Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration. Interestingly, replenishment of cell aggregates-derived extracellular vesicles (CA-EVs) rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5. Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. Collectively, our findings provide insights into Golgi regulation in stem cell senescence and bone aging, which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807224 | PMC |
| http://dx.doi.org/10.1038/s41413-024-00386-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging.
Blood
September 2025
University of Illinois at Chicago, Chicago, Illinois, United States.
Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging. PF4-deficient mice display several phenotypes reminiscent of accelerated HSC aging, including lymphopenia, increased myeloid output, and DNA damage, mimicking physiologically aged HSCs.
View Article and Find Full Text PDFIterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) for evaluation of early bone mass changes in ageing osteoporosis patients.
Magn Reson Lett
May 2025
GE Healthcare, Beijing, 100176, China.
This study explored the application value of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) technology in the early diagnosis of ageing osteoporosis (OP). 172 participants were enrolled and underwent magnetic resonance imaging (MRI) examinations on a 3.0T scanner.
View Article and Find Full Text PDFDiffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes.
Osteoarthr Cartil Open
December 2025
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China.
Objective: We developed and validated an artificial intelligence pipeline that leverages diffusion models to enhance prognostic assessment of knee osteoarthritis (OA) by analyzing longitudinal changes in patella shape on lateral knee radiographs.
Method: In this retrospective study of 2,913 participants from the Multicenter Osteoarthritis Study, left-knee weight-bearing lateral radiographs obtained at baseline and 60 months were analyzed. Our pipeline commences with an automatic segmentation for patella shapes, followed by a diffusion model to predict patella shape trajectories over 60 months.
Phytochemicals in Bone Therapy: Exploring Natural Alternatives for Bone Health.
Int J Nanomedicine
September 2025
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.
Bone diseases such as osteoporosis and osteoarthritis are increasingly prevalent, particularly in aging populations. While conventional treatments, including synthetic drugs and mineral supplements, are effective yet often associated with side effects and long-term economic burdens. Active compounds derived from nature, "Phytochemicals" have garnered attention due to their potential to provide safer and more sustainable alternative therapeutic options.
View Article and Find Full Text PDFSynthetic scaffolds functionalized with mesenchymal stem/stromal cells-derived extracellular matrix for bone tissue engineering: a review.
RSC Adv
August 2025
Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa Av. Rovisco Pais Lisboa 1049-001 Portugal
Bone-related injuries represent a major global challenge, particularly for the aging population. While bone has self-healing capabilities, large defects and non-union fractures often fail to completely regenerate, leading to long-term disability and the need for surgical intervention. Autologous bone grafts remain the gold standard for such procedures, but challenges such as limited donor availability and donor site comorbidity persist.
View Article and Find Full Text PDF