Prevalence and Outcomes of Competitive Athletes From the United States With Electrocardiographic Athletic Anterior Early Repolarization.

Background: Early repolarization associated with T-wave inversions in the anterior leads (V-V) is considered a normal electrocardiographic (ECG) finding for athletes who self-identify as Black. To date, data defining the prevalence and clinical outcomes of this ECG pattern among non-Black athletes are limited.

Objectives: The authors sought to determine the prevalence and outcomes of anterior early repolarization with T-wave inversions in a diverse, multicenter, and multisport cohort of U.

Cognitive function changes during a course of electroconvulsive therapy in patients with various psychiatric illnesses: A prospective observational study.

Background: Electroconvulsive therapy (ECT) is an effective treatment for severe psychiatric disorders, but concerns about cognitive side effects persist.

Aim: To assess cognitive function changes during ECT in patients with various psychiatric illnesses.

Materials And Methods: This prospective observational study included 100 patients (aged 18-60 years) with psychiatric disorders scheduled for ECT at a tertiary care hospital.

A Low-Grade Angiomyxofibromatous Tumor of the Falx Cerebelli: A Mimic of Fourth Ventricular Tumors.

Low-grade fibromyxoid tumors are very uncommon in children. A tumor of this type has never been reported in the posterior fossa to date. Such lesions may mimic more common lesions of the posterior fossa.

Transcatheter Mitral Valve Replacement Using Contemporary Dedicated Devices: A Systematic Review and Meta-Analysis.

Background: Dedicated transcatheter mitral valve replacement (TMVR) devices have emerged as a promising strategy for treating mitral regurgitation (MR) in high-risk patients with complex native valve anatomy. Early experience spans multiple devices utilizing both transapical and transseptal access. The aim of this study was to evaluate procedural, 30-day, and midterm outcomes of TMVR with contemporary dedicated mitral devices in patients with native MR.

Assessment of Patient Knowledge and Potential Screening Gaps in Vitamin B12 Deficiency.

Introduction Vitamin B12 is an essential nutrient that functions as a coenzyme in the nervous system and is critical for the synthesis of myelin and neurotransmitters. Vitamin B12 deficiency disrupts these processes and is associated with significant neurological impairment. Our study aimed to evaluate patient awareness of vitamin B12 deficiency and perceived health risks, as well as to identify potential gaps in its screening.

Direct in-scope suction (DISS) ureteroscopy: techniques, outcomes and future directions.

Objective: To provide an overview of direct in-scope suction (DISS) ureteroscopy, an emerging technology that integrates suction directly into the ureteroscope with the aim of enhancing stone clearance, improving visualisation, and reducing intrarenal pressure during ureteroscopic stone surgery.

Methods: We performed a narrative review of the current literature and incorporated insights from the authors' clinical experience using DISS ureteroscopy systems.

Results: Direct in-scope suction ureteroscopes are either single-channel or dual-channel.

An intranasal quadruple variant vaccine approach using SARS-CoV-2 and influenza A: Delta, Omicron, H1N1and H3N2.

Influenza and SARS-CoV-2 viruses are both responsible for respiratory tract infections that have caused global outbreaks. Due to frequent mutations, the CDC recommends annual COVID-19 vaccination (CDC Staying Up to Date with COVID-19 Vaccines, 2025), and studies confirm the safety of co-administering it with the flu shot (CDC Getting a Flu Vaccine and Other Recommended Vaccines at the Same Time, 2025). A combination vaccine streamlines dual immunization, reducing the need for separate vaccinations.

The Impact of Age on Aortic Root Replacement.

Objectives: Aortic root replacement is increasingly being performed in the treatment of aortic root and valve pathology. While many of these procedures are performed during the fifth or sixth decade of life, differences in outcomes based on age remain largely unknown. Therefore, we examined short- and long-term outcomes of root replacement stratified by age.

Ischemic monomelic neuropathy as a consequence of intraoperative in-sheath thrombosis.

Ischemic monomelic neuropathy (IMN) is a rare peripheral neuropathy caused by limb ischemia and subsequent nerve degeneration, typically manifesting with unilateral pain, paresthesia, and numbness without overt signs of limb ischemia. This case report describes a 59-year-old female with extensive peripheral artery disease who developed IMN in her right lower extremity following an acute, intraoperative in-sheath thrombosis during a right femoral endarterectomy and external iliac artery stent placement, a rare etiology distinct from the more commonly reported associations with bypass surgery or hemodialysis access. Despite successful intraoperative revascularization, the patient developed diminished motor and sensory function with unremitting pain, and subsequent electromyography confirmed a length-dependent neuropathy with features of denervation, consistent with IMN.

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain.

Background: Pain and sickness behaviors can be elicited by systemic inflammation. We sought to determine if mature rats displayed these behaviors following overuse injury and whether they correlated with inflammatory cytokines in musculoskeletal tissues, circulation, and the brain.

Methods: Mature female Sprague-Dawley rats were used: 26 controls and 41 rats trained across 6 weeks to pull at high force levels.

Valve-sparing root replacement: How old is too old?

Objective: Valve-sparing root replacement (VSRR) is associated with excellent short- and long-term outcomes. Although typically offered in young patients, VSRR is performed over a wide age range, including into the eighth decade of life. This study analyzed the influence of age and preoperative comorbidities on operative outcomes, reoperation, and survival following VSRR.

Engagement in Plastic Surgery Content on YouTube: A Comprehensive Analysis.

Background: As the digital age progresses, individuals are increasingly seeking online websites for the dissemination of information. YouTube, the most popular free video streaming platform worldwide, garners over 2 billion users. Plastic surgery information is widely available on YouTube and acts as a common interface for the distribution of plastic surgery-related information.

Guillain-Barré Syndrome Associated With COVID-19 Infection: A Case Report and Review of Pathophysiology, Risk Factors, and Management.

Guillain-Barré syndrome (GBS) is a rare but serious autoimmune neuropathy involving autoimmune destruction of peripheral nerves and rapidly ascending paralysis. Since the start of the COVID-19 pandemic, cases of COVID-19-associated GBS have been increasing in the literature. Although the definitive pathophysiology remains to be studied, SARS-CoV-2 infection is suspected to promote molecular mimicry and induce the development of autoantibodies against peripheral nerves, leading to GBS and its associated manifestations.

Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies.

Metabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of MASLD are still being elucidated.

Unplanned coronary artery bypass graft in aortic root replacement†.

Objectives: Trouble with coronary artery reimplantation at aortic root replacement (ARR) may require unexpected coronary artery bypass graft (CABG). This study aims to elucidate the outcomes of such unplanned CABG during ARR.

Methods: This is retrospective study from 2 aortic centres that underwent ARR from 2004 to 2021.

Twist of Fate: Life-Threatening SMA Thrombosis Caused by Mesenteric Torsion Post-Roux-en-Y Weight Loss.

Superior mesenteric artery (SMA) thrombosis is rare yet critical illness that can result in lethal bowel ischemia and infarction. This report details a case of SMA thrombosis with associated superior mesenteric vein (SMV) narrowing, secondary to mesenteric torsion in a 26-year-old female with history of Roux-en-Y gastric bypass surgery. The patient's presenting symptoms were severe epigastric pain, vomiting, and significant anemia.

An Increase in Mean Aortic Valve Gradients the Day After Transcatheter Aortic Valve Implantation: The Effects of Evolving Anesthesia Techniques.

: After transcatheter aortic valve implantation (TAVI), transvalvular gradients increase immediately following the procedure up to 24 h afterward. While factors such as anesthesia type and fluid status have been suggested as potential contributors, the underlying cause remains unclear. With advancements in TAVI techniques, there has been a shift in anesthesia protocols from general anesthesia (GA) to monitored anesthesia care (MAC).

Impact of atrial fibrillation on in-hospital outcomes following endoscopic retrograde cholangiopancreatography: a propensity score-matched analysis of the National Inpatient Sample (2016-2020).

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a critical tool in managing hepatobiliary and pancreatic diseases. Atrial fibrillation (AF) has been associated with greater morbidity in patients undergoing ERCP. This study compared in-hospital ERCP outcomes in patients with and without AF.

Fitness and Mortality Outcomes Associated With Supramaximal Peak Heart Rate on Treadmill Exercise Stress Testing.

Inability to reach age-predicted peak heart rate (APPHR) on treadmill exercise testing (TMET) is associated with lower fitness and increased mortality. The significance of a "supramaximal" heart rate (≥105% of APPHR) is poorly understood; as such, we sought to investigate this relationship. We queried the Mayo Stress database from 1993 to 2010 for patients >30 years old without cardiovascular disease and not on antichronotropic therapy.