Ion-Gradient Driven Drug-Loading Liposomes for Codelivery of Shikonin/Regorafenib for Cancer Immunometabolic Therapy and Postoperative Intervention.

Lactate emerges as a pivotal immunometabolite in tumor progression, orchestrating immunosuppression by polarizing tumor-associated macrophages (TAMs) toward pro-tumor M2 phenotypes and activating immunosuppressive cell populations. Targeting intratumoral lactate has emerged as a promising therapeutic strategy for tumors with poor immune responses. Shikonin (SHK) inhibited the lactate production of tumor cells by targeting pyruvate kinase M2 (PKM2).

Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia.

Cancer cachexia affects up to 80 % of advanced cancer patients and contributes to significant mortality. Impaired wound healing in cachectic patients limits physical activity, leads to nutrient loss, and increases infection risk. This study develops multifunctional hydrogels composed of oxidized polysaccharides (TPS) from Radix Trichosanthis and carboxymethyl chitosan (termed CMOT) to enhance wound healing and mitigate scar hyperplasia.

Effects of dichlorobenzene, toluene, benzene and formaldehyde chemicals on Drosophila melanogaster mortality.

Environmental exposures to volatile organic compound (VOC) mixtures have received increasing attention, yet the risks are under studied. This study aimed to explore the risks of combined exposures to several commonly detected VOCs and to draw attention to the necessity of studying long-term and low-concentration environmental exposure patterns. In this study, we examined the effects of long-term and low-concentration exposures to VOCs like 1,2-dichlorobenzene, benzene, toluene and formaldehyde either alone or in combination on D.

TaRLK2.4, a transgressive expression receptor like kinase, improves powdery mildew resistance in wheat.

Plants form two immune systems, pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI), to combat Blumeria graminis f. sp. tritici (Bgt) infection during the evolutionary process.

Genetic Basis Identification of a Gene, , That Confers Partial Powdery Mildew Resistance in Wheat SJ106.

Wheat powdery mildew is an important fungal disease that seriously jeopardizes wheat production, which poses a serious threat to food safety. SJ106 is a high-quality, disease-resistant spring wheat variety; this disease resistance is derived from Wheat-wheatgrass 33. In this study, the powdery mildew resistance genes in SJ106 were located at the end of chromosome 6DS, a new disease resistance locus tentatively named .

Comparative analysis of village doctors' relative deprivation: based on two cross-sectional surveys.

Background: Village doctors are the main health service providers in China's rural areas. Compared with other rural groups, they will have a sense of relative deprivation, which has an impact on their practice mentality and job stability. This study aims to analyze the changes and causes of relative deprivation among village doctors, so as to improve the stability of them.

The relationship between Internet use and loneliness of middle-aged and older adult people: the moderating effect of residence.

Objectives: The proportion of middle-aged and older adult people exposed to the Internet continues to grow. Internet use may have an impact on the mental health of the older adult, especially loneliness. This study analyzed the relationship between Internet use and presence of loneliness.

Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy.

Ferroptosis has emerged as a promising therapeutic approach for glioma. However, its efficacy is often compromised by the activated GPX4-reduced glutathione (GSH) system and the poor brain delivery efficiency of ferroptosis inducers. Therefore, suppression of the GPX4-GSH axis to induce the accumulation of lipid peroxides becomes an essential strategy to augment ferroptosis.

Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes.

Activated platelets promote tumor progression and metastasis through active interactions with cancer cells, especially in promoting epithelial-mesenchymal transition (EMT) of tumor cells and shedding tumor cells into the blood. Blocking platelet-tumor cell interactions can be a potential strategy to inhibit tumor metastasis. Platelet activation requires energy produced from aerobic glycolysis.

Genome-wide identification of TaCIPK gene family members in wheat and their roles in host response to Blumeria graminis f. sp. tritici infection.

Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a destructive disease affecting wheat crops worldwide.

Use of oxathiapiprolin for controlling soybean root rot caused by Phytophthora sojae: efficacy and mechanism of action.

Background: Oxathiapiprolin is a new isoxazoline fungicide developed by DuPont to control oomycete diseases. Although oxathiapiprolin has shown strong inhibitory activity against oomycete pathogens, little is known about its ability to control Phytophthora sojae.

Results: Oxathiapiprolin showed high inhibitory activity against Phytophthora sojae, with 50% effective concentration (EC ) values ranging from 1.

Antisocial and borderline personality traits and childhood trauma in male prisoners: Mediating effects of difficulties in emotional regulation.

Objective: To investigate the prevalence of probable antisocial personality disorder (ASPD) and borderline personality disorder (BPD) among prisoners, and further examine the mediating effect of difficulties in emotional regulation (ER) between childhood trauma and symptoms of ASPD and BPD.

Methods: A total of 1491 male participants (35.4 ± 9.

Fabrication of Robust and Porous Lead Chloride-Based Metal-Organic Frameworks toward a Selective and Sensitive Smart NH Sensor.

Organolead halide materials have shown promising optoelectronic properties that are suitable for light-emitting diodes (e.g., strong photoluminescence, narrow emission width, and high charge carrier mobility).

Clinical application of computed tomography angiography and fractional flow reserve computed tomography in patients with coronary artery disease: A meta-analysis based on pre- and post-test probability.

Purpose: To assess the diagnostic role of coronary computed tomography angiography (CCTA) and fractional flow reserve computed tomography (FFRCT) in confirming or excluding ischemic coronary artery disease (CAD) and to provide a rational use of CCTA and FFRCT in different pre-test probability (PTP) of CAD.

Methods: We searched the electronic databases from the earliest relevant literature to July 2020 comparing FFRCT or CCTA with FFR. The bivariate random-effects models and Bayes' theorem were used to investigate the diagnostic performance of CCTA and FFRCT with the sensitivity, specificity, pre- and post-test probability.

The Influence of Fiber Cross-Section on Fabric Far-Infrared Properties.

Far-infrared radiation (FIR) possesses various promising properties that are beneficial to an individuals' health. Exploring the interaction between fiber shapes and FIR performance is thought to be a significant means to develop highly-efficient FIR textile products. In this study, a non-additive triangular polyamide (PA) fiber showed excellent FIR properties in both theoretical simulation and experimental verification aspects.

Diagnostic performance of MRI for detecting intraplaque hemorrhage in the carotid arteries: a meta-analysis.

Objectives: To investigate the diagnostic performance of MRI in diagnosing carotid atherosclerotic intraplaque hemorrhage (IPH) and to provide a clinical guide for MRI application.

Methods: We searched MEDLINE, Embase, and Cochrane library from the earliest available date of indexing through November 30, 2017. All investigators screened and selected studies comparing the use of MRI with histology.

Fabric Organic Electrochemical Transistors for Biosensors.

Flexible fabric biosensors can find promising applications in wearable electronics. However, high-performance fabric biosensors have been rarely reported due to many special requirements in device fabrication. Here, the preparation of organic electrochemical transistors (OECTs) on Nylon fibers is reported.