bioequivalence and safety analysis of capecitabine tablets and Xeloda® under postprandial dosing conditions in Chinese patients with solid tumor.

Objectives: To compare the pharmacokinetic and safety of the test group capecitabine tablets (0.5 g) and the reference group capecitabine tablets (0.5 g).

Chitosan-based nanopesticides enhanced anti-fungal activity against strawberry anthracnose as "sugar-coated bombs".

A chitosan-based nanoparticle was prepared using chitosan (CS) and O-carboxymethyl chitosan (O-CMCS). Our study revealed that chitosan/O-carboxymethyl chitosan/tebuconazole nanoparticles (CS/O-CMCS/TBA NPs) exhibited superior antifungal activity, foliar adhesion, and microbial target adhesion performance compared to commercial suspension concentrate (SC). The antifungal activity of CS/O-CMCS/TBA NPs against C.

Green synthesis of a chlorfenapyr chitosan nanopesticide for maize root application: Reducing environmental pollution and risks to nontarget organisms.

Chlorfenapyr (CHL) is a pyrrole insecticide with a novel structure that is used to control resistant pests. However, its weak systemic activity limits its application to crop roots. Herein, a novel CHL formulation with improved effective utilization rates and suitability for root application is developed to avoid or reduce contamination caused by pesticide spraying.

Preparation and activity of sodium carboxymethyl cellulose (CMC-Na) and Metarhizium rileyi ZHKUMR1 composite membrane.

Improving the adhesion capability of Metarhizium rileyi ZHKUMR1 on leaves enabled by the combination with Carboxymethyl Cellulose (CMCNa) materials is feasible to improve the utilization rate of Metarhizium rileyi. Herein, the CMC-Na-ZHKUMR1 membrane was prepared by simply mixing Carboxymethyl Cellulose (CMCNa) with Metarhizium rileyi. Through compatibility test, it was found that the inhibition rates of spore germination and mycelial growth of ZHKUMR1 were only 1.

Effect of bifenthrin application at different maturity stages on its dissipation and residues in kumquat (Citrus japonica) and dietary intake risk assessment.

Bifenthrin is a pyrethroid pesticide widely used on kumquats, but the residues in the peel and pulp after bifenthrin application at different maturity stages of kumquats have not been evaluated. This study developed a simple and rapid high-performance liquid chromatography (HPLC) method for the quantitative analysis of bifenthrin residues in whole fruit, kumquat peel, kumquat pulp, and soil. The results showed that regardless of whether bifenthrin was applied one or three times during the near-mature period, the half-lives of the fruit peel and fruit pulp were longer than those in the immature period.

pH-responsive release and washout resistance of chitosan-based nano-pesticides for sustainable control of plumeria rust.

Controlled pesticide release in response to environmental stimuli by encapsulating pesticides in a carrier is a feasible approach to improve the effective utilization rate. In this study, pH-responsive release nanoparticles loaded with penconazole (PE) were prepared by ionic cross-linking of chitosan and carboxymethyl chitosan (PE@CS/CMCS-NPs). PE@CS/CMCS-NPs exhibited good washout resistance and wettability properties, increasing the washing resistance of the pesticide by approximately 20 times under continuous washing.

Patterns of gestational weight gain among women with obesity and its correlation with hypertensive disorders of pregnancy in Chinese women.

Gestational weight management in obese women is critical in clinical work. Adverse pregnancy outcomes are associated with improper gestational weight gain (GWG). However, the pattern of GWG (PGWG) and its correlation with hypertensive disorders of pregnancy (HDP) in obesity are still unclear in China.