Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived sp. and sp.

Three new arthrichitin derivatives I-K (-) and three known congeners (-) were isolated from a coculture of mangrove-derived fungi sp. and sp. using H NMR-guided fractionation.

Sonnerachromones A-G, Antiaging Chromones from the Fruit of Mangrove .

Seven novel chromone derivatives, sonnerachromones A-G (-), were isolated from the fruit of mangrove . Compounds - contain a 6/5/6/6/tetracyclic system with rare -glycosyl spirocyclic skeletons. The unusual structures were identified by analysis of HRESIMS data, NMR spectra, electronic circular dichroism (ECD), DFT-calculated C NMR chemical shifts, DP4plus probability analysis, and single-crystal X-ray diffraction.

Lipotrichaibol A and Trichoderpeptides A-D: Five New Peptaibiotics from a Sponge-Derived sp. GXIMD 01001.

Five previously undescribed peptaibiotics, including one 7-mer lipopeptaibol named lipotrichaibol A (), and four 11-mer peptaibiotics named trichoderpeptides A-D (-) were isolated from the rice culture medium of the sponge-derived fungus sp. GXIMD 01001. Their structures and absolute configurations were unambiguously established by extensive spectroscopic data analysis and advanced Marfey's method.

Curvulomycin E, a New Resorcylic Acid Lactone From the Beibu Gulf Coral-Derived Fungus Curvularia lunata GXIMD 02512.

One new resorcylic acid lactone (RAL), curvulomycin E (1), along with 10 known compounds (2-11), was obtained from the Beibu Gulf coral-derived fungus Curvularia lunata GXIMD 02512. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature. The absolute configurations of 1 and 10 were accomplished by ECD calculations.

Bioactive Sesterterpenoids from the Mangrove-Derived sp. GXIMD 03023.

Four novel sesterterpenoids, asperterpenoids Q-T (-), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated C NMR chemical shifts, and DP4plus probability analysis.

Integration of Transcriptomics and Proteomics to Elucidate Inhibitory Effect and Mechanism of Antifungalmycin B from Marine in Treating .

(TM) is an opportunistic pathogenic fungus that mainly infects immunocompromised patients. Currently, the global prevalence of talaromycosis caused by TM is increasing, leading to an increased demand for anti-TM drugs. In our previous study, a novel 28-membered macrolide compound, antifungalmycin B (ANB), was isolated from GXIMD 06359, exhibiting significant antifungal properties.

Chemical Constituents of the Deep-Sea-Derived Fungus Trichoderma simmonsii ZEN3.

Two new nor-rubrofusarin derivatives (trichsimins A and B, 1 and 2) and one new chromone derivative (trichsimin C, 5) were isolated from the deep-sea-derived Trichoderma simmonsii ZEN3 along with 20 known compounds (3, 4, and 6-23). The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and optical rotatory dispersion (ORD) data. Nafuredin (14) exhibited potent inhibition against RSL3-induced ferroptosis with an EC value of 5.

Asperhydrindane A, a new hydrindane derivate isolated from a mangrove-derived fungi GXIMD 03158.

A new hydrindane derivative, asperhydrindane A (), along with two known sterol analogues [isocyathisterol () and ganodermasides D ()] were isolated from the mangrove-derived fungus GXIMD 03158 attaching to the mangrove L. The structure of was elucidated based on extensive spectral analysis, HRESIMS, and calculated ECD methods. All compounds were evaluated for antibacterial activity.

Antifungal activity of bamemacrolactine C against Talaromyces marneffei and its possible mechanisms of action.

Aims: The present study aims to investigate the in vitro antifungal activity and mechanism of action of bamemacrolactine C (BAC), a new 24-membered macrolide compound, against Talaromyces marneffei.

Methods And Results: The test drug BAC initially demonstrated antifungal activity through a paper disk diffusion assay, followed by determination of the minimum inhibitory concentration value of 35.29 μg ml-1 using microdilution.

Antiproliferative effects of resorcylic acid lactones from the Beibu Gulf coral-derived fungus GXIMD 02512 on prostate cancer cells.

Four novel resorcylic acid lactones (RALs), curvulomycins A-D (1-4), and six known congeners were isolated from the Beibu Gulf coral-derived fungus GXIMD 02512. Their structures including absolute configurations were established by extensive spectroscopic analyses along with experimental and calculated ECD spectra. Structurally, compound 3 harbors a unique γ-pyrone moiety rarely found in the natural RAL family.

Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus sp. GXIMD 03101.

One new cyclic heptapeptide, cadophorin C (), and one known analogue cadophorin B () were isolated from the mangrove-derived fungus sp. GXIMD 03101 from the mangrove  L. The chemical structure of was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values.

Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.

Seven novel linear polyketides, talaketides A-G (1-7), were isolated from the rice media cultures of the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027. Among these, talaketides A-E (1-5) represented unprecedented unsaturated linear polyketides with an epoxy ring structure.

Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms.

Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties of anti-inflammatory natural products reported from marine microorganisms in the past three years (2021-2023). Approximately 252 anti-inflammatory compounds, including 129 new ones, were predominantly obtained from marine fungi and they are structurally divided into polyketides (51.

High-efficiency breeding of Bacillus siamensis with hyper macrolactins production using physical mutagenesis and a high-throughput culture system.

Macrolactins have attracted considerable attention due to their value and application in medicine and agriculture. However, poor yields severely hinder their broader application in these fields. This study aimed to improve macrolactins production in Bacillus siamensis using a combined atmospheric and room-temperature plasma mutagenesis and a microbial microdroplet culture system.

Millmerranones G, a meroterpene isolated from a mangrove-derived fungus sp. GXIMD 03004.

One new meroterpene derivative, millmerranones G (), and three known analogues (-) were identified from the mangrove-derived fungus sp. GXIMD 03004, which was isolated from the leaves of mangrove L. collected from Beibu Gulf in China.

Mauritone A, a new polyketide from a fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532.

A new polyketide, mauritone A () with six known polyketides curvulone B (), curvularin (), 12-oxocurvularin (), (10,15)-10,11-dehydrocurvularin (), (11,15)-11-hydroxycurvularin (), and (11,15)-11-hydroxycurvularin () were isolated from the fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532 derived from . Their structures were elucidated by extensive spectral analysis. All compounds (-) were evaluated for their anti-inflammatory effects.

New Cyclic Pentapeptides from the Mangrove-Derived GXIMD 03099.

Four new cyclic pentapeptides, avellanins D-G (-), together with four known compounds (-), were isolated from a mangrove-derived GXIMD 03099 fungus from L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method.

Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus GXIMD00544.

A pair of atropisomers secofumitremorgins C () and D (), together with fifteen known alkaloids (), were isolated from a saltern-derived fungus GXIMD00544. The structures of atropisomers and were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds and displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane sp.

Lactobacillus fermentum WC2020 increased the longevity of Caenorhabditis elegans via JNK-mediated antioxidant pathway.

Lactobacillus fermentum can exert antiaging effects, but their roles are strain-specific, and little is known about the molecular mechanisms in some strains. This study investigated the antiaging effects of L. fermentum WC2020 (WC2020) isolated from Chinese fermented pickles and the underlying mechanism of the action in Caenorhabditis elegans.

Peniditerpenoids A and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove-Sediment-Derived sp.

An unprecedented di--indole diterpenoid, peniditerpenoid A (), and a rare -oxide-containing indole diterpenoid derivative, peniditerpenoid B (), together with three known ones (-), were obtained from the mangrove-sediment-derived fungus sp. SCSIO 41411. Their structures were determined by the analysis of spectroscopic data, quantum chemical calculations, and X-ray diffraction analyses.

Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus sp.

Eleven new brominated depsidones, namely spiromastixones U-Z5 (-) along with five known analogues (-), were isolated from a deep-sea-derived fungus sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data.

Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus GXIMD00543.

Six benzophenone derivatives, carneusones A-F (-), along with seven known compounds (-) were isolated from a strain of sponge-derived marine fungus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds , , and exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.

New Alkaloids and Steroids from Hydranth of Goniopora columna Corals and Their Inhibiting Lung Cancer Cell Activities.

A new alkaloids, aplysingoniopora A (1), and new configuration pregnane type steroid compound, 9,17-α-pregn-1,4,20-en-3-one (2), and two known pregnane type steroid compounds (3 and 4) were isolated from hydranth of Goniopora columna corals. The compounds structures and absolute configurations were determined by extensive spectroscopic analysis, MS data, single-crystal X-ray diffraction analysis and quantum chemical calculation. The anticancer effect of the compounds were explored in human non-small-cell lung cancer (NSCLC) A549 cell lines.

Discovery of Anti-Hypercholesterolemia Agents Targeting LXRα from Marine Microorganism-Derived Natural Products.

A strategy integrating molecular docking with LXRα and phenotypic assays was adopted to discover anti-hypercholesterolemia agents in a small library containing 205 marine microorganism-derived natural products, collected by our group in recent years. Two fumitremorgin derivatives, 12,13-dihydroxyfumitremorgin C () and tryprostatin A (), were identified as potential LXRα agonists, by real-time qPCR and Western blot (WB) analysis, together with a surface plasmon resonance (SPR) assay. The anti-hypercholesterolemic effects of and , together with their mechanisms, were investigated in depth using different cell and mouse models, among which the study of LXRα is of crucial importance.