GenPoly: Learning Generalized and Tessellated Shape Priors via 3D Polymorphic Evolving.

We introduce GenPoly, a novel generalized 3D prior model designed for multiple 3D generation tasks, focusing on preserving fine details. While previous works learn generalizable representations by decomposing objects into coarse-grained components to reassemble a coherent global structure, this approach sacrifices small-scale details. In this paper, we take a different perspective, formulating 3D prior modeling as a bottom-up polymorphic evolving process.

Single-cell transcriptomics identifies PDGFRA progenitors orchestrating angiogenesis and periodontal tissue regeneration.

Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative medicine, harnessing developmental principles for tissue repair offers promising therapeutic potential. Of particular interest is the condensation of progenitor cells, an essential event in organogenesis that has inspired clinically effective cell aggregation approaches in dental regeneration.

Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.

The emergence of complex tissue architectures from homogeneous stem cell condensates persists as a central enigma in developmental biology. While biochemical signaling gradients have long dominated explanations of organ patterning, the mechanistic interplay between tissue-scale forces and thermodynamic constraints in driving symmetry breaking remains unresolved. This review unveils supracellular actin networks as mechanochemical integrators that establish developmental tensegrity structures, wherein Brownian ratchet-driven polymerization generates patterned stress fields to guide condensate stratification.

SHED aggregation-released extracellular vesicles rejuvenate Gli1 cells and improve diabetic wound healing.

Hair follicle stem cells (HFSCs) play an important role in skin tissue repair, exhibiting remarkable heterogeneity. However, the roles of distinct subpopulations in wound healing remain unclear. Here, we employed transgenic mice to specifically label and ablate Gli1 cells subpopulation, unraveling their pivotal function in cutaneous wound repair.

MYO1G promoter hypomethylation correlates with its mRNA expression, lymphocyte infiltration, and immunotherapy response in melanoma.

Objectives: Myosin IG () plays a vital role in triggering an immune response via regulating T cell migration to detect antigen-presenting cells. However, the biological and clinical significance of DNA methylation and gene expression in melanoma and its immune microenvironment remains unknown.

Materials And Methods: We investigated and corroborated the correlations of DNA methylation with gene expression, and clinicopathologic parameters in 461 melanomas from The Cancer Genome Atlas (TCGA).

Lysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration.

Ferroptosis, a form of regulated cell death driven by iron accumulation and lipid peroxidation, is implicated in various diseases, but effective therapeutic strategies remain limited. Lysosomal impairments cause iron dysregulation and initiate ferroptosis, which potentially contribute to ionizing radiation-induced tissue damages. Here, the role of intercellular lysosomal regulation in governing iron homeostasis and protecting against ferroptosis is investigated in models of stem cell aggregation and mandibular regeneration post-irradiation.

Gaussian Prompter: Linking 2D Prompts for 3D Gaussian Segmentation.

Interactive 3D segmentation in radiance fields is crucial for advanced 3D scene understanding and manipulation. However, existing methods often struggle to achieve both volumetric completeness and segmentation accuracy, primarily because they fail to consider the critical links between 2D prompt-based segmentations across multiple views. Motivated by this gap, we introduce Gaussian Prompter, a novel approach specifically designed for 3D Gaussian Splatting.

Development-Inspired Biomimetic Cell-Niche Coaggregates Safeguard Tooth Stem Cell-Based Functional Tissue Regeneration.

Harnessing natural developmental programs to repair and replace damaged organs represents promising approaches in regenerative medicine. However, effective strategies are still lacking for tissue regeneration in complicated conditions, such as the periodontal bone defect. Here, human dental follicle stem cells (hDFSCs) and their aggregates (hDFSCA) are cultured and characterized, which are formed based on the inherent property of these stem cells self-assembly into compact spheroid-like structures, mimicking mesenchymal condensation in development.

Alternant P-Type/N-Type Conjugated Bipolar Copolymer Cathodes for Advanced Aqueous Zinc-Ion Batteries.

To synergistically combine the features of high specific capacity of n-type organic materials with the high voltage of p-type organic materials, bipolar phenolthiazine-based cathodes with p-type/n-type structures are gaining increased attention for aqueous zinc-ion batteries (AZIBs). Nevertheless, their small molecular structure often leads to dissolution during cycling. To address the challenge, a bipolar poly(phenothiazine iodide-3,3'-diaminobenzidine), abbreviated as P(PTD-DAB), was synthesized as a cathode material.

Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in mice.

Background: Lipid metabolic disorder (LMD) serves as a systemic driver of osteoporosis (OP), with jawbone osteoporosis (JOP) representing a clinically significant yet underexplored complication. Current clinical treatments for JOP remain suboptimal, highlighting the need for innovative approaches. The use of metabolic regulators represents a promising therapeutic strategy for OP management.

The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy.

Mesenchymal stem cell (MSC) therapy shows great potential for treating tissue impairments and immune disorders. Epigenetic regulation is a core molecular signature that ensures long-lasting memory in MSC functional modulation and mediates therapeutic efficacy. Studies reveal that transplanted MSCs drive epigenetic changes in recipient cells, which contributes to restoration of organismal and microenvironmental homeostasis.

Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic Mice.

Type 2 diabetes (T2D) is a global metabolic condition associated with complications of multiple organs, including the bone. However, the exact impact of T2D on bone along the disease progression, particularly in the early phase, remains largely unknown. Four-week and sixteen-week high-fat diet (HFD) feeding-induced T2D mouse models were established, and the glucose metabolic status was examined.

Modulating the Spatio-Temporal Sequence of Lithium Plating and Stripping via a 3D Host for Solid State Batteries.

Solid-state lithium metal batteries (SSLMBs) are now under intensive research for their high energy density and excellent safety. However, the Li transport limitation in Li metal anode (LMA) leads to mass/stress accumulation, dendrite initiation and void formation at the interface, which seriously hinders the development of SSLMBs. Herein, it is demonstrated through in situ electron microscopies that a mixed ionic-electronic conducting (MIEC) 3D host can promote the Li transport in LMA by increasing the diffusion pathways along the carbonaceous framework, carbon/Li interface and Li metal surface, enabling a fast and long-distance (nearly 100 µm) diffusion of Li atoms in LMA.

promoter hypomethylation correlates with enhanced immune cell infiltration, favorable prognosis, and immunotherapy response in melanoma.

Background: Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating its potential as a prognostic and predictive biomarker for immunotherapy response.

Multimodal ultrasound assessment for monitoring keloid severity and treatment response.

The current understanding and a standardized assessment or treatment guidelines for keloids are not fully established, highlighting the need for an objective method to gauge keloid severity and treatment outcomes. This study investigated the clinical utility of multimodal ultrasound, integrating Shear Wave Elastography (SWE) and Angio planewave ultrasensitive imaging (AP), to assess keloid severity and treatment responses in 58 keloids across 31 patients. Keloids were categorized into mild, moderate, and severe based on Vancouver Scar Scale (VSS) scores.

Rotation-Adaptive Point Cloud Domain Generalization via Intricate Orientation Learning.

The vulnerability of 3D point cloud analysis to unpredictable rotations poses an open yet challenging problem: orientation-aware 3D domain generalization. Cross-domain robustness and adaptability of 3D representations are crucial but not easily achieved through rotation augmentation. Motivated by the inherent advantages of intricate orientations in enhancing generalizability, we propose an innovative rotation-adaptive domain generalization framework for 3D point cloud analysis.

Inflammation-triggered Gli1 stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology.

Periodontitis is a prevalent and progressive detrimental disease characterized by chronic inflammation, and the immunopathological mechanisms are not yet fully understood. Mesenchymal stem cells (MSCs) play crucial roles as immunoregulators and maintain tissue homeostasis and regeneration, but their in vivo function in immunopathology and periodontal tissue deterioration is still unclear. Here, we utilized multiple transgenic mouse models to specifically mark, ablate and modulate Gli1 cells, a critical and representative subset of MSCs in the periodontium, to explore their specific role in periodontal immunopathology.

The landscape of cell regulatory and communication networks in the human dental follicle.

Introduction: The dental follicle localizes the surrounding enamel organ and dental papilla of the developing tooth germ during the embryonic stage. It can differentiate and develop to form the periodontal ligament, cementum, and alveolar bone tissues. Postnatally, the dental follicle gradually degenerates, but some parts of the dental follicle remain around the impacted tooth.

Regulating Polysulfide Clustering with an Anion Acceptor for Low-Temperature Sulfur Batteries.

The performance of the lithium-sulfur battery at harsh conditions of lean electrolyte and low temperature is impeded by nanometric clustering of lithium polysulfides (LiPSs), which inherently hinders sulfur reaction kinetics. Here we describe a cluster-disrupting strategy wherein a fluorinated borane anion acceptor, tris(perfluorophenyl)borane, is exploited to regulate the LiPSs solvation structure and to promote their reactions under harsh conditions. The electron-deficient anion acceptor molecules bond with the electron-rich LiPSs via soft Lewis acid-base interactions, which disrupts LiPSs' clustering and promotes LiS solvation, facilitating a three-dimensional LiS growth via solution-mediated mechanism at low temperatures.

Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration.

Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration.

Solid Catholyte with Regulated Interphase Redox for All-Solid-State Lithium-Sulfur Batteries.

All-solid-state lithium-sulfur battery (ASSLSB) is considered one of the ultimate next-generation energy storage technologies due to the expected low cost, high safety, and high specific energy. The high-conductivity and low-modulus sulfide electrolytes hold promise as electrolytes in the cathode (i.e.

Osteoporosis under psychological stress: mechanisms and therapeutics.

Psychological stress has been associated with the onset of several diseases, including osteoporosis. However, the underlying pathogenic mechanism remains unknown, and effective therapeutic strategies are still unavailable. Growing evidence suggests that the sympathetic nervous system regulates bone homeostasis and vascular function under psychological stress, as well as the coupling of osteogenesis and angiogenesis in bone development, remodeling, and regeneration.

Optimizing natural human-derived decellularized tissue materials for periodontal bone defect repair.

Periodontal disease is a major contributor to tooth loss worldwide in adults. Particularly, periodontal bone defect is a common clinical condition, yet current therapeutic strategies exhibit limited effectiveness. Recently, natural bone graft materials have attracted considerable interest for enhancing bone defect repair due to their superior biocompatibility and osteogenic capabilities.

Neutrophils suppress osteogenic differentiation of Gli1 stem cells via neutrophil extracellular traps and contribute to bone loss in periodontitis.

Periodontitis is a severe and chronic oral inflammatory disease that leads to the progressive and irreversible destruction of periodontal tissues, ultimately resulting in tooth loss. Among the immune cell subtypes involved, neutrophils play a crucial role in the initiation and progression of periodontitis. Mesenchymal stem cells (MSCs) are essential components of periodontal tissue, contributing to tissue development, homeostasis, and regeneration.

Enhancing preoperative diagnosis of pancreatic ductal adenocarcinoma and mass-forming chronic pancreatitis: a study on normalized conventional MR imaging parameters.

Purpose: To assess the utility of signal intensity ratio (SIR) in distinguishing between mass-forming chronic pancreatitis (MFCP) and pancreatic ductal adenocarcinoma (PDAC), thereby reducing unnecessary pancreatectomies or delayed diagnosis brought by misdiagnosis.

Materials And Methods: This retrospective study included 170 participants (34 with MFCP and 136 with PDAC) who underwent radical pancreatic surgery and were diagnosed via specimen pathology. The study group was carefully selected with a 1:4 ratio matching for sex, age, and operation time between two entities.