Comparative analysis of pachymetry and assessment of corneal topography in pediatric congenital corneal opacities: A study of AS-OCT and UBM imaging modalities.

This study aimed to assess the interchangeability of pachymetry measurements obtained by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in children with congenital corneal opacity (CCO). In this single-centre, comparative case series, children with unilateral or bilateral CCO who underwent examination under anesthesia (EUA) were evaluated using both AS-OCT and UBM. Pachymetry values from both modalities were compared using Bland-Altman analysis, and topography maps from AS-OCT were examined.

Effect of gamma radiation on in vitro morphogenesis, anatomy and DNA polymorphism of Moringa concanensis Nimmo.

The current study explores the impact of gamma radiation on the in vitro morphogenesis of Moringa concanensis. In vitro regenerated shoots were exposed to Barium and Cobalt gamma radiation sources for varying lengths of time (3, 6, 9, and 15 min). All the treated shoots survived with 100% regeneration frequency.

A Rare Riding Horse on the Ovary: Metastatic Neuroendocrine Tumour from Liver.

Neuroendocrine tumours are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are benign, while some are malignant. Neuroendocrine tumours of the ovary are rare and of uncertain histogenesis.

Acute corneal hydrops secondary to acquired syphilis.

PurposeTo report a rare case of acute corneal hydrops and conjunctival ulceration secondary to acquired syphilis.MethodsA male in his late 30's presented with redness, pain, and watering in both eyes and sudden loss of vision in the left eye. Examination revealed bilateral conjunctival ulcers along with well-circumscribed corneal edema with blunt stunted intrinsic vessel in the left eye.

Assessment of Burnout among Healthcare Practitioners in India: A Survey-based Nationwide Study.

Background: Healthcare practitioners (HCPs) face high stress levels at work due to the demanding nature of their profession, making them more susceptible to burnout. The objective of the study is to assess the prevalence of burnout among HCPs in India and to examine its relationship with age, gender, and working hours.

Materials And Methods: A descriptive cross-sectional, pan India study was conducted from October 6 to 26, 2022.

A protocolised approach provides a favourable outcome in patients with severe pelvic trauma.

Background Pelvic fractures are often a result of injuries caused by a major force and lead to considerable morbidity and mortality. Despite advances in acute management protocols involving angioembolization as a prime intervention, mortality in complex pelvic fractures remains high. We analysed our experience with the outcomes of a pelvic trauma management protocol using surgical haemostatic techniques over 5 years.

Digital foundations for health equity: Rethinking primary care through the Ayushman Bharat digital mission.

The Ayushman Bharat Digital Mission (ABDM) marks a pivotal step in India's journey toward a unified, citizen-centric health ecosystem. Its integration with primary healthcare (PHC)-the most accessible and foundational tier of service delivery-offers transformative potential. By enabling unique digital health IDs, interoperable health records, and consent-based data sharing, ABDM promises to improve continuity of care, empower frontline health workers, and support the long-term management of chronic diseases at the community level.

Patient experience of head and neck treatment on a 1.5 T MR-Linac: is the ATS-lite adaptive solution tolerable?

Introduction: Head and neck cancer (HNC) treatment on the Unity MR-Linac (MRL) (Elekta AB, Stockholm, Sweden) has been developed using the novel adapt-to-shape Lite (ATS-lite) method to create clinically acceptable adaptive treatments clinician-free. Here we investigate patient experience and acceptability of this technique.

Methods: Ten HNC patients treated to 65 Gy in 30 fractions with MRI-guided adaptive radiotherapy (MRIgART) within the PERMIT trial (NCT03727698), were included.

Brittle Cornea Syndrome Type 1 in Siblings: Severe Presentation in One and Misdiagnosis as Primary Congenital Glaucoma in the Other.

Purpose: The purpose of this study was to present two cases of brittle cornea syndrome (BCS) in siblings, one with severe corneal perforation and the other misdiagnosed as primary congenital glaucoma, emphasizing clinical, histopathological, and genetic findings.

Methods: This was a case report involving a 4-year-old boy and his 8-year-old brother, both presenting with thin, steep corneas. Clinical examination, Pentacam imaging, genetic analysis, systemic evaluation, and corneal histopathology were performed.

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) Society and International Association of Trauma Surgery and Intensive Care (IATSIC) Recommendations: Paper 1: Initial Care-Pre and Intraoperative Care Until ICU, Including Non-Operative Management.

Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality.

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations.

Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality.

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Part 3: Trauma Ethics and Systems Aspects.

Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality.

Optimizing Bone Health in Diabetes: Strategies for Fracture Risk Reduction in Public Healthcare.

Purpose Of Review: In this review, we explore the under-recognized burden of fractures in diabetes, focusing on resource-constrained healthcare systems. We examine the epidemiology, assessment methodologies, and management approaches to osteoporosis in diabetes and discuss strategies to improve skeletal health outcomes.

Recent Findings: Public healthcare strategies for fracture risk reduction in diabetes include educating healthcare providers, empowering patients, and integrating fracture liaison services for secondary prevention.

Navigation Assistance in Orthopedic Oncosurgery: Our Early Experience.

The primary objective of orthopedic oncologists is to perform bone tumor surgeries with tumor-free margins for malignant tumors and complete clearance of benign bone diseases. The functional outcome depends on the salvage of important structures and optimal reconstruction of the bony defect. On-going advances in technology have helped in 3-dimensional templating of patient's anatomy and real-time tracking of instruments during surgery.

Management of post-cataract surgery corneal fungal tunnel infections.

Purpose: To describe the clinical presentation, microbiological evaluation, and management of post-cataract surgery corneal fungal tunnel infections.

Setting: Tertiary Eye Care Centre.

Methods: This was a retrospective observational study of 16 patients with corneal fungal tunnel infection post-cataract surgery.

Role of Tranexamic Acid in the Management of Chronic Subdural Hematoma: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Chronic subdural hematoma (cSDH) is a prevalent neurosurgical disorder with increasing incidence, especially among the geriatric population. Although surgical management has been the conventional approach, the optimal strategy remains debated. Tranexamic acid (TXA), an antifibrinolytic agent, has emerged as a potential alternative, but its efficacy and safety require thorough investigation.

Early perfusion computed tomography in severe acute pancreatitis: Predicting necrosis and guiding care.

Introduction: Early identification of pancreatic necrosis in severe acute pancreatitis (SAP) is essential for timely intervention and improved outcomes. While prior studies have established the diagnostic value of perfusion computed tomography (PCT), they often lacked early follow-up and clinical integration. This study aims to evaluate PCT not only as a predictive tool for early necrosis but also as a clinically actionable modality for risk stratification and management planning.

Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.

Introduction: While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored.

Methods: We conducted a comprehensive analysis of RNA editing across nine human brain regions affected by AD, utilizing RNA-seq data and matched whole-genome sequencing data from three human brain biobanks, adjusting for age, post mortem interval, sex, and apolipoprotein E4 (APOE4) status.

Results: RNA-editing events were identified in both AD and healthy control aging brains, highlighting 127 genes with significant RNA editing loci.

Guillain-Barré Syndrome Associated With COVID-19 Infection: A Case Report and Review of Pathophysiology, Risk Factors, and Management.

Guillain-Barré syndrome (GBS) is a rare but serious autoimmune neuropathy involving autoimmune destruction of peripheral nerves and rapidly ascending paralysis. Since the start of the COVID-19 pandemic, cases of COVID-19-associated GBS have been increasing in the literature. Although the definitive pathophysiology remains to be studied, SARS-CoV-2 infection is suspected to promote molecular mimicry and induce the development of autoantibodies against peripheral nerves, leading to GBS and its associated manifestations.