Background: Mitochondrial DNA (mtDNA) is an important genetic material in eukaryotic cells. Mitochondrial DNA maintenance-related gene (mtDNA MRG) variants contribute to mitochondrial dysfunction in cancer progression and are associated with cancer prognosis. However, the mechanism of mtDNA MRGs in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) remains unclear.
View Article and Find Full Text PDFObjective: Grandparental care has become a common phenomenon, yet there is still limited research on the long-term psychological effects on children raised by their grandparents. This study aims to explore the impact of early grandparental care experiences on university students' social networking sites addiction, social anxiety, and loneliness.
Methods: A random cluster sampling method was employed to select college students from a medical school in Jiangxi for a questionnaire survey.
Objective: The incidence of mild cognitive impairment among the elderly in China was increasing. Widowhood, depression, and disability were significant factors that impacted cognitive function. Yet, there was currently no research, both domestically and internationally, that comprehensively examines all these factors together.
View Article and Find Full Text PDFBMC Oral Health
February 2024
Background: Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown.
Methods: In this study, a premature stop at codon 167 in MHBS (MHBSt) was investigated into eukaryotic expression plasmid pcDNA3.
Medicine (Baltimore)
September 2015
Association between coffee consumption and gastric cancer risk remains controversial. Hence, we performed a meta-analysis to investigate and quantify the potential dose-response association between long-term coffee consumption and risk of gastric cancer.Pertinent studies were identified by searching PubMed and Embase from January 1996 through February 10, 2015 and by reviewing the reference lists of retrieved publications.
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