Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove , showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear. In this article, we studied the function of SDA in antiaging by using the animal model . Results showed that SDA inhibited production of reactive oxygen species (ROS) by 53%, and reduced the accumulation of aging markers such as lipids and lipofuscins. Moreover, SDA also enhanced the innate immune response to infection. Genetic analysis of a series of mutants showed that SDA extended the lifespan of the mutants of and . Together, this effect may be related to the enhanced resistance to oxidative stress via mitochondrial and insulin/insulin-like growth factor-1 signaling (IIS) pathways. The results of this study provided new evidence for an antiaging effect of SDA in as well as insights into the implication of antiaging activity of SDA in higher organisms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778700 | PMC |
| http://dx.doi.org/10.3390/md20010059 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prospective study on combined use of Sabouraud dextrose agar and blood agar for improved recovery of etiological agents in mycotic and Pythium keratitis.
J Microbiol Methods
September 2025
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:
We evaluated the effectiveness of using blood agar (BA) and Sabouraud dextrose agar (SDA) together to isolate fungi and Pythium insidiosum for the diagnosis of fungal and Pythium keratitis respectively. The overall recovery rate was higher in SDA than BA (93.75 % vs 88.
View Article and Find Full Text PDFHigh transposable element expression in sarcomas is associated with increased immune infiltrates and improved outcomes including after immunotherapy.
J Immunother Cancer
September 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background: Response to immune checkpoint inhibition (ICI) in sarcomas is overall low and heterogeneous. Understanding determinants of ICI outcomes may improve efficacy and patient selection. Thus, we investigated whether the expression of transposable elements (TEs), which are epigenetically silenced and can stimulate antitumor immunity, influence ICI outcomes and immune infiltrates in common sarcoma subtypes.
View Article and Find Full Text PDFMeso-organisational determinants of healthcare workers' resilience: results of a scoping review.
Health Policy
August 2025
MRM, University of Montpellier, Montpellier, France. Electronic address:
Background: Recent financial, environmental, and health crises have underscored the critical-but often overlooked-role of healthcare workers (HCWs) for health system resilience. Given the ongoing physical and psychological demands placed on this workforce, understanding the factors that influence their resilience is essential.
Objective: This scoping review aimed to map and synthesise multidisciplinary evidence on meso-level organisational factors that influence individual resilience among HCWs.
GCNMF-SDA: predicting snoRNA-disease associations based on graph convolution and non-negative matrix factorization.
Brief Bioinform
August 2025
College of Information and Artificial Intelligence, Anhui Agricultural University, 130, Changjiang West Road, Hefei, Anhui Province 230036, China.
Small nucleolar RNAs (snoRNAs) play crucial roles in a wide range of biological processes, and studying their association with diseases can enhance our understanding of disease pathogenesis. Nevertheless, current knowledge of these associations is limited traditional biological experiments are both costly and time-consuming. Consequently, developing efficient computational methods is essential for predicting potential snoRNA-disease associations.
View Article and Find Full Text PDFCRISPR-SDA: an integrated isothermal amplification and CRISPR-Cas12a biosensing platform for sensitive detection of microRNA-21.
Anal Methods
September 2025
College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471023, China.
MicroRNA-21 (miRNA-21), a critical oncogenic biomarker, poses detection challenges due to low abundance and limitations of conventional methods. Herein, we developed a novel CRISPR-SDA biosensing platform by integrating strand displacement amplification (SDA) with CRISPR-Cas12a, leveraging SDA's efficient isothermal amplification of miRNA-21 and Cas12a's precise target recognition and -cleavage activity for signal amplification. Optimized conditions achieved high sensitivity with a detection limit of 10.
View Article and Find Full Text PDF