Nrf2 pathway potentially confers protection against cigarette smoke-induced sarcopenia in a mouse model.

Background: Nuclear factor erythroid-2-related factor 2 (Nrf2) could alleviate chronic obstructive pulmonary disease (COPD)-induced muscle dysfunction, and this study aimed to explore the specific mechanisms involved.

Methods: We successfully established a 12-week cigarette smoke-induced mouse model to replicate COPD-related sarcopenia. The Nrf2 agonist sulforaphane (SFN) and inhibitor ML385 were used to comprehensively assess the regulatory function of Nrf2 in COPD-related sarcopenia.

Genetically modified CD19-targeting IL-15 secreting NK cells for the treatment of systemic lupus erythematosus.

Objectives: Given the efficacy of B-cell depletion therapy in systemic lupus erythematosus (SLE) treatment and the capacity of engineered natural killer (NK) cells in B-cell elimination, we explored the potential of genetically modified NK cells to target CD19 for the treatment of SLE.

Methods: Peripheral blood-derived NK cells were engineered with CAR.CD19/interleukin (IL)-15 (XB-19.

The miR172a-ERF416/413 module regulates soybean seed traits.

Soybean (Glycine max) provides vegetable oils and proteins for human consumption. Its production depends on seeds and other production-related agronomic traits. How the seed traits are regulated in soybean remains largely unclear.

BiOIF Solid Solutions with Suitable Surface Halogen Vacancies for Comprehensive and Enhanced Photocatalytic Performance.

Bismuth oxyiodide (BiOI) is a highly promising material for photocatalytic degradation of pollutants, owing to its distinctive hierarchical and band structures. However, the poor photo-oxidation capability and fast recombination of photogenerated carriers constrain the application potential of BiOI. Introducing surface defects offers a compelling strategy for enhancing the photocatalytic performance.

Comparison of the efficacy of fruquintinib monotherapy versus fruquintinib combined with immune checkpoint inhibitors in the treatment of advanced colorectal cancer: a retrospective study.

This study explored the efficacy of fruquintinib monotherapy versus fruquintinib combined with immune checkpoint inhibitors in the treatment of advanced proficient mismatch repair/microsatellite stable-type colorectal cancer. We retrospectively collected data from patients (n=75) diagnosed with advanced colorectal cancer at our hospital from January 2020 to December 2022 who chose to receive fruquintinib monotherapy or combine it with immune checkpoint inhibitors for treatment. The primary endpoint was progression-free survival (PFS) and overall survival (OS).

The Role of Bedtime Procrastination, Rumination, Loneliness, and Positive Body Image in Predicting Sleep Quality Among University Students: A Sex-Specific Analysis.

Objective: This study aimed to analyze the impact of bedtime procrastination, rumination, loneliness, and positive body image on university students' sleep quality, and to explore potential mediating pathways and sex differences.

Methods: A total of 674 students from a university in southern China were recruited. Assessments of participants' body measurements were conducted, followed by the completion of a general information questionnaire, Pittsburgh Sleep Quality Index, Bedtime Procrastination Scale, Body Appreciation Scale, Body Image-Acceptance and Action Questionnaire, Ruminative Responses Scale, and University of Loneliness Scale.

Efficacy and safety of short-term spinal cord stimulation and pulsed radiofrequency in the treatment of postherpetic neuralgia: a meta-analysis.

Objective: This study aimed to explore the efficacy and safety of short-term Spinal Cord Stimulation (stSCS) and Pulsed Radiofrequency (PRF) in the treatment of postherpetic neuralgia (PHN).

Methods: We searched the PubMed, Cochrane Library, Web of Science, Embase, China Biological Medicine Database (CBM-disk), Chinese National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for randomized controlled trials (RCTs) from the establishment of the database to August 1, 2024. Review Manager 5.

β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer.

Lung cancer is the most common cancer worldwide. The stemness and metastasis of tumor cells present major challenges to effective lung cancer treatment. Beta-hydroxybutyrate (BHB), a ketone body, plays a key role in various cancers.

A model predicting the 6-year all cause mortality of patients with advanced schistosomiasis after discharge: Derived from a large population-based cohort study.

Background: Advanced schistosomiasis imposed a heavy economic burden on society and had a high rate of mortality and disability. However, methods for assessing its long-term prognosis were currently insufficient, and there was a lack of predictive tools to aid clinical decision-making and personalized follow-up plans for patients. We sought to determine risk factors associated with six-year all-cause mortality in advanced schistosomiasis, deriving and validating a six-year all-cause mortality prediction model through a retrospective cohort study based on a large population-based cohort.

The associations between BMI, body appreciation, body image flexibility, sleep duration and loneliness in workers in southern China.

Background: Loneliness is a growing public health problem worldwide that can affect mental and emotional health and increase mortality. This study examined the relationship between body mass index (BMI), body image flexibility, body appreciation, and loneliness among Chinese workers, aiming to propose effective measures for reducing loneliness and promoting mental health.

Methods: A total of 464 workers were recruited for this study.

Exploring the relations between body dissatisfaction, rumination, physical activity, and restrained eating: a latent moderated structural equation approach.

Background: Previous studies have shown that body dissatisfaction is closely related to restrained eating, however, the specific mechanisms and conditions of body dissatisfaction need to be further explored. Therefore, this study aims to explore the mediating and moderating variables influencing the relations between body dissatisfaction and restrained eating, providing recommendations for the prevention of restrained eating among university students.

Methods: Participants comprised 1213 university students who completed the Negative Physical Self Scale, Ruminative Responses Scale, Restrained Eating Scale, and Physical Activity Scale.

Pollution and health risk assessment of rare earth elements in soil, water and vegetables from an ion-adsorption rare earth mining area in Ganzhou, China.

Rare earth elements (REEs) are increasingly recognized as significant environmental pollutants due to their environmental persistence, bioaccumulation, and chronic toxicity. This study assessed REEs pollution in soil, water, and vegetables in an ion-adsorption rare earth mining area in Ganzhou, and evaluated the associated health risks to the local population. Results indicated that the REEs content in soil ranged from 168.

Patients' loyalty to primary care institutions and associated factors in China: a cross-sectional study.

Objectives: This study aimed to examine patients' loyalty and explore some associated factors among PCIs in this country.

Methods: A multistage stratified random sampling method was employed to collect data for this study. A structured self-administered questionnaire was distributed to 2,697 patients who had ever involved in seeking healthcare from PCIs across China between July and September in 2021.

Mediating role of exercise in the relationship between body dissatisfaction and overeating using structural equation modeling.

Background: With the rapid development of society, teenagers have more access to individuals with perfect bodies and are becoming more concerned about their body image. Currently, few studies assess body image and eating disorders comprehensively in China. Given the seriousness of these issues, there is an urgent need to understand the current state of body image and eating behaviors among Chinese people and formulate preventive strategies.

Effects of physical activity on sleep quality among university students: chain mediation between rumination and depression levels.

Background: Colleges and universities are currently facing the major public health issue of poor sleep quality. Sleep quality must be taken seriously to maintain the students' emotional and physical well-being. Thus, this study sought to determine how university students' levels of physical activity related to the quality of their sleep, as well as to explore the mechanisms via which physical activity affects sleep and provide suggestions for improving it.

The effect of grandparental care on social networking sites addiction in college: mediated by social anxiety and loneliness.

Objective: Grandparental care has become a common phenomenon, yet there is still limited research on the long-term psychological effects on children raised by their grandparents. This study aims to explore the impact of early grandparental care experiences on university students' social networking sites addiction, social anxiety, and loneliness.

Methods: A random cluster sampling method was employed to select college students from a medical school in Jiangxi for a questionnaire survey.

Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K CD8 T cell activation in lupus kidney.

Objectives: B and T cells constitute the majority of infiltrating lymphocytes in the kidney and represent the local perpetrators in lupus nephritis (LN), but the underlying pathogenic mechanisms are not well elucidated. The aim of this study is to explore the kidney-specific adaptive immune landscape in patients with active LN at the single-cell level.

Methods: We performed single-cell RNA/B cell receptor (BCR)/T cell receptor (TCR) sequencing analysis on sorting-purified B and T cells from the kidney and paired peripheral blood of patients with active LN, and the periphery of matched controls.

Developmental Morphology, Physiology, and Molecular Basis of the Pentagram Fruit of .

, a key tropical and subtropical economic tree in the Oxalidaceae family, is distinguished by its unique pentagram-shaped fruit. This study investigates the developmental processes shaping the polarity of fruit and their underlying hormonal and genetic mechanisms. By analyzing the Y1, Y2, and Y3 developmental stages-defined by the fruit diameters of 3-4 mm, 4-6 mm, and 6-12 mm, respectively-we observed that both cell number and cell size contribute to fruit development.

Analysis of risk factors for postoperative anxiety and depression in endometriosis patients with reproductive intention.

Background: The occurrence of postoperative depression and anxiety in patients with endometriosis (EMS) not only causes psychological distress, but may also harm their physical health.

Aim: To explore the postoperative depression status, and its influencing factors, of EMS patients with reproductive intention.

Methods: A total of 321 EMS patients with reproductive intent were included.

Therapeutic effect and mechanism of Ento-PB on ulcerative colitis in BALB/c mice induced by sodium dextran sulfate.

The traditional Chinese medicine (TCM) formula Ento-PB containing (Linnaeus) (Blattidae) and Hand.-Mazz. (Compositae) has great potential for treating inflammation.

Prediction of glypican-3 expression in hepatocellular carcinoma using multisequence magnetic resonance imaging-based histology nomograms.

Background: Hepatocellular carcinoma (HCC) is often associated with the overexpression of multiple proteins and genes. For instance, patients with HCC and a high expression of the glypican-3 () gene have a poor prognosis, and noninvasive assessment of expression before surgery is helpful for clinical decision-making. Therefore, our primary aim in this study was to develop and validate multisequence magnetic resonance imaging (MRI) radiomics nomograms for predicting the expression of in individuals diagnosed with HCC.

The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.

Background: High-frequency repeated transcranial magnetic stimulation (rTMS) stimulating the primary motor cortex (M1) is an alternative, adjunctive therapy for improving the motor symptoms of Parkinson's disease (PD). However, whether the high frequency of rTMS positively correlates to the improvement of motor symptoms of PD is still undecided. By controlling for other parameters, a disease animal model may be useful to compare the neuroprotective effects of different high frequencies of rTMS.

Interconnected Periodic Macroporous NaNbO for High-Efficiency Solar-Driven Photocatalytic Hydrogen Evolution.

Highly ordered periodic macroporous structures have been extensively utilized to significantly enhance the photocatalytic activity. However, constructing 3D interconnected ordered porous ternary nanostructures with highly crystalline frameworks remains a formidable challenge. Here, we introduce the design and fabrication of 3D interconnected periodic macroporous NaNbO (PM NaNbO) to effectively increase the density of surface-active sites and optimize the photogenerated carrier-transfer efficiency.