98%
921
2 minutes
20
Introduction: The objective of this research was to evaluate the reliability of 2 methods (Andrews' Element III analysis and Yonsei transverse analysis) in maxillary transverse deficiency diagnosis.
Methods: Plaster casts and cone-beam computed tomography images of 80 outpatients with skeletal Class I malocclusion (29 males and 51 females, mean age, 20.16 ± 8.22 years) were selected. Maxillary and mandibular width were measured, respectively, and independently by 2 examiners at an interval of 2 weeks, using Andrews' Element III analysis and Yonsei transverse analysis. Intraclass correlation coefficients and Bland-Altman plots of intraexaminer and interexaminer reliability were evaluated. After diagnosis, Cohen's kappa statistics were calculated to evaluate the diagnostic agreement.
Results: The intraclass correlation coefficients were all above 0.85, indicating good to excellent reliability. Compared with Andrews' Element III analysis, Yonsei transverse analysis had higher intraexaminer and interexaminer reliability in both maxillary and mandibular width measurements. Thirty-one to 42 of the patients were diagnosed with maxillary transverse deficiency by 2 examiners using 2 methods. The intraexaminer and interexaminer Cohen's kappa values of Yonsei transverse analysis were all higher than those of Andrews' Element III analysis.
Conclusions: Both Andrews' Element III analysis and Yonsei transverse analysis had good to excellent reliability and substantial diagnostic agreement. Yonsei transverse analysis had higher reliability in maxillary and mandibular width measurements and higher diagnostic agreement, compared with Andrews' Element III analysis.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.ajodo.2020.02.019 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
12/15-lipoxygenase (12/15-LOX, ) generates bioactive oxygenated lipids during inflammation, however its homeostatic role(s) in normal healing are unclear. Here, the role of 12/15-LOX in resolving skin wounds was elucidated, focusing on how its lipids act together in physiologically relevant amounts. In mice, wounding caused acute appearance of 12/15-LOX-expressing macrophages and stem cells, coupled to early generation of ~12 monohydroxy-oxylipins and enzymatically oxidized phospholipids (eoxPL).
View Article and Find Full Text PDFBioinformatics
September 2025
eScience Institute, University of Washington, Seattle, WA United States.
Motivation: Many advances in biomedical research are driven by structural analysis, which investigates interconnections between elements in biological systems (e.g. structural analysis of proteins to infer their function).
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
September 2025
School of Biology, University of St Andrews, St Andrews, UK.
Most type III CRISPR-Cas systems facilitate immune responses against invading mobile genetic elements such as phages by generating cyclic oligoadenylates (cOAs). Downstream effectors activated by cOAs are typically non-specific proteins that induce damage to essential cellular components, thereby preventing phage epidemics. Owing to these toxic effects, it is crucial that the production and concentration of cOAs remain under tight regulatory control during infection-free periods or when deactivating the immune response after clearing an infection.
View Article and Find Full Text PDFEBioMedicine
September 2025
Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Linus Biotechnology, Inc., North Brunswick Township, NJ, USA. Electronic address:
Background: Amyotrophic lateral sclerosis (ALS) is a rare motor neurodegenerative disorder and is predominantly diagnosed in older adults. Altered levels of essential and toxic elements have been implicated in ALS pathophysiology; however, little is known about the longitudinal biodynamic patterns of these elements in patients with ALS.
Methods: Using a single individual hair strand, we generated time series data of 400-800 time points approximately at 2 to 4 hourly resolution on 17 elemental intensities in ALS-positive cases and ALS-negative controls from a national collection and a regional centre in the US (on a total sample of 391, with 295 cases and 96 controls, with median age at hair collection over 60 years).
Sports Med
September 2025
Department of Behavioural Sciences, Moi University School of Medicine, Eldoret, Kenya.
The causes of mental ill health in elite athletes are complex, influenced by socioeconomic and cultural factors. These factors are important in shaping discussions surrounding the mental health of athletes and the design of subsequent interventions to support them. However, such consideration is rare, particularly when considering the mental health of athletes in low- and middle-income countries.
View Article and Find Full Text PDF