Identification and validation of mitochondrial endoplasmic reticulum membrane-related genes in atherosclerosis.

The mitochondria-associated endoplasmic reticulum membrane is implicated in atherosclerosis (AS). However, its precise molecular mechanisms remain undefined. This study identified KLRC1 and SOCS2 as key protective genes against AS through transcriptomic analysis integrated with Mendelian randomization.

Impact of Laser-Assisted Hatching on Cognitive and Metabolic Development of Singletons Conceived Through Frozen-Thawed Embryo Transfer: A Matched Cohort Study.

Objective: This study aimed to examine the impact of laser-assisted hatching (LAH) on the physical, metabolic, cognitive and behavioural profiles of singletons conceived through frozen-thawed embryo transfer (FET) at the preschool age.

Design: A matched cohort study.

Setting: The reproductive centre of Women's Hospital, Zhejiang University School of Medicine.

Predictive Role of Pre-Thrombolytic Neutrophil-Platelet Ratio on Hemorrhagic Transformation After Intravenous Thrombolysis in Acute Ischemic Stroke.

To investigate the predictive role of the neutrophil-platelet ratio (NPR) before intravenous thrombolysis (IVT) on hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS). AIS patients treated with IVT without endovascular therapy between June 2019 and February 2023 were included. Patients were divided into high NPR (>35) and low NPR (≤35) groups according to the optimal threshold NPR value for identifying high-risk patients before IVT.

[Quality of Life and Its Influencing Factors Among Schizophrenia Patients Living in Urban and Rural Areas].

Objective: To investigate the status quo of the quality of life of schizophrenia patients in a city in Sichuan Province and to explore, thereof, the urban-rural differences in the factors influencing their quality of life.

Methods: A total of 824 schizophrenia patients were selected for the study through multistage stratified cluster random sampling method. All the subjects were selected from a pool of patients covered by the Sichuan Provincial Information System for the Comprehensive Management of Severe Mental Disorders.

A novel maxillary transverse deficiency diagnostic method based on ideal teeth position.

Background: This study proposed a novel maxillary transverse deficiency diagnostic method and evaluated the skeletal Class I and the mild skeletal Class III groups.

Methods: Pre-treatment data from 30 mild skeletal Class III and 30 skeletal Class I patients were collected and uploaded to the Emeiqi Case Management System to design the ideal teeth positions. On these positions, the first bi-molars width was measured at the central fossa and center resistance, the maxillary first bi-premolars width was measured at the central fossa, and the mandibular first bi-premolars width was measured at the distal contact point by Mimics, then width differences of two groups were calculated respectively.

Embryo morphologic quality in relation to the metabolic and cognitive development of singletons conceived by in vitro fertilization and intracytoplasmic sperm injection: a matched cohort study.

Background: Embryos with higher morphologic quality grading may have a greater potential to achieve clinical pregnancy that leads to a live birth regardless of the type of cleavage-stage embryos or blastocysts. Few studies have investigated the impacts of embryo grading on the long-term health of the offspring.

Objective: This pilot study aimed to examine the associations between embryo morphologic quality and the physical, metabolic, and cognitive development of singletons conceived by in vitro fertilization and intracytoplasmic sperm injection at preschool age.

Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis.

Vitamin D (VitD) shows a beneficial role in placentation, the immune system, and angiogenesis, and thus, VitD status may link to the risk of preeclampsia. A meta-analysis was conducted to investigate the association between VitD status in early and middle pregnancy and the risk of preeclampsia. A total of 22 studies with 25,530 participants were included for analysis.

Reliability of 2 methods in maxillary transverse deficiency diagnosis.

Introduction: The objective of this research was to evaluate the reliability of 2 methods (Andrews' Element III analysis and Yonsei transverse analysis) in maxillary transverse deficiency diagnosis.

Methods: Plaster casts and cone-beam computed tomography images of 80 outpatients with skeletal Class I malocclusion (29 males and 51 females, mean age, 20.16 ± 8.

Preliminary adipose removal did not prevent diet-induced metabolic disorders in mice.

Background: Obesity is a fundamental factor in metabolic disorders such as hyperlipidemia, insulin resistance, fatty liver, and atherosclerosis. However, effective preventive measures are still lacking. This study aimed to investigate different surgical protocols for removing partial adipose tissue before the onset of obesity and determine whether, and by which protocol, preliminary adipose removal could exert potent preventive effects against diet-induced metabolic disorders.

Effects of Twin-block vs sagittal-guidance Twin-block appliance on alveolar bone around mandibular incisors in growing patients with Class II Division 1 malocclusion.

Introduction: The purpose of this study was to comparatively evaluate the effects of Twin-block (TB) appliance and sagittal-guidance Twin-block (SGTB) appliance on alveolar bone around mandibular incisors in growing patients with Class II Division 1 malocclusion, using cone-beam computed tomography.

Methods: The sample consisted of 25 growing patients with Class II Division 1 malocclusion (14 boys and 11 girls, mean age 11.92 ± 1.

[ Rv3084 Encodes Functional Esterase and Suppresses the Pro-inflammatory Cytokines ].

Objective: To explore the biological characteristics of the esterase LipR encoded by (MTB) Rv3084 and its immunomodulatory function .

Methods: The gene was amplified from MTB H37Rv strain to construct recombinant expression plasmid. After sequencing, the recombinant plasmid was transformed into for expression and purification of LipR protein.

[Nicorandil improves cognitive dysfunction in mice with streptozotocin-induced diabetes].

Objective: To observe the protective effects of potassium channel opener nicorandil against cognitive dysfunction in mice with streptozotocin (STZ)-induced diabetes.

Methods: C57BL/6J mouse models of type 1 diabetes mellitus (T1DM) were established by intraperitoneal injection of STZ and received daily treatment with intragastric administration of nicorandil or saline (model group) for 4 consecutive weeks, with normal C57BL/6J mice serving as control. Fasting blood glucose level was recorded every week and Morris water maze was used to evaluate the cognitive behavior of the mice in the 4th week.

[Effects of CCN5 overexpression on the expression of alpha-SMA and collagen I in hepatic stellate cells and its mechanism].

Objective: To investigate the relationship between connective tissue growth factor (CCN5) and hepatic stellate cell (HSC) activation as well as the mechanism of action.

Methods: As the research object, LX-2 cells were stimulated with transforming growth factor-beta1 ( TGF-(beta1), and the protein expression levels of CCN5 and CCN2 were determined by Western blot; Hepatocyte high expression system of CCN5 was constructed and transfected hepatic stellate cells (HSC) to make CCN5 overexpression; The expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I were determined by RT-PCR and Western blot. To further study its mechanism of action, Smad2 and phosphorylation level of Smad2 were determined by RT-PCR and Western blot.

[Spectra and influences of Rayleigh and stimulated Brillouin scattering in fiber-optic distributed disturbance sensor].

Spectra and influences of Rayleigh backscattering (RB) and stimulated Brillouin scattering (SBS) in the fiber-optic distributed disturbance sensor (FDDS) were investigated. Models of RB, double RB (DRB) and SBS in long fibers were established. By numerical simulation, it was found that optical signal-to-noise ratio is extraordinarily reduced due to SBS and RB, which results in location errors.

Analysis of low F-number dual micro-axilens array with binary structures by rigorous electromagnetic theory.

We investigate a two-dimensional low F-number dual micro-axilens array with binary structures based on a rigorous electromagnetic theory. The focal characteristics of a binary dual micro-axilens array (BDMA), including axial performances (focal depth and focal shift) and transverse performances (focal spot size and diffraction efficiency), have been analyzed in detail for different F-numbers, different incident polarization (TE and TM) waves, and different distances between micro-axilens. Numerical results reveal that the interference effect of a BDMA is not very evident, which is useful for building a BDMA with a high fill factor, and the focal characteristics of a BDMA are sensitive to the polarization of an incident wave.

Sll1466, a glycosyl transferase homolog involved in global cellular regulation and high-light tolerance of Synechocystis PCC6803.

In Synechocystis sp. PCC 6803, the loop domain (aa 1-70) of the phycobilisome core-membrane linker, L(CM), was found to interact with the glycosyl transferase homolog, Sll1466. Growth of a Sll1466 knock-out mutant was slightly faster in low light, but strongly inhibited in high light; the phenotype is discussed in relation to the regulation of light energy transfer to photosystem II.

Third-order lensless ghost diffraction with classical fully incoherent light.

We theoretically demonstrate third-order lensless ghost diffraction by using a fully classical incoherent light source in which the light beam is detected by two detectors. The resolution and visibility of the obtained diffraction pattern are discussed. It is shown that the resolution of third-order ghost diffraction is determined by the transverse correlation length in the detection plane, while the visibility is affected by the ratio of the transverse length of the imaged object and the transverse size of the light source.

Binary sub-wavelength diffractive lenses with long focal depth and high transverse resolution.

This study explores two-dimensional binary sub-wavelength diffractive lenses (BSDLs) for implementing long focal depth and high transverse resolution based on the rigorous electromagnetic theory and the finite-difference time-domain method. Focusing performances, such as the actual focal depth, the ratio between the focal depth of the designed BSDL and the focal depth of the conventional sub-wavelength lens and the spot size of the central lobe at the actual focal plane, for different f-numbers, have been studied in the case of TE incidence polarization wave. The rigorous numerical results indicate that the designed BSDLs indeed have long focal depth and high transverse resolution by modulating the binary sub-wavelength characteristic sizes.

[Influence of polarization maintaining fibers and polarizer on the lightwave spectrum].

The parameters of polarization maintaining fibers and polarizer, and the splicing angles between them have important influence on the spectral characteristics of lightwave propagating in them. The transmission model of lightwave was established using Jones matrix. For the first time, the effect of degree of polarization, fiber lengths, splicing angles between fibers and between fiber and component on the output spectrum was discussed.

Optical generation of binary-phase-coded, direct-sequence ultra-wideband signals by polarization modulation and FBG-based multi-channel frequency discriminator.

In this paper a novel optical generation approach for binary-phase-coded, direct-sequence ultra-wideband (UWB) signals is experimentally demonstrated. Our system consists of a laser array, a polarization modulator (PolM), a fiber Bragg grating (FBG), a length of single mode fiber, and a photo detector (PD). The FBG, designed based on the superimposed, chirped grating, is used as the multi-channel frequency discriminator.