Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived sp. and sp.

Three new arthrichitin derivatives I-K (-) and three known congeners (-) were isolated from a coculture of mangrove-derived fungi sp. and sp. using H NMR-guided fractionation.

Sonnerachromones A-G, Antiaging Chromones from the Fruit of Mangrove .

Seven novel chromone derivatives, sonnerachromones A-G (-), were isolated from the fruit of mangrove . Compounds - contain a 6/5/6/6/tetracyclic system with rare -glycosyl spirocyclic skeletons. The unusual structures were identified by analysis of HRESIMS data, NMR spectra, electronic circular dichroism (ECD), DFT-calculated C NMR chemical shifts, DP4plus probability analysis, and single-crystal X-ray diffraction.

Bioactive Sesterterpenoids from the Mangrove-Derived sp. GXIMD 03023.

Four novel sesterterpenoids, asperterpenoids Q-T (-), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated C NMR chemical shifts, and DP4plus probability analysis.

Asperhydrindane A, a new hydrindane derivate isolated from a mangrove-derived fungi GXIMD 03158.

A new hydrindane derivative, asperhydrindane A (), along with two known sterol analogues [isocyathisterol () and ganodermasides D ()] were isolated from the mangrove-derived fungus GXIMD 03158 attaching to the mangrove L. The structure of was elucidated based on extensive spectral analysis, HRESIMS, and calculated ECD methods. All compounds were evaluated for antibacterial activity.

Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus sp. GXIMD 03101.

One new cyclic heptapeptide, cadophorin C (), and one known analogue cadophorin B () were isolated from the mangrove-derived fungus sp. GXIMD 03101 from the mangrove  L. The chemical structure of was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values.

Millmerranones G, a meroterpene isolated from a mangrove-derived fungus sp. GXIMD 03004.

One new meroterpene derivative, millmerranones G (), and three known analogues (-) were identified from the mangrove-derived fungus sp. GXIMD 03004, which was isolated from the leaves of mangrove L. collected from Beibu Gulf in China.

Mauritone A, a new polyketide from a fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532.

A new polyketide, mauritone A () with six known polyketides curvulone B (), curvularin (), 12-oxocurvularin (), (10,15)-10,11-dehydrocurvularin (), (11,15)-11-hydroxycurvularin (), and (11,15)-11-hydroxycurvularin () were isolated from the fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532 derived from . Their structures were elucidated by extensive spectral analysis. All compounds (-) were evaluated for their anti-inflammatory effects.

Sonneralignan A, a new lignan from the fruit of mangrove .

A new lignan, sonneralignan A (), along with two known lignan compounds, (+)-lariciresinol-9---D-glucopyranoside () and (-)isolariciresinol-9---D-glucopyranoside () were isolated from the n-butanol extract of the mangrove fruit. The structures of the compounds were elucidated on the basis of extensive spectral analysis. The evaluation of activity showed that compound exhibited significant anti-aging activity, which extended the mean lifespan of by up to 19.

Sonneradon A Extends Lifespan of by Modulating Mitochondrial and IIS Signaling Pathways.

Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove , showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear.

Marinoid J, a phenylglycoside from fruit, ameliorates cognitive impairment in rat vascular dementia: a quantitative iTRAQ proteomic study.

Context: Fruit of (Forsk.) Vierh. (Acanthaceae) is used as a Chinese herb.

Nocardioides kandeliae sp. nov., an endophytic actinomycete isolated from leaves of Kandelia candel.

A Gram-stain-positive, aerobic, non-spore-forming, atrichous and short rod-shaped endophytic actinomycete, designated strain BGMRC 2075, was isolated from the leaves of Kandelia candel, and was subjected to polyphasic characterization to unravel its taxonomic position. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain BGMRC 2075 belongs to the genus Nocardioides ,showing the highest 16S rRNA gene sequence similarity to Nocardioides aestuarii JC2056 (96.1 %), Nocardioides agariphilus MSL-28 (95.

An update on 2,5-diketopiperazines from marine organisms.

2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014.

New antioxidative secondary metabolites from the fruits of a Beibu Gulf mangrove, Avicennia marina.

Further chemical investigation of the fruits of the mangrove, Avicennia marina, afforded three new phenylethyl glycosides, marinoids J-L (1-3), and a new cinnamoyl glycoside, marinoid M (4). The structures of isolates were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related secondary metabolites. The antioxidant activity of the isolates was evaluated using the cellular antioxidant assay (CAA), and compounds 1-4 showed antioxidant activities, with EC50 values ranging from 23.

Four new Jacaranone analogs from the fruits of a Beibu Gulf mangrove Avicennia marina.

Four new jacaranone analogs, marinoids F-I (1-4), were isolated from the fruits of a Beibu Gulf mangrove Avicennia marina. The structures were elucidated based on analysis of spectroscopic data. Marinoids F and G are shown to be diastereoisomers of chlorocornoside, a new halogen containing marine secondary metabolite.